Aliases for TMEM2 Gene
External Ids for TMEM2 Gene
- HGNC: 11869
- Entrez Gene: 23670
- Ensembl: ENSG00000135048
- OMIM: 605835
- UniProtKB: Q9UHN6
Previous GeneCards Identifiers for TMEM2 Gene
- GC09M065342
- GC09M066154
- GC09M067868
- GC09M069755
- GC09M071527
- GC09M073488
- GC09M073371
- GC09M074298
- GC09M044121
Summaries for TMEM2 Gene
-
This gene encodes a type II transmembrane protein that belongs to the interferon-induced transmembrane (IFITM) protein superfamily. The encoded protein functions as a cell surface hyaluronidase that cleaves extracellular high molecular weight hyaluronan into intermediate size fragments before internalization and degradation in the lysosome. It also has an interferon-mediated antiviral function in humans through activation of the JAK STAT signaling pathway. The activation of this gene by transcription factor SOX4 in breast cancer cells has been shown to mediate the pathological effects of SOX4 on cancer progression. Naturally occurring mutations in this gene are associated with autosomal recessive non-syndromic hearing loss. [provided by RefSeq, Mar 2017]
GeneCards Summary for TMEM2 Gene
TMEM2 (Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with TMEM2 include Deafness, Autosomal Recessive 7 and Benign Familial Infantile Epilepsy. An important paralog of this gene is CEMIP.
UniProtKB/Swiss-Prot for TMEM2 Gene
-
May be required for the heart morphogenesis.
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM2 Gene
Genomics for TMEM2 Gene
Regulatory Elements for TMEM2 Gene
Enhancers for TMEM2 Gene
| GeneHancer Identifier | Enhancer Score | Enhancer Sources | Gene-Enhancer Score | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Gene Targets for Enhancer |
|---|---|---|---|---|---|---|---|---|
| GH09G071780 | 1.8 | FANTOM5 Ensembl ENCODE dbSUPER | 19.3 | +34.0 | 33978 | 4.1 | PKNOX1 NFIB ARID4B SIN3A BMI1 RAD21 FOS RCOR1 IKZF2 CREM | TMEM2 LOC100420790 GC09P071678 |
| GH09G071791 | 1.6 | FANTOM5 Ensembl ENCODE dbSUPER | 14.9 | +21.8 | 21810 | 6.1 | PKNOX1 FOXA2 TBL1XR1 TEAD4 YY1 TEAD3 ZNF316 ARID3A ETV6 IKZF2 | TMEM2 ABHD17B C9orf85 LOC100420790 GC09P071678 |
| GH09G072041 | 1.4 | FANTOM5 Ensembl ENCODE | 13.4 | -226.8 | -226797 | 4.8 | TBP CTCF TAF1 MAX ZNF644 ZNF48 RAD21 YY1 HNF4G CHD2 | TMEM2 LINC01504 ZFAND5 PIR33466 GC09P072037 GC09M072053 |
| GH09G072024 | 1 | Ensembl ENCODE | 11.6 | -209.1 | -209054 | 1.6 | CTCF USF1 MAX EBF1 RAD21 GATA3 ZNF143 SMC3 ZNF652 DEK | TMEM2 LOC101927108 HSPB1P1 |
| GH09G071778 | 0.9 | ENCODE | 11.8 | +38.4 | 38391 | 0.2 | ELF3 FOXA2 ATF1 MLX ARID4B DNMT3B THRB RARA TCF12 CREM | TMEM2 LOC100420790 GC09P071678 |
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around TMEM2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the TMEM2 gene promoter:
Regulatory Element Products
Genomic Location for TMEM2 Gene
- Chromosome:
- 9
- Start:
- 71,683,366 bp from pter
- End:
- 71,816,690 bp from pter
- Size:
- 133,325 bases
- Orientation:
- Minus strand
Genomic View for TMEM2 Gene
Genes around TMEM2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 9q21.13 by Ensembl
- 9q21.13 by Entrez Gene
- 9q21.13 by HGNC
TMEM2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM2 Gene
Proteins for TMEM2 Gene
-
Protein details for TMEM2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9UHN6-TMEM2_HUMAN
- Recommended name:
- Transmembrane protein 2
- Protein Accession:
- Q9UHN6
- A6H8W9
- B2RTQ6
- Q5T838
- Q5T839
- Q5T840
- Q5T841
- Q8NBP6
- Q9P2D5
Protein attributes for TMEM2 Gene
- Size:
- 1383 amino acids
- Molecular mass:
- 154374 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15172.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15174.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
Protein Expression for TMEM2 Gene
Post-translational modifications for TMEM2 Gene
Other Protein References for TMEM2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TMEM2
- Novus Biologicals Antibodies for TMEM2
- Invitrogen Antibodies for TMEM2
- antibodies-online Antibodies for TMEM2: See all 10
- GeneTex TMEM2 antibody for TMEM2
Protein Products
- Search Origene for Purified Proteins, MassSpec and Protein Over-expression Lysates for TMEM2
- Origene Custom Protein Services for TMEM2
- Novus Biologicals proteins for TMEM2
- Search GeneTex for Proteins for TMEM2
Assay Products
- antibodies-online Kits for TMEM2: See all 2
No data available for DME Specific Peptides for TMEM2 Gene
Domains & Families for TMEM2 Gene
Protein Domains for TMEM2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9UHN6- Family:
-
- Belongs to the TMEM2 family.
