Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM2 Gene

protein-coding   GIFtS: 50
GCID: GC09M074298

transmembrane protein 2
 Explore 6 diseases affiliated with
TMEM2 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM2    

Aliases
for TMEM2 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein 21 2
KIAA14123

External Ids:    HGNC: 118691   Entrez Gene: 236702   Ensembl: ENSG000001350487   OMIM: 6058355   UniProtKB: Q9UHN63   

Export aliases for TMEM2 gene to outside databases

Previous GC identifers: GC09M065342 GC09M066154 GC09M067868 GC09M069755 GC09M071527 GC09M073488 GC09M073371 GC09M044121


Summaries
for TMEM2 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6
Function: May be required for the heart morphogenesis (By similarity)




Genomic Views
for TMEM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000009.11  NC_018920.1  NT_008470.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM2 gene promoter:
         TBP   LHX3b/Lhx3b   GATA-3   GATA-2   GATA-1   AREB6   S8   LHX3a/Lhx3a   Sox9   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM2 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 9q21.13   Ensembl cytogenetic band:  9q21.13   HGNC cytogenetic band: 9q21.13

TMEM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM2 gene location

GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M074298:  view genomic region     (about GC identifiers)

Start:
 74,298,282 bp from pter      End:
 74,431,606 bp from pter
Size:
 133,325 bases      Orientation:
 minus strand

Proteins
for TMEM2 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6 (See protein sequence)
Recommended Name: Transmembrane protein 2  
Size: 1383 amino acids; 154374 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Sequence caution: Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAI15172.1;
Type=Erroneous gene model prediction; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Sequence=CAI15174.1;
Type=Erroneous gene model prediction; Sequence=CAI15175.1; Type=Erroneous gene model prediction;
Secondary accessions: A6H8W9 B2RTQ6 Q5T838 Q5T839 Q5T840 Q5T841 Q8NBP6 Q9P2D5
Alternative splicing: 2 isoforms:  Q9UHN6-1   Q9UHN6-2   

Explore the universe of human proteins at neXtProt for TMEM2: NX_Q9UHN6

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9UHN6

    • TMEM2 Protein expression data from MOPED and PaxDb:    About this image 
    TMEM2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001129292.1  NP_037522.1  

    ENSEMBL proteins: 
     ENSP00000366243   ENSP00000366266   ENSP00000437750   ENSP00000379569   ENSP00000366254  
     ENSP00000366242   ENSP00000444571  

    Human Recombinant Protein Products for TMEM2: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for TMEM2 
    GenScript Custom Purified and Recombinant Proteins Services for TMEM2
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for TMEM2

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM2 for ontologies           About GeneDecksing



    TMEM2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM2 
    GenScript Custom Superior Antibodies Services for TMEM2
    Novus Biologicals TMEM2 Antibodies
    Abcam antibodies for TMEM2 
    Uscn Antibodies for TMEM2
    Search ThermoFisher Antibodies for TMEM2

    Assay Products for TMEM2: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Immunoassay Development
    Browse OriGene Fluorogenic Cell Assay Kits
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM2
    Browse Enzo Life Sciences for kits & assays
    Uscn ELISAs and CLIAs for TMEM2

    Protein Domains /
    Families
    for TMEM2 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    TMEM2 for domains           About GeneDecksing

    2 InterPro domains/families:
     IPR011050 Pectin_lyase_fold/virulence
     IPR019316 G8_domain

    Graphical View of Domain Structure for InterPro Entry Q9UHN6

    ProtoNet protein and cluster: Q9UHN6

    UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6
    Similarity: Belongs to the TMEM2 family
    Similarity: Contains 1 G8 domain
    Similarity: Contains 3 PbH1 repeats


    Function
    for TMEM2 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMEM2_HUMAN, Q9UHN6
    Function: May be required for the heart morphogenesis (By similarity)

    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM2:

     Increased circadian period len 

    Animal Models:
       inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM2 

    miRNA
    Products:            		miRTarBase miRNAs that target TMEM2:
    hsa-let-7b (MIRT001585), hsa-mir-30a (MIRT001762)

