TMEM194A Gene
protein-coding GIFtS: 40
GCID: GC12M057449
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transmembrane protein 194A(Previous name: transmembrane protein 194 )
(Previous symbol: TMEM194)
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Aliases
for TMEM194A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 194A1 2 | | TMEM1941 2 3 | | Transmembrane Protein 1941 2 | | KIAA02861 3 |
Export aliases for TMEM194A gene to outside databasesPrevious GC identifers: GC12M055737 GC12M054487 |
Summaries
for TMEM194A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM194A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000012.11 NC_018923.1 NT_029419.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM194A gene promoter:
Oct-B1 Elk-1 oct-B3 oct-B2 Pax-5 PPAR-gamma1 POU2F1 POU2F1a COMP1 PPAR-gamma2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM194A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM194A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 12q13.3 Ensembl cytogenetic band: 12q13.3 HGNC cytogenetic band: 12q13.3TMEM194A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 12 GeneLoc Exon Structure GeneLoc location for GC12M057449: view genomic region
(about GC identifiers)
Start:
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57,449,426 bp from pter |
End:
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57,481,846 bp from pter |
Size:
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32,421 bases |
Orientation:
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minus strand |
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Proteins
for TMEM194A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T194A_HUMAN, O14524 (See
protein sequence)Recommended Name: Transmembrane protein 194A Size: 444 amino acids; 50640 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH71597.1; Type=Erroneous initiation; Sequence=BAA22955.2; Type=Erroneous initiation;
Secondary accessions: Q17R72 Q68DH0 Q6IQ25Alternative splicing: 2 isoforms: O14524-1 O14524-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM194A: NX_O14524
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_O14524
TMEM194A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001124435.1 NP_056072.2
ENSEMBL proteins: ENSP00000368701 ENSP00000300128 ENSP00000452391
Human Recombinant Protein Products for TMEM194A:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
NAS | -- |
TMEM194A for ontologies About GeneDecksing
TMEM194A Antibody Products:
Assay Products for TMEM194A: |
Protein
Domains /
Families
for TMEM194A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM194A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry O14524ProtoNet protein and cluster: O14524 UniProtKB/Swiss-Prot: T194A_HUMAN, O14524Similarity: Belongs to the TMEM194 family |
Function
for TMEM194A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM194A for ontologies About GeneDecksing
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM194A (NM_001130963) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM194A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM194A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM194A |
|
Pathways & Interactions
for TMEM194A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM194A
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
4 Interacting proteins for TMEM194A (ENSP000003001284) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM194A for ontologies About GeneDecksing
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Drugs & Compounds
for TMEM194A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM194A
Search CenterWatch for drugs/clinical trials and news about TMEM194A / T194A
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Transcripts
for TMEM194A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM194A gene (2 alternative transcripts): NM_001130963.1 NM_015257.2 Unigene Cluster for TMEM194A: Transmembrane protein 194A Hs.591040 [show with all ESTs]Unigene Representative Sequence: NM_0011309634 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000379391 ENST00000300128(uc001smy.3 uc001smx.3 uc010sra.2)
ENST00000554340 ENST00000553654
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A (see all 2)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM194A (NM_001130963) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM194A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM194A |
Additional cDNA sequence: AB006624.2 AK294566.1 AL833310.1 AL833311.1 BC071597.1 BC117436.1 BC126300.1 BC144029.1 CR749406.1 6 DOTS entries: DT.115593 DT.101979592 DT.100651820 DT.102827060 DT.444831 DT.99994710 24/158 AceView cDNA sequences (see all 158): AI656446 BU159139 AW500884 BQ437502 BF970831 AB006624 BU507418 CR607517 AI184358 AA604534 BE464009 AW193731 AA830414 AL601515 AW205215 CR749406 AU123814 AI188514 BQ012926 AW197049 BM996481 BQ018581 AU132953 AA258096
GeneLoc Exon Structure
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Expression
for TMEM194A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM194A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGTCTTATTT
About this image
See TMEM194A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM194A
SOURCE GeneReport for Unigene cluster: Hs.591040
SABiosciences Custom PCR Arrays for TMEM194A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM194A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM194A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM194A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM194A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM194A |
Orthologs
for TMEM194A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM194A gene from 7/19 species (see all 19) About this table
ENSEMBL Gene Tree for TMEM194A (if available)
TreeFam Gene Tree for TMEM194A (if available) |
Paralogs
for TMEM194A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM194A gene
- TMEM194B2
1 SIMAP similar gene for TMEM194A using alignment to 2 protein entries: T194A_HUMAN (see all proteins):TMEM194B
TMEM194A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM194A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 12 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM194A (57449426 - 57481846 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM194A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM194A |
|
Disorders
/ Diseases
for TMEM194A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM194A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM194A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM194A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. (PubMed id 12168954)1, 2 Nakajima D.... Nagase T. (2002)
- Construction and characterization of human brain cDNA libraries suitable for analysis of cDNA clones encoding relatively large proteins. (PubMed id 9179496)1, 2 Ohara O....Nomura N. (1997)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for TMEM194A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMEM194A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM194A gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TMEM194A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM194A | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM194A gene:
Search GeneIP for patents involving TMEM194A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM194A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM194A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM194A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM194A | | | OriGene Protein Over-expression Lysate for TMEM194A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM194A | | OriGene 3'-UTR Clone for TMEM194A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM194A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM194A | | OriGene Custom Protein Services for TMEM194A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM194A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM194A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM194A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM194A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM194A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM194A |
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 | | | TMEM194A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM194A |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM194A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM194A |
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