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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM2 Gene

protein-coding GIFtS: 53
GCID: GC09M074298

Transmembrane Protein 2

10 related diseases
at

MalaCards

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Transmembrane Protein 2¹ ²
KIAA1412³

External Ids:	HGNC: 11869¹	Entrez Gene: 23670²	Ensembl: ENSG00000135048⁷	OMIM: 605835⁵	UniProtKB: Q9UHN6³

Export aliases for TMEM2 gene to outside databases

Previous GC identifers: GC09M065342 GC09M066154 GC09M067868 GC09M069755 GC09M071527 GC09M073488 GC09M073371 GC09M044121

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM2 Gene:

TMEM2 (transmembrane protein 2) is a protein-coding gene. Diseases associated with TMEM2 include benign familial infantile epilepsy, and hepatitis b virus infection. An important paralog of this gene is PKHD1L1.

UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6

Function: May be required for the heart morphogenesis (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000009.11 NT_008470.19 NC_018920.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM2 gene promoter:
TBP LHX3b/Lhx3b GATA-3 GATA-2 GATA-1 AREB6 S8 LHX3a/Lhx3a Sox9 c-Myb
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM2 promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM2

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13 Ensembl cytogenetic band: 9q21.13 HGNC cytogenetic band: 9q21.13

TMEM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM2 gene location

GeneLoc information about chromosome 9 GeneLoc Exon Structure

GeneLoc location for GC09M074298: view genomic region (about GC identifiers)

Start:	74,298,282 bp from pter	End:	74,431,606 bp from pter
Size:	133,325 bases	Orientation:	minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6 (See protein sequence)

Recommended Name: Transmembrane protein 2

Size: 1383 amino acids; 154374 Da

Subcellular location: Membrane; Single-pass membrane protein (Potential)

Sequence caution: Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI15172.1;

Type=Erroneous gene model prediction; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Sequence=CAI15174.1;

Type=Erroneous gene model prediction; Sequence=CAI15175.1; Type=Erroneous gene model prediction;

Secondary accessions: A6H8W9 B2RTQ6 Q5T838 Q5T839 Q5T840 Q5T841 Q8NBP6 Q9P2D5

Alternative splicing: 2 isoforms: Q9UHN6-1 Q9UHN6-2

Explore the universe of human proteins at neXtProt for TMEM2: NX_Q9UHN6

Explore proteomics data for TMEM2 at MOPED

Post-translational modifications:

View modification sites using PhosphoSitePlus

View neXtProt modification sites for NX_Q9UHN6

TMEM2 Protein expression data from MOPED¹, PaxDb² and MAXQB³ : About this image

REFSEQ proteins (2 alternative transcripts):

NP_001129292.1 NP_037522.1

ENSEMBL proteins:

ENSP00000366243 ENSP00000366266 ENSP00000437750 ENSP00000379569 ENSP00000366254

ENSP00000366242 ENSP00000444571

Human Recombinant Protein Products for TMEM2:

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	Browse Sino Biological Recombinant Proteins Browse Sino Biological Cell Lysates
	Browse ProSpec Recombinant Proteins
	Cloud-Clone Corp. Proteins for TMEM2

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM2 for ontologies About GeneDecksing

TMEM2 Antibody Products:

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	Novus Biologicals TMEM2 Antibodies
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	LSBio Antibodies in human, mouse, rat for TMEM2

Assay Products for TMEM2:

	Browse Kits and Assays available from EMD Millipore
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	GenScript Custom Assay Services for TMEM2
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	Cloud-Clone Corp. ELISAs for TMEM2 Cloud-Clone Corp. CLIAs for TMEM2

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

2 InterPro protein domains:

IPR011050 Pectin_lyase_fold/virulence

IPR019316 G8_domain

Graphical View of Domain Structure for InterPro Entry Q9UHN6

ProtoNet protein and cluster: Q9UHN6

UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6

Similarity: Belongs to the TMEM2 family

Similarity: Contains 1 G8 domain

Similarity: Contains 3 PbH1 repeats

TMEM2 for domains About GeneDecksing

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: TMEM2_HUMAN, Q9UHN6

Function: May be required for the heart morphogenesis (By similarity)

Phenotypes:
1 GenomeRNAi human phenotype for TMEM2:

Increased circadian period len

Animal Models:

inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM2

inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM2

miRNA Products:		miRTarBase miRNAs that target TMEM2: hsa-let-7b (MIRT001585), hsa-mir-30a (MIRT001762)


