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Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3
  • MBC3205 3
  • UNQ501 3

External Ids for TMEM205 Gene

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

Genomic Location for TMEM205 Gene

Start:
11,342,776 bp from pter
End:
11,346,518 bp from pter
Size:
3,743 bases
Orientation:
Minus strand

Genomic View for TMEM205 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Regulatory Elements for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW68-TM205_HUMAN
    Recommended name:
    Transmembrane protein 205
    Protein Accession:
    Q6UW68
    Secondary Accessions:

    Protein attributes for TMEM205 Gene

    Size:
    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Proteomics data for TMEM205 Gene at MOPED

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains for TMEM205 Gene

Protein Domains for TMEM205 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM205_HUMAN
Family:
  • Belongs to the TMEM205 family.:
    • Q6UW68
genes like me logo Genes that share domains with TMEM205: view

No data available for Gene Families for TMEM205 Gene

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function: In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM205 Gene COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
extracellular 2
plasma membrane 2
cytosol 1
mitochondrion 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM205: view

Pathways for TMEM205 Gene

SuperPathways for TMEM205 Gene

No Data Available

Interacting Proteins for TMEM205 Gene

Gene Ontology (GO) - Biological Process for TMEM205 Gene

None

No data available for Pathways by source for TMEM205 Gene

Transcripts for TMEM205 Gene

Unigene Clusters for TMEM205 Gene

Transmembrane protein 205:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for
TMEM205
ECgene alternative splicing isoforms for
TMEM205

Expression for TMEM205 Gene

mRNA expression in normal human tissues for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM205 Gene

SOURCE GeneReport for Unigene cluster for TMEM205 Gene Hs.8036

mRNA Expression by UniProt/SwissProt for TMEM205 Gene

Q6UW68-TM205_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).
genes like me logo Genes that share expressions with TMEM205: view

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM205 36
  • 99.65 (n)
  • 100 (a)
TMEM205 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM205 36
  • 88.95 (n)
  • 88.57 (a)
TMEM205 37
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM205 36
  • 89.77 (n)
  • 88.89 (a)
TMEM205 37
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem205 36
  • 81.48 (n)
  • 79.37 (a)
Tmem205 16
Tmem205 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM205 37
  • 59 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem205 36
  • 80.78 (n)
  • 83.07 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM205 37
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem205 36
  • 59.57 (n)
  • 52.13 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem205 36
  • 54.75 (n)
  • 45.25 (a)
tmem205 37
  • 43 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 36
  • 43.35 (n)
  • 35.58 (a)
rice
(Oryza sativa)
Liliopsida Os11g0673100 36
  • 47.49 (n)
  • 35.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 24 (a)
OneToOne
Species with no ortholog for TMEM205:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

ENSEMBL:
Gene Tree for TMEM205 (if available)
TreeFam:
Gene Tree for TMEM205 (if available)

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

Sequence variations from dbSNP and Humsavar for TMEM205 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs7245780 -- 11,344,363(+) aaaag(A/G)aaaaa intron-variant
rs8109430 -- 11,342,647(+) GGAGA(A/G)GCTTA downstream-variant-500B
rs12976443 -- 11,342,542(+) AAACA(A/G)AACAA downstream-variant-500B
rs111937899 -- 11,343,362(+) CCCCC(A/C/T)GCAAA intron-variant
rs113667275 -- 11,342,769(+) AAAGA(C/T)AGCAG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680

Relevant External Links for TMEM205 Gene

HapMap Linkage Disequilibrium report
TMEM205

Disorders for TMEM205 Gene

No disorders were found for TMEM205 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen D.W. … Gottesman M.M. (J. Cell. Physiol. 2010) 3 4
  3. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PMID: 21139048) Danielsen J.M. … Nielsen M.L. (Mol. Cell Proteomics 2011) 3
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Global identification of modular cullin-RING ligase substrates. (PMID: 21963094) Emanuele M.J. … Elledge S.J. (Cell 2011) 3

Products for TMEM205 Gene

Sources for TMEM205 Gene

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