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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM191A Gene

pseudogene   GIFtS: 30
GCID: GC22P021063

Transmembrane Protein 191A (Pseudogene)

(Previous name: transmembrane protein 191A)
  Search for TMEM191A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 8

Aliases
Transmembrane Protein 191A (Pseudogene)1 2
Transmembrane Protein 191A1
TMEM191AP2

External Ids:    HGNC: 253171   Entrez Gene: 842222   Ensembl: ENSG000002262877   UniProtKB: Q9H0A33   
ORGUL members:         
NONCODE14:n378504 n378285 n378755 n378025 n378994 see all 12      

Export aliases for TMEM191A gene to outside databases

Previous GC identifers: GC22P019385 GC22P004323


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM191A Gene: 
TMEM191A (transmembrane protein 191A (pseudogene)) is a pseudogene, and is affiliated with the lncRNA class.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000022.10  NC_018933.2  NT_011520.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM191A gene promoter:
         GCNF   MyoD   LUN-1   Tal-1beta   Arnt   E47   YY1   GATA-2   GCNF-1   GCNF-2   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM191A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM191A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 22q11.21   Ensembl cytogenetic band:  22q11.21   HGNC cytogenetic band: 22q11.21

TMEM191A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM191A gene location

GeneLoc information about chromosome 22         GeneLoc Exon Structure

GeneLoc location for GC22P021063:  view genomic region     (about GC identifiers)

Start:
21,055,220 bp from pter      End:
21,058,894 bp from pter
Size:
3,675 bases      Orientation:
plus strand
ORGUL member locations:
Legend (see complete legend)

ORGUL Member Locations for TMEM191A

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T191A_HUMAN, Q9H0A3 (See protein sequence)
Recommended Name: Transmembrane protein 191A  
Size: 160 amino acids; 17963 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R8E2

Explore the universe of human proteins at neXtProt for TMEM191A: NX_Q9H0A3

TMEM191A Protein expression data from MOPED1, PaxDb2 and MAXQB3 : --

Human Recombinant Protein Products for TMEM191A: 

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM191A for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q9H0A3

UniProtKB/Swiss-Prot: T191A_HUMAN, Q9H0A3
Similarity: Belongs to the TMEM191 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 GenomeRNAi human phenotype for TMEM191A:
 Decreased influenza A virus in 

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM191A 
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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM191A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
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Browse Tocris compounds for TMEM191A (T191A)

Search CenterWatch for drugs/clinical trials and news about TMEM191A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM191A gene: 
NM_032262.1  

Unigene Cluster for TMEM191A:

Transmembrane protein 191A (pseudogene)
Hs.546454  [show with all ESTs]
Unigene Representative Sequence: AL136879
11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000450925(uc002zsx.1) ENST00000436618 ENST00000442222 ENST00000445836
ENST00000452055 ENST00000414022 ENST00000454833 ENST00000419950 ENST00000422715
ENST00000428752 ENST00000359859
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Additional mRNA sequence: 

AK313335.1 AL136879.1 BC126323.1 BC126325.1 CR456359.1 NR_026815.1 

10 DOTS entries:

DT.95071030  DT.86847391  DT.97812768  DT.102826374  DT.40127010  DT.120668123  DT.120668311  DT.95071034 
DT.40285479  DT.95071029 

24/70 AceView cDNA sequences (see all 70):

AL041506 BM725672 BM678384 BM713248 BM921521 BF590257 AL136879 AI024753 
BM914341 BM676370 NM_032262 AI277487 BV204813 AI244720 BV193265 BU688874 
BV193542 BI520371 BI909128 BU738778 BV192932 AI916182 AI027489 BQ013153 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM191A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM191A Expression
About this image


Genevestigator expression for TMEM191A

SOURCE GeneReport for Unigene cluster: Hs.546454
    SABiosciences Custom PCR Arrays for TMEM191A
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM191A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section
  --

ENSEMBL Gene Tree for TMEM191A (if available)
TreeFam Gene Tree for TMEM191A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM191A gene
1 SIMAP similar gene for TMEM191A using alignment to 1 protein entry:     T191A_HUMAN:
TMEM191B

TMEM191A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/111 SNPs in TMEM191A are shown (see all 111)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 22 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1853818991,2
--21053469(+) TAGAAC/TGTCTA 1 -- us2k10--------
rs1440082511,2
--21053508(+) TTTCTC/TGTTTG 1 -- us2k10--------
rs412775411,2
C--21053543(+) CTCATC/GGGTTC 1 -- us2k10--------
rs1893080541,2
--21053553(+) CCCTCC/TGTGAG 1 -- us2k10--------
rs557824921,2
C--21053556(+) TCCGTA/GAGTAC 1 -- us2k10--------
rs57600871,2
C,F,A,H--21053670(+) GTTTCT/CGTGAA 1 -- us2k115Minor allele frequency- C:0.47NS EA NA WA 1984
rs96101501,2
C,F,H--21053778(-) GGAAGC/TGTAAA 1 -- us2k13Minor allele frequency- T:0.33NA CSA 6
rs60039401,2
C,F--21053850(+) gtgagG/Cttttg 1 -- us2k11Minor allele frequency- C:0.03NA 120
rs1422226191,2
--21053909(+) GGGTGC/TTCTGT 1 -- us2k10--------
rs413072431,2
C--21053952(+) AAGCCC/TGGGGT 1 -- us2k10--------

HapMap Linkage Disequilibrium report for TMEM191A (21055220 - 21058894 bp)

Structural Variations
     Database of Genomic Variants (DGV) 9 variations for TMEM191A:    About this table     
Variant IDTypeSubtypePubMed ID
esv2678175CNV Deletion23128226
nsv471533CNV Duplication19718026
nsv436864CNV Insertion17901297
nsv436867CNV Insertion17901297
nsv518753CNV Loss19592680
nsv523162CNV Loss19592680
nsv914390CNV Gain21882294
nsv914417CNV Gain21882294
esv26322CNV Gain+Loss19812545

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM191A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM191A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
  2. A genome annotation-driven approach to cloning the human ORFeome. (PubMed id 15461802)1, 2 Collins J.E.... Dunham I. (2004)
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  5. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 84222 HGNC: 25317 AceView: DKFZp434N035 Ensembl:ENSG00000226287 euGenes: HUgn84222
ECgene: TMEM191A H-InvDB: TMEM191A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM191A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM191A gene:
Search GeneIP for patents involving TMEM191A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
GIFtS Group
The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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