TMEM201 Gene
protein-coding GIFtS: 40
GCID: GC01P009648
|
|
transmembrane protein 201
| |
Aliases
for TMEM201 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 2011 2 | | NET51 2 3 | | Spindle-Associated Membrane Protein 12 3 | | RP13-15M17.21 | | SAMP13 |
Export aliases for TMEM201 gene to outside databasesPrevious GC identifers: GC01P009572 GC01P008799 |
Summaries
for TMEM201 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TM201_HUMAN, Q5SNT2Function: Isoform SAMP1 may define a distinct membrane domain in the vicinity of the mitotic spindle
|
Genomic Views
for TMEM201 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_021937.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM201 gene promoter:
Elk-1 MyoD CBF-C HEN1 CBF-A CBF-B c-Myb CP1A CBF(2)
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM201
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM201 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p36.22 Ensembl cytogenetic band: 1p36.22 HGNC cytogenetic band: 1p36.22TMEM201 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P009648: view genomic region
(about GC identifiers)
Start:
|
9,648,932 bp from pter |
End:
|
9,674,935 bp from pter |
Size:
|
26,004 bases |
Orientation:
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plus strand |
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Proteins
for TMEM201 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM201_HUMAN, Q5SNT2 (See
protein sequence)Recommended Name: Transmembrane protein 201 Size: 666 amino acids; 72236 Da
Subcellular location: Isoform SAMP1: Nucleus inner membrane; Multi-pass membrane protein. Note=The C-terminal ofisoform SAMP1 is located on the nucleoplasmic side. During interphase, isoform SAMP1 is distributed in the innernuclear membrane and during mitosis, it is found in the ER but it also localizes to the polar regions of the mitoticspindle
Secondary accessions: B9EH90 Q5SNT3Alternative splicing: 2 isoforms: Q5SNT2-1 Q5SNT2-2 Explore the universe of human proteins at neXtProt for TMEM201: NX_Q5SNT2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q5SNT2
TMEM201 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001010866.1 NP_001124396.2
ENSEMBL proteins: ENSP00000344772 ENSP00000344503 ENSP00000393626 ENSP00000423430 ENSP00000366593
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005637 | nuclear inner membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM201 for ontologies About GeneDecksing
TMEM201 Antibody Products:
Assay Products for TMEM201: |
Protein
Domains /
Families
for TMEM201 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM201 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q5SNT2ProtoNet protein and cluster: Q5SNT2 |
Function
for TMEM201 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TM201_HUMAN, Q5SNT2Function: Isoform SAMP1 may define a distinct membrane domain in the vicinity of the mitotic spindle
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM201 (NM_001010866) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM201 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM201 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM201 |
|
Pathways & Interactions
for TMEM201 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM201
STRING Interaction
Network Preview (showing 5 interactants - click image to see 15)
5/15 Interacting proteins for TMEM201 (ENSP000003665934) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
|
Drugs & Compounds
for TMEM201 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM201
Search CenterWatch for drugs/clinical trials and news about TMEM201 / TM201
|
Transcripts
for TMEM201 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM201 gene (2 alternative transcripts): NM_001010866.3 NM_001130924.2 Unigene Cluster for TMEM201: Transmembrane protein 201 Hs.632365 [show with all ESTs]Unigene Representative Sequence: NM_0010108666 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000340305(uc001apy.3) ENST00000340381 ENST00000416541 ENST00000510900
ENST00000508400 ENST00000377376(uc021ofy.1 uc021ofz.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM201 (NM_001010866) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM201 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM201 |
Additional cDNA sequence: BC121187.1 BC137291.1 BX648377.1 5 DOTS entries: DT.97807153 DT.92057332 DT.407552 DT.100738001 DT.100738002 24/110 AceView cDNA sequences (see all 110): BU789566 BX648377 BI335097 BQ072123 BM126862 BQ000012 BE383313 BQ430135 BU069874 BQ940492 BU193876 F09075 BU153808 CR626314 BU195291 F11409 BQ070602 BM831807 BG259338 AI005087 BQ425762 AI360203 BU156024 BG825314
GeneLoc Exon Structure
5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM201 (see all 9) About this scheme
| ExUns: | 1 | ^ | 2 | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5a | · | 5b | · | 5c | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11a | · | 11b | ^ | 12 | ^ | 13a | · | 13b | ^ | 14a | · | 14b | · | 14c |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | - | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | - | | - | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM201
|
Expression
for TMEM201 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM201 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCGTAGAATT
About this image
See TMEM201 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM201
SOURCE GeneReport for Unigene cluster: Hs.632365
SABiosciences Custom PCR Arrays for TMEM201
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM201
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM201 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM201 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM201 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM201 |
Orthologs
for TMEM201 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM201 gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for TMEM201 (if available)
TreeFam Gene Tree for TMEM201 (if available) |
Paralogs
for TMEM201 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM201 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM201 (9648932 - 9674935 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM201: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM201 |
|
Disorders
/ Diseases
for TMEM201 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM201 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM201 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM201) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- An integral protein of the inner nuclear membrane loc alizes to the mitotic spindle in mammalian cells. (PubMed id 19494128)1, 2 Buch C....Hallberg E. (2009)
- A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for TMEM201 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM201 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM201 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM201 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM201 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM201 gene:
Search GeneIP for patents involving TMEM201
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM201 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM201 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM201 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM201 | | | OriGene Protein Over-expression Lysate for TMEM201 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM201 | | OriGene 3'-UTR Clone for TMEM201 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM201 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM201 | | OriGene Custom Protein Services for TMEM201 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM201 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM201 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM201 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM201 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM201 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM201 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM201 |
| |  |  |  |  | | | | |
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 | | | TMEM201 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM201 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM201 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM201 |
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