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Aliases for TMEM204 Gene

Aliases for TMEM204 Gene

  • Transmembrane Protein 204 2 3 5
  • Claudin-Like Protein Of 24 KDa 2 3
  • Claudin-Like Protein 24 3 4
  • C16orf30 3 4
  • CLP24 3 4
  • Chromosome 16 Open Reading Frame 30 2

External Ids for TMEM204 Gene

Previous HGNC Symbols for TMEM204 Gene

  • C16orf30

Previous GeneCards Identifiers for TMEM204 Gene

  • GC16P001524
  • GC16P001583
  • GC16P001509
  • GC16P001579

Summaries for TMEM204 Gene

Entrez Gene Summary for TMEM204 Gene

  • C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM204 Gene

TMEM204 (Transmembrane Protein 204) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM204 Gene

  • Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM204 Gene

Genomics for TMEM204 Gene

Regulatory Elements for TMEM204 Gene

Enhancers for TMEM204 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G001559 1.3 ENCODE dbSUPER 39 +31.7 31743 2.7 HDGF PKNOX1 CREB3L1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 FOS TMEM204 JPT2 ENSG00000261505 ZNF598 ENSG00000260051 TRAF7 ENSG00000255513 SNORA64 ENSG00000260954 RHOT2
GH16G001540 1.4 Ensembl ENCODE dbSUPER 27.6 +17.4 17429 10.2 ELF3 MLX KLF17 FEZF1 RAD21 SLC30A9 ZNF121 GATA2 SCRT2 FOS TMEM204 IFT140 TELO2 JPT2 EME2 CRAMP1 ENSG00000226890 PTX4 CCDC154 HAGH
GH16G001528 0.8 dbSUPER 25.9 +0.1 107 0.8 HDGF ZSCAN5A HDAC1 ZNF473 TAL1 ZSCAN4 MAX PAX8 TCF12 ZFHX2 TMEM204 ENSG00000262528 TELO2 PTX4 CCDC154 ENSG00000260646 ENSG00000280062
GH16G001526 0.7 ENCODE dbSUPER 25.5 -1.4 -1389 1.2 NFIC NFIA SCRT2 TMEM204 TELO2 PTX4 CCDC154 GC16M001518
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM204 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM204 Gene

1,528,688 bp from pter
1,555,580 bp from pter
26,893 bases
Plus strand

Genomic View for TMEM204 Gene

Genes around TMEM204 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM204 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM204 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM204 Gene

Proteins for TMEM204 Gene

  • Protein details for TMEM204 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 204
    Protein Accession:
    Secondary Accessions:
    • D3DU76
    • Q3KRC1
    • Q9H7G5

    Protein attributes for TMEM204 Gene

    226 amino acids
    Molecular mass:
    24540 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14926.1; Type=Frameshift; Positions=161; Evidence={ECO:0000305};

neXtProt entry for TMEM204 Gene

Post-translational modifications for TMEM204 Gene

  • Glycosylation at posLast=164164
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM204 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM204 Gene

Domains & Families for TMEM204 Gene

Protein Domains for TMEM204 Gene


Suggested Antigen Peptide Sequences for TMEM204 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM204: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM204 Gene

Function for TMEM204 Gene

Molecular function for TMEM204 Gene

UniProtKB/Swiss-Prot Function:
Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens.
UniProtKB/Swiss-Prot Induction:
By hypoxia.
genes like me logo Genes that share phenotypes with TMEM204: view

Animal Models for TMEM204 Gene

MGI Knock Outs for TMEM204:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM204

CRISPR Products

miRNA for TMEM204 Gene

miRTarBase miRNAs that target TMEM204

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM204 Gene

Localization for TMEM204 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM204 Gene

Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with the beta-catenin adherins.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM204 gene
Compartment Confidence
plasma membrane 4
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction IEA --
genes like me logo Genes that share ontologies with TMEM204: view

