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Aliases for TMEM190 Gene

Aliases for TMEM190 Gene

  • Transmembrane Protein 190 2 3 5
  • MDAC1 3 4

External Ids for TMEM190 Gene

Previous GeneCards Identifiers for TMEM190 Gene

  • GC19P060581
  • GC19P055888
  • GC19P052210

Summaries for TMEM190 Gene

GeneCards Summary for TMEM190 Gene

TMEM190 (Transmembrane Protein 190) is a Protein Coding gene. GO annotations related to this gene include protein self-association.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM190 Gene

Genomics for TMEM190 Gene

Regulatory Elements for TMEM190 Gene

Enhancers for TMEM190 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM190 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM190 Gene

Chromosome:
19
Start:
55,376,836 bp from pter
End:
55,378,244 bp from pter
Size:
1,409 bases
Orientation:
Plus strand

Genomic View for TMEM190 Gene

Genes around TMEM190 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM190 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM190 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM190 Gene

Proteins for TMEM190 Gene

  • Protein details for TMEM190 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WZ59-TM190_HUMAN
    Recommended name:
    Transmembrane protein 190
    Protein Accession:
    Q8WZ59
    Secondary Accessions:
    • A6NJL5

    Protein attributes for TMEM190 Gene

    Size:
    177 amino acids
    Molecular mass:
    19457 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM190 Gene

Proteomics data for TMEM190 Gene at MOPED

Post-translational modifications for TMEM190 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM190 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM190 Gene

Domains & Families for TMEM190 Gene

Protein Domains for TMEM190 Gene

Blocks:
InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM190 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WZ59

UniProtKB/Swiss-Prot:

TM190_HUMAN :
  • Contains 1 P-type (trefoil) domain.
Domain:
  • Contains 1 P-type (trefoil) domain.
genes like me logo Genes that share domains with TMEM190: view

No data available for Gene Families for TMEM190 Gene

Function for TMEM190 Gene

Gene Ontology (GO) - Molecular Function for TMEM190 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043621 protein self-association IEA --
genes like me logo Genes that share ontologies with TMEM190: view
genes like me logo Genes that share phenotypes with TMEM190: view

Animal Models for TMEM190 Gene

MGI Knock Outs for TMEM190:

Animal Model Products

CRISPR Products

miRNA for TMEM190 Gene

miRTarBase miRNAs that target TMEM190

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM190 Gene

Localization for TMEM190 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM190 Gene

Membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM190 Gene COMPARTMENTS Subcellular localization image for TMEM190 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM190 Gene

Pathways & Interactions for TMEM190 Gene

SuperPathways for TMEM190 Gene

No Data Available

Interacting Proteins for TMEM190 Gene

Gene Ontology (GO) - Biological Process for TMEM190 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM190 Gene

Drugs & Compounds for TMEM190 Gene

No Compound Related Data Available

Transcripts for TMEM190 Gene

mRNA/cDNA for TMEM190 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM190 Gene

Transmembrane protein 190:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM190 Gene

No ASD Table

Relevant External Links for TMEM190 Gene

GeneLoc Exon Structure for
TMEM190
ECgene alternative splicing isoforms for
TMEM190

Expression for TMEM190 Gene

mRNA expression in normal human tissues for TMEM190 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM190 Gene

This gene is overexpressed in Testis (x20.3), Fallopian Tube (x10.1), Cervix - Endocervix (x7.1), and Lung (x5.4).

Protein differential expression in normal tissues from HIPED for TMEM190 Gene

This gene is overexpressed in Testis (54.7) and Ovary (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM190 Gene



SOURCE GeneReport for Unigene cluster for TMEM190 Gene Hs.590943

genes like me logo Genes that share expression patterns with TMEM190: view

Protein tissue co-expression partners for TMEM190 Gene

- Elite partner

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM190 Gene

Orthologs for TMEM190 Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM190 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM190 35
  • 81.02 (n)
  • 78.15 (a)
TMEM190 36
  • 73 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM190 35
  • 80.59 (n)
  • 75.95 (a)
TMEM190 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem190 35
  • 75.41 (n)
  • 73.76 (a)
Tmem190 16
Tmem190 36
  • 67 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM190 35
  • 99.44 (n)
  • 99.44 (a)
TMEM190 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem190 35
  • 74.66 (n)
  • 74.66 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM190 36
  • 43 (a)
OneToOne
Species with no ortholog for TMEM190:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM190 Gene

ENSEMBL:
Gene Tree for TMEM190 (if available)
TreeFam:
Gene Tree for TMEM190 (if available)

Paralogs for TMEM190 Gene

No data available for Paralogs for TMEM190 Gene

Variants for TMEM190 Gene

Sequence variations from dbSNP and Humsavar for TMEM190 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs12975829 -- 55,375,028(+) agtcc(A/C)ggccc upstream-variant-2KB
rs12976074 -- 55,375,110(+) agtcc(A/G)ggccc upstream-variant-2KB
rs12977897 -- 55,375,002(+) ccagc(C/T)cctcc upstream-variant-2KB
rs12978132 -- 55,375,084(+) ccagc(C/T)cctcc upstream-variant-2KB
rs71181760 -- 55,375,230(-) GGGGC(-/T)GGGGG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM190 Gene

Variant ID Type Subtype PubMed ID
dgv4016n71 CNV Loss 21882294
nsv912457 CNV Loss 21882294
nsv912460 CNV Loss 21882294
nsv912461 CNV Loss 21882294
nsv470162 CNV Loss 18288195
dgv4017n71 CNV Loss 21882294
nsv912463 CNV Loss 21882294
nsv516199 CNV Loss 19592680
dgv4019n71 CNV Loss 21882294
dgv4020n71 CNV Loss 21882294
nsv912473 CNV Loss 21882294
esv2718965 CNV Deletion 23290073
esv2718966 CNV Deletion 23290073

Variation tolerance for TMEM190 Gene

Residual Variation Intolerance Score: 69.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.74; 15.58% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM190 Gene

Disorders for TMEM190 Gene

Relevant External Links for TMEM190

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM190

No disorders were found for TMEM190 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM190 Gene

Publications for TMEM190 Gene

  1. Characterization of mouse sperm TMEM190, a small transmembrane protein with the trefoil domain: evidence for co-localization with IZUMO1 and complex formation with other sperm proteins. (PMID: 21273369) Nishimura H. … Primakoff P. (Reproduction 2011) 2 3 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  3. Proteomic characterization of the human sperm nucleus. (PMID: 21630459) de Mateo S. … Oliva R. (Proteomics 2011) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for TMEM190 Gene

Sources for TMEM190 Gene

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