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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM198 Gene

protein-coding   GIFtS: 35
GCID: GC02P220408

Transmembrane Protein 198

  Search for TMEM198
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1981 2
TMEM198A2

External Ids:    HGNC: 337041   Entrez Gene: 1306122   Ensembl: ENSG000001887607   UniProtKB: Q66K663   

Export aliases for TMEM198 gene to outside databases

Previous GC identifers: GC02P220117 GC02P212261


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM198 Gene: 
TMEM198 (transmembrane protein 198) is a protein-coding gene.

UniProtKB/Swiss-Prot: TM198_HUMAN, Q66K66
Function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a
membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM198 gene promoter:
         Spz1   RFX1   HOXA3   Pax-5   STAT5A   PPAR-gamma1   HSF2   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM198 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM198

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM198


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q35   Ensembl cytogenetic band:  2q35   HGNC cytogenetic band: 2q35

TMEM198 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM198 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P220408:  view genomic region     (about GC identifiers)

Start:
220,408,385 bp from pter      End:
220,415,317 bp from pter
Size:
6,933 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM198_HUMAN, Q66K66 (See protein sequence)
Recommended Name: Transmembrane protein 198  
Size: 360 amino acids; 39475 Da
Subunit: Interacts with LRP6
Subcellular location: Membrane; Multi-pass membrane protein (Potential). Cell membrane (By similarity).
Cytoplasmic vesicle (By similarity). Note=Largely located to vesicle-like structures (By similarity)

Explore the universe of human proteins at neXtProt for TMEM198: NX_Q66K66

Explore proteomics data for TMEM198 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q66K66

  • TMEM198 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM198 Protein Expression
    REFSEQ proteins: NP_001005209.1  
    ENSEMBL proteins: 
     ENSP00000343507   ENSP00000388087   ENSP00000362990   ENSP00000415186  

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    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005886plasma membrane IDA--
    GO:0016021integral to membrane IEA--
    GO:0016023cytoplasmic membrane-bounded vesicle IDA--

    TMEM198 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR025256 DUF4203

    Graphical View of Domain Structure for InterPro Entry Q66K66

    ProtoNet protein and cluster: Q66K66

    UniProtKB/Swiss-Prot: TM198_HUMAN, Q66K66
    Similarity: Belongs to the TMEM198 family


    TMEM198 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM198_HUMAN, Q66K66
    Function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a
    membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity

    Animal Models:

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    SwitchGear 3'UTR luciferase reporter plasmidTMEM198 3' UTR sequence
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM198

    Gene Ontology (GO): 3 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007275multicellular organismal development IEA--
    GO:0016055Wnt receptor signaling pathway IEA--
    GO:0090263positive regulation of canonical Wnt receptor signaling pathway IDA--

    TMEM198 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM198 (TM198)

    Search CenterWatch for drugs/clinical trials and news about TMEM198 / TM198

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM198 gene: 
    NM_001005209.1  

    Unigene Cluster for TMEM198:

    Transmembrane protein 198
    Hs.446664  [show with all ESTs]
    Unigene Representative Sequence: BC068567
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000344458(uc002vme.3) ENST00000421791 ENST00000373883(uc002vmf.3)
    ENST00000451952
    miRNA
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    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-1271 hsa-miR-501-3p hsa-miR-4299 hsa-miR-340 hsa-miR-502-3p hsa-miR-124
    SwitchGear 3'UTR luciferase reporter plasmidTMEM198 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM198
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    Additional mRNA sequence: 

    AK123175.1 AK302369.1 BC068567.1 BC080573.1 

    10 DOTS entries:

    DT.100666060  DT.95237072  DT.91686634  DT.100754539  DT.80100285  DT.100754541  DT.40242615  DT.95137550 
    DT.95208865  DT.40242617 

    24/75 AceView cDNA sequences (see all 75):

