Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM200B Gene

Aliases for TMEM200B Gene

  • Transmembrane Protein 200B 2 3 5
  • Two Transmembrane Domain-Containing Family Member B 3 4
  • Transmembrane Protein TTMA 3 4
  • TTMB 3 4
  • Two Transmembrane B 3

External Ids for TMEM200B Gene

Previous GeneCards Identifiers for TMEM200B Gene

  • GC01M029318
  • GC01M029445
  • GC01M027698

Summaries for TMEM200B Gene

GeneCards Summary for TMEM200B Gene

TMEM200B (Transmembrane Protein 200B) is a Protein Coding gene. Diseases associated with TMEM200B include Suppression Of Tumorigenicity 12. An important paralog of this gene is TMEM200A.

Additional gene information for TMEM200B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM200B Gene

Genomics for TMEM200B Gene

GeneHancer (GH) Regulatory Elements for TMEM200B Gene

Promoters and enhancers for TMEM200B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH01I029121 Promoter/Enhancer 2.4 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 559.4 +5.4 5423 4.9 HDGF SMAD1 ATF1 SIN3A ETS1 ZNF121 GLIS2 ZNF143 KLF7 SP3 TMEM200B MECR EPB41 PIR34079 GC01M029107 GC01P029082
GH01I029236 Promoter/Enhancer 2.3 EPDnew FANTOM5 Ensembl ENCODE 55.4 -109.6 -109580 5.1 HDGF FOXA2 ARNT ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 DEK PTPRU SRSF4 GMEB1 TRNAU1AP YTHDF2 SNHG12 PHACTR4 TMEM200B RCC1 ENSG00000237934
GH01I028881 Promoter/Enhancer 2.8 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 44.7 +243.9 243892 6.8 CLOCK MLX ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 EPB41 LOC105376898 SRSF4 TRNAU1AP GMEB1 SNHG12 YTHDF2 PHACTR4 EYA3 TMEM200B
GH01I028647 Promoter/Enhancer 1.7 Ensembl ENCODE 21.4 +480.7 480689 2.7 CLOCK ZFP64 FEZF1 DMAP1 IRF4 YY1 SLC30A9 ZNF213 E2F8 ZNF143 ENSG00000270103 GC01P028651 GC01P028669 GC01P028670 GC01P028671 RNU11 GC01P028672 SRSF4 GMEB1 TRNAU1AP
GH01I028326 Promoter/Enhancer 2.3 EPDnew Ensembl ENCODE dbSUPER 14.2 +800.5 800546 4.4 PKNOX1 SMAD1 ZFP64 ARID4B SIN3A ZNF2 IRF4 YY1 SLC30A9 POLR2B MED18 PHACTR4 EYA3 GMEB1 TMEM200B SRSF4 FAM76A SESN2
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM200B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM200B gene promoter:

Genomic Locations for TMEM200B Gene

Genomic Locations for TMEM200B Gene
chr1:29,119,425-29,129,134
(GRCh38/hg38)
Size:
9,710 bases
Orientation:
Minus strand
chr1:29,445,937-29,450,447
(GRCh37/hg19)

Genomic View for TMEM200B Gene

Genes around TMEM200B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM200B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM200B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM200B Gene

Proteins for TMEM200B Gene

  • Protein details for TMEM200B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q69YZ2-T200B_HUMAN
    Recommended name:
    Transmembrane protein 200B
    Protein Accession:
    Q69YZ2
    Secondary Accessions:
    • Q6P2G8
    • Q6P2Q5

    Protein attributes for TMEM200B Gene

    Size:
    307 amino acids
    Molecular mass:
    32750 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM200B Gene

Post-translational modifications for TMEM200B Gene

No Post-translational modifications

Other Protein References for TMEM200B Gene

No data available for DME Specific Peptides for TMEM200B Gene

Domains & Families for TMEM200B Gene

Gene Families for TMEM200B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM200B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM200B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q69YZ2

UniProtKB/Swiss-Prot:

