Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM200A Gene

Aliases for TMEM200A Gene

  • Transmembrane Protein 200A 2 3 5
  • KIAA1913 2 3 4
  • Two Transmembrane C 3
  • TTMA 3
  • TTMC 3

External Ids for TMEM200A Gene

Previous HGNC Symbols for TMEM200A Gene

  • KIAA1913

Previous GeneCards Identifiers for TMEM200A Gene

  • GC06P130729
  • GC06P128339

Summaries for TMEM200A Gene

GeneCards Summary for TMEM200A Gene

TMEM200A (Transmembrane Protein 200A) is a Protein Coding gene. An important paralog of this gene is TMEM200B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM200A Gene

Genomics for TMEM200A Gene

Regulatory Elements for TMEM200A Gene

Promoters for TMEM200A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM200A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM200A Gene

Chromosome:
6
Start:
130,365,734 bp from pter
End:
130,443,424 bp from pter
Size:
77,691 bases
Orientation:
Plus strand

Genomic View for TMEM200A Gene

Genes around TMEM200A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM200A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM200A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM200A Gene

Proteins for TMEM200A Gene

  • Protein details for TMEM200A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86VY9-T200A_HUMAN
    Recommended name:
    Transmembrane protein 200A
    Protein Accession:
    Q86VY9
    Secondary Accessions:
    • Q96PX5

    Protein attributes for TMEM200A Gene

    Size:
    491 amino acids
    Molecular mass:
    54356 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB67806.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM200A Gene

Proteomics data for TMEM200A Gene at MOPED

Post-translational modifications for TMEM200A Gene

  • Glycosylation at Asn 100
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM200A Gene

No data available for DME Specific Peptides for TMEM200A Gene

Domains & Families for TMEM200A Gene

Protein Domains for TMEM200A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM200A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86VY9

UniProtKB/Swiss-Prot:

T200A_HUMAN :
  • Belongs to the TMEM200 family.
Family:
  • Belongs to the TMEM200 family.
genes like me logo Genes that share domains with TMEM200A: view

No data available for Gene Families for TMEM200A Gene

Function for TMEM200A Gene

genes like me logo Genes that share phenotypes with TMEM200A: view

Animal Model Products

CRISPR Products

miRNA for TMEM200A Gene

miRTarBase miRNAs that target TMEM200A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM200A Gene

Localization for TMEM200A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM200A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM200A Gene COMPARTMENTS Subcellular localization image for TMEM200A gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM200A Gene

Pathways & Interactions for TMEM200A Gene

SuperPathways for TMEM200A Gene

No Data Available

Interacting Proteins for TMEM200A Gene

Gene Ontology (GO) - Biological Process for TMEM200A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM200A Gene

Drugs & Compounds for TMEM200A Gene

No Compound Related Data Available

Transcripts for TMEM200A Gene

Unigene Clusters for TMEM200A Gene

Transmembrane protein 200A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM200A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c · 5d
SP1: - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:

Relevant External Links for TMEM200A Gene

GeneLoc Exon Structure for
TMEM200A
ECgene alternative splicing isoforms for
TMEM200A

Expression for TMEM200A Gene

mRNA expression in normal human tissues for TMEM200A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM200A Gene

This gene is overexpressed in Adrenal Gland (x5.7) and Uterus (x5.6).

Protein differential expression in normal tissues from HIPED for TMEM200A Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM200A Gene



SOURCE GeneReport for Unigene cluster for TMEM200A Gene Hs.591341

mRNA Expression by UniProt/SwissProt for TMEM200A Gene

Q86VY9-T200A_HUMAN
Tissue specificity: Expressed in cerebellum.
genes like me logo Genes that share expression patterns with TMEM200A: view

Protein tissue co-expression partners for TMEM200A Gene

Primer Products

In Situ Assay Products

Orthologs for TMEM200A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM200A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM200A 35
  • 85.47 (n)
  • 90.63 (a)
TMEM200A 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem200a 35
  • 82.01 (n)
  • 90.63 (a)
Tmem200a 16
Tmem200a 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM200A 35
  • 99.52 (n)
  • 99.39 (a)
TMEM200A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem200a 35
  • 81.92 (n)
  • 90.93 (a)
cow
(Bos Taurus)
Mammalia TMEM200A 36
  • 93 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM200A 36
  • 87 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM200A 36
  • 82 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM200A 35
  • 76.55 (n)
  • 79.96 (a)
TMEM200A 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM200A 36
  • 76 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem200a 35
  • 68.58 (n)
  • 72.28 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem200a 35
  • 62.98 (n)
  • 65.78 (a)
tmem200a 36
  • 63 (a)
OneToOne
Species with no ortholog for TMEM200A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM200A Gene

ENSEMBL:
Gene Tree for TMEM200A (if available)
TreeFam:
Gene Tree for TMEM200A (if available)

Paralogs for TMEM200A Gene

Paralogs for TMEM200A Gene

genes like me logo Genes that share paralogs with TMEM200A: view

Variants for TMEM200A Gene

Sequence variations from dbSNP and Humsavar for TMEM200A Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs169785 -- 130,390,043(+) GGTTT(C/G)TTAGA intron-variant
rs172401 -- 130,408,184(+) GGGCA(C/G)AGCAG intron-variant
rs188376 -- 130,408,071(+) GAGCA(C/G)TCTGG intron-variant
rs387654 -- 130,396,416(-) TTTAC(A/C)ACCTT intron-variant
rs394207 -- 130,409,882(+) AAACA(A/C)TGAAT intron-variant

Variation tolerance for TMEM200A Gene

Residual Variation Intolerance Score: 32.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.39; 27.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM200A Gene

HapMap Linkage Disequilibrium report
TMEM200A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM200A Gene

Disorders for TMEM200A Gene

Relevant External Links for TMEM200A

Genetic Association Database (GAD)
TMEM200A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM200A

No disorders were found for TMEM200A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM200A Gene

Publications for TMEM200A Gene

  1. Candidate psychiatric illness genes identified in patients with pericentric inversions of chromosome 18. (PMID: 15722956) Pickard B.S. … Muir W.J. (Psychiatr. Genet. 2005) 2 3 67
  2. No evidence of gene-calcium interactions from genome-wide analysis of colorectal cancer risk. (PMID: 25192705) Du M. … Potter J.D. (Cancer Epidemiol. Biomarkers Prev. 2014) 3
  3. A synthetic interaction screen identifies factors selectively required for proliferation and TERT transcription in p53-deficient human cancer cells. (PMID: 23284306) Xie L. … Green M.R. (PLoS Genet. 2012) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM200A Gene

Sources for TMEM200A Gene

Back to Top

Content