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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM194A Gene

protein-coding   GIFtS: 40
GCID: GC12M057449

Transmembrane Protein 194A

(Previous name: transmembrane protein 194)
(Previous symbol: TMEM194)
  Search for TMEM194A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 194A1 2
TMEM1941 2 3
Transmembrane Protein 1941 2
KIAA02863

External Ids:    HGNC: 290011   Entrez Gene: 233062   Ensembl: ENSG000001668817   UniProtKB: O145243   

Export aliases for TMEM194A gene to outside databases

Previous GC identifers: GC12M055737 GC12M054487


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM194A Gene: 
TMEM194A (transmembrane protein 194A) is a protein-coding gene. GO annotations related to this gene include molecular_function. An important paralog of this gene is TMEM194B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000012.11  NC_018923.2  NT_029419.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM194A gene promoter:
         Oct-B1   Elk-1   oct-B3   oct-B2   Pax-5   PPAR-gamma1   POU2F1   POU2F1a   COMP1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM194A promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM194A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM194A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 12q13.3   Ensembl cytogenetic band:  12q13.3   HGNC cytogenetic band: 12q13.3

TMEM194A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM194A gene location

GeneLoc information about chromosome 12         GeneLoc Exon Structure

GeneLoc location for GC12M057449:  view genomic region     (about GC identifiers)

Start:
57,449,426 bp from pter      End:
57,481,846 bp from pter
Size:
32,421 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T194A_HUMAN, O14524 (See protein sequence)
Recommended Name: Transmembrane protein 194A  
Size: 444 amino acids; 50640 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH71597.1; Type=Erroneous initiation; Sequence=BAA22955.2; Type=Erroneous initiation;
Secondary accessions: Q17R72 Q68DH0 Q6IQ25
Alternative splicing: 2 isoforms:  O14524-1   O14524-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM194A: NX_O14524

Explore proteomics data for TMEM194A at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O14524

  • TMEM194A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM194A Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001124435.1  NP_056072.2  

    ENSEMBL proteins: 
     ENSP00000368701   ENSP00000300128   ENSP00000452391  

    Human Recombinant Protein Products for TMEM194A: 
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    Novus Biologicals TMEM194A Protein
    Novus Biologicals TMEM194A Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane NAS--

    TMEM194A for ontologies           About GeneDecksing



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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019358 TMEM194

    Graphical View of Domain Structure for InterPro Entry O14524

    ProtoNet protein and cluster: O14524

    UniProtKB/Swiss-Prot: T194A_HUMAN, O14524
    Similarity: Belongs to the TMEM194 family


    TMEM194A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003674molecular_function ND--
         
    TMEM194A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM194A 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM194A 
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    miRNA
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    Gene Editing
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    Clone
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                         Customized lentivirus expression plasmids for stable overexpression of TMEM194A 

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    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM194A


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM194A

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    4 Interacting proteins for TMEM194A (ENSP000003001284) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    KPNB1ENSP000002901584STRING: ENSP00000290158
    UBCENSP000003448184STRING: ENSP00000344818
    RRM2ENSP000003029554STRING: ENSP00000302955
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008150biological_process ND--

    TMEM194A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM194A (T194A)

    Search CenterWatch for drugs/clinical trials and news about TMEM194A / T194A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM194A gene (2 alternative transcripts): 
    NM_001130963.1  NM_015257.2  

    Unigene Cluster for TMEM194A:

    Transmembrane protein 194A
    Hs.591040  [show with all ESTs]
    Unigene Representative Sequence: NM_001130963
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000379391 ENST00000300128(uc001smy.3 uc001smx.3 uc010sra.2)
    ENST00000554340 ENST00000553654
    miRNA
    Products:
         
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    8/65 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM194A (see all 65):
    hsa-miR-188-5p hsa-miR-3146 hsa-miR-146a hsa-miR-149 hsa-miR-761 hsa-miR-4324 hsa-miR-130a* hsa-miR-23c
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
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    Clone
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    OriGene clones in human, mouse for TMEM194A (see all 13)
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    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM194A (NM_001130963)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM194A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM194A
    Sirion Biotech Customized lentivirus for stable overexpression of TMEM194A 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM194A 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM194A
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM194A

    Additional mRNA sequence: 

