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Aliases for TMEM199 Gene

Aliases for TMEM199 Gene

  • Transmembrane Protein 199 2 3
  • C17orf32 3 4
  • Chromosome 17 Open Reading Frame 32 2

External Ids for TMEM199 Gene

Previous HGNC Symbols for TMEM199 Gene

  • C17orf32

Previous GeneCards Identifiers for TMEM199 Gene

  • GC17P023709
  • GC17P026684
  • GC17P022893

Summaries for TMEM199 Gene

GeneCards Summary for TMEM199 Gene

TMEM199 (Transmembrane Protein 199) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM199 Gene

Genomics for TMEM199 Gene

Regulatory Elements for TMEM199 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM199 Gene

Chromosome:
17
Start:
28,357,581 bp from pter
End:
28,363,683 bp from pter
Size:
6,103 bases
Orientation:
Plus strand

Genomic View for TMEM199 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM199 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM199 Gene

Proteins for TMEM199 Gene

  • Protein details for TMEM199 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N511-TM199_HUMAN
    Recommended name:
    Transmembrane protein 199
    Protein Accession:
    Q8N511

    Protein attributes for TMEM199 Gene

    Size:
    208 amino acids
    Molecular mass:
    23130 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM199 Gene

Proteomics data for TMEM199 Gene at MOPED

Post-translational modifications for TMEM199 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM199 Gene

Antibody Products

No data available for DME Specific Peptides for TMEM199 Gene

Domains & Families for TMEM199 Gene

Protein Domains for TMEM199 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM199 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM199: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM199 Gene

Function for TMEM199 Gene

Gene Ontology (GO) - Molecular Function for TMEM199 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM199: view

Phenotypes for TMEM199 Gene

GenomeRNAi human phenotypes for TMEM199:
genes like me logo Genes that share phenotypes with TMEM199: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM199

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM199 Gene

Localization for TMEM199 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM199 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM199 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0012505 endomembrane system IBA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM199: view

No data available for Subcellular locations from COMPARTMENTS for TMEM199 Gene

Pathways & Interactions for TMEM199 Gene

SuperPathways for TMEM199 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM199 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM199 Gene

Drugs & Compounds for TMEM199 Gene

No Compound Related Data Available

Transcripts for TMEM199 Gene

Unigene Clusters for TMEM199 Gene

Transmembrane protein 199:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM199

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM199 Gene

No ASD Table

Relevant External Links for TMEM199 Gene

GeneLoc Exon Structure for
TMEM199
ECgene alternative splicing isoforms for
TMEM199

Expression for TMEM199 Gene

mRNA expression in normal human tissues for TMEM199 Gene

Protein differential expression in normal tissues from HIPED for TMEM199 Gene

This gene is overexpressed in Nasal epithelium (52.2) and Bone (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM199 Gene



SOURCE GeneReport for Unigene cluster for TMEM199 Gene Hs.707906

genes like me logo Genes that share expression patterns with TMEM199: view

Protein tissue co-expression partners for TMEM199 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM199 Gene

Orthologs for TMEM199 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM199 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM199 35
  • 88.62 (n)
  • 94.15 (a)
TMEM199 36
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM199 35
  • 87.82 (n)
  • 90.38 (a)
TMEM199 36
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem199 35
  • 84.46 (n)
  • 89.42 (a)
Tmem199 16
Tmem199 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM199 35
  • 99.68 (n)
  • 100 (a)
TMEM199 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem199 35
  • 85.74 (n)
  • 90.87 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM199 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM199 36
  • 71 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM199 35
  • 65.98 (n)
  • 66.49 (a)
TMEM199 36
  • 67 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM199 36
  • 56 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15198 35
tmem199 35
  • 59.97 (n)
  • 60.82 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.26151 35
zebrafish
(Danio rerio)
Actinopterygii Dr.24936 35
tmem199 35
  • 59.42 (n)
  • 59.24 (a)
tmem199 36
  • 67 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7071 36
  • 19 (a)
OneToOne
Species with no ortholog for TMEM199:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM199 Gene

ENSEMBL:
Gene Tree for TMEM199 (if available)
TreeFam:
Gene Tree for TMEM199 (if available)

Paralogs for TMEM199 Gene

No data available for Paralogs for TMEM199 Gene

Variants for TMEM199 Gene

Sequence variations from dbSNP and Humsavar for TMEM199 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs730331 -- 28,362,410(+) TAATC(C/G)TAGCA utr-variant-3-prime
rs73989114 -- 28,363,411(+) TGTGT(A/G)GAACC utr-variant-3-prime
rs76813129 -- 28,361,256(+) AACTG(G/T)TGCTT utr-variant-3-prime
rs111715000 -- 28,363,369(+) TCCCA(C/G)CTGAA utr-variant-3-prime
rs113958301 -- 28,361,427(+) CCAAA(A/G)GGAGC utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM199 Gene

Variant ID Type Subtype PubMed ID
nsv519388 CNV Loss 19592680
nsv2017 CNV Insertion 18451855

Variation tolerance for TMEM199 Gene

Residual Variation Intolerance Score: 59.74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.36; 76.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM199 Gene

HapMap Linkage Disequilibrium report
TMEM199

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM199 Gene

Disorders for TMEM199 Gene

Relevant External Links for TMEM199

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM199
genes like me logo Genes that share disorders with TMEM199: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM199 Gene

Publications for TMEM199 Gene

  1. [Correction of five different types of errors of model REFSEQs appeared in NCBI human gene database only by using two novel human genes C17orf32 and ZNF362]. (PMID: 15487498) Zhang D.L. … Ji L. (Yi Chuan Xue Bao 2004) 23 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels. (PMID: 25080503) Kwan J.S. … Kung A.W. (Hum. Mol. Genet. 2014) 67
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  5. Comparative large scale characterization of plant versus mammal proteins reveals similar and idiosyncratic N-I+-acetylation features. (PMID: 22223895) Bienvenut W.V. … Giglione C. (Mol. Cell Proteomics 2012) 67

Products for TMEM199 Gene

Sources for TMEM199 Gene

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