    CB130374 BM672313 BG056047 CR597020 BM664765 NM_001005209 AW139465 BC080573 
    BF115238 CR596918 AI376907 BM703284 BF515430 CR592699 AI343486 BM142150 
    AI498947 AW118141 BG767789 BX375363 BI757051 BM700978 BI821451 BQ070204 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM198    About this scheme

    ExUns: 1a · 1b · 1c ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6
    SP1:                                                                  
    SP2:                    -                                             
    SP3:                                -                                 
    SP4:                                                                  


    ECgene alternative splicing isoforms for TMEM198

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM198 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM198 Expression
    About this image


    See TMEM198 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM198

    SOURCE GeneReport for Unigene cluster: Hs.446664
        SABiosciences Custom PCR Arrays for TMEM198
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM198

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM198 gene from 6/15 species (see all 15)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1981 , 5 transmembrane protein 1981, 5 90.28(n)1
    97.78(a)1
      1 (39.15 cM)5
    3199981  NM_177056.41  NP_796030.11 
     754795325 
    chicken
    (Gallus gallus)
    Aves TMEM1981 transmembrane protein 198 69.01(n)
    63.66(a)
      769377  XM_001232636.2  XP_001232637.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1986
    --
    Uncharacterized protein
    62(a)
    50(a)
    1 ↔ 1
    possible ortholog
    1(94606868-94631679)
    GL343198.1(3126720-3153563)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.297302 Xenopus laevis transcribed sequences 71.11(n)    BJ068161.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.74712 Transcribed sequences 73.81(n)    BG304666.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG142341 CG14234 48.2(n)
    29.5(a)
      32988  NM_134507.1  NP_608351.1 


    ENSEMBL Gene Tree for TMEM198 (if available)
    TreeFam Gene Tree for TMEM198 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM198 gene

    TMEM198 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for TMEM198
    PGOHUM00000233452


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/202 SNPs in TMEM198 are shown (see all 202)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs75812511,2
    C,F,H--219787393(+) CAAAAA/GGACAA 1 -- us2k114Minor allele frequency- G:0.05NA WA CSA EA 379
    rs1886410111,2
    --219787561(+) CATTTC/GGGAGA 1 -- us2k10--------
    rs1150416851,2
    F--219787616(+) TCCGGG/AGTTCG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1386328571,2
    --219787775(+) TGCCTA/CACATA 1 -- us2k10--------
    rs1493169381,2
    --219787869(+) CTTACC/TTTTTG 1 -- us2k10--------
    rs779430801,2
    C--219787894(+) AAATTG/TCAGAA 1 -- us2k10--------
    rs1925924051,2
    --219788016(+) ACCCAC/TTCAGG 1 -- us2k10--------
    rs1378607241,2
    C--219788089(+) CCTATA/GTATAA 1 -- us2k10--------
    rs116859121,2
    C,F,A,H--219788185(+) CCAGTG/AAGTTC 1 -- us2k121Minor allele frequency- A:0.49NS EA NA WA CSA 2345
    rs109328101,2
    C--219788367(+) CCCAGG/TGGGTA 1 -- us2k13Minor allele frequency- T:0.19WA NA 240

    HapMap Linkage Disequilibrium report for TMEM198 (220408385 - 220415317 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM198:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv508887CNV Insertion20534489
    dgv4438n71CNV Loss21882294
    nsv875876CNV Loss21882294
    nsv520958CNV Loss19592680
    nsv834545CNV Loss17160897
    nsv875875CNV Loss21882294
    nsv821906CNV Gain20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM198 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM198)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Transmembrane protein 198 promotes LRP6 phosphorylati on and Wnt signaling activation. (PubMed id 21536646)1, 2 Liang J....Wu W. (2011)
    2. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 130612 HGNC: 33704 AceView: MGC99813 Ensembl:ENSG00000188760 euGenes: HUgn130612
    ECgene: TMEM198 H-InvDB: TMEM198

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM198 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM198 gene:
    Search GeneIP for patents involving TMEM198

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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