Aliases for TMEM189-UBE2V1 Gene
Previous GeneCards Identifiers for TMEM189-UBE2V1 Gene
The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]
GeneCards Summary for TMEM189-UBE2V1 Gene
TMEM189-UBE2V1 (TMEM189-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are IL-1 signaling pathway. Gene Ontology (GO) annotations related to this gene include acid-amino acid ligase activity. An important paralog of this gene is TMEM189.