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Aliases for TMEM189-UBE2V1 Gene

Aliases for TMEM189-UBE2V1 Gene

  • TMEM189-UBE2V1 Readthrough 2 3
  • Transmembrane Protein 189-Ubiquitin-Conjugating Enzyme E2 Variant 1 Read-Through 3
  • TMEM189-UBE2V1 Readthrough Transcript 3
  • TMEM189-UBE2V1 Fusion Protein 3
  • CROC-1B 3
  • KUA-UEV 3
  • CROC1B 3

External Ids for TMEM189-UBE2V1 Gene

Summaries for TMEM189-UBE2V1 Gene

Entrez Gene Summary for TMEM189-UBE2V1 Gene

  • The TMEM189-UEV mRNA is an infrequent but naturally occurring read-through transcript of the neighboring TMEM189 and UBE2V1 genes. Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein produced by this transcript has UEV1 B domains but the protein is localized to the cytoplasm rather than to the nucleus. The significance of this read-through mRNA and the function of its protein product has not yet been determined. [provided by RefSeq, Oct 2010]

GeneCards Summary for TMEM189-UBE2V1 Gene

TMEM189-UBE2V1 (TMEM189-UBE2V1 Readthrough) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is UBE2V1.

Gene Wiki entry for TMEM189-UBE2V1 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM189-UBE2V1 Gene

Genomics for TMEM189-UBE2V1 Gene

Genomic Location for TMEM189-UBE2V1 Gene

Start:
50,081,124 bp from pter
End:
50,153,798 bp from pter
Size:
72,675 bases
Orientation:
Minus strand

Genomic View for TMEM189-UBE2V1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM189-UBE2V1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189-UBE2V1 Gene

Regulatory Elements for TMEM189-UBE2V1 Gene

Proteins for TMEM189-UBE2V1 Gene

  • Protein details for TMEM189-UBE2V1 Gene (UniProtKB/TrEMBL)

    Protein Symbol:
    I3L0A0-I3L0A0
    Recommended name:
    HCG2044781
    Protein Accession:
    I3L0A0
    Secondary Accessions:

    Protein attributes for TMEM189-UBE2V1 Gene

    Size:
    370 amino acids
    Molecular mass:
    42209 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM189-UBE2V1 Gene

Proteomics data for TMEM189-UBE2V1 Gene at MOPED

Protein Expression for TMEM189-UBE2V1 Gene

Post-translational modifications for TMEM189-UBE2V1 Gene

No Post-translational modifications

Other Protein References for TMEM189-UBE2V1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM189-UBE2V1 Gene

Domains for TMEM189-UBE2V1 Gene

Protein Domains for TMEM189-UBE2V1 Gene

genes like me logo Genes that share domains with TMEM189-UBE2V1: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Function for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Molecular Function for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016881 acid-amino acid ligase activity --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view
genes like me logo Genes that share phenotypes with TMEM189-UBE2V1: view

miRNA for TMEM189-UBE2V1 Gene

miRTarBase miRNAs that target TMEM189-UBE2V1

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM189-UBE2V1 Gene

Localization for TMEM189-UBE2V1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM189-UBE2V1 Gene COMPARTMENTS Subcellular localization image for TMEM189-UBE2V1 gene
Compartment Confidence
endoplasmic reticulum 5
nucleus 5
cytosol 4

No data available for Gene Ontology (GO) - Cellular Components for TMEM189-UBE2V1 Gene

Pathways for TMEM189-UBE2V1 Gene

genes like me logo Genes that share pathways with TMEM189-UBE2V1: view

Interacting Proteins for TMEM189-UBE2V1 Gene

Gene Ontology (GO) - Biological Process for TMEM189-UBE2V1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
genes like me logo Genes that share ontologies with TMEM189-UBE2V1: view

Transcripts for TMEM189-UBE2V1 Gene

mRNA/cDNA for TMEM189-UBE2V1 Gene

(2) REFSEQ mRNAs :
(1050) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189-UBE2V1 Gene

No ASD Table

Relevant External Links for TMEM189-UBE2V1 Gene

GeneLoc Exon Structure for
TMEM189-UBE2V1
ECgene alternative splicing isoforms for
TMEM189-UBE2V1

Expression for TMEM189-UBE2V1 Gene

mRNA expression in normal human tissues for TMEM189-UBE2V1 Gene

Integrated Proteomics: protein expression from PaxDb for TMEM189-UBE2V1 Gene

genes like me logo Genes that share expressions with TMEM189-UBE2V1: view

Orthologs for TMEM189-UBE2V1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM189-UBE2V1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM189 37
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM189 37
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 37
  • 83 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Gm20431 37
  • 92 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMEM189 37
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM189 37
  • 63 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM189 37
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 37
  • 51 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii tmem189 37
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kua 37
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.5 37
  • 37 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons MMZ1 36
  • 56.3 (n)
  • 54.07 (a)
rice
(Oryza sativa)
Liliopsida Os03g0712300 36
  • 55.47 (n)
  • 50.75 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 47 (a)
OneToMany
Species with no ortholog for TMEM189-UBE2V1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM189-UBE2V1 Gene

ENSEMBL:
Gene Tree for TMEM189-UBE2V1 (if available)
TreeFam:
Gene Tree for TMEM189-UBE2V1 (if available)

Paralogs for TMEM189-UBE2V1 Gene

Paralogs for TMEM189-UBE2V1 Gene

genes like me logo Genes that share paralogs with TMEM189-UBE2V1: view

Variants for TMEM189-UBE2V1 Gene

Sequence variations from dbSNP and Humsavar for TMEM189-UBE2V1 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs3092037 -- 50,120,101(+) TCTCT(-/A)AAAAA intron-variant
rs6012844 -- 50,118,491(+) CCTCC(C/T)TTCCA intron-variant
rs6012845 -- 50,118,793(+) tattt(C/T)ttttg intron-variant
rs6012846 -- 50,120,977(+) GGAAA(C/T)CCATG intron-variant
rs6020276 -- 50,118,160(+) AAAAC(C/T)GGGGT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM189-UBE2V1 Gene

Variant ID Type Subtype PubMed ID
nsv833999 CNV Loss 17160897
nsv834000 CNV Gain+Loss 17160897
esv34129 CNV Loss 18971310

Relevant External Links for TMEM189-UBE2V1 Gene

HapMap Linkage Disequilibrium report
TMEM189-UBE2V1

Disorders for TMEM189-UBE2V1 Gene

Relevant External Links for TMEM189-UBE2V1

Genetic Association Database (GAD)
TMEM189-UBE2V1
Human Genome Epidemiology (HuGE) Navigator
TMEM189-UBE2V1
genes like me logo Genes that share disorders with TMEM189-UBE2V1: view

No data available for UniProtKB/Swiss-Prot for TMEM189-UBE2V1 Gene

Publications for TMEM189-UBE2V1 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson T.M. … Guigo R. (Genome Res. 2000) 2 3 23
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49
  3. Expression of conjoined genes: another mechanism for gene regulation in eukaryotes. (PMID: 20967262) Prakash T. … Taylor T.D. (PLoS ONE 2010) 3
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  5. CROC-1 encodes a protein which mediates transcriptional activation of the human FOS promoter. (PMID: 9305758) Rothofsky M.L. … Lin S.L. (Gene 1997) 3

Products for TMEM189-UBE2V1 Gene

Sources for TMEM189-UBE2V1 Gene

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