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Aliases for TMEM189-UBE2V1 Gene

Aliases for TMEM189-UBE2V1 Gene

  • TMEM189-UBE2V1 Readthrough 2 3 5
  • Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1 Read-Through 3
  • TMEM189-UBE2V1 Readthrough Transcript 3
  • CROC-1B 3
  • KUA-UEV 3
  • CROC1B 3

External Ids for TMEM189-UBE2V1 Gene

Previous GeneCards Identifiers for TMEM189-UBE2V1 Gene

  • GC20M048133
  • GC20M048697
  • GC20M045446

Summaries for TMEM189-UBE2V1 Gene

Entrez Gene Summary for TMEM189-UBE2V1 Gene

  • The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for TMEM189-UBE2V1 Gene

TMEM189-UBE2V1 (TMEM189-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are Interleukin-1 signaling. GO annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is TMEM189.

Gene Wiki entry for TMEM189-UBE2V1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM189-UBE2V1 Gene

Genomics for TMEM189-UBE2V1 Gene

Regulatory Elements for TMEM189-UBE2V1 Gene

Enhancers for TMEM189-UBE2V1 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM189-UBE2V1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM189-UBE2V1 Gene

50,081,124 bp from pter
50,153,798 bp from pter
72,675 bases
Minus strand

Genomic View for TMEM189-UBE2V1 Gene

Genes around TMEM189-UBE2V1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM189-UBE2V1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM189-UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189-UBE2V1 Gene

Proteins for TMEM189-UBE2V1 Gene

  • Protein details for TMEM189-UBE2V1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    Recommended name:
    Protein Accession:

    Protein attributes for TMEM189-UBE2V1 Gene

    370 amino acids
    Molecular mass:
    42209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM189-UBE2V1 Gene

Proteomics data for TMEM189-UBE2V1 Gene at MOPED

Protein Expression for TMEM189-UBE2V1 Gene

Post-translational modifications for TMEM189-UBE2V1 Gene

No Post-translational modifications

Other Protein References for TMEM189-UBE2V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM189-UBE2V1 Gene

Domains & Families for TMEM189-UBE2V1 Gene

Protein Domains for TMEM189-UBE2V1 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM189-UBE2V1: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Function for TMEM189-UBE2V1 Gene

genes like me logo Genes that share phenotypes with TMEM189-UBE2V1: view

Animal Model Products

CRISPR Products

miRNA for TMEM189-UBE2V1 Gene

miRTarBase miRNAs that target TMEM189-UBE2V1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM189-UBE2V1 Gene

Localization for TMEM189-UBE2V1 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM189-UBE2V1 Gene

Pathways & Interactions for TMEM189-UBE2V1 Gene

SuperPathways for TMEM189-UBE2V1 Gene

Superpath Contained pathways
1 Interleukin-1 signaling
genes like me logo Genes that share pathways with TMEM189-UBE2V1: view

Pathways by source for TMEM189-UBE2V1 Gene

1 BioSystems pathway for TMEM189-UBE2V1 Gene

Interacting Proteins for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Biological Process for TMEM189-UBE2V1 Gene


No data available for SIGNOR curated interactions for TMEM189-UBE2V1 Gene

Drugs & Compounds for TMEM189-UBE2V1 Gene

No Compound Related Data Available

Transcripts for TMEM189-UBE2V1 Gene

mRNA/cDNA for TMEM189-UBE2V1 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189-UBE2V1 Gene

No ASD Table

Relevant External Links for TMEM189-UBE2V1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM189-UBE2V1 Gene

mRNA expression in normal human tissues for TMEM189-UBE2V1 Gene

Protein differential expression in normal tissues from HIPED for TMEM189-UBE2V1 Gene

This gene is overexpressed in Heart (38.6), Skin (20.4), and Brain (10.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from PaxDb for TMEM189-UBE2V1 Gene

genes like me logo Genes that share expression patterns with TMEM189-UBE2V1: view

Protein tissue co-expression partners for TMEM189-UBE2V1 Gene

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM189-UBE2V1 Gene

Orthologs for TMEM189-UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM189-UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM189 36
  • 82 (a)
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
(Monodelphis domestica)
Mammalia TMEM189 36
  • 66 (a)
(Mus musculus)
Mammalia Gm20431 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM189 36
  • 63 (a)
(Pan troglodytes)
Mammalia TMEM189 36
  • 88 (a)
(Gallus gallus)
Aves TMEM189 36
  • 70 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
(Danio rerio)
Actinopterygii tmem189 36
  • 60 (a)
fruit fly
(Drosophila melanogaster)
Insecta Kua 36
  • 43 (a)
(Caenorhabditis elegans)
Secernentea Y53C10A.5 36
  • 37 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons MMZ1 35
  • 56.3 (n)
  • 54.07 (a)
(Oryza sativa)
Liliopsida Os03g0712300 35
  • 55.47 (n)
  • 50.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
Species with no ortholog for TMEM189-UBE2V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM189-UBE2V1 Gene

Gene Tree for TMEM189-UBE2V1 (if available)
Gene Tree for TMEM189-UBE2V1 (if available)

Paralogs for TMEM189-UBE2V1 Gene

Paralogs for TMEM189-UBE2V1 Gene

genes like me logo Genes that share paralogs with TMEM189-UBE2V1: view

Variants for TMEM189-UBE2V1 Gene

Sequence variations from dbSNP and Humsavar for TMEM189-UBE2V1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type
rs3092037 -- 50,120,101(+) TCTCT(-/A)AAAAA intron-variant
rs6020276 -- 50,118,160(+) AAAAC(C/T)GGGGT intron-variant
rs6020278 -- 50,119,701(-) AGTAC(A/C/G/T)TGAGG intron-variant
rs6012845 -- 50,118,793(+) tattt(C/T)ttttg intron-variant
rs6012846 -- 50,120,977(+) GGAAA(C/T)CCATG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM189-UBE2V1 Gene

Variant ID Type Subtype PubMed ID
nsv833999 CNV Loss 17160897
nsv834000 CNV Gain+Loss 17160897
esv34129 CNV Loss 18971310

Variation tolerance for TMEM189-UBE2V1 Gene

Residual Variation Intolerance Score: 34.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.03; 68.60% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM189-UBE2V1 Gene

Disorders for TMEM189-UBE2V1 Gene

Relevant External Links for TMEM189-UBE2V1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM189-UBE2V1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM189-UBE2V1 Gene

Publications for TMEM189-UBE2V1 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson T.M. … Guigo R. (Genome Res. 2000) 2 3 23 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  4. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3
  5. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3

Products for TMEM189-UBE2V1 Gene

Sources for TMEM189-UBE2V1 Gene