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Aliases for TMEM196 Gene

Aliases for TMEM196 Gene

  • Transmembrane Protein 196 2 3 5

External Ids for TMEM196 Gene

Previous GeneCards Identifiers for TMEM196 Gene

  • GC07M019726

Summaries for TMEM196 Gene

GeneCards Summary for TMEM196 Gene

TMEM196 (Transmembrane Protein 196) is a Protein Coding gene.

Additional gene information for TMEM196 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM196 Gene

Genomics for TMEM196 Gene

Regulatory Elements for TMEM196 Gene

Enhancers for TMEM196 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H020598 1.3 FANTOM5 Ensembl ENCODE 10.7 -825.3 -825312 0 CTCF PKNOX1 ZNF654 JUN TRIM22 USF2 REST RAD21 RAD51 FOXK2 TWISTNB TMEM196 ITGB8 LOC402641 ABCB5
GH07H020119 0.7 ENCODE dbSUPER 10 -349.8 -349794 8 PAF1 POLR2A POU5F1 MACC1-AS1 TMEM196 LOC100506098 LOC101927668 LOC105375181
GH07H019915 0.5 ENCODE 11.1 -142.7 -142659 1 JUND BCL11A JUN NR2F1 BATF TMEM196 TWISTNB GC07P019961 ENSG00000237921
GH07H019982 0.5 ENCODE 10.3 -209.4 -209425 0 CTCF ZNF654 TRIM22 RAD21 TMEM196 RPL21P75 GC07P019961
GH07H019984 0.4 ENCODE 10.3 -210.7 -210735 0 CTCF TMEM196 RPL21P75 GC07P019961
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM196 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM196 Gene

Chromosome:
7
Start:
19,719,310 bp from pter
End:
19,773,598 bp from pter
Size:
54,289 bases
Orientation:
Minus strand

Genomic View for TMEM196 Gene

Genes around TMEM196 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM196 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM196 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM196 Gene

Proteins for TMEM196 Gene

  • Protein details for TMEM196 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5HYL7-TM196_HUMAN
    Recommended name:
    Transmembrane protein 196
    Protein Accession:
    Q5HYL7
    Secondary Accessions:
    • Q8N6I6

    Protein attributes for TMEM196 Gene

    Size:
    178 amino acids
    Molecular mass:
    19025 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BX648384; Type=Frameshift; Positions=72; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM196 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM196 Gene

Post-translational modifications for TMEM196 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM196 Gene

Domains & Families for TMEM196 Gene

Gene Families for TMEM196 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM196 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM196 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM196: view

No data available for UniProtKB/Swiss-Prot for TMEM196 Gene

Function for TMEM196 Gene

Phenotypes for TMEM196 Gene

genes like me logo Genes that share phenotypes with TMEM196: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM196
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM196 Gene

Localization for TMEM196 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM196 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM196 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM196 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM196: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM196 Gene

Pathways & Interactions for TMEM196 Gene

SuperPathways for TMEM196 Gene

No Data Available

Interacting Proteins for TMEM196 Gene

Selected Interacting proteins: Q5HYL7-TM196_HUMAN for TMEM196 Gene via IID

Symbol External ID(s) Details
TMEM196

Gene Ontology (GO) - Biological Process for TMEM196 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM196 Gene

Drugs & Compounds for TMEM196 Gene

No Compound Related Data Available

Transcripts for TMEM196 Gene

Unigene Clusters for TMEM196 Gene

Transmembrane protein 196:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM196
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM196 Gene

ExUns: 1 ^ 2 ^ 3a · 3b
SP1:
SP2:
SP3: -

Relevant External Links for TMEM196 Gene

GeneLoc Exon Structure for
TMEM196
ECgene alternative splicing isoforms for
TMEM196

Expression for TMEM196 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM196 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM196 Gene

This gene is overexpressed in Brain - Hypothalamus (x7.9), Brain - Anterior cingulate cortex (BA24) (x6.7), Brain - Frontal Cortex (BA9) (x5.6), Brain - Cortex (x5.4), Brain - Caudate (basal ganglia) (x4.4), Brain - Putamen (basal ganglia) (x4.4), and Pituitary (x4.3).

NURSA nuclear receptor signaling pathways regulating expression of TMEM196 Gene:

TMEM196

SOURCE GeneReport for Unigene cluster for TMEM196 Gene:

Hs.487670

Evidence on tissue expression from TISSUES for TMEM196 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM196: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM196 Gene

Orthologs for TMEM196 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM196 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM196 33 34
  • 98.45 (n)
cow
(Bos Taurus)
Mammalia TMEM196 33 34
  • 94.19 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM196 34
  • 94 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM196 33 34
  • 93.22 (n)
mouse
(Mus musculus)
Mammalia Tmem196 33 16 34
  • 91.28 (n)
rat
(Rattus norvegicus)
Mammalia Tmem196 33
  • 91.28 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM196 34
  • 84 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM196 33 34
  • 83.53 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM196 34
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem196 33
  • 76.02 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC798466 33
  • 68.42 (n)
TMEM196 (1 of 2) 34
  • 65 (a)
OneToMany
tmem196b 34
  • 57 (a)
OneToMany
Species where no ortholog for TMEM196 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM196 Gene

ENSEMBL:
Gene Tree for TMEM196 (if available)
TreeFam:
Gene Tree for TMEM196 (if available)

Paralogs for TMEM196 Gene

Pseudogenes.org Pseudogenes for TMEM196 Gene

genes like me logo Genes that share paralogs with TMEM196: view

No data available for Paralogs for TMEM196 Gene

Variants for TMEM196 Gene

Sequence variations from dbSNP and Humsavar for TMEM196 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000068718 -- 19,743,122(+) TCCCC(A/C)ATCAA intron-variant
rs1000083560 -- 19,746,791(+) TGATT(C/T)GTATA intron-variant
rs1000134045 -- 19,735,206(+) TAAAA(A/G)AAGAT intron-variant
rs1000213961 -- 19,774,873(+) ATGAT(C/T)CAATT intron-variant, upstream-variant-2KB
rs1000240247 -- 19,756,883(+) TGTTA(C/T)GGTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM196 Gene

Variant ID Type Subtype PubMed ID
esv2734097 CNV deletion 23290073
nsv1018601 CNV gain 25217958
nsv1078011 CNV duplication 25765185
nsv524807 CNV gain 19592680
nsv830918 CNV loss 17160897

Variation tolerance for TMEM196 Gene

Residual Variation Intolerance Score: 57.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.03; 21.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM196 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM196

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM196 Gene

Disorders for TMEM196 Gene

Relevant External Links for TMEM196

Genetic Association Database (GAD)
TMEM196
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM196

No disorders were found for TMEM196 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM196 Gene

Publications for TMEM196 Gene

  1. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PMID: 17903292) Hwang SJ … Fox CS (BMC medical genetics 2007) 3 45 60
  2. TMEM196 acts as a novel functional tumour suppressor inactivated by DNA methylation and is a potential prognostic biomarker in lung cancer. (PMID: 26056045) Liu WB … Liu JY (Oncotarget 2015) 3 60
  3. Genome-wide association study of intracranial aneurysm identifies a new association on chromosome 7. (PMID: 25256182) Foroud T … Familial Intracranial Aneurysm Study Investigators (Stroke 2014) 3 60
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60
  5. Genetic correlates of longevity and selected age-related phenotypes: a genome-wide association study in the Framingham Study. (PMID: 17903295) Lunetta KL … Murabito JM (BMC medical genetics 2007) 45 60

Products for TMEM196 Gene

Sources for TMEM196 Gene

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