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Aliases for TMEM191B Gene

Aliases for TMEM191B Gene

  • Transmembrane Protein 191B 2 3 5

External Ids for TMEM191B Gene

Previous GeneCards Identifiers for TMEM191B Gene

  • GC22P018757
  • GC22P020379
  • GC22P004856
  • GC22P020381
  • GC22P020383

Summaries for TMEM191B Gene

GeneCards Summary for TMEM191B Gene

TMEM191B (Transmembrane Protein 191B) is a Protein Coding gene. An important paralog of this gene is TMEM191C.

Additional gene information for TMEM191B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM191B Gene

Genomics for TMEM191B Gene

Regulatory Elements for TMEM191B Gene

Enhancers for TMEM191B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22H018528 0.6 ENCODE 0.7 +1.3 1307 1 MAZ RB1 NRF1 SP2 CTBP1 ZNF341 KLF9 PRDM10 ZFX ZBTB26 TMEM191B PI4KAP1
GH22H018552 0.4 Ensembl 0.3 +26.1 26099 2 NFIB PI4KAP1 TMEM191B
GH22H018557 0.2 Ensembl 0.3 +31.3 31299 3 PI4KAP1 TMEM191B
GH22H018570 0.2 Ensembl 0.3 +43.0 43000 0 PI4KAP1 TMEM191B
GH22H018548 0.2 Ensembl 0.3 +20.5 20499 0 TMEM191B PI4KAP1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM191B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM191B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000143657 898 1801 RB1 NRF1 SP2 CTBP1 ZNF341 KLF9 PRDM10 ZFX ZBTB26

Genomic Location for TMEM191B Gene

Chromosome:
22
Start:
18,527,802 bp from pter
End:
18,530,794 bp from pter
Size:
2,993 bases
Orientation:
Plus strand

Genomic View for TMEM191B Gene

Genes around TMEM191B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM191B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM191B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM191B Gene

Proteins for TMEM191B Gene

  • Protein details for TMEM191B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0C7N4-T191B_HUMAN
    Recommended name:
    Transmembrane protein 191B
    Protein Accession:
    P0C7N4
    Secondary Accessions:
    • A0A087WXW8

    Protein attributes for TMEM191B Gene

    Size:
    346 amino acids
    Molecular mass:
    39065 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM191B Gene

Post-translational modifications for TMEM191B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM191B Gene

No data available for DME Specific Peptides for TMEM191B Gene

Domains & Families for TMEM191B Gene

Gene Families for TMEM191B Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM191B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM191B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0C7N4

UniProtKB/Swiss-Prot:

T191B_HUMAN :
  • Belongs to the TMEM191 family.
Family:
  • Belongs to the TMEM191 family.
genes like me logo Genes that share domains with TMEM191B: view

Function for TMEM191B Gene

Animal Model Products

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TMEM191B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM191B Gene

Localization for TMEM191B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM191B Gene

Membrane; Single-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM191B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM191B: view

No data available for Subcellular locations from COMPARTMENTS and Subcellular locations from the Human Protein Atlas (HPA) for TMEM191B Gene

Pathways & Interactions for TMEM191B Gene

SuperPathways for TMEM191B Gene

No Data Available

Interacting Proteins for TMEM191B Gene

Gene Ontology (GO) - Biological Process for TMEM191B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM191B Gene

Drugs & Compounds for TMEM191B Gene

No Compound Related Data Available

Transcripts for TMEM191B Gene

mRNA/cDNA for TMEM191B Gene

(2) REFSEQ mRNAs :
(7) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Clone Products

  • Applied Biological Materials Clones for TMEM191B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM191B Gene

No ASD Table

Relevant External Links for TMEM191B Gene

GeneLoc Exon Structure for
TMEM191B
ECgene alternative splicing isoforms for
TMEM191B

Expression for TMEM191B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM191B Gene:

TMEM191B
No Expression Related Data Available

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM191B Gene

Orthologs for TMEM191B Gene

This gene was present in the common ancestor of human and chimp.

Orthologs for TMEM191B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM191C 33
  • 97.21 (n)
Species where no ortholog for TMEM191B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM191B Gene

ENSEMBL:
Gene Tree for TMEM191B (if available)
TreeFam:
Gene Tree for TMEM191B (if available)

Paralogs for TMEM191B Gene

Paralogs for TMEM191B Gene

(1) SIMAP similar genes for TMEM191B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM191B Gene

genes like me logo Genes that share paralogs with TMEM191B: view

Variants for TMEM191B Gene

Sequence variations from dbSNP and Humsavar for TMEM191B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000506001 -- 18,527,221(+) TCCAT(A/G)GATTT upstream-variant-2KB, reference, missense
rs1002176803 -- 18,530,677(+) AGCCA(C/T)TCCCC nc-transcript-variant, downstream-variant-500B, utr-variant-3-prime
rs1002312421 -- 18,530,046(+) CTGGA(A/G)CGGGA intron-variant
rs1005878171 -- 18,528,135(+) GACGC(A/G)GGAGC nc-transcript-variant, downstream-variant-500B, reference, missense
rs1006586266 -- 18,528,788(+) AGAGG(G/T)CGGCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM191B Gene

Variant ID Type Subtype PubMed ID
dgv1283e212 CNV gain 25503493
dgv16n31 CNV gain 19718026
dgv173e55 CNV gain 17911159
dgv2431n106 OTHER inversion 24896259
dgv4466n100 CNV gain+loss 25217958
dgv4467n100 CNV gain 25217958
dgv7963n54 CNV gain 21841781
dgv7964n54 CNV loss 21841781
dgv7965n54 CNV gain 21841781
dgv7987n54 CNV gain 21841781
dgv7988n54 CNV gain 21841781
dgv7989n54 CNV gain 21841781
dgv7990n54 CNV gain 21841781
dgv99e203 CNV gain+loss 21179565
esv22247 CNV gain+loss 19812545
esv26930 CNV gain+loss 19812545
esv2751935 CNV loss 17911159
esv2758824 CNV gain+loss 17122850
esv32687 CNV gain+loss 17666407
esv3381183 CNV duplication 20981092
esv3575418 CNV gain 25503493
nsv1055756 CNV gain 25217958
nsv1061694 CNV gain 25217958
nsv1071779 CNV deletion 25765185
nsv1144015 CNV deletion 24896259
nsv1146969 CNV duplication 26484159
nsv428385 CNV gain+loss 18775914
nsv469578 CNV gain 16826518
nsv471339 CNV gain 19718026
nsv471594 CNV gain+loss 15918152
nsv511636 CNV loss 21212237
nsv516997 CNV gain+loss 19592680
nsv588139 CNV loss 21841781
nsv588264 CNV loss 21841781
nsv820540 CNV duplication 20802225
nsv953028 CNV deletion 24416366
nsv962755 CNV duplication 23825009

Relevant External Links for TMEM191B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM191B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Variation tolerance for TMEM191B Gene

Disorders for TMEM191B Gene

Relevant External Links for TMEM191B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM191B

No disorders were found for TMEM191B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM191B Gene

Publications for TMEM191B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I … O'Brien KP (Nature 1999) 3 4 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 60

Products for TMEM191B Gene

Sources for TMEM191B Gene

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