    AB006624.2 AK294566.1 AL833310.1 AL833311.1 BC071597.1 BC117436.1 BC126300.1 BC144029.1 
    CR749406.1 

    6 DOTS entries:

    DT.115593  DT.101979592  DT.100651820  DT.102827060  DT.444831  DT.99994710 

    24/158 AceView cDNA sequences (see all 158):

    AI683656 AW205215 BQ018581 AL601515 AI656446 AA258096 AU123814 BE464009 
    BU159139 AA830414 BM996481 AW500884 AA773300 AW193731 BM824032 AI184358 
    AA604534 BF970831 AI188514 AI361588 AW197049 BX117682 AB006624 AU132953 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM194A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGTCTTATTT
    TMEM194A Expression
    About this image


    See TMEM194A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM194A

    SOURCE GeneReport for Unigene cluster: Hs.591040
        SABiosciences Custom PCR Arrays for TMEM194A
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM194A
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM194A
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM194A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM194A gene from 7/14 species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1941 , 5 transmembrane protein 1941, 5 86.82(n)1
    84.83(a)1
      10 (74.60 cM)5
    2100351  NM_001113211.11  NP_001106682.11 
     1276669015 
    chicken
    (Gallus gallus)
    Aves TMEM194A1 transmembrane protein 194A 65.55(n)
    62.77(a)
      769312  XM_001232566.2  XP_001232567.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM194A6
    transmembrane protein 194A
    61(a)
    1 ↔ 1
    GL343212.1(2718583-2739208)
    African clawed frog
    (Xenopus laevis)
    Amphibia 480297322   -- 76.62(n)    48029732 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem194a1 transmembrane protein 194A 59.97(n)
    54.59(a)
      555733  XM_678326.4  XP_683418.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG97236
    --
    21(a)
    1 → many
    X(16547253-16549045)
    worm
    (Caenorhabditis elegans)
    Secernentea F10C5.26
    Protein F10C5.2
    19(a)
    1 → many
    III(472301-475354)


    ENSEMBL Gene Tree for TMEM194A (if available)
    TreeFam Gene Tree for TMEM194A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM194A gene
    TMEM194B2  
    1 SIMAP similar gene for TMEM194A using alignment to 2 protein entries:     T194A_HUMAN (see all proteins):
    TMEM194B

    TMEM194A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/467 SNPs in TMEM194A are shown (see all 467)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 12 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1893839661,2
    --57448997(+) TTCCAC/TCCTAT 2 -- int10--------
    rs1998087991,2
    C--57449090(+) GCCAT-/AAAAAAA 2 -- int10--------
    rs111720861,2
    C,F,A,H--57449206(+) GAATAC/TCCCTT 2 -- int116Minor allele frequency- T:0.07NA NS EA WA 1338
    rs749565861,2
    F--57449250(+) AAGGAT/CGAAAG 2 -- int11Minor allele frequency- C:0.02WA 118
    rs726488591,2
    C--57449413(+) TTAAGA/CAAGAC 2 -- int10--------
    rs1411384171,2
    --57449428(+) ATATAG/TCTATA 2 -- ut310--------
    rs1917701661,2
    --57449436(+) ATAAAA/GCTTTT 2 -- ut310--------
    rs1843198191,2
    --57449445(+) TTATTA/GAAATT 2 -- ut310--------
    rs40391,2
    C,F,A,H--57449610(+) AATATT/GTAAAT 2 -- ut3117Minor allele frequency- G:0.11MN NS EA NA WA 2522
    rs1503064691,2
    --57449617(+) AAATAA/TCCCTA 2 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM194A (57449426 - 57481846 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 3 variations for TMEM194A:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv899111CNV Loss21882294
    nsv899110CNV Loss21882294
    nsv832428CNV Gain17160897

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM194A gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM194A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
    2. Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
    3. Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
    4. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    5. Global identification of modular cullin-RING ligase su bstrates. (PubMed id 21963094)1 Emanuele M.J....Elledge S.J. (2011)
    6. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
    7. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
    8. A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
    9. The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
    10. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23306 HGNC: 29001 AceView: KIAA0286 Ensembl:ENSG00000166881 euGenes: HUgn23306
    ECgene: TMEM194A H-InvDB: TMEM194A

    (According to HUGE)
    About This Section
    HUGE: KIAA0286

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM194A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM194A gene:
    Search GeneIP for patents involving TMEM194A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM194A
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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    (GIFtS: 73)
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