T200B_HUMAN :
  • Belongs to the TMEM200 family.
Family:
  • Belongs to the TMEM200 family.
genes like me logo Genes that share domains with TMEM200B: view

Function for TMEM200B Gene

genes like me logo Genes that share phenotypes with TMEM200B: view

miRNA for TMEM200B Gene

miRTarBase miRNAs that target TMEM200B

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM200B Gene

Localization for TMEM200B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM200B Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM200B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM200B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM200B Gene

Pathways & Interactions for TMEM200B Gene

SuperPathways for TMEM200B Gene

No Data Available

Interacting Proteins for TMEM200B Gene

Gene Ontology (GO) - Biological Process for TMEM200B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM200B Gene

Drugs & Compounds for TMEM200B Gene

No Compound Related Data Available

Transcripts for TMEM200B Gene

mRNA/cDNA for TMEM200B Gene

(3) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(9) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM200B Gene

Transmembrane protein 200B:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM200B Gene

No ASD Table

Relevant External Links for TMEM200B Gene

GeneLoc Exon Structure for
TMEM200B
ECgene alternative splicing isoforms for
TMEM200B

Expression for TMEM200B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM200B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM200B Gene

This gene is overexpressed in Uterus (x5.0).

NURSA nuclear receptor signaling pathways regulating expression of TMEM200B Gene:

TMEM200B

SOURCE GeneReport for Unigene cluster for TMEM200B Gene:

Hs.712722

Evidence on tissue expression from TISSUES for TMEM200B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM200B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM200B Gene

Orthologs for TMEM200B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM200B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM200B 34
  • 100 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM200B 33 34
  • 92.51 (n)
cow
(Bos Taurus)
Mammalia TMEM200B 33 34
  • 90.88 (n)
rat
(Rattus norvegicus)
Mammalia Tmem200b 33
  • 82.86 (n)
mouse
(Mus musculus)
Mammalia Tmem200b 33 16 34
  • 82.16 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM200B 34
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM200B 34
  • 34 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM200B 34
  • 36 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii TMEM200B 34
  • 21 (a)
OneToOne
Species where no ortholog for TMEM200B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM200B Gene

ENSEMBL:
Gene Tree for TMEM200B (if available)
TreeFam:
Gene Tree for TMEM200B (if available)

Paralogs for TMEM200B Gene

Paralogs for TMEM200B Gene

genes like me logo Genes that share paralogs with TMEM200B: view

Variants for TMEM200B Gene

Sequence variations from dbSNP and Humsavar for TMEM200B Gene

SNP ID Clin Chr 01 pos Variation AA Info Type
rs1000014912 -- 29,119,299(-) TGTGTGT/TGTGT downstream_transcript_variant
rs1000589464 -- 29,129,471(-) T/C upstream_transcript_variant
rs1000622094 -- 29,129,742(-) G/A upstream_transcript_variant
rs1000807939 -- 29,124,070(-) T/C genic_upstream_transcript_variant, intron_variant, upstream_transcript_variant
rs1000875243 -- 29,129,610(-) T/C/G upstream_transcript_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM200B Gene

Variant ID Type Subtype PubMed ID
nsv509091 CNV insertion 20534489

Variation tolerance for TMEM200B Gene

Gene Damage Index Score: 1.53; 29.70% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM200B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM200B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM200B Gene

Disorders for TMEM200B Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM200B Gene - From: DISEASES

Disorder Aliases PubMed IDs
suppression of tumorigenicity 12
  • st12
- elite association - COSMIC cancer census association via MalaCards

Additional Disease Information for TMEM200B

genes like me logo Genes that share disorders with TMEM200B: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM200B Gene

Publications for TMEM200B Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard BS … Muir WJ (Psychiatric genetics 2005) 2 3 58
  2. The full-ORF clone resource of the German cDNA Consortium. (PMID: 17974005) Bechtel S … Schupp I (BMC genomics 2007) 4 58
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 4 58
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 58

Products for TMEM200B Gene

Sources for TMEM200B Gene

Content
Loading form....