TMEM200B Gene
protein-coding GIFtS : 37
GCID: GC01 M029445
transmembrane protein 200B
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Aliasesfor TMEM200B gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Transmembrane Protein 200B 1 2 TTMB1 2 3 Transmembrane Protein TTMA2 3 Two Transmembrane Domain-Containing Family Member B2 3 Two Transmembrane B2
Export aliases for TMEM200B gene to outside databases Previous GC identifers: GC01M029318 GC01M027698
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Summariesfor TMEM200B gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section --
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Genomic Viewsfor TMEM200B gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000001.10 NC_018912.1 NT_004610.19 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM200B gene promoter: Pbx1a USF2 USF-1:USF-2 RORalpha1 Egr-2 CREB HFH-1 USF-1 deltaCREB Other transcription factors Search SABiosciences Chromatin IP Primers for TMEM200B Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM200B
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 1p35 Ensembl cytogenetic band: 1p35.3 HGNC cytogenetic band: 1p35 TMEM200B Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 1 GeneLoc Exon Structure
GeneLoc location for GC01M029445: view genomic region
(about GC identifiers )
Start:
29,445,937 bp from pter
End:
29,450,447 bp from pter
Size:
4,511 bases
Orientation:
minus strand
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Proteinsfor TMEM200B gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: T200B_HUMAN, Q69YZ2 (See
protein sequence )Recommended Name: Transmembrane protein 200B Size : 307 amino acids; 32750 Da
Subcellular location : Membrane; Multi-pass membrane protein (Potential)
Secondary accessions : Q6P2G8 Q6P2Q5Explore the universe of human proteins at neXtProt for TMEM200B: NX_Q69YZ2 Post-translational modifications:
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q69YZ2 TMEM200B Protein expression data from MOPED and PaxDb : --REFSEQ proteins (2 alternative transcripts):
NP_001003682.1 NP_001165339.1 ENSEMBL proteins: ENSP00000428459 ENSP00000428544 Human Recombinant Protein Products for TMEM200B: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0016021 integral to membrane
IEA --
TMEM200B for ontologies About GeneDecksing TMEM200B Antibody Products: Assay Products for TMEM200B:
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Protein
Domains / Familiesfor TMEM200B gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
TMEM200B for domains About GeneDecksing 1 InterPro domain/family :
Graphical View of Domain Structure for InterPro Entry Q69YZ2 ProtoNet protein and cluster: Q69YZ2
UniProtKB/Swiss-Prot: T200B_HUMAN, Q69YZ2 Similarity : Belongs to the TMEM200 family
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Functionfor TMEM200B gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory ,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase ,
shRNA from
OriGene ,
Sirion Biotech ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Sirion Biotech ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
Sirion Biotech ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Animal Models: Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM200B (NM_001003682 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM200B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM200B
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM200B
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Pathways & Interactionsfor TMEM200B gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM200B
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Drugs & Compoundsfor TMEM200B gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for TMEM200B Search CenterWatch for drugs/clinical trials and news about TMEM200B / T200B
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Transcriptsfor TMEM200B gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
Sirion Biotech ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for TMEM200B gene (2 alternative transcripts): NM_001003682.3 NM_001171868.1 Unigene Cluster for TMEM200B:
Transmembrane protein 200B Hs.712722 [show with all ESTs ] Unigene Representative Sequence: AL110282 2 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000521452 (uc001brn.2 ) ENST00000420504 (uc021okh.1 ) Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B (see all 2 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B (see all 2 )OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 2 ): TMEM200B (NM_001003682 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM200B Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM200B
Additional cDNA sequence: AL110282.1 BC033289.1 BC064375.1 BC064538.1 BC082989.1 BC110336.1
6 DOTS entries : DT.91996271 DT.444098
DT.100718032 DT.100827927 DT.99939612 DT.100827924 24/370 AceView cDNA sequences (see all 370 ):
BQ424914 AA730984 BX492942 CR601097 BU164992 AI810252 BX952914 BM704269 BF868865 J03796 AI656046 AA342636 BM454463 BF476313 AL041809 BC009063 NM_203343 BU736589 CD109824 BP364691 NM_203342 BU159552 CB158940 AL520065 GeneLoc Exon Structure
