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Aliases for TMEM203 Gene

Aliases for TMEM203 Gene

  • Transmembrane Protein 203 2 3 5
  • HBeAg-Binding Protein 1 2 3
  • HBEBP1 3

External Ids for TMEM203 Gene

Previous GeneCards Identifiers for TMEM203 Gene

  • GC09M139224
  • GC09M140098
  • GC09M109558

Summaries for TMEM203 Gene

GeneCards Summary for TMEM203 Gene

TMEM203 (Transmembrane Protein 203) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM203 Gene

  • Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM203 Gene

Genomics for TMEM203 Gene

Regulatory Elements for TMEM203 Gene

Promoters for TMEM203 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM203 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM203 Gene

137,204,082 bp from pter
137,205,638 bp from pter
1,557 bases
Minus strand

Genomic View for TMEM203 Gene

Genes around TMEM203 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM203 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM203 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM203 Gene

Proteins for TMEM203 Gene

  • Protein details for TMEM203 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 203
    Protein Accession:
    Secondary Accessions:
    • Q6NW08

    Protein attributes for TMEM203 Gene

    136 amino acids
    Molecular mass:
    15760 Da
    Quaternary structure:
    • Interacts with ATP2A2, ITPR3 and STIM1.

neXtProt entry for TMEM203 Gene

Proteomics data for TMEM203 Gene at MOPED

Post-translational modifications for TMEM203 Gene

No Post-translational modifications

Other Protein References for TMEM203 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM203 Gene

Domains & Families for TMEM203 Gene

Protein Domains for TMEM203 Gene


Suggested Antigen Peptide Sequences for TMEM203 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM203: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM203 Gene

Function for TMEM203 Gene

Molecular function for TMEM203 Gene

UniProtKB/Swiss-Prot Function:
Involved in the regulation of cellular calcium homeotasis (PubMed:25996873). Required for spermatogenesis (PubMed:25996873).
genes like me logo Genes that share phenotypes with TMEM203: view

Animal Model Products

CRISPR Products

miRNA for TMEM203 Gene

miRTarBase miRNAs that target TMEM203

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM203 Gene

Localization for TMEM203 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM203 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM203 Gene COMPARTMENTS Subcellular localization image for TMEM203 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
extracellular 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM203 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
genes like me logo Genes that share ontologies with TMEM203: view

Pathways & Interactions for TMEM203 Gene

SuperPathways for TMEM203 Gene

No Data Available

Interacting Proteins for TMEM203 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: Q969S6-TM203_HUMAN ENSP00000375053 for TMEM203 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for TMEM203 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006874 cellular calcium ion homeostasis IEA,IDA 25996873
GO:0098779 mitophagy in response to mitochondrial depolarization IGI 22020285
GO:0098792 xenophagy IMP 22020285
genes like me logo Genes that share ontologies with TMEM203: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM203 Gene

Drugs & Compounds for TMEM203 Gene

No Compound Related Data Available

Transcripts for TMEM203 Gene

mRNA/cDNA for TMEM203 Gene

(1) REFSEQ mRNAs :
(4) Additional mRNA sequences :
(387) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM203 Gene

Transmembrane protein 203:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM203 Gene

No ASD Table

Relevant External Links for TMEM203 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM203 Gene

mRNA expression in normal human tissues for TMEM203 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM203 Gene

This gene is overexpressed in Liver (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM203 Gene

SOURCE GeneReport for Unigene cluster for TMEM203 Gene Hs.231029

genes like me logo Genes that share expression patterns with TMEM203: view

Protein tissue co-expression partners for TMEM203 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM203 Gene

