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Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3 5
  • MBC3205 3
  • UNQ501 3

External Ids for TMEM205 Gene

Previous GeneCards Identifiers for TMEM205 Gene

  • GC19M011316
  • GC19M011453
  • GC19M011029

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

Regulatory Elements for TMEM205 Gene

Enhancers for TMEM205 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G011380 1.4 ENCODE dbSUPER 12.2 -35.8 -35848 5.1 CREB3L1 MLX ZFP64 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC RGL3 RAB3D TMEM205 CCDC159 ZNF136 TIMM29 KANK2 EPOR PIR61774
GH19G011369 0.7 ENCODE 12.6 -23.3 -23272 0.1 HDAC1 SUZ12 ARID4B SIN3A MAX ZBTB40 KLF8 CREM EZH2 ZNF740 RAB3D TMEM205 CCDC159 TSPAN16 SWSAP1 PLPPR2
GH19G011379 0.5 ENCODE 12.2 -33.1 -33122 0.2 TCF12 TAL1 KLF9 KDM1A CCDC159 RAB3D TMEM205 PIR61774 EPOR
GH19G011034 1 ENCODE 4.3 +310.8 310755 2.6 HDGF PKNOX1 ARID4B SIN3A BRCA1 ZNF2 ZNF207 ZNF143 FOS DEK ILF3-AS1 ZNF441 ZNF627 ZNF439 SMARCA4 TMEM205 ENSG00000278643 PIR38577
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM205 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM205 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000107168 14 1201 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 DEK SP3
ENSR00000107168 118 1201 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS KLF13 DEK SP3

Genomic Location for TMEM205 Gene

11,342,776 bp from pter
11,346,518 bp from pter
3,743 bases
Minus strand

Genomic View for TMEM205 Gene

Genes around TMEM205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 205
    Protein Accession:

    Protein attributes for TMEM205 Gene

    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains & Families for TMEM205 Gene

Protein Domains for TMEM205 Gene


Suggested Antigen Peptide Sequences for TMEM205 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM205 family.
  • Belongs to the TMEM205 family.
genes like me logo Genes that share domains with TMEM205: view

No data available for Gene Families for TMEM205 Gene

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function:
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
genes like me logo Genes that share phenotypes with TMEM205: view

Animal Model Products

CRISPR Products

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
extracellular 5
plasma membrane 3
nucleus 2
cytosol 2
mitochondrion 1
endosome 1

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM205: view

Pathways & Interactions for TMEM205 Gene

SuperPathways for TMEM205 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM205 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene

Drugs & Compounds for TMEM205 Gene

No Compound Related Data Available

Transcripts for TMEM205 Gene

Unigene Clusters for TMEM205 Gene

Transmembrane protein 205:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - -

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM205 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM205 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM205 Gene

Protein tissue co-expression partners for TMEM205 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM205 Gene:


SOURCE GeneReport for Unigene cluster for TMEM205 Gene:


mRNA Expression by UniProt/SwissProt for TMEM205 Gene:

Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).

Evidence on tissue expression from TISSUES for TMEM205 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Pancreas(4.3)
  • Nervous system(3.2)
  • Adrenal gland(2.2)
genes like me logo Genes that share expression patterns with TMEM205: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM205 Gene

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM205 34 35
  • 99.65 (n)
(Canis familiaris)
Mammalia TMEM205 34 35
  • 89.77 (n)
(Bos Taurus)
Mammalia TMEM205 34 35
  • 88.95 (n)
(Mus musculus)
Mammalia Tmem205 34 16 35
  • 81.48 (n)
(Rattus norvegicus)
Mammalia Tmem205 34
  • 80.78 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM205 35
  • 59 (a)
(Anolis carolinensis)
Reptilia TMEM205 35
  • 48 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem205 34
  • 59.57 (n)
(Danio rerio)
Actinopterygii tmem205 34 35
  • 54.75 (n)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 34
  • 43.35 (n)
(Oryza sativa)
Liliopsida Os11g0673100 34
  • 47.49 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 24 (a)
Species where no ortholog for TMEM205 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

Gene Tree for TMEM205 (if available)
Gene Tree for TMEM205 (if available)

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

Sequence variations from dbSNP and Humsavar for TMEM205 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000270331 -- 11,344,732(+) CTGTT(C/G)TACAG intron-variant, upstream-variant-2KB
rs1001271723 -- 11,346,682(+) CCAGG(A/G)GGCGG intron-variant, upstream-variant-2KB
rs1002544834 -- 11,343,856(+) AATCC(C/T)GGTGC intron-variant
rs1002597718 -- 11,343,599(+) GCAAC(A/G)TGGGC intron-variant
rs1002668936 -- 11,345,023(+) GCTAA(C/T)TTTTT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv519802 CNV loss 19592680
nsv578615 CNV loss 21841781
nsv833752 CNV loss 17160897

Variation tolerance for TMEM205 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.83% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM205 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM205 Gene

Disorders for TMEM205 Gene

Relevant External Links for TMEM205

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen D.W. … Gottesman M.M. (J. Cell. Physiol. 2010) 3 4 64
  3. Mitochondrial Protein Interaction Mapping Identifies Regulators of Respiratory Chain Function. (PMID: 27499296) Floyd B.J. … Pagliarini D.J. (Mol. Cell 2016) 3 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. N-terminome analysis of the human mitochondrial proteome. (PMID: 25944712) Vaca Jacome A.S. … Carapito C. (Proteomics 2015) 4 64

Products for TMEM205 Gene

Sources for TMEM205 Gene

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