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Aliases for TMEM192 Gene

Aliases for TMEM192 Gene

  • Transmembrane Protein 192 2 3 5

External Ids for TMEM192 Gene

Previous GeneCards Identifiers for TMEM192 Gene

  • GC04M166219
  • GC04M165997
  • GC04M161750

Summaries for TMEM192 Gene

GeneCards Summary for TMEM192 Gene

TMEM192 (Transmembrane Protein 192) is a Protein Coding gene. GO annotations related to this gene include protein homodimerization activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM192 Gene

Genomics for TMEM192 Gene

Regulatory Elements for TMEM192 Gene

Promoters for TMEM192 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM192 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM192 Gene

165,070,608 bp from pter
165,208,549 bp from pter
137,942 bases
Minus strand

Genomic View for TMEM192 Gene

Genes around TMEM192 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM192 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM192 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM192 Gene

Proteins for TMEM192 Gene

  • Protein details for TMEM192 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 192
    Protein Accession:
    Secondary Accessions:
    • Q7Z3A1
    • Q8N928

    Protein attributes for TMEM192 Gene

    271 amino acids
    Molecular mass:
    30922 Da
    Quaternary structure:
    • Homodimer.
    • Sequence=CAD97974.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM192 Gene


neXtProt entry for TMEM192 Gene

Proteomics data for TMEM192 Gene at MOPED

Post-translational modifications for TMEM192 Gene

Other Protein References for TMEM192 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM192 Gene

Domains & Families for TMEM192 Gene

Protein Domains for TMEM192 Gene


Suggested Antigen Peptide Sequences for TMEM192 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM192 family.
  • Belongs to the TMEM192 family.
genes like me logo Genes that share domains with TMEM192: view

No data available for Gene Families for TMEM192 Gene

Function for TMEM192 Gene

Phenotypes for TMEM192 Gene

genes like me logo Genes that share phenotypes with TMEM192: view

Animal Model Products

CRISPR Products

miRNA for TMEM192 Gene

miRTarBase miRNAs that target TMEM192

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM192 Gene

Localization for TMEM192 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM192 Gene

Lysosome membrane; Multi-pass membrane protein. Late endosome.

Subcellular locations from

Jensen Localization Image for TMEM192 Gene COMPARTMENTS Subcellular localization image for TMEM192 gene
Compartment Confidence
endosome 5
extracellular 5
lysosome 5
nucleus 5
vacuole 5
plasma membrane 4
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM192 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 NOT nucleus IDA 22736246
GO:0005654 nucleoplasm IDA --
GO:0005764 lysosome IDA 22736246
GO:0005765 lysosomal membrane IDA 20370317
GO:0005770 late endosome IDA 20370317
genes like me logo Genes that share ontologies with TMEM192: view

Pathways & Interactions for TMEM192 Gene

SuperPathways for TMEM192 Gene

No Data Available

Interacting Proteins for TMEM192 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000305069 for TMEM192 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM192 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM192 Gene

Drugs & Compounds for TMEM192 Gene

No Compound Related Data Available

Transcripts for TMEM192 Gene

Unigene Clusters for TMEM192 Gene

Transmembrane protein 192:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM192 Gene

No ASD Table

Relevant External Links for TMEM192 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM192 Gene

mRNA expression in normal human tissues for TMEM192 Gene

Protein differential expression in normal tissues from HIPED for TMEM192 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (11.9), Bone (8.2), and Urine (6.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM192 Gene

SOURCE GeneReport for Unigene cluster for TMEM192 Gene Hs.704511

mRNA Expression by UniProt/SwissProt for TMEM192 Gene

Tissue specificity: Strongly expressed in kidney, liver, lung and pancreas.
genes like me logo Genes that share expression patterns with TMEM192: view

Protein tissue co-expression partners for TMEM192 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM192 Gene

Orthologs for TMEM192 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM192 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM192 35
  • 83.4 (n)
  • 83.65 (a)
TMEM192 36
  • 79 (a)
(Canis familiaris)
Mammalia TMEM192 35
  • 83.27 (n)
  • 80.84 (a)
TMEM192 36
  • 77 (a)
(Mus musculus)
Mammalia Tmem192 35
  • 82.08 (n)
  • 79.32 (a)
Tmem192 16
Tmem192 36
  • 79 (a)
(Pan troglodytes)
Mammalia TMEM192 35
  • 99.51 (n)
  • 99.63 (a)
TMEM192 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem192 35
  • 81.45 (n)
  • 81.95 (a)
(Monodelphis domestica)
Mammalia TMEM192 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM192 36
  • 71 (a)
(Gallus gallus)
Aves TMEM192 36
  • 65 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 70 (a)
-- 36
  • 60 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem192 35
  • 58.24 (n)
  • 53.26 (a)
(Danio rerio)
Actinopterygii tmem192 35
  • 49.14 (n)
  • 39.92 (a)
tmem192 36
  • 37 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG7523 36
  • 21 (a)
Species with no ortholog for TMEM192:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM192 Gene

Gene Tree for TMEM192 (if available)
Gene Tree for TMEM192 (if available)

Paralogs for TMEM192 Gene Pseudogenes for TMEM192 Gene

genes like me logo Genes that share paralogs with TMEM192: view

No data available for Paralogs for TMEM192 Gene

Variants for TMEM192 Gene

Sequence variations from dbSNP and Humsavar for TMEM192 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1133361 -- 165,078,036(-) ctgta(A/G)tctta downstream-variant-500B, utr-variant-3-prime
rs1707534 -- 165,111,466(+) GCGTT(A/C/G/T)TTGGA intron-variant
rs1059001 -- 165,112,499(+) GCCCA(A/C)CGCCC intron-variant
rs2056255 -- 165,114,022(-) ACCAT(C/T)TCTTC upstream-variant-2KB
rs2056256 -- 165,113,835(-) ccagc(C/T)tgacc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM192 Gene

Variant ID Type Subtype PubMed ID
nsv881168 CNV Gain 21882294
nsv511271 CNV Loss 21212237
esv1000719 CNV Deletion 20482838
esv2558277 CNV Deletion 19546169
nsv513175 CNV Loss 21212237
esv2728686 CNV Deletion 23290073
dgv908n67 CNV Loss 20364138
nsv820721 CNV Deletion 20802225
esv22270 CNV Gain 19812545
dgv132e180 CNV Gain 20482838
nsv518959 CNV Loss 19592680
nsv507211 CNV Insertion 20534489

Variation tolerance for TMEM192 Gene

Residual Variation Intolerance Score: 36% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.49; 10.74% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM192 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM192 Gene

Disorders for TMEM192 Gene

Relevant External Links for TMEM192

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM192 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM192 Gene

Publications for TMEM192 Gene

  1. Molecular characterisation of 'transmembrane protein 192' (TMEM192), a novel protein of the lysosomal membrane. (PMID: 20370317) Schroder B. … Saftig P. (Biol. Chem. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Proteomic analysis of podocyte exosome-enriched fraction from normal human urine. (PMID: 23376485) Prunotto M. … Moll S. (J Proteomics 2013) 3
  5. Global landscape of HIV-human protein complexes. (PMID: 22190034) JAoger S. … Krogan N.J. (Nature 2012) 3

Products for TMEM192 Gene

Sources for TMEM192 Gene

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