No data available for Gene Families for TMEM2 Gene
Function for TMEM2 Gene
Molecular function for TMEM2 Gene
- UniProtKB/Swiss-Prot Function:
- May be required for the heart morphogenesis.
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0004415 | hyalurononglucosaminidase activity | IDA | 28246172 |
| GO:0005509 | calcium ion binding | IDA | 28246172 |
| GO:0045296 | cadherin binding | IDA | 25468996 |
Phenotypes for TMEM2 Gene
- GenomeRNAi human phenotypes for TMEM2:
Animal Model Products
-
Taconic Biosciences Mouse Models for TMEM2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM2 gene
- Search ViGene Biosciences for TMEM2
CRISPR Products
-
OriGene CRISPR knockouts for TMEM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM2
- GenScript: Design CRISPR guide RNA sequences for TMEM2
miRNA for TMEM2 Gene
- miRTarBase miRNAs that target TMEM2
-
- hsa-let-7b-5p (MIRT001585)
- hsa-mir-30a-3p (MIRT001762)
- hsa-mir-215-5p (MIRT024372)
- hsa-mir-196a-5p (MIRT026078)
- hsa-mir-192-5p (MIRT026372)
- hsa-mir-98-5p (MIRT027580)
- hsa-mir-26b-5p (MIRT029299)
- hsa-mir-21-5p (MIRT030825)
- hsa-let-7d-5p (MIRT032147)
- hsa-mir-331-3p (MIRT043348)
- hsa-mir-125b-5p (MIRT046046)
- hsa-mir-519c-3p (MIRT107945)
- hsa-mir-519b-3p (MIRT107948)
- hsa-mir-519a-3p (MIRT107955)
- hsa-mir-32-3p (MIRT228700)
- hsa-mir-5587-5p (MIRT465899)
- hsa-mir-603 (MIRT542629)
- hsa-mir-8485 (MIRT542630)
- hsa-mir-6759-3p (MIRT610311)
- hsa-mir-519e-5p (MIRT652454)
- hsa-mir-515-5p (MIRT652455)
- hsa-mir-302d-5p (MIRT652456)
- hsa-mir-302b-5p (MIRT652457)
- hsa-mir-942-5p (MIRT652458)
- hsa-mir-5695 (MIRT652459)
- hsa-mir-519d-5p (MIRT652460)
- hsa-mir-4762-5p (MIRT652461)
- hsa-mir-141-5p (MIRT652462)
- hsa-mir-5580-3p (MIRT652463)
- hsa-mir-186-5p (MIRT652464)
- hsa-mir-3133 (MIRT652465)
- hsa-mir-2113 (MIRT698242)
- hsa-mir-3682-5p (MIRT698243)
- hsa-mir-19b-3p (MIRT698244)
- hsa-mir-19a-3p (MIRT698245)
- hsa-mir-4696 (MIRT698246)
- hsa-mir-617 (MIRT698247)
- hsa-mir-570-3p (MIRT698248)
- hsa-mir-302a-5p (MIRT698249)
- hsa-mir-138-1-3p (MIRT698250)
- hsa-mir-499b-5p (MIRT698251)
- hsa-mir-4714-3p (MIRT698252)
- hsa-mir-454-3p (MIRT698253)
- hsa-mir-4295 (MIRT698254)
- hsa-mir-3666 (MIRT698255)
- hsa-mir-301b-3p (MIRT698256)
