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Aliases for TMEM204 Gene

Aliases for TMEM204 Gene

  • Transmembrane Protein 204 2 3
  • C16orf30 3 4 6
  • CLP24 3 4 6
  • Claudin-Like Protein Of 24 KDa 2 3
  • Claudin-Like Protein 24 3 4
  • Chromosome 16 Open Reading Frame 30 2

External Ids for TMEM204 Gene

Previous Symbols for TMEM204 Gene

  • C16orf30

Summaries for TMEM204 Gene

Entrez Gene Summary for TMEM204 Gene

  • C16ORF30 plays a role in cell adhesion and cellular permeability at adherens junctions (Kearsey et al., 2004 [PubMed 15206924]).[supplied by OMIM, Mar 2008]

GeneCards Summary for TMEM204 Gene

TMEM204 (Transmembrane Protein 204) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM204 Gene

  • Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM204 Gene

Genomics for TMEM204 Gene

Genomic Location for TMEM204 Gene

Start:
1,528,688 bp from pter
End:
1,555,580 bp from pter
Size:
26,893 bases
Orientation:
Plus strand

Genomic View for TMEM204 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM204 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM204 Gene

Regulatory Elements for TMEM204 Gene

Proteins for TMEM204 Gene

  • Protein details for TMEM204 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSN7-TM204_HUMAN
    Recommended name:
    Transmembrane protein 204
    Protein Accession:
    Q9BSN7
    Secondary Accessions:
    • D3DU76
    • Q3KRC1
    • Q9H7G5

    Protein attributes for TMEM204 Gene

    Size:
    226 amino acids
    Molecular mass:
    24540 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14926.1; Type=Frameshift; Positions=161; Evidence={ECO:0000305};

neXtProt entry for TMEM204 Gene

Proteomics data for TMEM204 Gene at MOPED

Post-translational modifications for TMEM204 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn164

Other Protein References for TMEM204 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM204 Gene

Domains for TMEM204 Gene

Protein Domains for TMEM204 Gene

ProtoNet:
genes like me logo Genes that share domains with TMEM204: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM204 Gene

Function for TMEM204 Gene

Molecular function for TMEM204 Gene

UniProtKB/Swiss-Prot Function: Can influence paracellular permeability. Appears to be involved in cell-cell interactions through adherens
UniProtKB/Swiss-Prot Induction: By hypoxia

Gene Ontology (GO) - Molecular Function for TMEM204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM204: view
genes like me logo Genes that share phenotypes with TMEM204: view

Animal Models for TMEM204 Gene

MGI Knock Outs for TMEM204:

miRNA for TMEM204 Gene

miRTarBase miRNAs that target TMEM204

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for TMEM204 Gene

Localization for TMEM204 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM204 Gene

Cell junction, adherens junction. Cell membrane; Multi-pass membrane protein. Note=Colocalizes with the beta-catenin adherins.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM204 Gene COMPARTMENTS Subcellular localization image for TMEM204 gene
Compartment Confidence
plasma membrane 5
extracellular 2

Gene Ontology (GO) - Cellular Components for TMEM204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IEA --
GO:0005912 adherens junction IEA --
GO:0016021 integral component of membrane IEA --
GO:0030054 cell junction --
genes like me logo Genes that share ontologies with TMEM204: view

Pathways for TMEM204 Gene

SuperPathways for TMEM204 Gene

No Data Available

Interacting Proteins for TMEM204 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000253934%0d%0a9606.ENSP00000263923%0d%0a
Selected Interacting proteins: ENSP00000253934 for TMEM204 Gene via STRING

Symbol External ID(s) Details
KDR

Gene Ontology (GO) - Biological Process for TMEM204 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0001945 lymph vessel development IEA --
GO:0006950 response to stress --
GO:0030947 regulation of vascular endothelial growth factor receptor signaling pathway IEA --
GO:0051145 smooth muscle cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM204: view

No data available for Pathways by source for TMEM204 Gene

Transcripts for TMEM204 Gene

mRNA/cDNA for TMEM204 Gene

Unigene Clusters for TMEM204 Gene

Transmembrane protein 204:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM204 Gene

No ASD Table

Relevant External Links for TMEM204 Gene

GeneLoc Exon Structure for
TMEM204
ECgene alternative splicing isoforms for
TMEM204

Expression for TMEM204 Gene

mRNA expression in normal human tissues for TMEM204 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM204 Gene

SOURCE GeneReport for Unigene cluster for TMEM204 Gene Hs.459652

mRNA Expression by UniProt/SwissProt for TMEM204 Gene

Q9BSN7-TM204_HUMAN
Tissue specificity: Highly expressed in lung, heart, kidney and placenta. Lower expression in thymus, spleen, liver, testis and ovary. Expressed in endothelial and restricted epithelial cell populations.
genes like me logo Genes that share expressions with TMEM204: view

Orthologs for TMEM204 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM204 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM204 37
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM204 36
  • 85.4 (n)
  • 88.05 (a)
TMEM204 37
  • 88 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM204 36
  • 86.87 (n)
  • 87.56 (a)
TMEM204 37
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem204 36
  • 83.92 (n)
  • 88.05 (a)
Tmem204 16
Tmem204 37
  • 88 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM204 37
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM204 37
  • 46 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem204 36
  • 84.37 (n)
  • 88.94 (a)
chicken
(Gallus gallus)
Aves TMEM204 36
  • 78.32 (n)
  • 81.42 (a)
TMEM204 37
  • 81 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM204 37
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100135192 36
  • 72.5 (n)
  • 76.68 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem204 36
  • 70.79 (n)
  • 72.38 (a)
tmem204 37
  • 70 (a)
OneToOne
Species with no ortholog for TMEM204:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM204 Gene

ENSEMBL:
Gene Tree for TMEM204 (if available)
TreeFam:
Gene Tree for TMEM204 (if available)

Paralogs for TMEM204 Gene

No data available for Paralogs for TMEM204 Gene

Variants for TMEM204 Gene

Sequence variations from dbSNP and Humsavar for TMEM204 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
VAR_051435 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM204 Gene

Variant ID Type Subtype PubMed ID
esv2422427 CNV Duplication 17116639
dgv2505n71 CNV Loss 21882294
nsv904950 CNV Loss 21882294
nsv904954 CNV Loss 21882294
dgv2527n71 CNV Loss 21882294
dgv2536n71 CNV Loss 21882294
nsv905015 CNV Loss 21882294
dgv2537n71 CNV Loss 21882294
nsv905017 CNV Loss 21882294
nsv905020 CNV Gain 21882294
esv2750347 CNV Deletion 23290073
nsv428317 CNV Gain 18775914
nsv833118 CNV Loss 17160897

Relevant External Links for TMEM204 Gene

HapMap Linkage Disequilibrium report
TMEM204

Disorders for TMEM204 Gene

No disorders were found for TMEM204 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM204 Gene

Publications for TMEM204 Gene

  1. A novel four transmembrane spanning protein, CLP24. (PMID: 15206924) Kearsey J. … Schweighoffer F. (Eur. J. Biochem. 2004) 2 3 4 23
  2. Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16. (PMID: 11157797) Daniels R.J. … Higgs D.R. (Hum. Mol. Genet. 2001) 3 4
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM204 Gene

Sources for TMEM204 Gene

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