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Aliases for TMEM2 Gene

Aliases for TMEM2 Gene

  • Transmembrane Protein 2 2 3 5
  • KIAA1412 4

External Ids for TMEM2 Gene

Previous GeneCards Identifiers for TMEM2 Gene

  • GC09M065342
  • GC09M066154
  • GC09M067868
  • GC09M069755
  • GC09M071527
  • GC09M073488
  • GC09M073371
  • GC09M074298
  • GC09M044121

Summaries for TMEM2 Gene

GeneCards Summary for TMEM2 Gene

TMEM2 (Transmembrane Protein 2) is a Protein Coding gene. Diseases associated with TMEM2 include benign familial infantile epilepsy. An important paralog of this gene is CEMIP.

UniProtKB/Swiss-Prot for TMEM2 Gene

  • May be required for the heart morphogenesis.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM2 Gene

Genomics for TMEM2 Gene

Regulatory Elements for TMEM2 Gene

Genomic Location for TMEM2 Gene

Chromosome:
9
Start:
71,683,366 bp from pter
End:
71,816,690 bp from pter
Size:
133,325 bases
Orientation:
Minus strand

Genomic View for TMEM2 Gene

Genes around TMEM2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM2 Gene

Proteins for TMEM2 Gene

  • Protein details for TMEM2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UHN6-TMEM2_HUMAN
    Recommended name:
    Transmembrane protein 2
    Protein Accession:
    Q9UHN6
    Secondary Accessions:
    • A6H8W9
    • B2RTQ6
    • Q5T838
    • Q5T839
    • Q5T840
    • Q5T841
    • Q8NBP6
    • Q9P2D5

    Protein attributes for TMEM2 Gene

    Size:
    1383 amino acids
    Molecular mass:
    154374 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAA92650.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=BAC11574.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15172.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15173.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15174.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15175.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM2 Gene

Proteomics data for TMEM2 Gene at MOPED

Post-translational modifications for TMEM2 Gene

  • Glycosylation at Asn 248, Asn 292, Asn 914, Asn 980, and Asn 1234
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM2 Gene

Domains & Families for TMEM2 Gene

Protein Domains for TMEM2 Gene

Suggested Antigen Peptide Sequences for TMEM2 Gene

Graphical View of Domain Structure for InterPro Entry

Q9UHN6

UniProtKB/Swiss-Prot:

TMEM2_HUMAN :
  • Contains 1 G8 domain.
  • Belongs to the TMEM2 family.
  • Contains 3 PbH1 repeats.
Domain:
  • Contains 1 G8 domain.
Family:
  • Belongs to the TMEM2 family.
Similarity:
  • Contains 3 PbH1 repeats.
genes like me logo Genes that share domains with TMEM2: view

No data available for Gene Families for TMEM2 Gene

Function for TMEM2 Gene

Molecular function for TMEM2 Gene

UniProtKB/Swiss-Prot Function:
May be required for the heart morphogenesis.

Phenotypes for TMEM2 Gene

genes like me logo Genes that share phenotypes with TMEM2: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM2

miRNA for TMEM2 Gene

miRTarBase miRNAs that target TMEM2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM2 Gene

Localization for TMEM2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM2 Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM2 Gene COMPARTMENTS Subcellular localization image for TMEM2 gene
Compartment Confidence
extracellular 5
cytosol 4
plasma membrane 3
nucleus 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM2 Gene

Pathways & Interactions for TMEM2 Gene

SuperPathways for TMEM2 Gene

No Data Available

Interacting Proteins for TMEM2 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366243%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000385269%0d%0a
Selected Interacting proteins: ENSP00000366243 Q9UHN6-TMEM2_HUMAN for TMEM2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM2 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM2 Gene

Drugs & Compounds for TMEM2 Gene

No Compound Related Data Available

Transcripts for TMEM2 Gene

Unigene Clusters for TMEM2 Gene

Transmembrane protein 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM2 Gene

No ASD Table

Relevant External Links for TMEM2 Gene

GeneLoc Exon Structure for
TMEM2
ECgene alternative splicing isoforms for
TMEM2

Expression for TMEM2 Gene

mRNA expression in normal human tissues for TMEM2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM2 Gene

