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TMEM189 Gene

protein-coding   GIFtS: 41
GCID: GC20M048699

Transmembrane Protein 189

  Search for TMEM189
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1891 2
KUA2 3

External Ids:    HGNC: 167351   Entrez Gene: 3875212   Ensembl: ENSG000002408497   OMIM: 6109945   UniProtKB: A5PLL73   

Export aliases for TMEM189 gene to outside databases

Previous GC identifers: GC20M048134 GC20M048740 GC20M045488


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM189 Gene:
Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1)
generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity
with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes
three transmembrane regions. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Jun 2009)

GeneCards Summary for TMEM189 Gene:
TMEM189 (transmembrane protein 189) is a protein-coding gene. An important paralog of this gene is TMEM189-UBE2V1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM189 gene promoter:
         AhR   AP-4   NF-kappaB   AP-2gamma   CREB   deltaCREB   ARP-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM189

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM189


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

TMEM189 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM189 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048699:  view genomic region     (about GC identifiers)

Start:
48,697,663 bp from pter      End:
48,770,335 bp from pter
Size:
72,673 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM189_HUMAN, A5PLL7 (See protein sequence)
Recommended Name: Transmembrane protein 189  
Size: 270 amino acids; 31135 Da
Miscellaneous: TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also
be fused to form a TMEM189-UBE2V1 hybrid protein

Explore the universe of human proteins at neXtProt for TMEM189: NX_A5PLL7

Explore proteomics data for TMEM189 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM189 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001155977.1  NP_954580.1  

    ENSEMBL proteins: 
     ENSP00000360713   ENSP00000360719   ENSP00000360715   ENSP00000411045   ENSP00000360721  
     ENSP00000450635  

    TMEM189 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for TMEM189
    OriGene Protein Over-expression Lysate for TMEM189
    OriGene MassSpec for TMEM189
    OriGene Custom Protein Services for TMEM189
    GenScript Custom Purified and Recombinant Proteins Services for TMEM189
    Novus Biologicals TMEM189 Protein
    Novus Biologicals TMEM189 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM189

     
    Search eBioscience for Proteins for TMEM189 

    TMEM189 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for TMEM189
    Search for Antibodies for TMEM189 at Abcam
    Cloud-Clone Corp. Antibodies for TMEM189
    Search ThermoFisher Antibodies for TMEM189
    Search LSBio for Antibodies for TMEM189

    TMEM189 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for TMEM189
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for TMEM189
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM189
    Cloud-Clone Corp. CLIAs for TMEM189
    Search eBioscience for ELISAs for TMEM189 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR019547 KuaUb-conj-enz_UEV1

    Graphical View of Domain Structure for InterPro Entry A5PLL7

    ProtoNet protein and cluster: A5PLL7


    Find genes that share domains with TMEM189           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016881acid-amino acid ligase activity ----
         
    Find genes that share ontologies with TMEM189           About GenesLikeMe


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmem189):
     adipose tissue  growth/size/body  hematopoietic system  homeostasis/metabolism  immune system 
     pigmentation  skeleton  vision/eye 

    Find genes that share phenotypes with TMEM189           About GenesLikeMe

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM189
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM189

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM189
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM189

    miRNA
    Products:
        
    miRTarBase miRNAs that target TMEM189:
    hsa-mir-181b-5p (MIRT047235), hsa-mir-744-5p (MIRT037701)

    Block miRNA regulation of human, mouse, rat TMEM189 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM189 (see all 24):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-411 hsa-miR-3660 hsa-miR-3605-3p hsa-miR-1271 hsa-miR-340 hsa-miR-1297
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM189
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM189

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM189

    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM189 (see all 11)
    OriGene ORF clones in mouse, rat for TMEM189
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM189 (NM_199129)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM189
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for TMEM189
    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM189 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM189_HUMAN, A5PLL7: Endoplasmic reticulum membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol4

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM189           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMEM189 About   (see all 10)  
    See pathways by source

