Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM198 Gene

Aliases for TMEM198 Gene

  • Transmembrane Protein 198 2 3 5
  • TMEM198A 3

External Ids for TMEM198 Gene

Previous GeneCards Identifiers for TMEM198 Gene

  • GC02P220117
  • GC02P220408
  • GC02P212261

Summaries for TMEM198 Gene

GeneCards Summary for TMEM198 Gene

TMEM198 (Transmembrane Protein 198) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM198 Gene

  • Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM198 Gene

Genomics for TMEM198 Gene

Regulatory Elements for TMEM198 Gene

Enhancers for TMEM198 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02G219641 1.6 Ensembl ENCODE dbSUPER 12.1 +98.8 98788 1.7 HDGF ZFP64 WRNIP1 ARID4B SIN3A DMAP1 ZNF2 ZNF207 ZNF143 ZNF263 NHEJ1 OBSL1 TMEM198 CHPF ENSG00000267919 GC02M219631
GH02G219574 1.3 ENCODE dbSUPER 12.3 +32.7 32670 3.6 PKNOX1 FOXA2 ATF1 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 YY1 INHA TMEM198 CHPF SLC4A3 ENSG00000228973 OBSL1 ASIC4 GMPPA RN7SKP213
GH02G219397 1.4 Ensembl ENCODE dbSUPER 10.9 -144.6 -144636 3.7 PKNOX1 ATF1 FOXA2 FEZF1 YY1 FOS ZNF263 ZHX2 ZNF592 ZNF579 ASIC4 ENSG00000227432 DNPEP SPEG GMPPA CHPF TMEM198 OBSL1 GLB1L LOC105373884
GH02G219438 1.4 Ensembl ENCODE dbSUPER 10.3 -100.3 -100340 9.5 PKNOX1 ZFP64 BMI1 RAD21 ZNF335 GLIS2 EGR1 EGR2 ZNF263 ZNF426 USP37 ASIC4 GMPPA DES STK36 ENSG00000227432 CDK5R2 TMEM198 PTPRN SPEG
GH02G219294 1.4 ENCODE dbSUPER 10.3 -248.8 -248817 1.6 HDGF PKNOX1 MLX AGO1 ZFP64 WRNIP1 ARID4B SIN3A DMAP1 YBX1 PTPRN ASIC4 BCS1L TMEM198 TTLL4 ENSG00000230432 MIR153-1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM198 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM198 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000130573 -63 1601 HDGF PKNOX1 MLX CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZBTB7B SLC30A9

Genomic Location for TMEM198 Gene

Chromosome:
2
Start:
219,543,663 bp from pter
End:
219,550,595 bp from pter
Size:
6,933 bases
Orientation:
Plus strand

Genomic View for TMEM198 Gene

Genes around TMEM198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM198 Gene

Proteins for TMEM198 Gene

  • Protein details for TMEM198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K66-TM198_HUMAN
    Recommended name:
    Transmembrane protein 198
    Protein Accession:
    Q66K66

    Protein attributes for TMEM198 Gene

    Size:
    360 amino acids
    Molecular mass:
    39475 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for TMEM198 Gene

Post-translational modifications for TMEM198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM198 Gene

No data available for DME Specific Peptides for TMEM198 Gene

Domains & Families for TMEM198 Gene

Protein Domains for TMEM198 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM198 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q66K66

UniProtKB/Swiss-Prot:

TM198_HUMAN :
  • Belongs to the TMEM198 family.
Family:
  • Belongs to the TMEM198 family.
genes like me logo Genes that share domains with TMEM198: view

No data available for Gene Families for TMEM198 Gene

Function for TMEM198 Gene

Molecular function for TMEM198 Gene

UniProtKB/Swiss-Prot Function:
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

Phenotypes for TMEM198 Gene

GenomeRNAi human phenotypes for TMEM198:
genes like me logo Genes that share phenotypes with TMEM198: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM198 Gene

Localization for TMEM198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM198 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM198 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21536646
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031410 cytoplasmic vesicle IDA,IEA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