Orthologs for TMEM203 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM203 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM203 35
  • 91.67 (n)
  • 97.79 (a)
TMEM203 36
  • 98 (a)
(Canis familiaris)
Mammalia TMEM203 35
  • 91.18 (n)
  • 97.79 (a)
TMEM203 36
  • 98 (a)
(Mus musculus)
Mammalia Tmem203 35
  • 88.24 (n)
  • 97.79 (a)
Tmem203 16
Tmem203 36
  • 98 (a)
(Pan troglodytes)
Mammalia TMEM203 35
  • 97.3 (n)
  • 96.32 (a)
(Rattus norvegicus)
Mammalia Tmem203 35
  • 88.24 (n)
  • 97.79 (a)
(Monodelphis domestica)
Mammalia TMEM203 36
  • 69 (a)
(Gallus gallus)
Aves TMEM203 36
  • 86 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14635 35
tmem203 35
  • 78.43 (n)
  • 82.35 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.10105 35
(Danio rerio)
Actinopterygii tmem203 35
  • 72.79 (n)
  • 80.88 (a)
wufb52h09 35
tmem203 36
  • 76 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33932 36
  • 39 (a)
Species with no ortholog for TMEM203:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM203 Gene

Gene Tree for TMEM203 (if available)
Gene Tree for TMEM203 (if available)

Paralogs for TMEM203 Gene

No data available for Paralogs for TMEM203 Gene

Variants for TMEM203 Gene

Sequence variations from dbSNP and Humsavar for TMEM203 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs528978087 -- 137,203,633(+) ACAGG(A/C)GTGAG downstream-variant-500B
rs548843200 -- 137,203,662(+) TTTTG(C/T)TTTTA downstream-variant-500B
rs563327534 -- 137,203,629(+) GATTA(C/G)AGGCG downstream-variant-500B
rs575280322 -- 137,203,618(+) CAAAG(C/T)GCTGG downstream-variant-500B
rs760045374 -- 137,203,609(+) TCGGC(C/T)TCCCA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM203 Gene

Variant ID Type Subtype PubMed ID
nsv894387 CNV Gain 21882294
esv2422220 CNV Deletion 17116639
dgv8412n71 CNV Loss 21882294
dgv8416n71 CNV Loss 21882294
nsv524322 CNV Loss 19592680
nsv894469 CNV Loss 21882294
dgv8423n71 CNV Loss 21882294
nsv894502 CNV Loss 21882294
nsv894506 CNV Gain 21882294
dgv8428n71 CNV Loss 21882294
nsv894521 CNV Loss 21882294
dgv8437n71 CNV Gain 21882294
dgv8441n71 CNV Loss 21882294
dgv8442n71 CNV Loss 21882294
dgv8445n71 CNV Loss 21882294
dgv8446n71 CNV Loss 21882294
dgv8447n71 CNV Loss 21882294
dgv8450n71 CNV Loss 21882294
nsv894603 CNV Gain+Loss 21882294
dgv8451n71 CNV Loss 21882294
dgv8452n71 CNV Gain+Loss 21882294
dgv8453n71 CNV Gain 21882294
dgv8454n71 CNV Gain 21882294
dgv8455n71 CNV Gain+Loss 21882294
nsv894629 CNV Loss 21882294
dgv8456n71 CNV Loss 21882294
nsv894631 CNV Loss 21882294
dgv8457n71 CNV Gain 21882294
nsv894637 CNV Loss 21882294

Variation tolerance for TMEM203 Gene

Residual Variation Intolerance Score: 52.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 2.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM203 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM203 Gene

Disorders for TMEM203 Gene

Relevant External Links for TMEM203

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM203 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM203 Gene

Publications for TMEM203 Gene

  1. TMEM203 is a novel regulator of intracellular calcium homeostasis and is required for spermatogenesis. (PMID: 25996873) Shambharkar P.B. … Labow M.A. (PLoS ONE 2015) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Next-generation sequencing to generate interactome datasets. (PMID: 21516116) Yu H. … Vidal M. (Nat. Methods 2011) 3
  4. Image-based genome-wide siRNA screen identifies selective autophagy factors. (PMID: 22020285) Orvedahl A. … Levine B. (Nature 2011) 3
  5. Defining the human deubiquitinating enzyme interaction landscape. (PMID: 19615732) Sowa M.E. … Harper J.W. (Cell 2009) 3

Products for TMEM203 Gene

Sources for TMEM203 Gene

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