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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM190 Gene

protein-coding   GIFtS: 38
GCID: GC19P055888

Transmembrane Protein 190

  Search for TMEM190
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1901 2
MDAC12 3

External Ids:    HGNC: 296321   Entrez Gene: 1477442   Ensembl: ENSG000001604727   UniProtKB: Q8WZ593   

Export aliases for TMEM190 gene to outside databases

Previous GC identifers: GC19P060581 GC19P052210


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM190 Gene: 
TMEM190 (transmembrane protein 190) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NC_018930.2  NT_011109.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM190 gene promoter:
         NF-1   Pax-5   AML1a   NRSF form 1   NRSF form 2   HEN1   PPAR-gamma1   STAT3   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM190 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM190

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM190


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.42   Ensembl cytogenetic band:  19q13.42   HGNC cytogenetic band: 19q13.42

TMEM190 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM190 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P055888:  view genomic region     (about GC identifiers)

Start:
55,888,204 bp from pter      End:
55,889,612 bp from pter
Size:
1,409 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM190_HUMAN, Q8WZ59 (See protein sequence)
Recommended Name: Transmembrane protein 190 precursor  
Size: 177 amino acids; 19457 Da
Subcellular location: Membrane; Single-pass type I membrane protein (By similarity)
Secondary accessions: A6NJL5

Explore the universe of human proteins at neXtProt for TMEM190: NX_Q8WZ59

Explore proteomics data for TMEM190 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q8WZ59

  • TMEM190 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM190 Protein Expression
    REFSEQ proteins: NP_631911.1  
    ENSEMBL proteins: 
     ENSP00000291934  

    Human Recombinant Protein Products for TMEM190: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002079inner acrosomal membrane IEA--
    GO:0016021integral to membrane IEA--

    TMEM190 for ontologies           About GeneDecksing



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    Cloud-Clone Corp. ELISAs for TMEM190 
    Cloud-Clone Corp. CLIAs for TMEM190


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR000519 P_trefoil

    Graphical View of Domain Structure for InterPro Entry Q8WZ59

    ProtoNet protein and cluster: Q8WZ59

    1 Blocks protein domain: IPB000519 P-type trefoil domain

    UniProtKB/Swiss-Prot: TM190_HUMAN, Q8WZ59
    Similarity: Contains 1 P-type (trefoil) domain


    TMEM190 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0043621protein self-association IEA--
         
    TMEM190 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM190:
     Increased HPV18 LCR reporter a 

         1 MGI mutant phenotype (inferred from 1 allele(MGI details for Tmem190):
     normal 

    TMEM190 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmem190tm1Pmkf for TMEM190

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM190 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM190

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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM190

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM190 (TM190)

    Search CenterWatch for drugs/clinical trials and news about TMEM190 / TM190

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM190 gene: 
    NM_139172.1  

    Unigene Cluster for TMEM190:

    Transmembrane protein 190
    Hs.590943  [show with all ESTs]
    Unigene Representative Sequence: BC128190
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000291934(uc002qkt.1)
    miRNA
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                         Customized lentivirus expression plasmids for stable overexpression of TMEM190 
    Primer
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM190

    Additional mRNA sequence: 

    AF442729.1 BC128189.1 BC128190.1 

    1 DOTS entry:

    DT.439060 

    3 AceView cDNA sequences:

    AF442729 NM_139172 N26223 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM190 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCCAAGTCCG
    TMEM190 Expression
    About this image


    See TMEM190 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM190

    SOURCE GeneReport for Unigene cluster: Hs.590943
        SABiosciences Custom PCR Arrays for TMEM190
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM190

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of human and mouse.

    Orthologs for TMEM190 gene from 1/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1901 , 5 transmembrane protein 1901, 5 70.71(n)1
    67.88(a)1
      7 (2.77 cM)5
    780521  NM_030028.11  NP_084304.11 
     47829405 


    ENSEMBL Gene Tree for TMEM190 (if available)
    TreeFam Gene Tree for TMEM190 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/138 SNPs in TMEM190 are shown (see all 138)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs722829621,2
    C--55886323(+) CAGGC-/ACCCCCA 1 -- us2k10--------
    rs1455594501,2
    --55886356(+) GAGTCC/TGGGAC 1 -- us2k10--------
    rs129778971,2
    --55886370(+) ccagcC/Tcctcc 1 -- us2k1 trp30--------
    rs129781321,2
    --55886452(+) ccagcC/Tcctcc 1 -- us2k1 trp30--------
    rs361554261,2
    C--55886557(+) TGGGAA/C/GCCCCC 1 -- us2k11NA 2
    rs589076581,2
    C--55886595(+) CAGGCC/TCCCGC 1 -- us2k11Minor allele frequency- T:0.00NA 2
    rs1123350401,2
    C--55886598(+) GCTCCA/CGCCCC 1 -- us2k11Minor allele frequency- C:0.00CSA 1
    rs579606291,2
    C,F--55886605(+) CCCCTC/TCTCCC 1 -- us2k13Minor allele frequency- T:0.50NA 6
    rs1878516021,2
    --55886639(+) CCCAGC/TCCCTC 1 -- us2k10--------
    rs599794611,2
    C--55886709(+) GGCTCC/TAGCCC 1 -- us2k12Minor allele frequency- T:0.25NA 4

    HapMap Linkage Disequilibrium report for TMEM190 (55888204 - 55889612 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/13 variations for TMEM190 (see all 13):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718966CNV Deletion23290073
    esv2718965CNV Deletion23290073
    dgv4017n71CNV Loss21882294
    nsv912461CNV Loss21882294
    nsv516199CNV Loss19592680
    nsv912463CNV Loss21882294
    nsv912473CNV Loss21882294
    nsv912457CNV Loss21882294
    dgv4016n71CNV Loss21882294
    dgv4019n71CNV Loss21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM190 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM190)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Characterization of mouse sperm TMEM190, a small tran smembrane protein with the trefoil domain: evidence for co-localization with IZ UMO1 and complex formation with other sperm proteins. (PubMed id 21273369)1, 3 Nishimura H....Primakoff P. (2011)
    2. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    5. Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 147744 HGNC: 29632 AceView: MDAC1 Ensembl:ENSG00000160472 euGenes: HUgn147744
    ECgene: TMEM190 H-InvDB: TMEM190

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM190 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM190 gene:
    Search GeneIP for patents involving TMEM190

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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     Proteins for TMEM190
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     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM190
     Browse SwitchGear 3'UTR luciferase reporter plasmids for TMEM190
     SwitchGear Promoter luciferase reporter plasmids for TMEM190
     Search ThermoFisher Antibodies for TMEM190
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM190
     inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM190
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM190
    Customized:
     lentivirus for stable overexpression of TMEM190
     lentivirus expression plasmids for stable overexpression of TMEM190
     adenovirus for overexpression of TMEM190
     Search LSBio for Antibodies for TMEM190
    Customized transgenic rodents for:
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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