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Aliases for TMEM205 Gene

Aliases for TMEM205 Gene

  • Transmembrane Protein 205 2 3 5
  • MBC3205 3
  • UNQ501 3

External Ids for TMEM205 Gene

Previous GeneCards Identifiers for TMEM205 Gene

  • GC19M011316
  • GC19M011453
  • GC19M011029

Summaries for TMEM205 Gene

GeneCards Summary for TMEM205 Gene

TMEM205 (Transmembrane Protein 205) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM205 Gene

  • In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM205 Gene

Genomics for TMEM205 Gene

Regulatory Elements for TMEM205 Gene


Promoters for TMEM205 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM205 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM205 Gene

Chromosome:
19
Start:
11,342,776 bp from pter
End:
11,346,518 bp from pter
Size:
3,743 bases
Orientation:
Minus strand

Genomic View for TMEM205 Gene

Genes around TMEM205 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM205 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM205 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM205 Gene

Proteins for TMEM205 Gene

  • Protein details for TMEM205 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UW68-TM205_HUMAN
    Recommended name:
    Transmembrane protein 205
    Protein Accession:
    Q6UW68

    Protein attributes for TMEM205 Gene

    Size:
    189 amino acids
    Molecular mass:
    21198 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM205 Gene

Proteomics data for TMEM205 Gene at MOPED

Post-translational modifications for TMEM205 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM205 Gene

Domains & Families for TMEM205 Gene

Protein Domains for TMEM205 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM205 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UW68

UniProtKB/Swiss-Prot:

TM205_HUMAN :
  • Belongs to the TMEM205 family.
Family:
  • Belongs to the TMEM205 family.
genes like me logo Genes that share domains with TMEM205: view

No data available for Gene Families for TMEM205 Gene

Function for TMEM205 Gene

Molecular function for TMEM205 Gene

UniProtKB/Swiss-Prot Function:
In cancer cells, plays a role in resistance to the chemotherapeutic agent cisplatin.
genes like me logo Genes that share phenotypes with TMEM205: view

Animal Model Products

CRISPR Products

miRNA for TMEM205 Gene

miRTarBase miRNAs that target TMEM205

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM205 Gene

Localization for TMEM205 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM205 Gene

Membrane; Multi-pass membrane protein. Note=Located on cell surface microvilli. In cancer cells, transition in subcellular location from cell surface to intracellular regions correlates the progression of cisplatin resistance.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM205 Gene COMPARTMENTS Subcellular localization image for TMEM205 gene
Compartment Confidence
extracellular 5
plasma membrane 3
cytosol 2
nucleus 2
endosome 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for TMEM205 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070062 extracellular exosome IDA 23376485
genes like me logo Genes that share ontologies with TMEM205: view

Pathways & Interactions for TMEM205 Gene

SuperPathways for TMEM205 Gene

No Data Available

Interacting Proteins for TMEM205 Gene

Gene Ontology (GO) - Biological Process for TMEM205 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM205 Gene

Drugs & Compounds for TMEM205 Gene

No Compound Related Data Available

Transcripts for TMEM205 Gene

Unigene Clusters for TMEM205 Gene

Transmembrane protein 205:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM205 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c · 5d · 5e · 5f · 5g
SP1: -
SP2: - -
SP3:
SP4: - -
SP5: - - -
SP6: -
SP7: - - -
SP8:

Relevant External Links for TMEM205 Gene

GeneLoc Exon Structure for
TMEM205
ECgene alternative splicing isoforms for
TMEM205

Expression for TMEM205 Gene

mRNA expression in normal human tissues for TMEM205 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM205 Gene

This gene is overexpressed in Nasal epithelium (28.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM205 Gene



SOURCE GeneReport for Unigene cluster for TMEM205 Gene Hs.8036

mRNA Expression by UniProt/SwissProt for TMEM205 Gene

Q6UW68-TM205_HUMAN
Tissue specificity: Widely expressed with highest levels in pancreas, followed by adrenal gland, thyroid, liver, mammary gland, prostate, kidney, and retina; lowest levels in skeletal muscle. Overexpressed in cisplatin-resistant cancer cells (at protein level).
genes like me logo Genes that share expression patterns with TMEM205: view

Protein tissue co-expression partners for TMEM205 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues for TMEM205 Gene

Orthologs for TMEM205 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM205 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM205 35
  • 88.95 (n)
  • 88.57 (a)
TMEM205 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM205 35
  • 89.77 (n)
  • 88.89 (a)
TMEM205 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem205 35
  • 81.48 (n)
  • 79.37 (a)
Tmem205 16
Tmem205 36
  • 79 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM205 35
  • 99.65 (n)
  • 100 (a)
TMEM205 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem205 35
  • 80.78 (n)
  • 83.07 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM205 36
  • 59 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM205 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem205 35
  • 59.57 (n)
  • 52.13 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem205 35
  • 54.75 (n)
  • 45.25 (a)
tmem205 36
  • 43 (a)
OneToOne
thale cress
(Arabidopsis thaliana)
eudicotyledons AT3G62580 35
  • 43.35 (n)
  • 35.58 (a)
rice
(Oryza sativa)
Liliopsida Os11g0673100 35
  • 47.49 (n)
  • 35.95 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 24 (a)
OneToOne
Species with no ortholog for TMEM205:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM205 Gene

ENSEMBL:
Gene Tree for TMEM205 (if available)
TreeFam:
Gene Tree for TMEM205 (if available)

Paralogs for TMEM205 Gene

No data available for Paralogs for TMEM205 Gene

Variants for TMEM205 Gene

Sequence variations from dbSNP and Humsavar for TMEM205 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12976443 -- 11,342,542(+) AAACA(A/G)AACAA downstream-variant-500B
rs8109430 -- 11,342,647(+) GGAGA(A/G)GCTTA downstream-variant-500B
rs140369613 -- 11,342,552(+) AAACA(-/AAACAAAAC)AAAAC downstream-variant-500B
rs141633785 -- 11,342,935(+) GCACT(A/G)TACTT reference, synonymous-codon
rs142660145 -- 11,343,059(+) TGGTG(C/T)GGGGT reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM205 Gene

Variant ID Type Subtype PubMed ID
nsv833752 CNV Loss 17160897
nsv519802 CNV Loss 19592680

Variation tolerance for TMEM205 Gene

Residual Variation Intolerance Score: 59.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.24; 24.83% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM205 Gene

Disorders for TMEM205 Gene

Relevant External Links for TMEM205

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM205

No disorders were found for TMEM205 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM205 Gene

Publications for TMEM205 Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The association of transporter genes polymorphisms and lung cancer chemotherapy response. (PMID: 24643204) Wang Y. … Liu Z.Q. (PLoS ONE 2014) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Elevated expression of TMEM205, a hypothetical membrane protein, is associated with cisplatin resistance. (PMID: 20589834) Shen D.W. … Gottesman M.M. (J. Cell. Physiol. 2010) 3

Products for TMEM205 Gene

Sources for TMEM205 Gene

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