    OriGene 3'-UTR Clone (see all 2): TMEM2
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM2 (see all 59):
    hsa-let-7d hsa-miR-218-1* hsa-miR-938 hsa-let-7a-2* hsa-miR-1304 hsa-let-7g hsa-miR-208b hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM2 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM2 (see all 7)
    OriGene shRNA RFP: TMEM2
    OriGene siRNA: TMEM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM2 

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for TMEM2
    Sirion Biotech Customized adenovirus for overexpression of TMEM2 
    Sirion Biotech Customized adenovirus for potent knockdown of TMEM2

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM2 (NM_013390)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for TMEM2
    Search LifeMap BioReagents cell lines for TMEM2
    Sirion Biotech Customized stable knockdown cell line services for TMEM2 
    Sirion Biotech Customized inducible knockdown cell line services for TMEM2
    Sirion Biotech Customized stable overexpressing cell line services for TMEM2
    Sirion Biotech Customized inducible overexpressing cell line services for TMEM2

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2


    Pathways & Interactions
    for TMEM2 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM2

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    2 Interacting proteins for TMEM2 (Q9UHN63 ENSP000003662664) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAPK6Q166593I2D: score=2 
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--

    TMEM2 for ontologies           About GeneDecksing



    Drugs & Compounds
    for TMEM2 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM2
    Search CenterWatch for drugs/clinical trials and news about TMEM2 

    Transcripts
    for TMEM2 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM2 gene (2 alternative transcripts): 
    NM_001135820.1  NM_013390.2  

    Unigene Cluster for TMEM2:

    Transmembrane protein 2
    Hs.494146  [show with all ESTs]
    Unigene Representative Sequence: NM_013390
    13 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000377044(uc011lrz.1 uc011lsa.1 uc010mos.2 uc011lsb.1)
    ENST00000377057(uc004aik.2) ENST00000538669 ENST00000377066 ENST00000542935
    ENST00000396272 ENST00000474495 ENST00000377055 ENST00000377043 ENST00000537329
    ENST00000546219 ENST00000543165 ENST00000545719

    miRNA
    Products:             		 OriGene 3'-UTR Clone (see all 2): TMEM2
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM2
    8/59 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM2 (see all 59):
    hsa-let-7d hsa-miR-218-1* hsa-miR-938 hsa-let-7a-2* hsa-miR-1304 hsa-let-7g hsa-miR-208b hsa-miR-208a
    SwitchGear 3'UTR luciferase reporter plasmid: TMEM2 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM2 (see all 7)
    OriGene shRNA RFP: TMEM2
    OriGene siRNA: TMEM2
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM2
    Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM2 
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2 (see all 5)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2 (see all 2)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM2 (NM_013390)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM2
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM2
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM2

    Additional cDNA sequence: 

    AB037833.2 AF137030.1 AK027818.1 AK056807.1 AK075370.1 AK300405.1 AK303765.1 BC044850.1 
    BC140773.1 BC144510.1 BC146780.1 BC171782.1 

    13 DOTS entries:

    DT.100791735  DT.87017186  DT.99954500  DT.100791734  DT.95264391  DT.91740592  DT.75188529  DT.95199914 
    DT.121198652  DT.97819885  DT.99963636  DT.100791732  DT.75194011 

    24/184 AceView cDNA sequences (see all 184):

    AI825648 AI394177 BU633767 BM990972 BG956525 BP364451 AK075370 N67011 
    BM978442 AA344223 CA418327 CB129477 CA417845 AB037833 AI632442 W38979 
    BG957014 AA282507 N24834 BX476241 BM787925 BU161728 BP336996 CD678578 

    GeneLoc Exon Structure


    Expression
    for TMEM2 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: --
    TMEM2 Expression
    About this image

