TMEM2 Gene

Aliases
for TMEM2 gene

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
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Previous GC identifers: GC09M065342 GC09M066154 GC09M067868 GC09M069755 GC09M071527 GC09M073488 GC09M073371 GC09M044121

Summaries
for TMEM2 gene

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Genomic Views
for TMEM2 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:

NC_000009.11  NT_008470.20  NC_018920.2  

SwitchGear Promoter luciferase reporter plasmid: TMEM2 promoter sequence

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM2

TMEM2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)


GeneLoc information about chromosome 9         GeneLoc Exon Structure

GeneLoc location for GC09M074298:  view genomic region     (about GC identifiers)

Proteins
for TMEM2 gene

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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Explore the universe of human proteins at neXtProt for TMEM2: NX_Q9UHN6

Explore proteomics data for TMEM2 at MOPED

Post-translational modifications: 

TMEM2 Human Recombinant Protein Products:

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	Cloud-Clone Corp. Proteins for TMEM2
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	Search GeneTex for Proteins for TMEM2
	Search antibodies-online for proteins for TMEM2
	antibodies-online peptides for TMEM2

TMEM2 Antibody Products:

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	antibodies-online antibodies for TMEM2 (9 products)

TMEM2 Assay Products:

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	antibodies-online kits for TMEM2 (4 products)

Domains /
Families
for TMEM2 gene

(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
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ProtoNet protein and cluster: Q9UHN6

Find genes that share domains with TMEM2           About GenesLikeMe

Function
for TMEM2 gene

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Phenotypes:
     1 GenomeRNAi human phenotype for TMEM2:

genOway: Develop your customized and physiologically relevant rodent model for TMEM2

miRNA Products:		miRTarBase miRNAs that target TMEM2: hsa-mir-125b-5p (MIRT046046), hsa-mir-26b-5p (MIRT029299), hsa-mir-196a-5p (MIRT026078), hsa-mir-98-5p (MIRT027580), hsa-mir-30a-3p (MIRT001762), hsa-mir-331-3p (MIRT043348), hsa-let-7b-5p (MIRT001585), hsa-mir-192-5p (MIRT026372), hsa-mir-215-5p (MIRT024372), hsa-let-7d-5p (MIRT032147), hsa-mir-21-5p (MIRT030825)
		Block miRNA regulation of human, mouse, rat TMEM2 using miScript Target Protectors
		Selected qRT-PCR Assays for microRNAs that regulate TMEM2 (see all 59):
		hsa-let-7d hsa-miR-218-1* hsa-miR-938 hsa-let-7a-2* hsa-miR-1304 hsa-let-7g hsa-miR-208b hsa-miR-208a
		SwitchGear 3'UTR luciferase reporter plasmid: TMEM2 3' UTR sequence

Inhib. RNA Products:		OriGene RNAi products in human, mouse, rat for TMEM2
		Predesigned siRNA for gene silencing in human, mouse, rat TMEM2

Gene Editing Products:

DNA2.0 Custom Protein Engineering Service for TMEM2

Clone Products:		OriGene clones in human, mouse for TMEM2 (see all 11) OriGene ORF clones in mouse, rat for TMEM2 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 2): TMEM2 (NM_013390)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM2
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM2

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for TMEM2
		Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2

Localization
for TMEM2 gene

(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Subcellular locations from COMPARTMENTS: 

Compartment	Confidence
cytosol	3
plasma membrane	3
nucleus	1

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Gene Ontology (GO): 2 cellular component terms:    About this table

Pathways & Interactions
for TMEM2 gene

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
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Gene Ontology (GO): 1 biological process term:    About this table

Drugs & Compounds
for TMEM2 gene

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
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Transcripts
for TMEM2 gene

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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Expression
for TMEM2 gene

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: --

About this image

Brain (Nervous System)    fully expand to see all 6 entries
Cerebral Cortex
Neural Tube (Nervous System)    fully expand to see all 3 entries
Metencephalon
Heart (Cardiovascular System)
Endocardial Tube Cells Endocardium
Neural Ectoderm (Nervous System)
Neural ectoderm cells
Bone (Muscoskeletal System)
Bone Marrow

Primer Products:		OriGene qSTAR qPCR primer pairs in human, mouse for TMEM2
		Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM2
		QuantiTect SYBR Green Assays in human, mouse, rat TMEM2
		QuantiFast Probe-based Assays in human, mouse, rat TMEM2

