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Aliases for TMEM192 Gene

Aliases for TMEM192 Gene

  • Transmembrane Protein 192 2 3

External Ids for TMEM192 Gene

Summaries for TMEM192 Gene

GeneCards Summary for TMEM192 Gene

TMEM192 (Transmembrane Protein 192) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM192 Gene

Genomics for TMEM192 Gene

Genomic Location for TMEM192 Gene

Start:
165,070,608 bp from pter
End:
165,208,549 bp from pter
Size:
137,942 bases
Orientation:
Minus strand

Genomic View for TMEM192 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM192 Gene

Regulatory Elements for TMEM192 Gene

Proteins for TMEM192 Gene

  • Protein details for TMEM192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IY95-TM192_HUMAN
    Recommended name:
    Transmembrane protein 192
    Protein Accession:
    Q8IY95
    Secondary Accessions:
    • Q7Z3A1
    • Q8N928

    Protein attributes for TMEM192 Gene

    Size:
    271 amino acids
    Molecular mass:
    30922 Da
    Quaternary structure:
    • Homodimer.
    SequenceCaution:
    • Sequence=CAD97974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM192 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM192 Gene

Proteomics data for TMEM192 Gene at MOPED

Post-translational modifications for TMEM192 Gene

Other Protein References for TMEM192 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM192 Gene

Domains for TMEM192 Gene

Protein Domains for TMEM192 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM192_HUMAN
Family:
  • Belongs to the TMEM192 family.:
    • Q8IY95
genes like me logo Genes that share domains with TMEM192: view

No data available for Gene Families for TMEM192 Gene

Function for TMEM192 Gene

Gene Ontology (GO) - Molecular Function for TMEM192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0042803 protein homodimerization activity IDA 20370317
genes like me logo Genes that share ontologies with TMEM192: view

miRNA for TMEM192 Gene

miRTarBase miRNAs that target TMEM192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM192 Gene

Localization for TMEM192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM192 Gene

Lysosome membrane; Multi-pass membrane protein. Late endosome.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM192 Gene COMPARTMENTS Subcellular localization image for TMEM192 gene
Compartment Confidence
endosome 5
lysosome 5
vacuole 5
plasma membrane 3
cytosol 2
golgi apparatus 2
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 22736246
GO:0005764 lysosome IDA 22736246
GO:0005765 lysosomal membrane IDA 20370317
GO:0005770 late endosome IDA 20370317
GO:0005783 NOT endoplasmic reticulum IDA 20370317
genes like me logo Genes that share ontologies with TMEM192: view

Pathways for TMEM192 Gene

SuperPathways for TMEM192 Gene

No Data Available

Interacting Proteins for TMEM192 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000305069%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000234396%0d%0a9606.ENSP00000273398%0d%0a
Selected Interacting proteins: ENSP00000305069 for TMEM192 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM192 Gene

None

No data available for Pathways by source for TMEM192 Gene

Transcripts for TMEM192 Gene

Unigene Clusters for TMEM192 Gene

Transmembrane protein 192:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM192 Gene

No ASD Table

Relevant External Links for TMEM192 Gene

GeneLoc Exon Structure for
TMEM192
ECgene alternative splicing isoforms for
TMEM192

Expression for TMEM192 Gene

mRNA expression in normal human tissues for TMEM192 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM192 Gene

SOURCE GeneReport for Unigene cluster for TMEM192 Gene Hs.704511

mRNA Expression by UniProt/SwissProt for TMEM192 Gene

Q8IY95-TM192_HUMAN
Tissue specificity: Strongly expressed in kidney, liver, lung and pancreas.
genes like me logo Genes that share expressions with TMEM192: view

Orthologs for TMEM192 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM192 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM192 36
  • 99.51 (n)
  • 99.63 (a)
TMEM192 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM192 36
  • 83.4 (n)
  • 83.65 (a)
TMEM192 37
  • 79 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM192 36
  • 83.27 (n)
  • 80.84 (a)
TMEM192 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem192 36
  • 82.08 (n)
  • 79.32 (a)
Tmem192 16
Tmem192 37
  • 79 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM192 37
  • 77 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM192 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem192 36
  • 81.45 (n)
  • 81.95 (a)
chicken
(Gallus gallus)
Aves TMEM192 37
  • 65 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 70 (a)
OneToMany
-- 37
  • 60 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem192 36
  • 58.24 (n)
  • 53.26 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem192 36
  • 49.14 (n)
  • 39.92 (a)
tmem192 37
  • 37 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG7523 37
  • 21 (a)
OneToOne
Species with no ortholog for TMEM192:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM192 Gene

ENSEMBL:
Gene Tree for TMEM192 (if available)
TreeFam:
Gene Tree for TMEM192 (if available)

Paralogs for TMEM192 Gene

Pseudogenes.org Pseudogenes for TMEM192 Gene

genes like me logo Genes that share paralogs with TMEM192: view

No data available for Paralogs for TMEM192 Gene

Variants for TMEM192 Gene

Sequence variations from dbSNP and Humsavar for TMEM192 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1059001 -- 165,112,499(+) GCCCA(A/C)CGCCC intron-variant
rs1133361 -- 165,078,036(-) ctgta(A/G)tctta utr-variant-3-prime
rs1707532 -- 165,112,234(-) CGCCA(C/G)GGTCC intron-variant
rs1707534 -- 165,111,466(-) GCGTT(C/T)TTGGA intron-variant
rs1849458 -- 165,109,607(-) CGGGT(A/G)GATCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM192 Gene

Variant ID Type Subtype PubMed ID
nsv881168 CNV Gain 21882294
nsv511271 CNV Loss 21212237
esv1000719 CNV Deletion 20482838
esv2558277 CNV Deletion 19546169
nsv513175 CNV Loss 21212237
esv2728686 CNV Deletion 23290073
dgv908n67 CNV Loss 20364138
nsv820721 CNV Deletion 20802225
esv22270 CNV Gain 19812545
dgv132e180 CNV Gain 20482838
nsv518959 CNV Loss 19592680
nsv507211 CNV Insertion 20534489

Relevant External Links for TMEM192 Gene

HapMap Linkage Disequilibrium report
TMEM192

Disorders for TMEM192 Gene

No disorders were found for TMEM192 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM192 Gene

Publications for TMEM192 Gene

  1. Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. (PMID: 20370317) Schroder B. … Saftig P. (Biol. Chem. 2010) 3 4
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  5. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3

Products for TMEM192 Gene

Sources for TMEM192 Gene

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