TMEM205 Gene
protein-coding GIFtS: 41
GCID: GC19M011453
|
|
transmembrane protein 205
| |
Aliases
for TMEM205 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2051 2 | | MBC32051 2 | | UNQ5011 2 |
Export aliases for TMEM205 gene to outside databasesPrevious GC identifers: GC19M011316 GC19M011029 |
Summaries
for TMEM205 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM205_HUMAN, Q6UW68Function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin
|
Genomic Views
for TMEM205 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000019.9 NC_018930.1 NT_011295.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM205 gene promoter:
E2F-4 E2F-3a E2F-5 E2F-2 c-Ets-1 Max E2F E2F-1 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM205
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM205 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19p13.2 Ensembl cytogenetic band: 19p13.2 HGNC cytogenetic band: 19p13.2TMEM205 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M011453: view genomic region
(about GC identifiers)
Start:
|
11,453,452 bp from pter |
End:
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11,457,194 bp from pter |
Size:
|
3,743 bases |
Orientation:
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minus strand |
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Proteins
for TMEM205 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM205_HUMAN, Q6UW68 (See
protein sequence)Recommended Name: Transmembrane protein 205 Size: 189 amino acids; 21198 Da
Subcellular location: Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells,transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatinresistanceExplore the universe of human proteins at neXtProt for TMEM205: NX_Q6UW68
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q6UW68
TMEM205 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001138888.1 NP_212133.1 NP_940938.1
ENSEMBL proteins: ENSP00000467493 ENSP00000346954 ENSP00000466986 ENSP00000465483 ENSP00000465553 ENSP00000465149 ENSP00000468733 ENSP00000466495 ENSP00000466310 ENSP00000466672 ENSP00000466180 ENSP00000465283 ENSP00000468056 ENSP00000398258
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM205 for ontologies About GeneDecksing
TMEM205 Antibody Products:
Assay Products for TMEM205: |
Protein
Domains /
Families
for TMEM205 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM205 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q6UW68ProtoNet protein and cluster: Q6UW68 UniProtKB/Swiss-Prot: TM205_HUMAN, Q6UW68Similarity: Belongs to the TMEM205 family |
Function
for TMEM205 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM205_HUMAN, Q6UW68Function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM205 (NM_001145416) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM205 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM205 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM205 |
|
Pathways & Interactions
for TMEM205 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM205
|
Drugs & Compounds
for TMEM205 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM205
Search CenterWatch for drugs/clinical trials and news about TMEM205 / TM205
|
Transcripts
for TMEM205 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM205 gene (3 alternative transcripts): NM_001145416.1 NM_033408.3 NM_198536.2 Unigene Cluster for TMEM205: Transmembrane protein 205 Hs.8036 [show with all ESTs]Unigene Representative Sequence: NM_19853616 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000586218 ENST00000354882(uc002mqz.2) ENST00000585722 ENST00000586590
ENST00000586956 ENST00000589555 ENST00000587948 ENST00000593256 ENST00000588560
ENST00000588321 ENST00000586701 ENST00000592952 ENST00000590482 ENST00000591677
ENST00000590788 ENST00000447337(uc002mra.2 uc002mrb.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM205 (NM_001145416) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM205 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM205 |
Additional cDNA sequence: AK291979.1 AY358949.1 BC008365.1 BC064948.1 BC091472.1 18 DOTS entries: DT.91764791 DT.100036621 DT.95100343 DT.100656512 DT.99949269 DT.121497492 DT.121497424 DT.91764793 DT.117229 DT.121497430 DT.86854680 DT.100036622 DT.121497423 DT.121497458 DT.95228555 DT.121497414 DT.121497451 DT.97859438 24/424 AceView cDNA sequences (see all 424): AW407316 AA303056 BU179008 BQ478425 BI758107 BQ233209 BU732118 AW002095 AA402550 BG686934 BU734255 AI200178 BM792080 BU539806 BQ182295 CK299243 AI418957 W67281 BE673346 BU153815 BX509018 BE645743 BM826449 BM974589
GeneLoc Exon Structure
5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 (see all 8) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5a | · | 5b | · | 5c | · | 5d | · | 5e | · | 5f | · | 5g |
|---|
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| SP1: | | | | | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | - | | - | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM205
|
Expression
for TMEM205 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM205 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTAATAAATG
About this image
See TMEM205 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM205
SOURCE GeneReport for Unigene cluster: Hs.8036
UniProtKB/Swiss-Prot: TM205_HUMAN, Q6UW68Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver,mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistantcancer cells (at protein level)
SABiosciences Custom PCR Arrays for TMEM205
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM205
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM205 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM205 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM205 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM205 |
Orthologs
for TMEM205 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM205 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for TMEM205 (if available)
TreeFam Gene Tree for TMEM205 (if available) |
Paralogs
for TMEM205 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM205 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM205 (11453452 - 11457194 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM205: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM205 |
|
Disorders
/ Diseases
for TMEM205 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM205 for disorders About GeneDecksing
OMIM gene information: 613771
OMIM disorders: --
2  diseases for TMEM205: About MalaCardsthyroiditis prostatitis
Export disorders for TMEM205 gene to outside databases
|
Publications
for TMEM205 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM205 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM205) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
- Elevated expression of TMEM205, a hypothetical membra ne protein, is associated with cisplatin resistance. (PubMed id 20589834)1, 2 Shen D.W....Gottesman M.M. (2010)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM205 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM205 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM205 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM205 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM205 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM205 gene:
Search GeneIP for patents involving TMEM205
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM205 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM205 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM205 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM205 | | | OriGene Protein Over-expression Lysate for TMEM205 | | Browse OriGene Fluorogenic Cell Assay Kits | | | Browse OriGene siRNAs | | OriGene 3'-UTR Clone for TMEM205 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM205 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM205 | | OriGene Custom Protein Services for TMEM205 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM205 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM205 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM205 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM205 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM205 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM205 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM205 |
| |  |  |  |  | | | | |
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 | | | TMEM205 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM205 |
|  |  |  | | | | ThermoFisher Antibodies for TMEM205 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM205 |
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