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Aliases for TMEM200A Gene

Aliases for TMEM200A Gene

  • Transmembrane Protein 200A 2 3 5
  • KIAA1913 2 3 4
  • Two Transmembrane C 3
  • TTMA 3
  • TTMC 3

External Ids for TMEM200A Gene

Previous HGNC Symbols for TMEM200A Gene

  • KIAA1913

Previous GeneCards Identifiers for TMEM200A Gene

  • GC06P130729
  • GC06P128339

Summaries for TMEM200A Gene

GeneCards Summary for TMEM200A Gene

TMEM200A (Transmembrane Protein 200A) is a Protein Coding gene. An important paralog of this gene is TMEM200C.

Additional gene information for TMEM200A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM200A Gene

Genomics for TMEM200A Gene

Regulatory Elements for TMEM200A Gene

Enhancers for TMEM200A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06H130600 1.4 FANTOM5 Ensembl ENCODE 29.8 +237.1 237096 5 PKNOX1 JUN INSM2 FEZF1 BCL11B HIC1 POLR2A ZNF366 ZSCAN5C FOS TMEM200A SAMD3 GC06P130596 ENSG00000229923
GH06H130575 1 Ensembl ENCODE 11.4 +210.4 210393 1 PKNOX1 BATF RELA EED ATF7 ETV6 RUNX3 IKZF2 CHD2 CBFB SAMD3 TMEM200A ENSG00000202438 GC06P130596
GH06H130258 1 Ensembl ENCODE 10 -105.1 -105105 3 HDGF FOXA2 BMI1 DPF2 RARA TARDBP IKZF1 ZNF143 KDM1A MLLT1 TMEM200A SAMD3 ENSG00000227678
GH06H130625 0.9 ENCODE 10.9 +260.6 260565 0 PKNOX1 BMI1 FEZF1 BATF ZNF366 FOS ATF7 ETV6 RUNX3 CREM SAMD3 TMEM200A GC06P130596 ENSG00000229923
GH06H130453 0.9 FANTOM5 ENCODE 10.8 +87.7 87695 0 JUND POLR2A JUNB FOS RUNX3 CREM SAMD3 TMEM200A GC06M130284 GC06M130560
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM200A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM200A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000202694 766 2600 RB1 ARID4B KLF17 RAD21 GLIS2 SCRT2 ZNF143 FOS EGR2 SMARCA5

Genomic Location for TMEM200A Gene

Chromosome:
6
Start:
130,365,734 bp from pter
End:
130,443,424 bp from pter
Size:
77,691 bases
Orientation:
Plus strand

Genomic View for TMEM200A Gene

Genes around TMEM200A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM200A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM200A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM200A Gene

Proteins for TMEM200A Gene

  • Protein details for TMEM200A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VY9-T200A_HUMAN
    Recommended name:
    Transmembrane protein 200A
    Protein Accession:
    Q86VY9
    Secondary Accessions:
    • Q96PX5

    Protein attributes for TMEM200A Gene

    Size:
    491 amino acids
    Molecular mass:
    54356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM200A Gene

Post-translational modifications for TMEM200A Gene

  • Glycosylation at posLast=100100
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM200A Gene

Domains & Families for TMEM200A Gene

Gene Families for TMEM200A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM200A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM200A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VY9

UniProtKB/Swiss-Prot:

T200A_HUMAN :
  • Belongs to the TMEM200 family.
Family:
  • Belongs to the TMEM200 family.
genes like me logo Genes that share domains with TMEM200A: view

Function for TMEM200A Gene

Phenotypes From GWAS Catalog for TMEM200A Gene

genes like me logo Genes that share phenotypes with TMEM200A: view

Animal Model Products

CRISPR Products

miRNA for TMEM200A Gene

miRTarBase miRNAs that target TMEM200A

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM200A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM200A Gene

Localization for TMEM200A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM200A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM200A gene
Compartment Confidence
plasma membrane 3
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM200A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM200A: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM200A Gene

