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Aliases for TMEM199 Gene

Aliases for TMEM199 Gene

  • Transmembrane Protein 199 2 3 5
  • C17orf32 3 4
  • Chromosome 17 Open Reading Frame 32 2
  • CDG2P 3
  • VMA12 3
  • VPH2 3

External Ids for TMEM199 Gene

Previous HGNC Symbols for TMEM199 Gene

  • C17orf32

Previous GeneCards Identifiers for TMEM199 Gene

  • GC17P023709
  • GC17P026684
  • GC17P022893

Summaries for TMEM199 Gene

Entrez Gene Summary for TMEM199 Gene

  • The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER)-Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) in some human cells. The encoded protein shares some homology with the yeast protein Vma12. Defects in this gene are a cause of congenital disorder of glycosylation, type IIp. [provided by RefSeq, Mar 2016]

GeneCards Summary for TMEM199 Gene

TMEM199 (Transmembrane Protein 199) is a Protein Coding gene. Diseases associated with TMEM199 include congenital disorder of glycosylation 2p.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM199 Gene

Genomics for TMEM199 Gene

Regulatory Elements for TMEM199 Gene

Genomic Location for TMEM199 Gene

Chromosome:
17
Start:
28,357,581 bp from pter
End:
28,363,683 bp from pter
Size:
6,103 bases
Orientation:
Plus strand

Genomic View for TMEM199 Gene

Genes around TMEM199 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM199 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM199 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM199 Gene

Proteins for TMEM199 Gene

  • Protein details for TMEM199 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N511-TM199_HUMAN
    Recommended name:
    Transmembrane protein 199
    Protein Accession:
    Q8N511

    Protein attributes for TMEM199 Gene

    Size:
    208 amino acids
    Molecular mass:
    23130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM199 Gene

Proteomics data for TMEM199 Gene at MOPED

Post-translational modifications for TMEM199 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM199 Gene

Antibody Products

No data available for DME Specific Peptides for TMEM199 Gene

Domains & Families for TMEM199 Gene

Protein Domains for TMEM199 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM199 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM199: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM199 Gene

Function for TMEM199 Gene

genes like me logo Genes that share phenotypes with TMEM199: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM199 Gene

Localization for TMEM199 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM199 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM199 Gene COMPARTMENTS Subcellular localization image for TMEM199 gene
Compartment Confidence
golgi apparatus 2
plasma membrane 2
cytosol 1
endoplasmic reticulum 1
lysosome 1
mitochondrion 1
peroxisome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM199 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0030663 COPI-coated vesicle membrane IDA 26833330
genes like me logo Genes that share ontologies with TMEM199: view

Pathways & Interactions for TMEM199 Gene

SuperPathways for TMEM199 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM199 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM199 Gene

Drugs & Compounds for TMEM199 Gene

No Compound Related Data Available

Transcripts for TMEM199 Gene

Unigene Clusters for TMEM199 Gene

Transmembrane protein 199:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM199 Gene

No ASD Table

Relevant External Links for TMEM199 Gene

GeneLoc Exon Structure for
TMEM199
ECgene alternative splicing isoforms for
TMEM199

Expression for TMEM199 Gene

mRNA expression in normal human tissues for TMEM199 Gene

Protein differential expression in normal tissues from HIPED for TMEM199 Gene

This gene is overexpressed in Nasal epithelium (52.2) and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM199 Gene



SOURCE GeneReport for Unigene cluster for TMEM199 Gene Hs.707906

genes like me logo Genes that share expression patterns with TMEM199: view

Protein tissue co-expression partners for TMEM199 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM199 Gene

Orthologs for TMEM199 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM199 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM199 35
  • 88.62 (n)
  • 94.15 (a)
TMEM199 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM199 35
  • 87.82 (n)
  • 90.38 (a)
TMEM199 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem199 35
  • 84.46 (n)
  • 89.42 (a)
Tmem199 16
Tmem199 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM199 35
  • 99.68 (n)
  • 100 (a)
TMEM199 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem199 35
  • 85.74 (n)
  • 90.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM199 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM199 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM199 35
  • 65.98 (n)
  • 66.49 (a)
TMEM199 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM199 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15198 35
tmem199 35
  • 59.97 (n)
  • 60.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26151 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24936 35
tmem199 35
  • 59.42 (n)
  • 59.24 (a)
tmem199 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7071 36
  • 19 (a)
OneToOne
Species with no ortholog for TMEM199:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM199 Gene

ENSEMBL:
Gene Tree for TMEM199 (if available)
TreeFam:
Gene Tree for TMEM199 (if available)

Paralogs for TMEM199 Gene

No data available for Paralogs for TMEM199 Gene

Variants for TMEM199 Gene

Sequence variations from dbSNP and Humsavar for TMEM199 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
VAR_033749 -
VAR_033750 -
rs9184 -- 28,361,740(+) TGCTG(A/G)AAGAG utr-variant-3-prime
rs708100 -- 28,361,641(-) GTGAT(C/T)AGTTT utr-variant-3-prime
rs730331 -- 28,362,410(+) TAATC(C/G)TAGCA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM199 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Variation tolerance for TMEM199 Gene

Residual Variation Intolerance Score: 59.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM199 Gene

HapMap Linkage Disequilibrium report
TMEM199

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM199 Gene

Disorders for TMEM199 Gene

MalaCards: The human disease database

(1) MalaCards diseases for TMEM199 Gene - From: ClinVar and Swiss-Prot

Disorder Aliases PubMed IDs
congenital disorder of glycosylation 2p
  • cdg iip
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for TMEM199

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM199
genes like me logo Genes that share disorders with TMEM199: view

No data available for UniProtKB/Swiss-Prot and Genatlas for TMEM199 Gene

Publications for TMEM199 Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  2. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan J.S. … Kung A.W. (Hum. Mol. Genet. 2014) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3
  5. [Correction of five different types of errors of model REFSEQs appeared in NCBI human gene database only by using two novel human genes C17orf32 and ZNF362]. (PMID: 15487498) Zhang D.L. … Ji L. (Yi Chuan Xue Bao 2004) 23

Products for TMEM199 Gene

Sources for TMEM199 Gene

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