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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM200B Gene

protein-coding   GIFtS: 37
GCID: GC01M029445

Transmembrane Protein 200B

  Search for TMEM200B
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 200B1 2
Transmembrane Protein TTMA2 3
Two Transmembrane Domain-Containing Family Member B2 3
TTMB2 3
Two Transmembrane B2

External Ids:    HGNC: 337851   Entrez Gene: 3994742   Ensembl: ENSG000002533047   UniProtKB: Q69YZ23   

Export aliases for TMEM200B gene to outside databases

Previous GC identifers: GC01M029318 GC01M027698


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM200B Gene: 
TMEM200B (transmembrane protein 200B) is a protein-coding gene. An important paralog of this gene is TMEM200A.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004610.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM200B gene promoter:
         Pbx1a   USF2   USF-1:USF-2   RORalpha1   Egr-2   CREB   HFH-1   USF-1   deltaCREB   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM200B promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM200B

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM200B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1p35   Ensembl cytogenetic band:  1p35.3   HGNC cytogenetic band: 1p35

TMEM200B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM200B gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01M029445:  view genomic region     (about GC identifiers)

Start:
29,445,937 bp from pter      End:
29,450,447 bp from pter
Size:
4,511 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T200B_HUMAN, Q69YZ2 (See protein sequence)
Recommended Name: Transmembrane protein 200B  
Size: 307 amino acids; 32750 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6P2G8 Q6P2Q5

Explore the universe of human proteins at neXtProt for TMEM200B: NX_Q69YZ2

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q69YZ2

  • TMEM200B Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --
    REFSEQ proteins (2 alternative transcripts): 
    NP_001003682.1  NP_001165339.1  

    ENSEMBL proteins: 
     ENSP00000428459   ENSP00000428544  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM200B for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR018787 DUF2371_TMEM200

    Graphical View of Domain Structure for InterPro Entry Q69YZ2

    ProtoNet protein and cluster: Q69YZ2

    UniProtKB/Swiss-Prot: T200B_HUMAN, Q69YZ2
    Similarity: Belongs to the TMEM200 family


    TMEM200B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Animal Models:
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM200B 3' UTR sequence
    Inhib. RNA
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM200B

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM200B (T200B)

    Search CenterWatch for drugs/clinical trials and news about TMEM200B / T200B

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM200B gene (2 alternative transcripts): 
    NM_001003682.3  NM_001171868.1  

    Unigene Cluster for TMEM200B:

    Transmembrane protein 200B
    Hs.712722  [show with all ESTs]
    Unigene Representative Sequence: AL110282
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521452(uc001brn.2) ENST00000420504(uc021okh.1)
    miRNA
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    8/47 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM200B (see all 47):
    hsa-miR-140-5p hsa-miR-199a-3p hsa-miR-25 hsa-miR-578 hsa-miR-449a hsa-miR-766 hsa-miR-3167 hsa-miR-1244
    SwitchGear 3'UTR luciferase reporter plasmidTMEM200B 3' UTR sequence
    Inhib. RNA
    Products:
         
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM200B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM200B
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM200B 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM200B 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM200B
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM200B

    Additional mRNA sequence: 

    AL110282.1 BC033289.1 BC064375.1 BC064538.1 BC082989.1 BC110336.1 

    7 DOTS entries:

    DT.91996271  DT.444098  DT.100827927  DT.100718032  DT.99939612  DT.100827922  DT.100827924 

    24/370 AceView cDNA sequences (see all 370):

    BX492942 BP364691 BC039079 CD109824 BU164992 AI656046 BM452936 CF136825 
    BQ424914 BQ422444 BU663983 AA730984 CB158940 CA390275 BM454463 NM_004437 
    BE693495 J03796 AI810252 AL520065 AI241891 BF868865 BX952914 BM704269 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM200B expression in normal human tissues (normalized intensities)      TMEM200B embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGCTTGGAG
    TMEM200B Expression
    About this image


    TMEM200B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/1 selected tissues (see all 1) fully expand
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...

    Genevestigator expression for TMEM200B

    SOURCE GeneReport for Unigene cluster: Hs.712722
        SABiosciences Custom PCR Arrays for TMEM200B
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM200B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM200B gene from 4/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem200b1 , 5 transmembrane protein 200B1, 5 83.8(n)1
    91.2(a)1
      4 (64.54 cM)5
    6232301  NM_001201367.11  NP_001188296.11 
     1319217715 
    chicken
    (Gallus gallus)
    Aves TMEM200B1 transmembrane protein 200B 57.77(n)
    49.32(a)
      428217  XM_425776.3  XP_425776.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM200B6
    Uncharacterized protein
    35(a)
    1 ↔ 1
    GL344047.1(5599-6816)
    zebrafish
    (Danio rerio)
    Actinopterygii TMEM200B6
    transmembrane protein 200B
    20(a)
    1 ↔ 1
    19(17148138-17154245)


    ENSEMBL Gene Tree for TMEM200B (if available)
    TreeFam Gene Tree for TMEM200B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM200B gene
    TMEM200A2  TMEM200C2  

    TMEM200B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/120 SNPs in TMEM200B are shown (see all 120)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1401657671,2
    C--29447079(+) TCTTGA/GGTTTG 2 -- ut310--------
    rs763462361,2
    C,F--29447242(+) CAGCTG/AGCATT 2 -- ut311Minor allele frequency- A:0.03WA 118
    rs1456835211,2
    --29447256(+) CTGCCC/TGCATG 2 -- ut310--------
    rs757350551,2
    F--29447307(+) CCATCC/ACCAGC 2 -- ut311Minor allele frequency- A:0.03EA 120
    rs1453064411,2
    C--29447411(+) CTCCCC/TTCTCT 2 -- ut310--------
    rs1449252281,2
    C,F--29447425(+) GACCCG/AGGCCC 4 /R /W mis11Minor allele frequency- A:0.00NA 3692
    rs1491930141,2
    --29447509(+) AGCACA/TGTCCC 4 S C mis10--------
    rs1392817501,2
    C,F--29447639(+) CCCCAG/AGGTGG 4 /P syn11Minor allele frequency- A:0.00NA 4252
    rs1404932211,2
    C,F--29447663(+) CCCTTC/TAGCGG 4 L syn11Minor allele frequency- T:0.00NA 4234
    rs560404561,2
    C,F--29447699(+) CCCAAG/ACGAGG 4 /R syn13Minor allele frequency- A:0.02NS NA EU 5541

    HapMap Linkage Disequilibrium report for TMEM200B (29445937 - 29450447 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM200B:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv509091CNV Insertion20534489

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM200B gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM200B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PubMed id 15722956)1, 3 Pickard B.S.... Muir W.J. (2005)
    2. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 399474 HGNC: 33785 AceView: EPB41 Ensembl:ENSG00000253304 euGenes: HUgn399474
    ECgene: TMEM200B H-InvDB: TMEM200B

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM200B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM200B gene:
    Search GeneIP for patents involving TMEM200B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
    transforming growth factor, beta 1
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