This gene is overexpressed in Breast (30.2) and Nasal epithelium (25.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM2 Gene



SOURCE GeneReport for Unigene cluster for TMEM2 Gene Hs.494146

mRNA Expression by UniProt/SwissProt for TMEM2 Gene

Q9UHN6-TMEM2_HUMAN
Tissue specificity: Widely expressed.
genes like me logo Genes that share expression patterns with TMEM2: view

Protein tissue co-expression partners for TMEM2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues for TMEM2 Gene

Orthologs for TMEM2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM2 35
  • 99.45 (n)
  • 99.71 (a)
TMEM2 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM2 36
  • 91 (a)
OneToOne
TMEM2 35
  • 90.43 (n)
  • 90.89 (a)
dog
(Canis familiaris)
Mammalia TMEM2 35
  • 89.97 (n)
  • 91.83 (a)
TMEM2 36
  • 92 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem2 36
  • 87 (a)
OneToOne
Tmem2 16
Tmem2 35
  • 84.42 (n)
  • 86.83 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM2 36
  • 81 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM2 36
  • 82 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem2 35
  • 84.4 (n)
  • 87.3 (a)
chicken
(Gallus gallus)
Aves TMEM2 36
  • 71 (a)
OneToOne
LOC427250 35
  • 72.9 (n)
  • 71.5 (a)
lizard
(Anolis carolinensis)
Reptilia TMEM2 36
  • 73 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia Xl.23798 35
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.19937 35
tmem2 35
  • 69.5 (n)
  • 69.59 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem2 36
  • 58 (a)
OneToOne
tmem2 35
  • 60.17 (n)
  • 58.61 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.3786 36
  • 6 (a)
OneToMany
Species with no ortholog for TMEM2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM2 Gene

ENSEMBL:
Gene Tree for TMEM2 (if available)
TreeFam:
Gene Tree for TMEM2 (if available)

Paralogs for TMEM2 Gene

Paralogs for TMEM2 Gene

(1) SIMAP similar genes for TMEM2 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM2: view

Variants for TMEM2 Gene

Sequence variations from dbSNP and Humsavar for TMEM2 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs25688 - 71,745,318(-) GGCAA(A/G)GACCC reference, missense
rs25689 -, -, - 71,745,180(-) ATACC(A/C/G/T)CAATG reference, missense
rs25695 - 71,734,930(-) GATGA(A/T)GTTAG intron-variant, reference, missense
rs25692 - 71,718,054(-) CAAAC(C/T)CCGAA reference, missense
rs17057133 - 71,704,761(+) TGTAA(C/T)GGTCA reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM2 Gene

Variant ID Type Subtype PubMed ID
nsv831617 CNV Gain 17160897
nsv893444 CNV Gain 21882294
nsv507516 CNV Insertion 20534489
nsv416322 CNV Insertion 16902084
esv2677935 CNV Deletion 23128226

Variation tolerance for TMEM2 Gene

Residual Variation Intolerance Score: 8.09% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 16.12; 97.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM2 Gene

HapMap Linkage Disequilibrium report
TMEM2
Human Gene Mutation Database (HGMD)
TMEM2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM2 Gene

Disorders for TMEM2 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
benign familial infantile epilepsy
  • benign familial infantile convulsion
- elite association - COSMIC cancer census association via MalaCards
Search TMEM2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for TMEM2

Genetic Association Database (GAD)
TMEM2
Human Genome Epidemiology (HuGE) Navigator
TMEM2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM2
genes like me logo Genes that share disorders with TMEM2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM2 Gene

Publications for TMEM2 Gene

  1. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 48 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells. (PMID: 22268729) Liu B. … Wang L.S. (J. Proteome Res. 2012) 3
  4. Rare inborn errors associated with chronic hepatitis B virus infection. (PMID: 22610944) Zhao Q. … Wang Y. (Hepatology 2012) 3
  5. MHC class II-associated proteins in B-cell exosomes and potential functional implications for exosome biogenesis. (PMID: 20458337) Buschow S.I. … Stoorvogel W. (Immunol. Cell Biol. 2010) 3

Products for TMEM2 Gene

Sources for TMEM2 Gene

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