		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM2
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM2 (see all 59):
		hsa-let-7d hsa-miR-218-1* hsa-miR-938 hsa-let-7a-2* hsa-miR-1304 hsa-let-7g hsa-miR-208b hsa-miR-208a

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for TMEM2
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Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene clones in human, mouse for TMEM2 (see all 11) OriGene ORF clones in mouse, rat for TMEM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMEM2 (NM_013390)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM2
		Search LifeMap BioReagents cell lines for TMEM2
		Sirion Biotech Customized stable knockdown cell line services for TMEM2 Customized inducible knockdown cell line services for TMEM2 Customized stable overexpressing cell line services for TMEM2 Customized inducible overexpressing cell line services for TMEM2

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM2

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

2 Interacting proteins for TMEM2 (Q9UHN6³ ENSP00000366266⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAPK6	Q16659³	I2D: score=2
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007275	multicellular organismal development	IEA	--

TMEM2 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, IUPHAR, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM2

Search CenterWatch for drugs/clinical trials and news about TMEM2

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM2 gene (2 alternative transcripts):

NM_001135820.1 NM_013390.2

Unigene Cluster for TMEM2:

Transmembrane protein 2

Hs.494146 [show with all ESTs]

Unigene Representative Sequence: NM_013390

13 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000377044(uc011lrz.1 uc011lsa.1 uc010mos.2 uc011lsb.1)

ENST00000377057(uc004aik.2) ENST00000538669 ENST00000377066 ENST00000542935

ENST00000396272 ENST00000474495 ENST00000377055 ENST00000377043 ENST00000537329

ENST00000546219 ENST00000543165 ENST00000545719

miRNA Products:
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM2
		8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM2 (see all 59):
		hsa-let-7d hsa-miR-218-1* hsa-miR-938 hsa-let-7a-2* hsa-miR-1304 hsa-let-7g hsa-miR-208b hsa-miR-208a

		SwitchGear 3'UTR luciferase reporter plasmid: TMEM2 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene RNAi products in human, mouse, rat for TMEM2
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM2
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM2

Clone Products:		OriGene clones in human, mouse for TMEM2 (see all 11) OriGene ORF clones in mouse, rat for TMEM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMEM2 (NM_013390)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TMEM2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM2
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM2
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM2

Additional mRNA sequence:

AB037833.2 AF137030.1 AK027818.1 AK056807.1 AK075370.1 AK300405.1 AK303765.1 BC044850.1

BC140773.1 BC144510.1 BC146780.1 BC171782.1

13 DOTS entries:

DT.100791735 DT.87017186 DT.99954500 DT.100791734 DT.95264391 DT.91740592 DT.75188529 DT.95199914

DT.121198652 DT.97819885 DT.99963636 DT.100791732 DT.75194011

24/184 AceView cDNA sequences (see all 184):

CA417845 N24834 CB129477 CA418327 CD678578 AK075370 BP364451 BM978442

N67011 BX476241 AI632442 AA282507 BG957014 BP336996 W38979 BU161728

AB037833 BM787925 AA344223 BU633767 BG956525 BM990972 AI825648 AI394177

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM2 expression in normal human tissues (normalized intensities) TMEM2 embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

TMEM2 expression in embryonic tissues and stem cells About this table

Data from LifeMap, the Embryonic Development and Stem Cells Database

5/11 selected tissues (see all 11) fully expand


Brain (Nervous System) fully expand to see all 9 entries
Thalamus
ganglion/cranial

Neural Tube (Nervous System) fully expand to see all 3 entries
Metencephalon

Nose (Sensory Organs)
sensory organ/nose/nasal cavity

Neural Ectoderm (Nervous System)
Neural ectoderm cells (Generation of functional floor plate or neuroectoderm cells...