Pathways & Interactions for TMEM204 Gene

SuperPathways for TMEM204 Gene

No Data Available

Interacting Proteins for TMEM204 Gene

Gene Ontology (GO) - Biological Process for TMEM204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001945 lymph vessel development IEA --
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IEA --
GO:0051145 smooth muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM204: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM204 Gene

Drugs & Compounds for TMEM204 Gene

No Compound Related Data Available

Transcripts for TMEM204 Gene

mRNA/cDNA for TMEM204 Gene

Unigene Clusters for TMEM204 Gene

Transmembrane protein 204:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM204 Gene

No ASD Table

Relevant External Links for TMEM204 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM204 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM204 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM204 Gene

This gene is overexpressed in Pancreas (34.1), Testis (21.6), and Adipocyte (13.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM204 Gene

Protein tissue co-expression partners for TMEM204 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM204 Gene:


SOURCE GeneReport for Unigene cluster for TMEM204 Gene:


mRNA Expression by UniProt/SwissProt for TMEM204 Gene:

Tissue specificity: Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.

Evidence on tissue expression from TISSUES for TMEM204 Gene

  • Lung(4.3)
  • Heart(4.2)
  • Pancreas(4.1)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TMEM204: view

Primer Products

No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM204 Gene

Orthologs for TMEM204 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM204 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM204 35
  • 97 (a)
(Canis familiaris)
Mammalia TMEM204 34 35
  • 86.87 (n)
(Bos Taurus)
Mammalia TMEM204 34 35
  • 85.4 (n)
(Rattus norvegicus)
Mammalia Tmem204 34
  • 84.37 (n)
(Mus musculus)
Mammalia Tmem204 34 16 35
  • 83.92 (n)
(Monodelphis domestica)
Mammalia TMEM204 35
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM204 35
  • 46 (a)
(Gallus gallus)
Aves TMEM204 34 35
  • 78.32 (n)
(Anolis carolinensis)
Reptilia TMEM204 35
  • 76 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135192 34
  • 72.5 (n)
(Danio rerio)
Actinopterygii tmem204 34 35
  • 70.79 (n)
Species where no ortholog for TMEM204 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM204 Gene

Gene Tree for TMEM204 (if available)
Gene Tree for TMEM204 (if available)

Paralogs for TMEM204 Gene

No data available for Paralogs for TMEM204 Gene

Variants for TMEM204 Gene

Sequence variations from dbSNP and Humsavar for TMEM204 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs34668993 Likely benign 1,526,742(-) CTGGA(C/T)GTGGC upstream-variant-2KB, reference, synonymous-codon
rs375979698 Uncertain significance 1,526,772(+) ATGCG(C/T)GCCAT upstream-variant-2KB, reference, synonymous-codon
rs748463111 Uncertain significance 1,526,773(+) TGCGC(A/G)CCATG upstream-variant-2KB, reference, missense
rs1000032230 -- 1,537,767(+) CAGAT(A/G)ACCGT intron-variant, downstream-variant-500B
rs1000054839 -- 1,550,499(+) AAGCA(G/T)CGTGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM204 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV duplication 17116639
esv2750347 CNV deletion 23290073
nsv1051692 CNV loss 25217958
nsv428317 CNV gain 18775914
nsv833118 CNV loss 17160897
nsv952899 CNV deletion 24416366

Variation tolerance for TMEM204 Gene

Residual Variation Intolerance Score: 39.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.43; 54.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM204 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM204 Gene

Disorders for TMEM204 Gene

Relevant External Links for TMEM204

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM204 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM204 Gene

Publications for TMEM204 Gene

  1. A novel four transmembrane spanning protein, CLP24. (PMID: 15206924) Kearsey J. … Schweighoffer F. (Eur. J. Biochem. 2004) 2 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4 64
  5. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4 64

Products for TMEM204 Gene

Sources for TMEM204 Gene

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