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Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3 5
  • MBC3205 3
  • UNQ501 3

External Ids for TMEM205 Gene

Previous GeneCards Identifiers for TMEM205 Gene

  • GC19M011316
  • GC19M011453
  • GC19M011029

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Additional gene information for TMEM205 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

Regulatory Elements for TMEM205 Gene

Enhancers for TMEM205 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19H011373 1.7 FANTOM5 ENCODE dbSUPER 12.2 -29.8 -29802 6.2 HDGF PKNOX1 ARNT ZFP64 ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ILF3 ZNF136 KRI1 ZNF627 ZNF442 ZNF625 ZNF823 ZNF844 ZNF491 ZNF44
GH19H011380 1.4 ENCODE dbSUPER 12.2 -35.8 -35848 5.1 HDGF PKNOX1 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B ILF3 ZNF136 KRI1 TIMM29 ZNF627 ZNF433 ZNF844 ZNF442 ZNF44 ZNF563
GH19H011379 0.5 ENCODE 12.2 -33.1 -33122 0.2 TCF12 TAL1 KLF9 KDM1A CCDC159 TMEM205 RAB3D PIR61774 EPOR
GH19H011034 0.9 ENCODE 4.3 +310.8 310755 2.6 TBP HDGF PKNOX1 RB1 ARID4B SIN3A BRCA1 ZNF2 RAD21 SMARCC2 SMARCA4 ILF3-AS1 TMEM205 ENSG00000278643 PIR38577
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM205 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM205 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Locations for TMEM205 Gene

Genomic Locations for TMEM205 Gene
3,743 bases
Minus strand

Genomic View for TMEM205 Gene

Genes around TMEM205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 205
    Protein Accession:

    Protein attributes for TMEM205 Gene

    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains & Families for TMEM205 Gene

Gene Families for TMEM205 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for TMEM205 Gene


Suggested Antigen Peptide Sequences for TMEM205 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM205 family.
  • Belongs to the TMEM205 family.
genes like me logo Genes that share domains with TMEM205: view

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function:
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

Phenotypes From GWAS Catalog for TMEM205 Gene

genes like me logo Genes that share phenotypes with TMEM205: view

Animal Model Products

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 2
mitochondrion 1
endosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
  • Nuclear membrane (2)
  • Nucleoplasm (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM205: view

Pathways & Interactions for TMEM205 Gene

SuperPathways for TMEM205 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM205 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene

Drugs & Compounds for TMEM205 Gene

No Compound Related Data Available

Transcripts for TMEM205 Gene

Unigene Clusters for TMEM205 Gene

Transmembrane protein 205:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM205 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM205 Gene

Protein tissue co-expression partners for TMEM205 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM205 Gene:


SOURCE GeneReport for Unigene cluster for TMEM205 Gene:


mRNA Expression by UniProt/SwissProt for TMEM205 Gene:

Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

Evidence on tissue expression from TISSUES for TMEM205 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Pancreas(4.3)
  • Nervous system(3.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with TMEM205: view

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM205 Gene

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM205 33 34
  • 99.65 (n)
(Canis familiaris)
Mammalia TMEM205 33 34
  • 89.77 (n)
(Bos Taurus)
Mammalia TMEM205 33 34
  • 88.95 (n)
(Mus musculus)
Mammalia Tmem205 33 16 34
  • 81.48 (n)
(Rattus norvegicus)
Mammalia Tmem205 33
  • 80.78 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM205 34
  • 59 (a)
(Anolis carolinensis)
Reptilia TMEM205 34
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem205 33
  • 59.57 (n)
(Danio rerio)
Actinopterygii tmem205 33 34
  • 54.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 33
  • 43.35 (n)
(Oryza sativa)
Liliopsida Os11g0673100 33
  • 47.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 24 (a)
Species where no ortholog for TMEM205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

Gene Tree for TMEM205 (if available)
Gene Tree for TMEM205 (if available)

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

Sequence variations from dbSNP and Humsavar for TMEM205 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000270331 -- 11,344,732(+) CTGTT(C/G)TACAG intron-variant, upstream-variant-2KB
rs1001271723 -- 11,346,682(+) CCAGG(A/G)GGCGG intron-variant, upstream-variant-2KB
rs1002544834 -- 11,343,856(+) AATCC(C/T)GGTGC intron-variant
rs1002597718 -- 11,343,599(+) GCAAC(A/G)TGGGC intron-variant
rs1002668936 -- 11,345,023(+) GCTAA(C/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv578615 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for TMEM205 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM205 Gene

Disorders for TMEM205 Gene

Relevant External Links for TMEM205

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen DW … Gottesman MM (Journal of cellular physiology 2010) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd BJ … Pagliarini DJ (Molecular cell 2016) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM205 Gene

Sources for TMEM205 Gene

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