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Aliases for TMEM19 Gene

Aliases for TMEM19 Gene

  • Transmembrane Protein 19 2 3

External Ids for TMEM19 Gene

Previous GeneCards Identifiers for TMEM19 Gene

  • GC12P070367
  • GC12P070368
  • GC12P072079
  • GC12P069128

Summaries for TMEM19 Gene

GeneCards Summary for TMEM19 Gene

TMEM19 (Transmembrane Protein 19) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM19 Gene

Genomics for TMEM19 Gene

Regulatory Elements for TMEM19 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM19 Gene

71,686,087 bp from pter
71,705,046 bp from pter
18,960 bases
Plus strand

Genomic View for TMEM19 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM19 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM19 Gene

Proteins for TMEM19 Gene

  • Protein details for TMEM19 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 19
    Protein Accession:
    Secondary Accessions:
    • B2RDL2
    • Q53FY3
    • Q9NV41

    Protein attributes for TMEM19 Gene

    336 amino acids
    Molecular mass:
    36392 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM19 Gene


neXtProt entry for TMEM19 Gene

Proteomics data for TMEM19 Gene at MOPED

Post-translational modifications for TMEM19 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM19 Gene

No data available for DME Specific Peptides for TMEM19 Gene

Domains & Families for TMEM19 Gene

Protein Domains for TMEM19 Gene


Suggested Antigen Peptide Sequences for TMEM19 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM19 family.
  • Belongs to the TMEM19 family.
genes like me logo Genes that share domains with TMEM19: view

No data available for Gene Families for TMEM19 Gene

Function for TMEM19 Gene

Gene Ontology (GO) - Molecular Function for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 16189514
genes like me logo Genes that share ontologies with TMEM19: view

Phenotypes for TMEM19 Gene

GenomeRNAi human phenotypes for TMEM19:
genes like me logo Genes that share phenotypes with TMEM19: view

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM19 Gene

Localization for TMEM19 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM19 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM19 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM19: view

No data available for Subcellular locations from COMPARTMENTS for TMEM19 Gene

Pathways & Interactions for TMEM19 Gene

SuperPathways for TMEM19 Gene

No Data Available

Interacting Proteins for TMEM19 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q96HH6-TMM19_HUMAN ENSP00000266673 for TMEM19 Gene via I2D MINT UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMEM19 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM19 Gene

Drugs & Compounds for TMEM19 Gene

No Compound Related Data Available

Transcripts for TMEM19 Gene

Unigene Clusters for TMEM19 Gene

Transmembrane protein 19:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM19 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b ^ 8
SP1: -
SP3: -

Relevant External Links for TMEM19 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM19 Gene

mRNA expression in normal human tissues for TMEM19 Gene

Protein differential expression in normal tissues from HIPED for TMEM19 Gene

This gene is overexpressed in Retina (19.0), Lung (13.9), and Blymphocyte (13.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM19 Gene

SOURCE GeneReport for Unigene cluster for TMEM19 Gene Hs.644802

genes like me logo Genes that share expression patterns with TMEM19: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM19 Gene

Orthologs for TMEM19 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM19 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM19 35
  • 88.26 (n)
  • 88.36 (a)
TMEM19 36
  • 88 (a)
(Canis familiaris)
Mammalia TMEM19 35
  • 90 (n)
  • 94.48 (a)
TMEM19 36
  • 93 (a)
(Mus musculus)
Mammalia Tmem19 35
  • 83.98 (n)
  • 87.46 (a)
Tmem19 16
Tmem19 36
  • 87 (a)
(Pan troglodytes)
Mammalia TMEM19 35
  • 99.6 (n)
  • 98.81 (a)
TMEM19 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem19 35
  • 86.56 (n)
  • 89.06 (a)
(Monodelphis domestica)
Mammalia TMEM19 36
  • 77 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 86 (a)
-- 36
  • 82 (a)
(Gallus gallus)
Aves TMEM19 35
  • 72.24 (n)
  • 74.93 (a)
TMEM19 36
  • 52 (a)
(Anolis carolinensis)
Reptilia TMEM19 36
  • 65 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.11046 35
tmem19 35
  • 73.13 (n)
  • 78.21 (a)
(Danio rerio)
Actinopterygii tmem19 35
  • 64.69 (n)
  • 66.36 (a)
tmem19 36
  • 69 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13441 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP012271 35
  • 53.8 (n)
  • 49.82 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10171 35
  • 51.22 (n)
  • 47.3 (a)
CG10171 36
  • 45 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G19930 35
  • 48.74 (n)
  • 41.52 (a)
(Oryza sativa)
Liliopsida Os01g0507300 35
  • 44.32 (n)
  • 36.7 (a)
Species with no ortholog for TMEM19:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM19 Gene

Gene Tree for TMEM19 (if available)
Gene Tree for TMEM19 (if available)

Paralogs for TMEM19 Gene

No data available for Paralogs for TMEM19 Gene

Variants for TMEM19 Gene

Sequence variations from dbSNP and Humsavar for TMEM19 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type MAF
rs1043780 -- 71,703,559(+) TGGGG(A/T)AGTAC utr-variant-3-prime
rs1043781 -- 71,703,638(+) AAAAA(C/G)TAATA utr-variant-3-prime
rs1048897 -- 71,701,179(+) TCTAG(C/T)GAAAG utr-variant-3-prime
rs1880893 -- 71,704,338(-) ACTAG(A/T)CCTTT downstream-variant-500B
rs2013933 -- 71,702,461(-) gtgca(C/T)gcctg utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM19 Gene

Variant ID Type Subtype PubMed ID
nsv832451 CNV Loss 17160897
nsv524634 CNV Loss 19592680

Variation tolerance for TMEM19 Gene

Residual Variation Intolerance Score: 66.37% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.45; 54.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM19 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM19 Gene

Disorders for TMEM19 Gene

Relevant External Links for TMEM19

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with TMEM19: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM19 Gene

Publications for TMEM19 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67
  4. Towards a proteome-scale map of the human protein-protein interaction network. (PMID: 16189514) Rual J.F. … Vidal M. (Nature 2005) 67
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 67

Products for TMEM19 Gene

Sources for TMEM19 Gene

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