Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM203 Gene

Aliases for TMEM203 Gene

  • Transmembrane Protein 203 2 3 5
  • HBeAg-Binding Protein 1 2 3
  • HBEBP1 3

External Ids for TMEM203 Gene

Previous GeneCards Identifiers for TMEM203 Gene

  • GC09M139224
  • GC09M140098
  • GC09M109558

Summaries for TMEM203 Gene

GeneCards Summary for TMEM203 Gene

TMEM203 (Transmembrane Protein 203) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM203 Gene

  • Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM203 Gene

Genomics for TMEM203 Gene

Regulatory Elements for TMEM203 Gene

Enhancers for TMEM203 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09G137233 1.8 FANTOM5 ENCODE dbSUPER 10.3 -32.7 -32668 9.9 MLX CREB3L1 AGO1 FEZF1 DMAP1 YY1 ZNF416 ZNF143 ZNF263 SP3 NDOR1 DPH7 TMEM203 NELFB LCN15 ABCA2 TOR4A UAP1L1 RNF224 CYSRT1
GH09G136549 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.1 +653.8 653796 4.5 HDGF GLIS2 GATA2 EGR1 ZNF366 SCRT2 ZNF416 FOS RELB IKZF2 SEC16A C9orf163 INPP5E TMEM203 NOTCH1 NALT1 SDCCAG3 TMEM141 MIR4674 LINC01451
GH09G137292 1.7 FANTOM5 ENCODE dbSUPER 10.4 -94.8 -94764 15.3 PKNOX1 FOXA2 ARNT CREB3L1 AGO1 ZFP64 SIN3A DMAP1 ZNF2 ZBTB7B NRARP DPH7 NDOR1 TMEM203 EXD3 GC09M137300
GH09G137149 1.1 Ensembl ENCODE 11.4 +54.8 54765 1.9 HDGF E2F7 DEAF1 BRCA1 ZEB1 PCBP1 KLF7 RELB IKZF2 SP3 TMEM210 ANAPC2 TPRN DPP7 MAN1B1 NDOR1 TMEM203 UAP1L1 LOC105376328 GRIN1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM203 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM203 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000243159 38 1201 CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 SP3

Genomic Location for TMEM203 Gene

137,204,082 bp from pter
137,205,638 bp from pter
1,557 bases
Minus strand

Genomic View for TMEM203 Gene

Genes around TMEM203 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM203 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM203 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM203 Gene

Proteins for TMEM203 Gene

  • Protein details for TMEM203 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 203
    Protein Accession:
    Secondary Accessions:
    • Q6NW08

    Protein attributes for TMEM203 Gene

    136 amino acids
    Molecular mass:
    15760 Da
    Quaternary structure:
    • Interacts with ATP2A2, ITPR3 and STIM1.

neXtProt entry for TMEM203 Gene

Post-translational modifications for TMEM203 Gene

No Post-translational modifications

Other Protein References for TMEM203 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM203 Gene

Domains & Families for TMEM203 Gene

Protein Domains for TMEM203 Gene


Suggested Antigen Peptide Sequences for TMEM203 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM203: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM203 Gene

Function for TMEM203 Gene

Molecular function for TMEM203 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).

Gene Ontology (GO) - Molecular Function for TMEM203 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25996873
genes like me logo Genes that share ontologies with TMEM203: view
genes like me logo Genes that share phenotypes with TMEM203: view

Animal Models for TMEM203 Gene

MGI Knock Outs for TMEM203:

Animal Model Products

CRISPR Products

miRNA for TMEM203 Gene

miRTarBase miRNAs that target TMEM203

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM203 Gene

Localization for TMEM203 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM203 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM203 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM203 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum IEA,IDA 25996873
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM203: view

Pathways & Interactions for TMEM203 Gene

SuperPathways for TMEM203 Gene

No Data Available

Interacting Proteins for TMEM203 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000375053 Q969S6-TM203_HUMAN for TMEM203 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM203 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IDA 25996873
GO:0007283 spermatogenesis IEA,ISS --
genes like me logo Genes that share ontologies with TMEM203: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM203 Gene

Drugs & Compounds for TMEM203 Gene

No Compound Related Data Available

Transcripts for TMEM203 Gene

mRNA/cDNA for TMEM203 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(387) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM203 Gene

Transmembrane protein 203:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM203 Gene

No ASD Table

Relevant External Links for TMEM203 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM203 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM203 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM203 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM203 Gene

Protein tissue co-expression partners for TMEM203 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM203 Gene:


SOURCE GeneReport for Unigene cluster for TMEM203 Gene:


Evidence on tissue expression from TISSUES for TMEM203 Gene

  • Nervous system(4.7)
  • Lung(4.2)
genes like me logo Genes that share expression patterns with TMEM203: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM203 Gene

Orthologs for TMEM203 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM203 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM203 34
  • 97.3 (n)
(Bos Taurus)
Mammalia TMEM203 34 35
  • 91.67 (n)
(Canis familiaris)
Mammalia TMEM203 34 35
  • 91.18 (n)
(Mus musculus)
Mammalia Tmem203 34 16 35
  • 88.24 (n)
(Rattus norvegicus)
Mammalia Tmem203 34
  • 88.24 (n)
(Monodelphis domestica)
Mammalia TMEM203 35
  • 69 (a)
(Gallus gallus)
Aves TMEM203 35
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem203 34
  • 78.43 (n)
Str.14635 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.10105 34
(Danio rerio)
Actinopterygii tmem203 34 35
  • 72.79 (n)
wufb52h09 34
fruit fly
(Drosophila melanogaster)
Insecta CG33932 35
  • 39 (a)
Species where no ortholog for TMEM203 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM203 Gene

Gene Tree for TMEM203 (if available)
Gene Tree for TMEM203 (if available)

Paralogs for TMEM203 Gene

No data available for Paralogs for TMEM203 Gene

Variants for TMEM203 Gene

Sequence variations from dbSNP and Humsavar for TMEM203 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs1000316314 -- 137,205,948(+) GACGA(A/G)CAGGC intron-variant, upstream-variant-2KB
rs1001913493 -- 137,205,120(+) CAGCA(C/T)CTCGA upstream-variant-2KB, reference, missense
rs1001986964 -- 137,204,743(+) CCTCC(A/T)CATGA upstream-variant-2KB, utr-variant-3-prime
rs1002966087 -- 137,206,627(+) CTGAC(A/C)ATCTT intron-variant, upstream-variant-2KB
rs1003091122 -- 137,206,889(+) GTCAC(A/G)GAAGG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM203 Gene

Variant ID Type Subtype PubMed ID
dgv13009n54 CNV loss 21841781
dgv13010n54 CNV loss 21841781
esv2422220 CNV deletion 17116639
nsv1161918 CNV duplication 26073780
nsv524322 CNV loss 19592680
nsv616007 CNV loss 21841781
nsv616012 CNV loss 21841781
nsv951207 CNV deletion 24416366

Variation tolerance for TMEM203 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM203 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM203 Gene

Disorders for TMEM203 Gene

Relevant External Links for TMEM203

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM203 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM203 Gene

Publications for TMEM203 Gene

  1. TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis. (PMID: 25996873) Shambharkar P.B. … Labow M.A. (PLoS ONE 2015) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3 64
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3 64
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3 64

Products for TMEM203 Gene

Sources for TMEM203 Gene

Loading form....