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Aliases for TMEM206 Gene

Aliases for TMEM206 Gene

  • Transmembrane Protein 206 2 3
  • C1orf75 3 4
  • Chromosome 1 Open Reading Frame 75 2

External Ids for TMEM206 Gene

Previous Symbols for TMEM206 Gene

  • C1orf75

Summaries for TMEM206 Gene

GeneCards Summary for TMEM206 Gene

TMEM206 (Transmembrane Protein 206) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM206 Gene

Genomics for TMEM206 Gene

Genomic Location for TMEM206 Gene

Start:
212,363,931 bp from pter
End:
212,414,925 bp from pter
Size:
50,995 bases
Orientation:
Minus strand

Genomic View for TMEM206 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM206 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM206 Gene

Regulatory Elements for TMEM206 Gene

Proteins for TMEM206 Gene

  • Protein details for TMEM206 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H813-TM206_HUMAN
    Recommended name:
    Transmembrane protein 206
    Protein Accession:
    Q9H813
    Secondary Accessions:
    • B7Z4D6
    • Q6IA87
    • Q9NV85

    Protein attributes for TMEM206 Gene

    Size:
    350 amino acids
    Molecular mass:
    40043 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM206 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM206 Gene

Proteomics data for TMEM206 Gene at MOPED

Post-translational modifications for TMEM206 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys166
  • Glycosylation at Asn148, Asn155, and Asn162

Other Protein References for TMEM206 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM206 Gene

Domains for TMEM206 Gene

Protein Domains for TMEM206 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM206_HUMAN
Family:
  • Belongs to the TMEM206 family.:
    • Q9H813
genes like me logo Genes that share domains with TMEM206: view

No data available for Gene Families for TMEM206 Gene

Function for TMEM206 Gene

Phenotypes for TMEM206 Gene

GenomeRNAi human phenotypes for TMEM206:
genes like me logo Genes that share phenotypes with TMEM206: view

miRNA for TMEM206 Gene

miRTarBase miRNAs that target TMEM206

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM206 Gene

Localization for TMEM206 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM206 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM206 Gene COMPARTMENTS Subcellular localization image for TMEM206 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM206 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009986 cell surface IDA 19581412
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM206: view

Pathways for TMEM206 Gene

SuperPathways for TMEM206 Gene

No Data Available

Interacting Proteins for TMEM206 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000438863%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000438863 for TMEM206 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM206 Gene

None

No data available for Pathways by source for TMEM206 Gene

Transcripts for TMEM206 Gene

Unigene Clusters for TMEM206 Gene

Transmembrane protein 206:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM206 Gene

No ASD Table

Relevant External Links for TMEM206 Gene

GeneLoc Exon Structure for
TMEM206
ECgene alternative splicing isoforms for
TMEM206

Expression for TMEM206 Gene

mRNA expression in normal human tissues for TMEM206 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM206 Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (10.4) and Brain - Substantia nigra (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM206 Gene

SOURCE GeneReport for Unigene cluster for TMEM206 Gene Hs.445386

genes like me logo Genes that share expressions with TMEM206: view

Orthologs for TMEM206 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM206 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM206 36
  • 99.24 (n)
  • 99.14 (a)
TMEM206 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM206 36
  • 90.1 (n)
  • 92.57 (a)
TMEM206 37
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM206 36
  • 92.67 (n)
  • 94.29 (a)
TMEM206 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem206 36
  • 86.38 (n)
  • 90.57 (a)
Tmem206 16
Tmem206 37
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM206 37
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM206 37
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem206 36
  • 87.05 (n)
  • 90.86 (a)
chicken
(Gallus gallus)
Aves TMEM206 36
  • 71.54 (n)
  • 73.93 (a)
TMEM206 37
  • 72 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM206 37
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem206 36
  • 69.16 (n)
  • 67.82 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem206 36
  • 64.28 (n)
  • 61.09 (a)
tmem206 37
  • 55 (a)
OneToOne
zgc63579 36
Species with no ortholog for TMEM206:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM206 Gene

ENSEMBL:
Gene Tree for TMEM206 (if available)
TreeFam:
Gene Tree for TMEM206 (if available)

Paralogs for TMEM206 Gene

No data available for Paralogs for TMEM206 Gene

Variants for TMEM206 Gene

Sequence variations from dbSNP and Humsavar for TMEM206 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs14643 -- 212,364,566(+) CTTTT(A/G)AGTGT utr-variant-3-prime
rs512458 -- 212,415,551(-) TTCAT(A/G)GGCCT upstream-variant-2KB
rs518793 -- 212,414,864(-) GGACC(C/G)GTTTC utr-variant-5-prime
rs701905 -- 212,379,769(+) GGCCA(C/G)TGGGT intron-variant
rs701906 -- 212,376,202(+) GGCTC(A/G)GATCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM206 Gene

Variant ID Type Subtype PubMed ID
esv6419 CNV Gain 19470904
nsv873156 CNV Gain 21882294

Relevant External Links for TMEM206 Gene

HapMap Linkage Disequilibrium report
TMEM206

Disorders for TMEM206 Gene

No disorders were found for TMEM206 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM206 Gene

Publications for TMEM206 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM206 Gene

  • antibodies-online peptides for TMEM206
  • antibodies-online antibodies for TMEM206
  • antibodies-online kits for TMEM206

Sources for TMEM206 Gene

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