- hsa-mir-301a-3p (MIRT698257)
- hsa-mir-130b-3p (MIRT698258)
- hsa-mir-130a-3p (MIRT698259)
- hsa-mir-6882-5p (MIRT698260)
- hsa-mir-7-2-3p (MIRT698261)
- hsa-mir-7-1-3p (MIRT698262)
- hsa-mir-5688 (MIRT698263)
- hsa-mir-495-3p (MIRT698264)
- hsa-mir-548as-3p (MIRT698265)
- hsa-mir-585-5p (MIRT698266)
- hsa-mir-873-5p (MIRT698267)
- hsa-mir-198 (MIRT698268)
- hsa-mir-2861 (MIRT698269)
- hsa-mir-5589-3p (MIRT698270)
- hsa-mir-571 (MIRT698271)
- hsa-mir-219a-1-3p (MIRT698272)
- hsa-mir-4487 (MIRT698273)
- hsa-mir-558 (MIRT698274)
- hsa-mir-3160-3p (MIRT698275)
- hsa-mir-4682 (MIRT698276)
- hsa-mir-4673 (MIRT698277)
- hsa-mir-4645-5p (MIRT698278)
- hsa-mir-4742-5p (MIRT698279)
- hsa-mir-556-5p (MIRT698280)
- hsa-mir-4761-3p (MIRT698281)
- hsa-mir-3972 (MIRT698282)
- hsa-mir-1202 (MIRT698283)
- hsa-mir-4715-3p (MIRT698284)
- hsa-mir-6852-3p (MIRT698285)
- hsa-mir-3909 (MIRT698286)
- hsa-mir-6131 (MIRT698287)
- hsa-mir-222-3p (MIRT698288)
- hsa-mir-221-3p (MIRT698289)
- hsa-mir-548v (MIRT698290)
- hsa-mir-187-5p (MIRT698291)
- hsa-mir-3194-5p (MIRT698292)
- hsa-mir-7152-3p (MIRT698293)
- hsa-mir-520f-5p (MIRT698294)
- hsa-mir-4509 (MIRT698295)
- hsa-mir-4744 (MIRT698296)
- hsa-mir-551b-3p (MIRT698297)
- hsa-mir-551a (MIRT698298)
- hsa-mir-3691-3p (MIRT698299)
- hsa-mir-484 (MIRT698300)
- hsa-mir-3155b (MIRT698301)
- hsa-mir-3155a (MIRT698302)
- hsa-mir-4691-3p (MIRT698303)
- hsa-mir-5697 (MIRT698304)
- hsa-mir-4761-5p (MIRT698305)
- hsa-mir-338-5p (MIRT698306)
- hsa-mir-7161-5p (MIRT698307)
- hsa-mir-548u (MIRT698308)
- hsa-mir-4465 (MIRT698309)
- hsa-mir-26a-5p (MIRT698310)
- hsa-mir-1297 (MIRT698311)
- hsa-mir-18b-5p (MIRT698312)
- hsa-mir-18a-5p (MIRT698313)
- hsa-mir-4735-3p (MIRT698314)
miRNA Products
- Search ViGene Biosciences for TMEM2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TMEM2
- Browse OriGene Inhibitory RNA Products For TMEM2
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TMEM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for TMEM2
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM2 gene
Flow Cytometry Products
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM2 Gene
Localization for TMEM2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM2 Gene
- Membrane; Single-pass membrane protein.