In Situ Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM2

Orthologs
for TMEM2 gene

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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Paralogs
for TMEM2 gene

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
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Paralogs for TMEM2 gene

PKHD1L1²  PKHD1²  CEMIP²  

1 SIMAP similar gene for TMEM2 using alignment to 6 protein entries:     TMEM2_HUMAN (see all proteins):

KIAA1199

Find genes that share paralogs with TMEM2           About GenesLikeMe

Genomic Variants
for TMEM2 gene

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM2 (see all 2166)    About this table

Genomic Data					Transcription Related Data				Allele Frequencies
SNP ID	Valid	Clinical significance	Chr 9 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd	--	--	--	-1st2nd3rd	--	--	-1st2nd3rd	-1st2nd3rd	-1st2nd3rd
rs78572231,2	C,F,H	--	74297830(+)	CAATAT/CTTACT	2	--	int1		4		NS EA	418
rs1133466451,2	C,F	--	74297845(+)	GGATTC/TTGTCC	2	--	int1		1		NA	2
rs1897561571,2		--	74297897(+)	CTGGAA/TTCTGG	2	--	int1		0	--	--	--	--
rs746744411,2	C,F	--	74297902(+)	ATCTGG/TAATTT	2	--	int1		1		EA	120
rs1835542511,2		--	74297956(+)	CGGTGA/GCTCAT	2	--	int1		0	--	--	--	--
rs107810371,2	C,F,A,H	--	74298081(+)	TAGCAG/ATGCAT	2	--	int1		3		NA WA CSA	6
rs1451623851,2		--	74298222(+)	CCATCG/TCAAAA	2	--	int1		0	--	--	--	--
rs1388776391,2	C	--	74298254(+)	TAAAT-/AATA           AATAA	2	--	int1		0	--	--	--	--
rs132964711,2	H	--	74298422(+)	AAGATA/TTTTAA	2	--	ut31		4		NS EA	416
rs2020897281,2	C	--	74298435(+)	CATAAA/CACACA	2	--	ut31		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM2 (74298282 - 74431606 bp)

Structural Variations
     Database of Genomic Variants (DGV) 5 variations for TMEM2:    About this table    

Variant ID	Type	Subtype	PubMed ID
esv2677935	CNV	Deletion	23128226
nsv507516	CNV	Insertion	20534489
nsv416322	CNV	Insertion	16902084
nsv893444	CNV	Gain	21882294
nsv831617	CNV	Gain	17160897

Human Gene Mutation Database (HGMD): TMEM2

Site Specific Mutation Identification with PCR Assays

SeqTarget long-range PCR primers for resequencing TMEM2

DNA2.0 Custom Variant and Variant Library Synthesis for TMEM2

Disorders / Diseases
for TMEM2 gene

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
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Publications
for TMEM2 gene

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
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PubMed articles for TMEM2 gene, integrated from 10 sources (see all 35): (articles sorted by number of sources associating them with TMEM2)

Utopia: connect your pdf to the dynamic world of online information

1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)^{1, 4} Rose J.E....Uhl G.R. (Mol. Med. 2010)
2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
3. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)^{1, 2} Nagase T.... Ohara O. (DNA Res. 2000)
4. Refining the DFNB7-DFNB11 deafness locus using intragenic polymorphisms in a novel gene, TMEM2. (PubMed id 10767548)^{1, 2} Scott D.A.... Smith R.J.H. (Gene 2000)
5. Rare inborn errors associated with chronic hepatitis B virus infection. (PubMed id 22610944)¹ Zhao Q....Wang Y. (Hepatology 2012)
6. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)¹ Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
7. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PubMed id 22268729)¹ Liu B....Wang L.S. (J. Proteome Res. 2012)
8. Initial characterization of the human central proteome. (PubMed id 21269460)² Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
9. Mass spectrometric analysis of lysine ubiquitylation reveals promiscuity at site level. (PubMed id 21139048)¹ Danielsen J.M....Nielsen M.L. (amp 2011)
10. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PubMed id 19056867)¹ Gonzales P.A....Knepper M.A. (J. Am. Soc. Nephrol. 2009)

External Searches for TMEM2 gene

Genome Databases showing TMEM2 gene

Other Databases showing TMEM2 gene

Specialized Databases showing TMEM2 gene

Products
for TMEM2 gene

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from genOway)
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