    TMEM2 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table

    7 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    PancreasDorsal Pancreatic BudImmature Beta Progenitor CellsPancreas
    PancreasVentral Pancreatic BudImmature Beta Progenitor CellsPancreas
    BrainHypothalamusBrain
    BrainThalamusBrain
    Neural TubeDiencephalonNeural Tube
    Neural TubeTelencephalonNeural Tube
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ progenitor EN2 (Embryonic Progenitor Cell)
    PureStem™ progenitor EN27 (Embryonic Progenitor Cell)

    See TMEM2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM2

    SOURCE GeneReport for Unigene cluster: Hs.494146

    UniProtKB/Swiss-Prot: TMEM2_HUMAN, Q9UHN6
    Tissue specificity: Widely expressed

        SABiosciences Expression via Pathway-Focused PCR Array including TMEM2: 
              Hepatotoxicity in human mouse rat

    Primer
    Products:    		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM2
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM2
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM2
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM2
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2

    Orthologs
    for TMEM2 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM2 gene from 4/18 species (see all 18)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves LOC4272501 transmembrane protein 2-like 72.9(n)
    71.5(a)    		   427250  XM_003643023.1  XP_003643071.1 
    lizard
    (Anolis carolinensis)    		 Reptilia --
    --
    		 --
    		 74(a)
    68(a)
    		 1 ↔ many
    1 ↔ many
    		 2(48408493-48433028)
    2(48380733-48399980)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.237982 Xenopus laevis transcribed sequence with weak similarity more 76.44(n)    BU909223.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii tmem21 transmembrane protein 2 60.17(n)
    58.61(a)    		   566851  NM_001099449.1  NP_001092919.1 


    ENSEMBL Gene Tree for TMEM2 (if available)
    TreeFam Gene Tree for TMEM2 (if available) 

    Paralogs
    for TMEM2 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM2 gene
    PKHD1L12  PKHD12  KIAA11992  
    1 SIMAP similar gene for TMEM2 using alignment to 6 protein entries:     TMEM2_HUMAN (see all proteins):
    KIAA1199

    TMEM2 for paralogs           About GeneDecksing



    Genomic Variants
    for TMEM2 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1785 NCBI SNPs in TMEM2 are shown (see all 1785)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 9 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs78572231,2
    		C,F,H--74297830(+) CAATAT/CTTACT 2 -- int14Minor allele frequency- C:0.01NS EA 418
    rs1133466451,2
    		C--74297845(+) GGATTC/TTGTCC 2 -- int11Minor allele frequency- T:0.50NA 2
    rs1897561571,2
    		--74297897(+) CTGGAA/TTCTGG 2 -- int10--------
    rs746744411,2
    		F--74297902(+) ATCTGG/TAATTT 2 -- int11Minor allele frequency- T:0.08EA 120
    rs1835542511,2
    		--74297956(+) CGGTGA/GCTCAT 2 -- int10--------
    rs107810371,2
    		C,F,A,H--74298081(+) TAGCAG/ATGCAT 2 -- int13Minor allele frequency- A:0.50NA WA CSA 6
    rs1451623851,2
    		--74298222(+) CCATCG/TCAAAA 2 -- int10--------
    rs1388776391,2
    		C--74298254(+) TAAAT-/AATA  
                AATAA     		2 -- int10--------
    rs132964711,2
    		H--74298422(+) AAGATA/TTTTAA 2 -- ut314Minor allele frequency- T:0.00NS EA 416
    rs2020897281,2
    		C--74298435(+) CATAAA/CACACA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM2 (74298282 - 74431606 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM2: --
    Human Gene Mutation Database (HGMD): TMEM2

    SABiosciences Cancer Mutation PCR Assays
    QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM2
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM2

    Disorders / Diseases
    for TMEM2 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    TMEM2 for disorders           About GeneDecksing

    OMIM gene information: 605835    OMIM disorders: --

    6 diseases for TMEM2:    About MalaCards
    polycystic kidney disease    multiple sclerosis    kidney disease    astrocytoma
    prostate cancer    prostatitis