| Compartment | Confidence |
|---|---|
| extracellular | 5 |
| cytosol | 4 |
| plasma membrane | 3 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005887 | integral component of plasma membrane | IDA | 28246172 |
| GO:0016020 | membrane | IEA | -- |
| GO:0016021 | integral component of membrane | IEA,TAS | 10767548 |
| GO:0070062 | extracellular exosome | IDA | 19056867 |
Pathways & Interactions for TMEM2 Gene
No Data Available
Interacting Proteins for TMEM2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0007275 | multicellular organism development | IEA | -- |
| GO:0030214 | hyaluronan catabolic process | IDA | 28246172 |
| GO:1903670 | regulation of sprouting angiogenesis | ISS | -- |
No data available for Pathways by source and SIGNOR curated interactions for TMEM2 Gene
Transcripts for TMEM2 Gene
mRNA/cDNA for TMEM2 Gene
- (4) REFSEQ mRNAs :
- (12) Additional mRNA sequences :
- (184) Selected AceView cDNA sequences:
- (13) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM2 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM2
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM2
- GenScript: Design CRISPR guide RNA sequences for TMEM2
miRNA Products
- Search ViGene Biosciences for TMEM2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for TMEM2
- Browse OriGene Inhibitory RNA Products For TMEM2
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM2 gene
Clone Products
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for TMEM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
Expression for TMEM2 Gene
mRNA expression in embryonic tissues and stem cells from LifeMap Discovery
- Brain (Nervous System)
- Neural Tube (Nervous System)
-
Heart (Cardiovascular System)
- Endocardial Tube Cells Endocardium
- Bone (Muscoskeletal System)
- Neural Ectoderm (Nervous System)
-
Placenta (Extraembryonic Tissues)
-
Gall Bladder (Hepatobiliary System)
-
Liver (Hepatobiliary System)
This gene is overexpressed in Breast (30.2) and Nasal epithelium (25.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM2 Gene
NURSA nuclear receptor signaling pathways regulating expression of TMEM2 Gene:
TMEM2SOURCE GeneReport for Unigene cluster for TMEM2 Gene:
Hs.494146mRNA Expression by UniProt/SwissProt for TMEM2 Gene:
Q9UHN6-TMEM2_HUMAN
Tissue specificity:
Widely expressed.
Evidence on tissue expression from TISSUES for TMEM2 Gene
- Nervous system(4.2)
- Intestine(2.4)
Primer Products
-
OriGene qPCR primer pairs for TMEM2
No data available for mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM2 Gene
Orthologs for TMEM2 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | TMEM2 34 35 |
|
||
| dog (Canis familiaris) |
Mammalia | TMEM2 34 35 |
|
||
| mouse (Mus musculus) |
Mammalia | Tmem2 34 16 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Tmem2 34 |
|
||
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM2 35 |
|
OneToOne | |
| oppossum (Monodelphis domestica) |
Mammalia | TMEM2 35 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | LOC427250 34 |
|
||
| TMEM2 35 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TMEM2 35 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem2 34 |
|
||
| Str.19937 34 |
|
||||
| African clawed frog (Xenopus laevis) |
Amphibia | Xl.23798 34 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem2 34 35 |
|
||
| sea squirt (Ciona savignyi) |
Ascidiacea | CSA.3786 35 |
|
OneToMany |
- Species where no ortholog for TMEM2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TMEM2 Gene
(1) SIMAP similar genes for TMEM2 Gene using alignment to 6 proteins:
Variants for TMEM2 Gene
| SNP ID | Clin | Chr 09 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs146439095 | Uncertain significance | 71,745,561(+) | TATTG(A/T)CCCCA | reference, missense | |
| rs1000027792 | -- | 71,702,461(+) | AATTA(C/T)GGCAC | intron-variant | |
| rs1000092378 | -- | 71,751,910(+) | AAAGT(C/G)TAAAG | intron-variant | |
| rs1000113205 | -- | 71,707,444(+) | TATTC(C/G)TCTTA | intron-variant | |
| rs1000128102 | -- | 71,708,056(+) | GTGGC(A/G)GGCGC | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2677935 | CNV | deletion | 23128226 |
| esv3544903 | CNV | deletion | 23714750 |
| nsv416322 | CNV | insertion | 16902084 |
