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Aliases for TMEM190 Gene

Aliases for TMEM190 Gene

  • Transmembrane Protein 190 2 3 5
  • MDAC1 3 4

External Ids for TMEM190 Gene

Previous GeneCards Identifiers for TMEM190 Gene

  • GC19P060581
  • GC19P055888
  • GC19P052210

Summaries for TMEM190 Gene

GeneCards Summary for TMEM190 Gene

TMEM190 (Transmembrane Protein 190) is a Protein Coding gene. GO annotations related to this gene include protein self-association.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM190 Gene

Genomics for TMEM190 Gene

Regulatory Elements for TMEM190 Gene

Enhancers for TMEM190 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F055371 1.5 FANTOM5 Ensembl ENCODE 15.9 -1.4 -1436 7.1 ELF3 SIN3A ZNF48 RAD21 RARA GLIS2 FOS THAP11 SP5 CEBPB TMEM190 RPL28 FAM71E2 EPS8L1 ZNF628 IL11
GH19F055368 1.3 FANTOM5 ENCODE 14.4 -6.8 -6846 2.9 ZNF76 KLF17 SIN3A GLI4 ZNF48 ZNF121 GLIS2 EGR1 ZNF366 SCRT2 TMEM190 RPL28 COX6B2 IL11 NAT14 ZNF579 FAM71E2
GH19F055337 1.5 FANTOM5 ENCODE 12.4 -37.0 -37009 4.0 HDGF PKNOX1 CREB3L1 MLX WRNIP1 ARID4B SIN3A FEZF1 DMAP1 ZNF2 LENG8-AS1 HSPBP1 FAM71E2 KMT5C PPP6R1 ZNF628 U2AF2 TMEM238 IL11 TMEM190
GH19F055319 1.5 FANTOM5 Ensembl ENCODE 11.5 -55.2 -55159 4.0 SUZ12 CREB3L1 ZNF76 DEAF1 ZNF384 CEBPG ZNF644 ETS1 ZNF316 ELK1 FCAR CDC42EP5 TMEM150B FAM71E2 IL11 TMEM190 BRSK1 HSPBP1 PPP6R1 MIR6805
GH19F055291 1.1 Ensembl ENCODE 11.7 -84.8 -84803 1.0 ELF3 TBP HDAC1 PKNOX1 ARNT ARID4B SIN3A RAD21 RFX5 GTF3C2 ZNF581 U2AF2 ENSG00000267523 ENSG00000235681 ENSG00000267265 LENG8-AS1 ZNF628 PPP6R1 MIR6805 RPL28
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM190 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM190 Gene

Chromosome:
19
Start:
55,376,836 bp from pter
End:
55,378,244 bp from pter
Size:
1,409 bases
Orientation:
Plus strand

Genomic View for TMEM190 Gene

Genes around TMEM190 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM190 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM190 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM190 Gene

Proteins for TMEM190 Gene

  • Protein details for TMEM190 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ59-TM190_HUMAN
    Recommended name:
    Transmembrane protein 190
    Protein Accession:
    Q8WZ59
    Secondary Accessions:
    • A6NJL5

    Protein attributes for TMEM190 Gene

    Size:
    177 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM190 Gene

Post-translational modifications for TMEM190 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM190 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM190 Gene

Domains & Families for TMEM190 Gene

Protein Domains for TMEM190 Gene

Suggested Antigen Peptide Sequences for TMEM190 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ59

UniProtKB/Swiss-Prot:

TM190_HUMAN :
  • Contains 1 P-type (trefoil) domain.
Domain:
  • Contains 1 P-type (trefoil) domain.
genes like me logo Genes that share domains with TMEM190: view

No data available for Gene Families for TMEM190 Gene

Function for TMEM190 Gene

Gene Ontology (GO) - Molecular Function for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with TMEM190: view
genes like me logo Genes that share phenotypes with TMEM190: view

Animal Models for TMEM190 Gene

MGI Knock Outs for TMEM190:

Animal Model Products

miRNA for TMEM190 Gene

miRTarBase miRNAs that target TMEM190

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM190 Gene

Localization for TMEM190 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM190 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM190 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002079 inner acrosomal membrane IEA --
GO:0005634 nucleus IDA 21630459
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM190: view

Pathways & Interactions for TMEM190 Gene

SuperPathways for TMEM190 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002244 hematopoietic progenitor cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM190: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM190 Gene

Transcripts for TMEM190 Gene

mRNA/cDNA for TMEM190 Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM190 Gene

Transmembrane protein 190:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM190 Gene

No ASD Table

Relevant External Links for TMEM190 Gene

GeneLoc Exon Structure for
TMEM190
ECgene alternative splicing isoforms for
TMEM190

Expression for TMEM190 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM190 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM190 Gene

This gene is overexpressed in Testis (x20.3), Fallopian Tube (x10.1), Cervix - Endocervix (x7.1), and Lung (x5.4).

Protein differential expression in normal tissues from HIPED for TMEM190 Gene

This gene is overexpressed in Testis (54.7) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM190 Gene



Protein tissue co-expression partners for TMEM190 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM190 Gene:

TMEM190

SOURCE GeneReport for Unigene cluster for TMEM190 Gene:

Hs.590943
genes like me logo Genes that share expression patterns with TMEM190: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM190 Gene

Orthologs for TMEM190 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM190 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM190 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia TMEM190 34 35
  • 81.02 (n)
dog
(Canis familiaris)
Mammalia TMEM190 34 35
  • 80.59 (n)
mouse
(Mus musculus)
Mammalia Tmem190 34 16 35
  • 75.41 (n)
rat
(Rattus norvegicus)
Mammalia Tmem190 34
  • 74.66 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM190 35
  • 43 (a)
OneToOne
Species where no ortholog for TMEM190 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM190 Gene

ENSEMBL:
Gene Tree for TMEM190 (if available)
TreeFam:
Gene Tree for TMEM190 (if available)

Paralogs for TMEM190 Gene

No data available for Paralogs for TMEM190 Gene

Variants for TMEM190 Gene

Sequence variations from dbSNP and Humsavar for TMEM190 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs10420274 -- 55,377,193(+) cctgg(A/G)tctga intron-variant
rs10420436 -- 55,377,187(+) tggat(A/C)cctgg intron-variant
rs10420631 -- 55,377,257(+) ctgga(C/T)tcctg intron-variant
rs10420846 -- 55,377,230(+) ccttg(A/G)tctga intron-variant
rs10421029 -- 55,377,266(+) tgggt(C/G)tgagg intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM190 Gene

Variant ID Type Subtype PubMed ID
nsv953624 CNV deletion 24416366
nsv516199 CNV loss 19592680
nsv470162 CNV loss 18288195
esv2718966 CNV deletion 23290073
esv2718965 CNV deletion 23290073

Variation tolerance for TMEM190 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM190 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM190

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM190 Gene

Disorders for TMEM190 Gene

Relevant External Links for TMEM190

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM190

No disorders were found for TMEM190 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM190 Gene

Publications for TMEM190 Gene

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. (PMID: 21273369) Nishimura H. … Primakoff P. (Reproduction 2011) 2 3 64
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3 64
  4. The DNA sequence and biology of human chromosome 19. (PMID: 15057824) Grimwood J. … Lucas S.M. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM190 Gene

Sources for TMEM190 Gene

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