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Aliases for TMEM201 Gene

Aliases for TMEM201 Gene

  • Transmembrane Protein 201 2 3
  • Spindle-Associated Membrane Protein 1 3 4
  • NET5 3 4
  • RP13-15M17.2 3
  • SAMP1 4

External Ids for TMEM201 Gene

Previous GeneCards Identifiers for TMEM201 Gene

  • GC01P009572
  • GC01P008799

Summaries for TMEM201 Gene

GeneCards Summary for TMEM201 Gene

TMEM201 (Transmembrane Protein 201) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM201 Gene

  • Isoform SAMP1 may define a distinct membrane domain in the vicinity of the mitotic spindle.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM201 Gene

Genomics for TMEM201 Gene

Regulatory Elements for TMEM201 Gene

Genomic Location for TMEM201 Gene

Start:
9,588,874 bp from pter
End:
9,614,877 bp from pter
Size:
26,004 bases
Orientation:
Plus strand

Genomic View for TMEM201 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM201 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM201 Gene

Proteins for TMEM201 Gene

  • Protein details for TMEM201 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5SNT2-TM201_HUMAN
    Recommended name:
    Transmembrane protein 201
    Protein Accession:
    Q5SNT2
    Secondary Accessions:
    • B9EH90
    • Q5SNT3

    Protein attributes for TMEM201 Gene

    Size:
    666 amino acids
    Molecular mass:
    72236 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM201 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM201 Gene

Proteomics data for TMEM201 Gene at MOPED

Post-translational modifications for TMEM201 Gene

  • Ubiquitination at Lys133 and Lys192
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM201 Gene

No data available for DME Specific Peptides for TMEM201 Gene

Domains for TMEM201 Gene

Protein Domains for TMEM201 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM201 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM201: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM201 Gene

Function for TMEM201 Gene

Molecular function for TMEM201 Gene

UniProtKB/Swiss-Prot Function: Isoform SAMP1 may define a distinct membrane domain in the vicinity of the mitotic spindle.

Gene Ontology (GO) - Molecular Function for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0005521 lamin binding IEA --
GO:0051015 actin filament binding IEA --
genes like me logo Genes that share ontologies with TMEM201: view

miRNA for TMEM201 Gene

miRTarBase miRNAs that target TMEM201

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM201 Gene

Localization for TMEM201 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM201 Gene

Isoform SAMP1: Nucleus inner membrane; Multi-pass membrane protein. Note=The C-terminal of isoform SAMP1 is located on the nucleoplasmic side. During interphase, isoform SAMP1 is distributed in the inner nuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitotic spindle.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM201 Gene COMPARTMENTS Subcellular localization image for TMEM201 gene
Compartment Confidence
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005637 nuclear inner membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane --
genes like me logo Genes that share ontologies with TMEM201: view

Pathways for TMEM201 Gene

SuperPathways for TMEM201 Gene

No Data Available

Interacting Proteins for TMEM201 Gene

Gene Ontology (GO) - Biological Process for TMEM201 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007097 nuclear migration IEA --
GO:0010761 fibroblast migration IEA --
genes like me logo Genes that share ontologies with TMEM201: view

No data available for Pathways by source for TMEM201 Gene

Transcripts for TMEM201 Gene

Unigene Clusters for TMEM201 Gene

Transmembrane protein 201:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM201 Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4a · 4b ^ 5a · 5b · 5c ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - - -
SP2:
SP3: -
SP4:
SP5: - -
SP6: - -
SP7:
SP8:
SP9:

Relevant External Links for TMEM201 Gene

GeneLoc Exon Structure for
TMEM201
ECgene alternative splicing isoforms for
TMEM201

Expression for TMEM201 Gene

mRNA expression in normal human tissues for TMEM201 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM201 Gene

This gene is overexpressed in Muscle - Skeletal (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM201 Gene

SOURCE GeneReport for Unigene cluster for TMEM201 Gene Hs.632365

genes like me logo Genes that share expressions with TMEM201: view

No data available for mRNA Expression by UniProt/SwissProt for TMEM201 Gene

Orthologs for TMEM201 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM201 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM201 35
  • 95.94 (n)
  • 95.61 (a)
cow
(Bos Taurus)
Mammalia TMEM201 35
  • 88.89 (n)
  • 89.15 (a)
TMEM201 36
  • 86 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM201 35
  • 84.51 (n)
  • 84.29 (a)
TMEM201 36
  • 84 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem201 35
  • 83.41 (n)
  • 83.71 (a)
Tmem201 16
Tmem201 36
  • 83 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM201 36
  • 73 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM201 36
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem201 35
  • 82.55 (n)
  • 83.41 (a)
chicken
(Gallus gallus)
Aves TMEM201 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM201 36
  • 62 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem201 35
  • 58.53 (n)
  • 56.81 (a)
tmem201 36
  • 54 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7744 36
  • 17 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea samp-1 36
  • 19 (a)
OneToOne
Species with no ortholog for TMEM201:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM201 Gene

ENSEMBL:
Gene Tree for TMEM201 (if available)
TreeFam:
Gene Tree for TMEM201 (if available)

Paralogs for TMEM201 Gene

No data available for Paralogs for TMEM201 Gene

Variants for TMEM201 Gene

Sequence variations from dbSNP and Humsavar for TMEM201 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1128650 -- 9,604,763(+) CCACA(C/T)TCAGC utr-variant-3-prime, intron-variant
rs1128651 -- 9,604,764(+) CACAT(C/T)CAGCC utr-variant-3-prime, intron-variant
rs3923984 -- 9,593,777(-) TCCTA(C/T)CCCCA intron-variant
rs4073292 -- 9,611,877(+) GAGGC(C/T)GCCAC reference, synonymous-codon, nc-transcript-variant
rs4073293 -- 9,612,033(+) CCGGC(A/G)CCTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM201 Gene

Variant ID Type Subtype PubMed ID
nsv871521 CNV Loss 21882294
esv2743619 CNV Deletion 23290073
nsv871610 CNV Gain 21882294
nsv2187 CNV Insertion 18451855
nsv508847 CNV Insertion 20534489

Relevant External Links for TMEM201 Gene

HapMap Linkage Disequilibrium report
TMEM201
Human Gene Mutation Database (HGMD)
TMEM201

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM201 Gene

Disorders for TMEM201 Gene

No disorders were found for TMEM201 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM201 Gene

Publications for TMEM201 Gene

  1. An integral protein of the inner nuclear membrane localizes to the mitotic spindle in mammalian cells. (PMID: 19494128) Buch C. … Hallberg E. (J. Cell Sci. 2009) 3 4
  2. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PMID: 21890473) Wagner S.A. … Choudhary C. (Mol. Cell Proteomics 2011) 3
  3. Defining human ERAD networks through an integrative mapping strategy. (PMID: 22119785) Christianson J.C. … Kopito R.R. (Nat. Cell Biol. 2012) 3
  4. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  5. A promiscuous biotin ligase fusion protein identifies proximal and interacting proteins in mammalian cells. (PMID: 22412018) Roux K.J. … Burke B. (J. Cell Biol. 2012) 3

Products for TMEM201 Gene

Sources for TMEM201 Gene

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