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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM189-UBE2V1 Gene

protein-coding   GIFtS: 40
GCID: GC20M048697

TMEM189-UBE2V1 readthrough

 Explore 3 diseases affiliated with
TMEM189-UBE2V1 via our new
 Human Malady Compendium 
Biological research products
for TMEM189-UBE2V1
    

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section

Aliases
TMEM189-UBE2V1 Readthrough1 2     TMEM189-UBE2V1 Fusion Protein2
CROC-1B1 2     TMEM189-UBE2V1 Readthrough Transcript2
Kua-UEV1     Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1
Read-Through2
CROC1B2     Protein TMEM189-UBE2V14
KUA-UEV2     Transmembrane Protein 1894

External Ids:    HGNC: 335211   Entrez Gene: 3875222   Ensembl: ENSG000001242087   UniProtKB: G3V2F74   

Export aliases for TMEM189-UBE2V1 gene to outside databases

Previous GC identifers: GC20M048133 GC20M045446


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM189-UBE2V1:
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and
UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein
family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue
that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the
protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the
function of its protein product has not yet been determined. (provided by RefSeq, Oct 2010)

Gene Wiki entry for TMEM189-UBE2V1 (Kua-UEV)


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM189-UBE2V1 gene promoter:
         c-Myb   SEF-1 (1)   ZID   Tal-1beta   ITF-2   NF-kappaB1   E47   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 6): TMEM189-UBE2V1 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM189-UBE2V1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM189-UBE2V1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

TMEM189-UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM189-UBE2V1 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048697:  view genomic region     (about GC identifiers)

Start:
48,697,661 bp from pter      End:
48,770,335 bp from pter
Size:
72,675 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/TrEMBL: G3V2F7 (See protein sequence)
Recommended Name: HCG2044781  
Size: 370 amino acids; 42209 Da

TMEM189-UBE2V1 Protein expression data from MOPED and PaxDb:    About this image 

Estimated protein expression log10 (pmol).

REFSEQ proteins: NP_954673.1  
ENSEMBL proteins: 
 ENSP00000344166  

Human Recombinant Protein Products: 
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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM189-UBE2V1 for domains           About GeneDecksing

3 InterPro domains/families:
 IPR019547 KuaUb-conj-enz_UEV1
 IPR016135 UBQ-conjugating_enzyme/RWD
 IPR000608 UBQ-conjugat_E2

Graphical View of Domain Structure for InterPro Entry G3V2F7

ProtoNet protein and cluster: G3V2F7


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

miRNA
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8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM189-UBE2V1 (see all 33):
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SwitchGear 3'UTR luciferase reporter plasmidTMEM189-UBE2V1 3' UTR sequence
Inhib. RNA
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189-UBE2V1

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016881acid-amino acid ligase activity ----


TMEM189-UBE2V1 for ontologies           About GeneDecksing


4 GenomeRNAi human phenotypes for TMEM189-UBE2V1:
 Decreased melanin production  Decreased viability of wild-ty  G0/1 arrest  Increased G1 DNA content 


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways  About this table 
See pathways by source

Super-pathwaycontained gene-specific pathways
1Interleukin-1 signaling
IL1-mediated signaling events0.39


1 BioSystems Pathway for TMEM189-UBE2V1 
    IL1-mediated signaling events


Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM189-UBE2V1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/35 Interacting proteins for TMEM189-UBE2V1 (ENSP000003441664) via UniProtKB, MINT, STRING, and/or I2D (see all 35)
InteractantInteraction Details
GeneCardExternal ID(s)
UBE2NENSP000003161764STRING: ENSP00000316176
UBE2AENSP000003606134STRING: ENSP00000360613
UBE2V1ENSP000003403054STRING: ENSP00000340305
RNF20ENSP000003737724STRING: ENSP00000373772
RNF40ENSP000003256774STRING: ENSP00000325677
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM189-UBE2V1
Search CenterWatch for drugs/clinical trials and news about TMEM189-UBE2V1 

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM189-UBE2V1 gene (2 alternative transcripts): 
NM_199203.2  NM_003349.4  

1 Ensembl transcript including schematic representation, and UCSC links where relevant:
ENST00000341698

miRNA
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8/33 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM189-UBE2V1 (see all 33):
hsa-miR-576-3p hsa-miR-140-5p hsa-miR-607 hsa-miR-429 hsa-miR-15a hsa-miR-513a-5p hsa-miR-128 hsa-miR-219-5p
SwitchGear 3'UTR luciferase reporter plasmidTMEM189-UBE2V1 3' UTR sequence
Inhib. RNA
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Clone
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM189-UBE2V1

24/1050 AceView cDNA sequences (see all 1050):

CB321772 CD672005 AI215669 W78157 BU857507 BU539260 T33008 NM_199129 
BE880298 BM556348 CA445314 BU156219 BM792698 BG034562 AA582403 CA445919 
BQ005310 BM471901 BX375182 R20495 BM702289 AA307470 BQ948378 BM974797 

GeneLoc Exon Structure

5/16 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189-UBE2V1 (see all 16)    About this scheme

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11 ^ 12 ^ 13a · 13b · 13c ^ 14 ^ 15a · 15b ^ 16 ^ 17 ^ 18 ^
SP1:                    -           -                 -                                                                                                         
SP2:                    -           -                                                                                                                           
SP3:                                                                                                                                                            
SP4:                                -                                                                                                                           
SP5:                    -           -     -     -     -                                                                                                         