Pathways & Interactions for TMEM198 Gene

SuperPathways for TMEM198 Gene

No Data Available

Interacting Proteins for TMEM198 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://version10.5.string-db.org/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343507%0d%0a9606.ENSP00000324897%0d%0a
Selected Interacting proteins: ENSP00000343507 for TMEM198 Gene via STRING

Symbol External ID(s) Details
UBE2I

Gene Ontology (GO) - Biological Process for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0016055 Wnt signaling pathway IEA --
GO:0090263 positive regulation of canonical Wnt signaling pathway IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM198 Gene

Drugs & Compounds for TMEM198 Gene

No Compound Related Data Available

Transcripts for TMEM198 Gene

Unigene Clusters for TMEM198 Gene

Transmembrane protein 198:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM198 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for TMEM198 Gene

GeneLoc Exon Structure for
TMEM198
ECgene alternative splicing isoforms for
TMEM198

Expression for TMEM198 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM198 Gene

Protein differential expression in normal tissues from HIPED for TMEM198 Gene

This gene is overexpressed in Lung (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM198 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM198 Gene:

TMEM198

SOURCE GeneReport for Unigene cluster for TMEM198 Gene:

Hs.446664

Evidence on tissue expression from TISSUES for TMEM198 Gene

  • Nervous system(4.2)
genes like me logo Genes that share expression patterns with TMEM198: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM198 Gene

Orthologs for TMEM198 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM198 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM198 34 35
  • 99.63 (n)
cow
(Bos Taurus)
Mammalia TMEM198 35
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM198 34 35
  • 91.57 (n)
mouse
(Mus musculus)
Mammalia Tmem198 34 16 35
  • 90.28 (n)
rat
(Rattus norvegicus)
Mammalia Tmem198 34
  • 89.91 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM198 35
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM198 35
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM198 34 35
  • 69.01 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem198 34
  • 57.72 (n)
Str.5257 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.29730 34
zebrafish
(Danio rerio)
Actinopterygii tmem198b 34
  • 62.37 (n)
tmem198a 35
  • 53 (a)
OneToMany
Dr.7471 34
fruit fly
(Drosophila melanogaster)
Insecta CG14234 35
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4659 35
  • 44 (a)
OneToOne
Species where no ortholog for TMEM198 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM198 Gene

ENSEMBL:
Gene Tree for TMEM198 (if available)
TreeFam:
Gene Tree for TMEM198 (if available)

Paralogs for TMEM198 Gene

Pseudogenes.org Pseudogenes for TMEM198 Gene

genes like me logo Genes that share paralogs with TMEM198: view

No data available for Paralogs for TMEM198 Gene

Variants for TMEM198 Gene

Sequence variations from dbSNP and Humsavar for TMEM198 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs538538342 Uncertain significance 219,550,732(+) TGAGC(-/TA)TGTAG intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1000457868 -- 219,544,407(+) GAGCC(G/T)CCCAC intron-variant, upstream-variant-2KB
rs1000540037 -- 219,550,885(+) AGGGG(G/T)TACCA intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-3-prime
rs1001518587 -- 219,550,664(+) AGTGT(C/T)GCTCA intron-variant, downstream-variant-500B, upstream-variant-2KB
rs1001738725 -- 219,544,056(+) TCCAT(C/T)AGCAC intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM198 Gene

Variant ID Type Subtype PubMed ID
nsv508887 CNV insertion 20534489
nsv520958 CNV loss 19592680
nsv584502 CNV gain 21841781
nsv821906 CNV gain 20364138
nsv834545 CNV loss 17160897

Variation tolerance for TMEM198 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM198 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM198

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM198 Gene

Disorders for TMEM198 Gene

Relevant External Links for TMEM198

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM198

No disorders were found for TMEM198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM198 Gene

Publications for TMEM198 Gene

  1. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. (PMID: 21536646) Liang J. … Wu W. (Mol. Cell. Biol. 2011) 3 4 64
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3 64

Products for TMEM198 Gene

Sources for TMEM198 Gene

Content
Loading form....