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Aliases for TMEM198 Gene

Aliases for TMEM198 Gene

  • Transmembrane Protein 198 2 3 5
  • TMEM198A 3

External Ids for TMEM198 Gene

Previous GeneCards Identifiers for TMEM198 Gene

  • GC02P220117
  • GC02P220408
  • GC02P212261

Summaries for TMEM198 Gene

GeneCards Summary for TMEM198 Gene

TMEM198 (Transmembrane Protein 198) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM198 Gene

  • Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM198 Gene

Genomics for TMEM198 Gene

Regulatory Elements for TMEM198 Gene

Enhancers for TMEM198 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM198 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM198 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM198 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM198 Gene

Chromosome:
2
Start:
219,543,663 bp from pter
End:
219,550,595 bp from pter
Size:
6,933 bases
Orientation:
Plus strand

Genomic View for TMEM198 Gene

Genes around TMEM198 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM198 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM198 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM198 Gene

Proteins for TMEM198 Gene

  • Protein details for TMEM198 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q66K66-TM198_HUMAN
    Recommended name:
    Transmembrane protein 198
    Protein Accession:
    Q66K66

    Protein attributes for TMEM198 Gene

    Size:
    360 amino acids
    Molecular mass:
    39475 Da
    Quaternary structure:
    • Interacts with LRP6.

neXtProt entry for TMEM198 Gene

Proteomics data for TMEM198 Gene at MOPED

Post-translational modifications for TMEM198 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM198 Gene

No data available for DME Specific Peptides for TMEM198 Gene

Domains & Families for TMEM198 Gene

Protein Domains for TMEM198 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM198 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q66K66

UniProtKB/Swiss-Prot:

TM198_HUMAN :
  • Belongs to the TMEM198 family.
Family:
  • Belongs to the TMEM198 family.
genes like me logo Genes that share domains with TMEM198: view

No data available for Gene Families for TMEM198 Gene

Function for TMEM198 Gene

Molecular function for TMEM198 Gene

UniProtKB/Swiss-Prot Function:
Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.

Phenotypes for TMEM198 Gene

GenomeRNAi human phenotypes for TMEM198:
genes like me logo Genes that share phenotypes with TMEM198: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM198 Gene

Localization for TMEM198 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM198 Gene

Membrane; Multi-pass membrane protein. Cell membrane. Cytoplasmic vesicle. Note=Largely located to vesicle-like structures. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM198 Gene COMPARTMENTS Subcellular localization image for TMEM198 gene
Compartment Confidence
plasma membrane 5

Gene Ontology (GO) - Cellular Components for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005886 plasma membrane IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

Pathways & Interactions for TMEM198 Gene

SuperPathways for TMEM198 Gene

No Data Available

Interacting Proteins for TMEM198 Gene

Gene Ontology (GO) - Biological Process for TMEM198 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0090263 positive regulation of canonical Wnt signaling pathway IDA 21536646
genes like me logo Genes that share ontologies with TMEM198: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM198 Gene

Drugs & Compounds for TMEM198 Gene

No Compound Related Data Available

Transcripts for TMEM198 Gene

Unigene Clusters for TMEM198 Gene

Transmembrane protein 198:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM198 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
SP1:
SP2: -
SP3: -
SP4:

Relevant External Links for TMEM198 Gene

GeneLoc Exon Structure for
TMEM198
ECgene alternative splicing isoforms for
TMEM198

Expression for TMEM198 Gene

mRNA expression in normal human tissues for TMEM198 Gene

Protein differential expression in normal tissues from HIPED for TMEM198 Gene

This gene is overexpressed in Lung (22.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM198 Gene



SOURCE GeneReport for Unigene cluster for TMEM198 Gene Hs.446664

genes like me logo Genes that share expression patterns with TMEM198: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM198 Gene

Orthologs for TMEM198 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM198 Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM198 35
  • 91.57 (n)
  • 98.89 (a)
TMEM198 36
  • 51 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem198 35
  • 90.28 (n)
  • 97.78 (a)
Tmem198 16
Tmem198 36
  • 98 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM198 35
  • 99.63 (n)
  • 99.72 (a)
TMEM198 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem198 35
  • 89.91 (n)
  • 97.5 (a)
cow
(Bos Taurus)
Mammalia TMEM198 36
  • 97 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM198 36
  • 89 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM198 36
  • 53 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM198 35
  • 69.01 (n)
  • 63.38 (a)
TMEM198 36
  • 63 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 64 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.5257 35
tmem198 35
  • 57.72 (n)
  • 54.28 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.29730 35
zebrafish
(Danio rerio)
Actinopterygii Dr.7471 35
tmem198b 35
  • 62.37 (n)
  • 59.94 (a)
tmem198a 36
  • 53 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG14234 36
  • 20 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4659 36
  • 44 (a)
OneToOne
Species with no ortholog for TMEM198:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM198 Gene

ENSEMBL:
Gene Tree for TMEM198 (if available)
TreeFam:
Gene Tree for TMEM198 (if available)

Paralogs for TMEM198 Gene

Pseudogenes.org Pseudogenes for TMEM198 Gene

genes like me logo Genes that share paralogs with TMEM198: view

No data available for Paralogs for TMEM198 Gene

Variants for TMEM198 Gene

Sequence variations from dbSNP and Humsavar for TMEM198 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs8179770 -- 219,547,534(+) CTCTT(C/T)CTCAC reference, synonymous-codon
rs10206507 -- 219,546,059(+) CCTGA(C/T)ATCCT intron-variant
rs56387533 -- 219,546,926(+) GGTGC(A/G)TGCCA intron-variant
rs34601464 -- 219,547,771(+) CAGGC(-/T)TCCGT reference, frameshift-variant
rs34740415 -- 219,548,299(+) CACCA(-/G)GGGAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM198 Gene

Variant ID Type Subtype PubMed ID
nsv520958 CNV Loss 19592680
dgv4438n71 CNV Loss 21882294
nsv875875 CNV Loss 21882294
nsv875876 CNV Loss 21882294
nsv834545 CNV Loss 17160897
nsv508887 CNV Insertion 20534489
nsv821906 CNV Gain 20364138

Variation tolerance for TMEM198 Gene

Residual Variation Intolerance Score: 10.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.33; 41.56% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM198 Gene

Disorders for TMEM198 Gene

Relevant External Links for TMEM198

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM198

No disorders were found for TMEM198 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM198 Gene

Publications for TMEM198 Gene

  1. Transmembrane protein 198 promotes LRP6 phosphorylation and Wnt signaling activation. (PMID: 21536646) Liang J. … Wu W. (Mol. Cell. Biol. 2011) 3 4 67
  2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM198 Gene

Sources for TMEM198 Gene

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