Pathways & Interactions for TMEM200A Gene

SuperPathways for TMEM200A Gene

No Data Available

Interacting Proteins for TMEM200A Gene

Gene Ontology (GO) - Biological Process for TMEM200A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM200A Gene

Drugs & Compounds for TMEM200A Gene

No Compound Related Data Available

Transcripts for TMEM200A Gene

Unigene Clusters for TMEM200A Gene

Transmembrane protein 200A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM200A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM200A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for TMEM200A Gene

GeneLoc Exon Structure for
TMEM200A
ECgene alternative splicing isoforms for
TMEM200A

Expression for TMEM200A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM200A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM200A Gene

This gene is overexpressed in Adrenal Gland (x5.7) and Uterus (x5.6).

Protein differential expression in normal tissues from HIPED for TMEM200A Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM200A Gene



Protein tissue co-expression partners for TMEM200A Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM200A Gene:

TMEM200A

SOURCE GeneReport for Unigene cluster for TMEM200A Gene:

Hs.591341

mRNA Expression by UniProt/SwissProt for TMEM200A Gene:

Q86VY9-T200A_HUMAN
Tissue specificity: Expressed in cerebellum.

Evidence on tissue expression from TISSUES for TMEM200A Gene

  • Intestine(4.2)
  • Nervous system(4.2)
  • Urine(2.4)
genes like me logo Genes that share expression patterns with TMEM200A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM200A Gene

Orthologs for TMEM200A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM200A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM200A 33 34
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia TMEM200A 34
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM200A 34
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM200A 33 34
  • 85.47 (n)
mouse
(Mus musculus)
Mammalia Tmem200a 33 16 34
  • 82.01 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM200A 34
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem200a 33
  • 81.92 (n)
chicken
(Gallus gallus)
Aves TMEM200A 33 34
  • 76.55 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM200A 34
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem200a 33
  • 68.58 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem200a 33 34
  • 62.98 (n)
Species where no ortholog for TMEM200A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM200A Gene

ENSEMBL:
Gene Tree for TMEM200A (if available)
TreeFam:
Gene Tree for TMEM200A (if available)

Paralogs for TMEM200A Gene

Paralogs for TMEM200A Gene

genes like me logo Genes that share paralogs with TMEM200A: view

Variants for TMEM200A Gene

Sequence variations from dbSNP and Humsavar for TMEM200A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000038218 -- 130,379,562(+) TAACA(C/T)GATCT intron-variant
rs1000051908 -- 130,399,829(+) TCCCT(C/T)GCCCC intron-variant
rs1000086538 -- 130,413,012(+) TAAAT(A/T)ACTTA intron-variant
rs1000143156 -- 130,423,012(+) CATAA(A/C)AACAA intron-variant
rs1000231720 -- 130,372,771(+) TGTGT(A/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM200A Gene

Variant ID Type Subtype PubMed ID
esv2732698 CNV deletion 23290073
esv3610789 CNV loss 21293372
nsv478007 CNV novel sequence insertion 20440878
nsv507360 OTHER sequence alteration 20534489
nsv604663 CNV gain 21841781

Variation tolerance for TMEM200A Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM200A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM200A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM200A Gene

Disorders for TMEM200A Gene

Relevant External Links for TMEM200A

Genetic Association Database (GAD)
TMEM200A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM200A

No disorders were found for TMEM200A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM200A Gene

Publications for TMEM200A Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard BS … Muir WJ (Psychiatric genetics 2005) 2 3 60
  2. Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins. (PMID: 11572484) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2001) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. (PMID: 25192705) Du M … Colon Cancer Family Registry and Genetics and Epidemiology of Colorectal Cancer Consortium (Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology 2014) 3 60
  5. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L … Green MR (PLoS genetics 2012) 3 60

Products for TMEM200A Gene

Sources for TMEM200A Gene

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