Lower Urinary Tract (Urinary System)
visceral organ

See TMEM2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM2

SOURCE GeneReport for Unigene cluster: Hs.494146

UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6

Tissue specificity: Widely expressed

SABiosciences Expression via Pathway-Focused PCR Array including TMEM2:

Hepatotoxicity in human mouse rat

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TMEM2
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat TMEM2
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM2

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM2 gene from 5/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem2^{1 , 5}	transmembrane protein 2^{1, 5}	84.46(n)¹ 86.89(a)¹		19 (15.54 cM)⁵ 83921¹ NM_001033759.1¹ NP_001028931.1¹ 21778342⁵
chicken (Gallus gallus)	Aves	LOC427250¹	transmembrane protein 2-like	72.9(n) 71.5(a)		427250 XM_003643023.1 XP_003643071.1
lizard (Anolis carolinensis)	Reptilia	TMEM2⁶	transmembrane protein 2	73(a)	1 ↔ 1	2(48366509-48437676)
African clawed frog (Xenopus laevis)	Amphibia	Xl.23798²	Xenopus laevis transcribed sequence with weak similarity more	76.44(n)		BU909223.1
zebrafish (Danio rerio)	Actinopterygii	tmem2¹	transmembrane protein 2	60.17(n) 58.61(a)		566851 NM_001099449.1 NP_001092919.1

ENSEMBL Gene Tree for TMEM2 (if available)
TreeFam Gene Tree for TMEM2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM2 gene

PKHD1L1² PKHD1² KIAA1199²

1 SIMAP similar gene for TMEM2 using alignment to 6 protein entries: TMEM2_HUMAN (see all proteins):

KIAA1199

TMEM2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7857223^1,2	C,F,H	--	74297830(+)	`CAATAT/CTTACT`	2	--	int¹		4		NS EA	418
rs113346645^1,2	C,F	--	74297845(+)	`GGATTC/TTGTCC`	2	--	int¹		1		NA	2
rs189756157^1,2		--	74297897(+)	`CTGGAA/TTCTGG`	2	--	int¹		0	--	--	--	--
rs74674441^1,2	C,F	--	74297902(+)	`ATCTGG/TAATTT`	2	--	int¹		1		EA	120
rs183554251^1,2		--	74297956(+)	`CGGTGA/GCTCAT`	2	--	int¹		0	--	--	--	--
rs10781037^1,2	C,F,A,H	--	74298081(+)	`TAGCAG/ATGCAT`	2	--	int¹		3		NA WA CSA	6
rs145162385^1,2		--	74298222(+)	`CCATCG/TCAAAA`	2	--	int¹		0	--	--	--	--
rs138877639^1,2	C	--	74298254(+)	`TAAAT-/AATA AATAA`	2	--	int¹		0	--	--	--	--
rs13296471^1,2	H	--	74298422(+)	`AAGATA/TTTTAA`	2	--	ut3¹		4		NS EA	416
rs202089728^1,2	C	--	74298435(+)	`CATAAA/CACACA`	2	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM2 (74298282 - 74431606 bp)

Structural Variations
Database of Genomic Variants (DGV) 5 variations for TMEM2: About this table

Variant ID	Type	Subtype	PubMed ID
esv2677935	CNV	Deletion	23128226
nsv507516	CNV	Insertion	20534489
nsv416322	CNV	Insertion	16902084
nsv893444	CNV	Gain	21882294
nsv831617	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): TMEM2

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM2

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM2

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM2 for disorders           About GeneDecksing

OMIM gene information: 605835    OMIM disorders: --

10 diseases for TMEM2:    About MalaCards

benign familial infantile epilepsy hepatitis b virus infection polycystic kidney disease kidney disease

astrocytoma multiple sclerosis hepatitis b prostate cancer

prostatitis hepatitis

1 disease from the University of Copenhagen DISEASES database for TMEM2:

Benign familial infantile epilepsy

Genetic Association Database (GAD): TMEM2
Human Genome Epidemiology (HuGE) Navigator: TMEM2 (1 document)

Export disorders for TMEM2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM2 gene, integrated from 9 sources (see all 33):
(articles sorted by number of sources associating them with TMEM2)

Utopia: connect your pdf to the dynamic
world of online information

Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (2000)
Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. (PubMed id 10767548)^{1, 2} Scott D.A.... Smith R.J.H. (2000)
Rare inborn errors associated with chronic hepatitis B virus infection. (PubMed id 22610944)¹ Zhao Q....Wang Y. (2012)
Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (2012)
Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (2011)
Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (2011)
Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)¹ Abdelmohsen K....Gorospe M. (2009)
A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)² Dephoure N.... Gygi S.P. (2008)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 23670	HGNC: 11869	AceView: TMEM2	Ensembl:ENSG00000135048	euGenes: HUgn23670
ECgene: TMEM2	H-InvDB: TMEM2

(According to HUGE)
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HUGE: KIAA1412

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for TMEM2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for TMEM2 gene:
Search GeneIP for patents involving TMEM2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
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