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Expression for TMEM200B gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section TMEM200B expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: TGGCTTGGAGAbout this image TMEM200B expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table
Stem Cell Differentiation: 1 LifeMap Cell Name Category Definitive endoderm-like cells (A scalable, suspensi... )Expression: Positive Negative
Selective markerExperimental details:
Curated
Microarrays
In-situ hybridization
Genevestigator expression for TMEM200B SOURCE GeneReport for Unigene cluster: Hs.712722 SABiosciences Custom PCR Arrays for TMEM200B Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM200BBrowse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse / rat TMEM200B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM200B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM200B In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM200B
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Orthologsfor TMEM200B gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for TMEM200B gene from 3/9 species (see all 9 ) About this table
Organism
Taxonomic classification
Gene
Description
Human Similarity
Orthology Type
Details
chicken (Gallus gallus)
Aves
TMEM200B1
transmembrane protein 200B
57.77(n) 49.32(a)
 
428217 XM_425776.3 XP_425776.2
lizard (Anolis carolinensis)
Reptilia
TMEM200B6
--
33(a)
1 ↔ 1
GL344047.1(5599-6816)
zebrafish (Danio rerio)
Actinopterygii
si:ch211-204a13.26
si:ch211-204a13.2
20(a)
1 ↔ 1
19(17148138-17154245)
ENSEMBL Gene Tree for TMEM200B (if available)TreeFam Gene Tree for TMEM200B (if available)
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Paralogsfor TMEM200B gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section Paralogs for TMEM200B gene TMEM200A 2 TMEM200C 2
TMEM200B for paralogs About GeneDecksing
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Genomic Variantsfor TMEM200B gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 1 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for TMEM200B (29445937 - 29450447 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMEM200B: --
SABiosciences Cancer Mutation PCR Assays
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Disorders
/ Diseasesfor TMEM200B gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
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Publicationsfor TMEM200B gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for TMEM200B gene integrated from 9 sources : (articles sorted by number of sources associating them with TMEM200B) Utopia : connect your pdf to the dynamic world of online information
Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PubMed id 15722956) 1 , 3 Pickard B.S.... Muir W.J. (2005) The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005) 2 Bechtel S.... Schupp I. (2007) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMEM200B gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing TMEM200B gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing TMEM200B gene
(According to HUGE )
About This Section --
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Specialized Databases showing TMEM200B gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for TMEM200B Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for TMEM200B gene: Search GeneIP for patents involving TMEM200B GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor TMEM200B gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 and Sirion Biotech , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript , LifeMap BioReagents , and Sirion Biotech , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences , In Situ Hybridization Assays from Advanced Cell Diagnostics , Animal models from inGenious Targeting Laboratory )About This Section
Browse OriGene Antibodies OriGene shRNA RFP for TMEM200B OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for TMEM200B OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for TMEM200B OriGene Protein Over-expression Lysate for TMEM200B Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for TMEM200B Browse 3'-UTR reporter clones for miRNA target validation OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for TMEM200B Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs Browse OriGene full length recombinant human proteins expressed in human HEK293 cells OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for TMEM200B OriGene Custom Protein Services for TMEM200B OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM200B Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM200B QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM200B QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat TMEM200B QIAGEN QuantiFast Probe-based Assays in human , mouse , rat TMEM200B QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat TMEM200B
TMEM200B Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM200B
Search ThermoFisher Antibodies for TMEM200B
Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat TMEM200B
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Databases for TMEM200B
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Function for TMEM200B
Genomic Views for TMEM200B
Intellectual Property for TMEM200B
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