    1 disease from the University of Copenhagen DISEASES database for TMEM2:
    Benign familial infantile epilepsy
    Human Genome Epidemiology (HuGE) Navigator: TMEM2 (1 document)

    Export disorders for TMEM2 gene to outside databases

    Publications
    for TMEM2 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM2 gene, integrated from 9 sources (see all 31):
    (articles sorted by number of sources associating them with TMEM2)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    3. Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. (PubMed id 10767548)1, 2 Scott D.A.... Smith R.J.H. (2000)
    4. Rare inborn errors associated with chronic hepatitis B virus infection. (PubMed id 22610944)1 Zhao Q....Wang Y. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    8. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    9. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    External Searches for TMEM2 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM2 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23670 HGNC: 11869 AceView: TMEM2 Ensembl:ENSG00000135048 euGenes: HUgn23670
    ECgene: TMEM2 H-InvDB: TMEM2

    Other Databases showing TMEM2 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1412

    Specialized Databases showing TMEM2 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM2 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM2 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM2 gene:
    Search GeneIP for patents involving TMEM2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TMEM2 gene

    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Phosphatase Activity Assays/Reagents   Browse Recombinant/Natural Proteins  
     Browse OriGene Antibodies   OriGene shRNA RFP for TMEM2  
     OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM2   OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM2  
     Browse OriGene Protein Over-expression Lysates   Browse OriGene Fluorogenic Cell Assay Kits  
     OriGene siRNA for TMEM2   OriGene 3'-UTR Clone for TMEM2  
     OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2   OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM2  
     Browse OriGene GFP tagged cDNA clones in CMV expression vector   Browse OriGene MicroRNA Expression Plasmids  
     Browse OriGene basic RS shRNAs   Browse OriGene validated miRNA SYBR primer pairs  
     Browse OriGene full length recombinant human proteins expressed in human HEK293 cells   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for TMEM2   OriGene Custom Protein Services for TMEM2  
     OriGene Custom Immunoassay Development  

         		 
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM2
     QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM2
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM2
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM2
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM2
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM2
     GenScript Custom Purified and Recombinant Proteins Services for TMEM2 GenScript cDNA clones with any tag delivered in your preferred vector for TMEM2
     GenScript Custom Assay Services for TMEM2 GenScript Custom Superior Antibodies Services for TMEM2
     GenScript Custom overexpressing Cell Line Services for TMEM2 CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in TMEM2 promoter
     Search Chromatin IP Primers for TMEM2
     RT2 qPCR Primer Assay in human, mouse, rat TMEM2
     Search GNC Networks for TMEM2
     SABiosciences PCR Arrays including human, mouse, rat TMEM2
     Search Tocris compounds for TMEM2
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological cDNA Clones
     Antibodies/Proteins Production Services
     Rabbit Monoclonal Antibody Platform
     Bulk Purchasing
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     TMEM2 antibodies
     Antibodies for TMEM2
     See all of Abcam's Antibodies, Kits and Proteins for TMEM2
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     TMEM2 Proteins, Antibodies, CLIAs, and ELISAs
     Search LifeMap BioReagents cell lines for TMEM2
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2
     SwitchGear 3'UTR luciferase reporter plasmids for TMEM2
     SwitchGear Promoter luciferase reporter plasmids for TMEM2
     Search ThermoFisher Antibodies for TMEM2
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2
     inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM2
    Sirion Biotech Customized:
     stable knockdown cell line services for TMEM2
     inducible knockdown cell line services for TMEM2
     design and validation of potent shRNA sequences against TMEM2
     adenovirus for potent knockdown of TMEM2
     adenovirus for overexpression of TMEM2
     stable overexpressing cell line services for TMEM2
     inducible overexpressing cell line services for TMEM2
           
    GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

    View Random Gene

    Category
    VWF
    (GIFTS: 73)
    von Willebrand factor
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 

    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Copyright © 1996-2013 , Weizmann Institute of Science. All Rights Reserved.
    Hot genes      Disease genes      TMEM2 gene at Home site.
    hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4