ExUns: 19a · 19b · 19c ^ 20a · 20b · 20c
SP1:                                    
SP2:                                    
SP3:                                    
SP4:                                    
SP5:                                    


ECgene alternative splicing isoforms for TMEM189-UBE2V1

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM189-UBE2V1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

Microarray
RNAseq (Illumina Body Map)
(100×FPKM)½
SAGE (Serial Analysis of Gene Expression)

About this image
See TMEM189-UBE2V1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM189-UBE2V1
    SABiosciences Custom PCR Arrays for TMEM189-UBE2V1
Primer
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In Situ
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(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM189-UBE2V1 gene from 7/18 species (see all 18)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
chicken
(Gallus gallus)
Aves TMEM189-UBE2V16
Uncharacterized protein
92(a)
1 → many
20(13775889-13807095)
lizard
(Anolis carolinensis)
Reptilia UBE2V16
--
95(a)
1 → many
4(147633606-147637769)
zebrafish
(Danio rerio)
Actinopterygii ube2v16
ubiquitin-conjugating enzyme E2 variant 1
87(a)
1 → many
11(2394479-2407613)
fruit fly
(Drosophila melanogaster)
Insecta Uev1A6
Uev1A
67(a)
1 → many
3L(5355984-5359325)
worm
(Caenorhabditis elegans)
Secernentea uev-16
Ubiquitin E2 (conjugating enzyme) variant family m...
66(a)
1 → many
I(14790233-14790928)
thale cress
(Arabidopsis thaliana)
eudicotyledons MMZ11 ubiquitin-conjugating enzyme E2 variant 1A 56.47(n)
54.48(a)
  838935  NM_102175.3  NP_564191.1 
rice
(Oryza sativa)
Liliopsida Os03g07123001 hypothetical protein 55.47(n)
50.75(a)
  4333892  NM_001057598.1  NP_001051063.1 


ENSEMBL Gene Tree for TMEM189-UBE2V1 (if available)
TreeFam Gene Tree for TMEM189-UBE2V1 (if available) 

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM189-UBE2V1 gene
TMEM1892  UBE2V12  UBE2V22  

TMEM189-UBE2V1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/86 NCBI SNPs in TMEM189-UBE2V1 are shown (see all 86    About this table
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 20 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1387391441,2
--48734565(+) TCTTGA/GTGTAC 1 -- int10--------
rs560274441,2
--48734603(+) TCTAAG/ATTGTT 1 -- int11Minor allele frequency- A:0.01NA 120
rs60202761,2
C,A,--48734697(+) AAAACT/CGGGGT 1 -- int12Minor allele frequency- C:0.09WA 120
rs1870122951,2
--48734746(+) TTAACC/GTATAA 1 -- int10--------
rs1914948501,2
--48734906(+) TATTAG/TTCCCA 1 -- int10--------
rs60128441,2
H--48735028(+) CCTCCC/TTTCCA 1 -- int1 trp34Minor allele frequency- T:0.00NS EA 418
rs126247951,2
C,F,H,--48735077(+) CAAATG/ACATTT 1 -- int18Minor allele frequency- A:0.29NA WA EA 370
rs1840281311,2
--48735216(+) CAGTGA/GCGCGA 1 -- int10--------
rs1865478461,2
--48735268(+) TCTCCC/TGCCTC 1 -- int10--------
rs1427292471,2
--48735305(+) GCACCC/TGCCAC 1 -- int10--------

HapMap Linkage Disequilibrium report for TMEM189-UBE2V1 (48697661 - 48770335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMEM189-UBE2V1
     2 CNVs: 47899 5140

SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM189-UBE2V1
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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM189-UBE2V1 for disorders           About GeneDecksing

3 diseases for TMEM189-UBE2V1:    About MalaCards
colon adenocarcinoma    adenocarcinoma    thyroiditis

Human Genome Epidemiology (HuGE) Navigator: TMEM189-UBE2V1 (1 document)

Export disorders for TMEM189-UBE2V1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM189-UBE2V1 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TMEM189-UBE2V1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)1, 3, 9 Thomson T.M.... Guigo R. (2000)
  2. Methods for quantification of in vivo changes in prote in ubiquitination following proteasome and deubiquitinase inhibition. (PubMed id 22505724)1 Udeshi N.D....Carr S.A. (2012)
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1 Shimada M....Tokunaga K. (2010)
  4. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PubMed id 20967262)1 Prakash T....Taylor T.D. (2010)
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
  6. Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress. (PubMed id 16236267)1 Guo D.... Wang C.-Y. (2005)
  7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
  8. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. (PubMed id 11057907)1 Deng L.... Chen Z.J. (2000)
  9. A new function evolved from gene fusion. (PubMed id 11076848)1 Long M. (2000)
  10. Noncanonical MMS2-encoded ubiquitin-conjugating enzyme functions in assembly of novel polyubiquitin chains for DNA repair. (PubMed id 10089880)1 Hofmann R.M. and Pickart C.M. (1999)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 387522 HGNC: 33521 AceView: Kua-UEV Ensembl:ENSG00000124208 euGenes: HUgn387522
ECgene: TMEM189-UBE2V1 H-InvDB: TMEM189-UBE2V1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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NameDescription
PharmGKB entry for TMEM189-UBE2V1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
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IP news from LifeMap Sciences, Inc.)
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Patent Information for TMEM189-UBE2V1 gene:
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