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Aliases for TMEM200C Gene

Aliases for TMEM200C Gene

  • Transmembrane Protein 200C 2 3
  • Two Transmembrane Domain-Containing Family Member A 3 4
  • Transmembrane Protein TTMA 3 4
  • TTMA 3 4
  • Two Transmembrane Domain Family Member A 3

External Ids for TMEM200C Gene

Summaries for TMEM200C Gene

GeneCards Summary for TMEM200C Gene

TMEM200C (Transmembrane Protein 200C) is a Protein Coding gene. An important paralog of this gene is TMEM200B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM200C Gene

Genomics for TMEM200C Gene

Genomic Location for TMEM200C Gene

Start:
5,882,072 bp from pter
End:
5,896,145 bp from pter
Size:
14,074 bases
Orientation:
Minus strand

Genomic View for TMEM200C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM200C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM200C Gene

No data available for Regulatory Elements for TMEM200C Gene

Proteins for TMEM200C Gene

  • Protein details for TMEM200C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NKL6-T200C_HUMAN
    Recommended name:
    Transmembrane protein 200C
    Protein Accession:
    A6NKL6
    Secondary Accessions:

    Protein attributes for TMEM200C Gene

    Size:
    621 amino acids
    Molecular mass:
    63928 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM200C Gene

Proteomics data for TMEM200C Gene at MOPED

Post-translational modifications for TMEM200C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM200C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM200C Gene

Domains for TMEM200C Gene

Protein Domains for TMEM200C Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

T200C_HUMAN
Family:
  • Belongs to the TMEM200 family.:
    • A6NKL6
genes like me logo Genes that share domains with TMEM200C: view

No data available for Gene Families for TMEM200C Gene

Function for TMEM200C Gene

Phenotypes for TMEM200C Gene

GenomeRNAi human phenotypes for TMEM200C:
genes like me logo Genes that share phenotypes with TMEM200C: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM200C Gene

Localization for TMEM200C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM200C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM200C Gene COMPARTMENTS Subcellular localization image for TMEM200C gene
Compartment Confidence
plasma membrane 3
nucleus 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM200C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM200C: view

Pathways for TMEM200C Gene

SuperPathways for TMEM200C Gene

No Data Available

Interacting Proteins for TMEM200C Gene

Gene Ontology (GO) - Biological Process for TMEM200C Gene

None

No data available for Pathways by source for TMEM200C Gene

Transcripts for TMEM200C Gene

mRNA/cDNA for TMEM200C Gene

(3) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM200C Gene

Transmembrane protein 200C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM200C Gene

No ASD Table

Relevant External Links for TMEM200C Gene

GeneLoc Exon Structure for
TMEM200C
ECgene alternative splicing isoforms for
TMEM200C

Expression for TMEM200C Gene

mRNA expression in normal human tissues for TMEM200C Gene

mRNA differential expression in normal tissues according to GTEx for TMEM200C Gene

This gene is overexpressed in Brain - Cortex (4.5), Brain - Frontal Cortex (BA9) (4.3), and Adrenal Gland (4.2).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM200C Gene

SOURCE GeneReport for Unigene cluster for TMEM200C Gene Hs.346566

genes like me logo Genes that share expressions with TMEM200C: view

Orthologs for TMEM200C Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM200C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM200C 36
  • 94.82 (n)
  • 92.93 (a)
TMEM200C 37
  • 91 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM200C 36
  • 81.82 (n)
  • 74.44 (a)
TMEM200C 37
  • 57 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem200c 36
  • 78.71 (n)
  • 75.86 (a)
Tmem200c 16
Tmem200c 37
  • 56 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM200C 37
  • 55 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem200c 36
  • 78.75 (n)
  • 76.1 (a)
chicken
(Gallus gallus)
Aves LOC421054 36
  • 65.97 (n)
  • 65.65 (a)
TMEM200C 37
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM200C 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem200c 36
  • 52.57 (n)
  • 53.52 (a)
zebrafish
(Danio rerio)
Actinopterygii CABZ01081294.1 37
  • 40 (a)
OneToMany
TMEM200C (1 of 2) 37
  • 34 (a)
OneToMany
Species with no ortholog for TMEM200C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM200C Gene

ENSEMBL:
Gene Tree for TMEM200C (if available)
TreeFam:
Gene Tree for TMEM200C (if available)

Paralogs for TMEM200C Gene

Paralogs for TMEM200C Gene

genes like me logo Genes that share paralogs with TMEM200C: view

Variants for TMEM200C Gene

Sequence variations from dbSNP and Humsavar for TMEM200C Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs7190 -- 5,889,766(+) TGGAG(A/G)AAAAA downstream-variant-500B, utr-variant-3-prime
rs11751 -- 5,890,386(-) CGCGA(G/T)ACTCT reference, missense
rs1940600 -- 5,888,921(+) AGCTC(G/T)GAATC downstream-variant-500B
rs1940601 -- 5,888,975(+) AATGA(A/C)GACAT downstream-variant-500B
rs1940605 -- 5,893,970(-) ACCAC(A/G)TAATA upstream-variant-2KB, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM200C Gene

Variant ID Type Subtype PubMed ID
dgv184n21 CNV Gain 19592680
nsv909327 CNV Gain 21882294

Relevant External Links for TMEM200C Gene

HapMap Linkage Disequilibrium report
TMEM200C

Disorders for TMEM200C Gene

No disorders were found for TMEM200C Gene.

No data available for UniProtKB/Swiss-Prot for TMEM200C Gene

Publications for TMEM200C Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard B.S. … Muir W.J. (Psychiatr. Genet. 2005) 2 3 4
  2. DNA sequence and analysis of human chromosome 18. (PMID: 16177791) Nusbaum C. … Lander E.S. (Nature 2005) 3 4

Products for TMEM200C Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate TMEM200C
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM200C
    • Block miRNA regulation of TMEM200C using miScript Target Protectors

    Sources for TMEM200C Gene

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