| nsv507516 | OTHER | sequence alteration | 20534489 |
| nsv831617 | CNV | gain | 17160897 |
Residual Variation Intolerance Score:
8.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
16.12;
97.56% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for TMEM2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM2 Gene
Disorders for TMEM2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| deafness, autosomal recessive 7 |
|
|
| benign familial infantile epilepsy |
|
|
Search TMEM2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for TMEM2
No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM2 Gene
Publications for TMEM2 Gene
- A Mammalian Homolog of the Zebrafish Transmembrane Protein 2 (TMEM2) Is the Long-sought-after Cell Surface Hyaluronidase. (PMID: 28246172) Yamamoto H. … Yamaguchi Y. (J. Biol. Chem. 2017) 2 3 64
- Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 46 64
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64
- Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. (PMID: 10767548) Scott D.A. … Smith R.J.H. (Gene 2000) 3 4 64
Products for TMEM2 Gene
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- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
- Sino Biological qPCR Primers
- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for TMEM2
- Novus Biologicals proteins for TMEM2
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for TMEM2
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- antibodies-online Antibodies for TMEM2: See all 10
- antibodies-online Kits for TMEM2: See all 2
- Search antibodies-online for proteins
- Search antibodies-online for peptides
- GeneTex TMEM2 antibody for TMEM2
- Search GeneTex for Proteins for TMEM2
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM2 gene
- Search ViGene Biosciences for TMEM2
- Horizon Cell Lines for TMEM2
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM2
- VectorBuilder custom plasmid, inducible vectors for TMEM2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for TMEM2 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) RNAdb
- (29) ASD
- (30) ECgene
- (31) GeneAnnot
- (32) CGAP SAGE
- (33) SOURCE
- (34) HomoloGene
- (35) PanEnsembl
- (36) euGenes
- (37) SGD
- (38) FlyBase
- (39) WormBase
- (40) Pseudogene
- (41) DGV
- (42) dbSNP
- (43) GenAtlas
- (44) GeneTests
- (45) HGMD
- (46) GAD
- (47) LSDB
- (48) BGMUT
- (49) HuGE
- (50) eBioscience
- (51) Atlas
- (52) Cell Signaling Technology
- (53) GenBank
- (54) H-invDB
- (55) HORDE
- (56) HUGE
- (57) IMGT
- (58) Leiden
- (59) MILLIPORE
- (60) miRBase
- (61) DME
- (62) NCBI
- (63) OriGene
- (64) PubMed
- (65) R&D Systems
- (66) TGDB
- (67) Tocris
- (68) Abcam
- (69) Novus
- (70) ProSpec
- (71) Sino Biological
- (72) GenScript
- (73) Qiagen
- (74) Cloud-Clone Corp.
- (75) Enzo Life Sciences
- (76) OCA
- (77) Proteopedia
- (78) MOPED
- (79) SPIRE
- (80) neXtProt
- (81) Reactome
- (82) GeneGo (Thomson Reuters)
- (83) fRNAdb
- (84) DISEASES
- (85) SIMAP
- (86) GenomeRNAi
- (87) LifeMap
- (88) miRTarBase
- (89) MalaCards
- (90) Invitrogen
- (91) BitterDB
- (92) Vector BioLabs
- (93) ESI-BIO
- (94) RefSeq
- (95) BioSystems
- (96) MaxQB
- (97) IUPHAR
- (98) BioGPS
- (99) Illumina
- (100) COMPARTMENTS
- (101) HOMER
- (102) PaxDb
- (103) ApexBio
- (104) Addgene
- (105) antibodies-online
- (106) CYP
- (107) NONCODE
- (108) SwitchGear Genomics
- (109) TreeFam
- (110) PathCards
- (111) GeneReviews
- (112) GeneTex
- (113) Taconic Biosciences
- (114) GTEx
- (115) ProteomicsDB
- (116) SCBT
- (117) DGIdb
- (118) ClinicalTrials
- (119) FDA Approved Drugs
- (120) RVIS
- (121) SIGNOR
- (122) diseasecard
- (123) NIH Rare Diseases
- (124) Orphanet
- (125) UMLS
- (126) GTR
- (127) Disease Ontology
- (128) Genetics Home Reference
- (129) MeSH
- (130) MedlinePlus
- (131) CDC
- (132) NINDS
- (133) NCBI Bookshelf
- (134) ClinVar
- (135) Gene Damage Index
- (136) ViGene Biosciences
- (137) HPO
- (138) UDN
- (139) VISTA
- (140) FANTOM5
- (141) ENCODE
- (142) ProSci
- (143) Horizon
- (144) NURSA
- (145) IID
- (146) Cyagen
- (147) VectorBuilder
- (148) SNPedia
- (149) BRCA Exchange
- (150) St John's Lab
- (151) CIViC
- (152) ProteoGenix
- (153) dbSUPER
- (154) TISSUES
- (155) Gene ORGANizer