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Aliases for TMEM2 Gene

Aliases for TMEM2 Gene

  • Transmembrane Protein 2 2 3
  • KIAA1412 4

External Ids for TMEM2 Gene

Summaries for TMEM2 Gene

GeneCards Summary for TMEM2 Gene

TMEM2 (Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with TMEM2 include benign familial infantile epilepsy. An important paralog of this gene is CEMIP.

UniProtKB/Swiss-Prot for TMEM2 Gene

  • May be required for the heart morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM2 Gene

Genomics for TMEM2 Gene

Genomic Location for TMEM2 Gene

Start:
71,683,366 bp from pter
End:
71,816,690 bp from pter
Size:
133,325 bases
Orientation:
Minus strand

Genomic View for TMEM2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM2 Gene

Regulatory Elements for TMEM2 Gene

Proteins for TMEM2 Gene

  • Protein details for TMEM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHN6-TMEM2_HUMAN
    Recommended name:
    Transmembrane protein 2
    Protein Accession:
    Q9UHN6
    Secondary Accessions:
    • A6H8W9
    • B2RTQ6
    • Q5T838
    • Q5T839
    • Q5T840
    • Q5T841
    • Q8NBP6
    • Q9P2D5

    Protein attributes for TMEM2 Gene

    Size:
    1383 amino acids
    Molecular mass:
    154374 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15172.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15174.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM2 Gene

Proteomics data for TMEM2 Gene at MOPED

Post-translational modifications for TMEM2 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn292, Asn914, Asn980, and Asn1234

No data available for DME Specific Peptides for TMEM2 Gene

Domains for TMEM2 Gene

Protein Domains for TMEM2 Gene

UniProtKB/Swiss-Prot:

TMEM2_HUMAN
Domain:
  • Contains 1 G8 domain.:
    • Q9UHN6
Family:
  • Belongs to the TMEM2 family.:
    • Q9UHN6
Similarity:
  • Contains 3 PbH1 repeats.:
    • Q9UHN6
genes like me logo Genes that share domains with TMEM2: view

No data available for Gene Families for TMEM2 Gene

Function for TMEM2 Gene

Molecular function for TMEM2 Gene

UniProtKB/Swiss-Prot Function: May be required for the heart morphogenesis.

Phenotypes for TMEM2 Gene

GenomeRNAi human phenotypes for TMEM2:
genes like me logo Genes that share phenotypes with TMEM2: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM2 Gene

Localization for TMEM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM2 Gene COMPARTMENTS Subcellular localization image for TMEM2 gene
Compartment Confidence
cytosol 3
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with TMEM2: view

Pathways for TMEM2 Gene

SuperPathways for TMEM2 Gene

No Data Available

Interacting Proteins for TMEM2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366243%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000366243 Q9UHN6-TMEM2_HUMAN for TMEM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organismal development IEA --
genes like me logo Genes that share ontologies with TMEM2: view

No data available for Pathways by source for TMEM2 Gene

Transcripts for TMEM2 Gene

Unigene Clusters for TMEM2 Gene

Transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM2 Gene

No ASD Table

Relevant External Links for TMEM2 Gene

GeneLoc Exon Structure for
TMEM2
ECgene alternative splicing isoforms for
TMEM2

Expression for TMEM2 Gene

mRNA expression in normal human tissues for TMEM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM2 Gene

SOURCE GeneReport for Unigene cluster for TMEM2 Gene Hs.494146

mRNA Expression by UniProt/SwissProt for TMEM2 Gene

Q9UHN6-TMEM2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expressions with TMEM2: view

Orthologs for TMEM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM2 36
  • 99.45 (n)
  • 99.71 (a)
TMEM2 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM2 36
  • 90.43 (n)
  • 90.89 (a)
TMEM2 37
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM2 36
  • 89.97 (n)
  • 91.83 (a)
TMEM2 37
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem2 36
  • 84.42 (n)
  • 86.83 (a)
Tmem2 16
Tmem2 37
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM2 37
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM2 37
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem2 36
  • 84.4 (n)
  • 87.3 (a)
chicken
(Gallus gallus)
Aves LOC427250 36
  • 72.9 (n)
  • 71.5 (a)
TMEM2 37
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM2 37
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23798 36
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19937 36
tmem2 36
  • 69.5 (n)
  • 69.59 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem2 36
  • 60.17 (n)
  • 58.61 (a)
tmem2 37
  • 58 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3786 37
  • 6 (a)
OneToMany
Species with no ortholog for TMEM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM2 Gene

ENSEMBL:
Gene Tree for TMEM2 (if available)
TreeFam:
Gene Tree for TMEM2 (if available)

Paralogs for TMEM2 Gene

Paralogs for TMEM2 Gene

Selected SIMAP similar genes for TMEM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM2: view

Variants for TMEM2 Gene

Sequence variations from dbSNP and Humsavar for TMEM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type MAF
rs1293 -- 71,697,831(+) CTTAC(A/G)CGCTT intron-variant
rs1294 -- 71,697,825(+) TTGCT(G/T)CTTAC intron-variant
rs25688 - 71,745,318(-) GGCAA(A/G)GACCC missense, reference
rs25689 -, -, - 71,745,180(-) ATACC(A/C/G/T)CAATG missense, reference
rs25690 -- 71,740,112(-) TATAC(C/T)GTGGA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for TMEM2 Gene

Variant ID Type Subtype PubMed ID
nsv831617 CNV Gain 17160897
nsv893444 CNV Gain 21882294
nsv507516 CNV Insertion 20534489
nsv416322 CNV Insertion 16902084
esv2677935 CNV Deletion 23128226

Relevant External Links for TMEM2 Gene

HapMap Linkage Disequilibrium report
TMEM2
Human Gene Mutation Database (HGMD)
TMEM2

Disorders for TMEM2 Gene

(1) University of Copenhagen DISEASES for TMEM2 Gene

Relevant External Links for TMEM2

Genetic Association Database (GAD)
TMEM2
Human Genome Epidemiology (HuGE) Navigator
TMEM2
genes like me logo Genes that share disorders with TMEM2: view

No data available for UniProtKB/Swiss-Prot for TMEM2 Gene

Publications for TMEM2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 49
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  4. Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. (PMID: 10767548) Scott D.A. … Smith R.J.H. (Gene 2000) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM2 Gene

Sources for TMEM2 Gene

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