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TMEM190 Gene

protein-coding   GIFtS: 38
GCID: GC19P055888

Transmembrane Protein 190

  Search for TMEM190
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1901 2
MDAC12 3

External Ids:    HGNC: 296321   Entrez Gene: 1477442   Ensembl: ENSG000001604727   UniProtKB: Q8WZ593   

Export aliases for TMEM190 gene to outside databases

Previous GC identifers: GC19P060581 GC19P052210


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM190 Gene:
TMEM190 (transmembrane protein 190) is a protein-coding gene. GO annotations related to this gene include protein self-association.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000019.10  NC_018930.2  NT_011109.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM190 gene promoter:
         NF-1   Pax-5   AML1a   NRSF form 1   NRSF form 2   HEN1   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM190 promoter sequence
   Search Chromatin IP Primers for TMEM190

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM190


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

TMEM190 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM190 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055888:  view genomic region     (about GC identifiers)

Start:
55,888,204 bp from pter      End:
55,889,612 bp from pter
Size:
1,409 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM190_HUMAN, Q8WZ59 (See protein sequence)
Recommended Name: Transmembrane protein 190 precursor  
Size: 177 amino acids; 19457 Da
Secondary accessions: A6NJL5

Explore the universe of human proteins at neXtProt for TMEM190: NX_Q8WZ59

Explore proteomics data for TMEM190 at MOPED


See TMEM190 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins: NP_631911.1  
ENSEMBL proteins: 
 ENSP00000291934  

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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2 InterPro protein domains:
 IPR000519 P_trefoil
 IPR028248 TMEM190

Graphical View of Domain Structure for InterPro Entry Q8WZ59

ProtoNet protein and cluster: Q8WZ59

1 Blocks protein domain: IPB000519 P-type trefoil domain

UniProtKB/Swiss-Prot: TM190_HUMAN, Q8WZ59
Similarity: Contains 1 P-type (trefoil) domain


TMEM190 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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     Gene Ontology (GO): 1 molecular function term:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0043621protein self-association IEA--
     
TMEM190 for ontologies           About GeneDecksing


Phenotypes:
     1 GenomeRNAi human phenotype for TMEM190:
 Increased HPV18 LCR reporter a 

     1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmem190):
 normal 

TMEM190 for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tmem190tm1Pmkf for TMEM190

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot
TM190_HUMAN, Q8WZ59: Membrane; Single-pass type I membrane protein (By similarity)
Subcellular locations from COMPARTMENTS: 

CompartmentConfidence
extracellular3
plasma membrane2

Gene Ontology (GO): 2 cellular component terms:    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0002079inner acrosomal membrane IEA--
GO:0016021integral component of membrane IEA--

TMEM190 for ontologies           About GeneDecksing


(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM190
Interactions:

    Search GeneGlobe Interaction Network for TMEM190

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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Browse Small Molecules at EMD Millipore
   Browse drugs & compounds from Enzo Life Sciences
  Browse compounds at ApexBio 

Browse Tocris compounds for TMEM190 (TM190)



(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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REFSEQ mRNAs for TMEM190 gene: 
NM_139172.1  

Unigene Cluster for TMEM190:

Transmembrane protein 190
Hs.590943  [show with all ESTs]
Unigene Representative Sequence: BC128190
1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000291934(uc002qkt.1)
miRNA
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Additional mRNA sequence: 

AF442729.1 BC128189.1 BC128190.1 

1 DOTS entry:

DT.439060 

3 AceView cDNA sequences:

NM_139172 AF442729 N26223 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM190 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCCAAGTCCG
TMEM190 Expression
About this image

TMEM190 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

TMEM190 Protein Expression

SOURCE GeneReport for Unigene cluster: Hs.590943
    Custom PCR Arrays for TMEM190
Primer
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In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM190

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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This gene was present in the common ancestor of human and mouse.

Orthologs for TMEM190 gene from Selected species (see all 6)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1901 , 5 transmembrane protein 1901, 5 75.41(n)1
73.76(a)1
  7 (2.77 cM)5
780521  NM_030028.11  NP_084304.11 
 47829405 


ENSEMBL Gene Tree for TMEM190 (if available)
TreeFam Gene Tree for TMEM190 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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Selected SNPs for TMEM190 (see all 138)    About this table    
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs722829621,2
C--55886323(+) CAGGC-/ACCCCCA 1 -- us2k10--------
rs1455594501,2
--55886356(+) GAGTCC/TGGGAC 1 -- us2k10--------
rs129778971,2
--55886370(+) ccagcC/Tcctcc 1 -- us2k1 trp30--------
rs129781321,2
--55886452(+) ccagcC/Tcctcc 1 -- us2k1 trp30--------
rs361554261,2
C--55886557(+) TGGGAA/C/GCCCCC 1 -- us2k11NA 2
rs589076581,2
C--55886595(+) CAGGCC/TCCCGC 1 -- us2k11Minor allele frequency- T:0.00NA 2
rs1123350401,2
C--55886598(+) GCTCCA/CGCCCC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
rs579606291,2
C,F--55886605(+) CCCCTC/TCTCCC 1 -- us2k13Minor allele frequency- T:0.50NA 6
rs1878516021,2
--55886639(+) CCCAGC/TCCCTC 1 -- us2k10--------
rs599794611,2
C--55886709(+) GGCTCC/TAGCCC 1 -- us2k12Minor allele frequency- T:0.25NA 4

HapMap Linkage Disequilibrium report for TMEM190 (55888204 - 55889612 bp)

Structural Variations
     Database of Genomic Variants (DGV) Selected variations for TMEM190 (see all 13):    About this table    
Variant IDTypeSubtypePubMed ID
esv2718966CNV Deletion23290073
esv2718965CNV Deletion23290073
dgv4017n71CNV Loss21882294
nsv912461CNV Loss21882294
nsv516199CNV Loss19592680
nsv912463CNV Loss21882294
nsv912473CNV Loss21882294
nsv912457CNV Loss21882294
dgv4016n71CNV Loss21882294
dgv4019n71CNV Loss21882294

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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PubMed articles for TMEM190 gene integrated from 10 sources:
(articles sorted by number of sources associating them with TMEM190)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. (PubMed id 21273369)1, 3 Nishimura H....Primakoff P. (Reproduction 2011)
  2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
  5. (PubMed id )2 

(in PubMed, OMIM, and NCBI Bookshelf)
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 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 147744 HGNC: 29632 AceView: MDAC1 Ensembl:ENSG00000160472 euGenes: HUgn147744
ECgene: TMEM190 H-InvDB: TMEM190

(According to HUGE)
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  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM190 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM190 gene:
Search GeneIP for patents involving TMEM190

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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