    SuperPathContained pathways About
    1Toll Like Receptor 7/8 (TLR7/8) Cascade
    TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation0.93
    MyD88-independent cascade0.69
    Toll Like Receptor 9 (TLR9) Cascade0.93
    Toll Like Receptor 3 (TLR3) Cascade0.69
    Toll Like Receptor 7/8 (TLR7/8) Cascade0.69
    TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling0.00
    MyD88 dependent cascade initiated on endosome0.69
    2Class I MHC mediated antigen processing and presentation
    Class I MHC mediated antigen processing and presentation0.84
    Adaptive Immune System0.41
    Antigen processing- Ubiquitination and Proteasome degradation0.84
    3TCR signaling (REACTOME)
    Downstream TCR signaling0.73
    TCR signaling0.73
    4Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways
    Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways0.68
    NOD1/2 Signaling Pathway0.68
    5IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
    IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
    IRAK1 recruits IKK complex0.00



        Pathway & Disease-focused RT2 Profiler PCR Array including TMEM189: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TMEM189

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TMEM189 (A5PLL73 ENSP000003607154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    TRAF6Q9Y4K33I2D: score=1 
    HGSENSP000003312014STRING: ENSP00000331201
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM189 (TM189)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM189 gene (2 alternative transcripts): 
    NM_001162505.1  NM_199129.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371650(uc010zyq.1 uc002xvg.2 uc010gif.2) ENST00000371656(uc010zyp.1)
    ENST00000371652 ENST00000453505 ENST00000371658 ENST00000557021(uc002xvf.3)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM189 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM189 (see all 24):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-411 hsa-miR-3660 hsa-miR-3605-3p hsa-miR-1271 hsa-miR-340 hsa-miR-1297
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM189
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM189
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM189 (see all 11)
    OriGene ORF clones in mouse, rat for TMEM189
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): TMEM189 (NM_199129)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM189
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM189
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM189
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM189
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM189
      QuantiFast Probe-based Assays in human, mouse, rat TMEM189

    Selected AceView cDNA sequences (see all 1050):

    AW409773 AI371745 CN482774 CR591292 BU628670 BM903970 BG943639 BI909653 
    CB528660 NM_022442 BM561707 BU628678 AW014611 BX647511 AI753175 CD672004 
    AA778376 BC008944 AI077910 CR610565 BM463781 AF049671 CA393362 AA948616 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM189 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM189 Expression
    About this image

    TMEM189 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM189 Protein Expression
        Pathway & Disease-focused RT2 Profiler PCR Array including TMEM189: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM189
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM189
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM189
    QuantiTect SYBR Green Assays in human, mouse, rat TMEM189
    QuantiFast Probe-based Assays in human, mouse, rat TMEM189
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM189 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1891 , 5 transmembrane protein 1891, 5 88.52(n)1
    93.33(a)1
      2 (87.50 cM)5
    4072431  NM_145538.21  NP_663513.11 
     1676426085 
    chicken
    (Gallus gallus)
    Aves TMEM1891 transmembrane protein 189 72.4(n)
    81.25(a)
      100538348  NM_001205100.1  NP_001192029.1 
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    51(a)
    1 → many
    4(147672785-147713455)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1891 transmembrane protein 189 70.16(n)
    73.79(a)
      100551495  NM_001205105.1  NP_001192034.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1891 transmembrane protein 189 69.42(n)
    72.83(a)
      450031  NM_001006052.1  NP_001006052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Kua6
    Kua
    43(a)
    1 → many
    2L(20097581-20103375)
    worm
    (Caenorhabditis elegans)
    Secernentea Y53C10A.56
    Protein Y53C10A.5 (Y53C10A.5) mRNA, complete cds
    37(a)
    1 → many
    I(11998781-12002735) WBGene00013136


    ENSEMBL Gene Tree for TMEM189 (if available)
    TreeFam Gene Tree for TMEM189 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM189 gene
    TMEM189-UBE2V12  
    2 SIMAP similar genes for TMEM189 using alignment to 6 protein entries:     TM189_HUMAN (see all proteins):
    UBE2V1    UBE2V2

    Find genes that share paralogs with TMEM189           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    1 SNPs for TMEM189    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs20267571,2,4
    ----see VAR_0597322 mis40--------

    HapMap Linkage Disequilibrium report for TMEM189 (48697663 - 48770335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM189:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv34129CNV Loss18971310
    nsv834000CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM189
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM189

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610994    OMIM disorders: --


    Find genes that share disorders with TMEM189           About GenesLikeMe

    Human Genome Epidemiology (HuGE) Navigator: TMEM189 (1 document)

    Export disorders for TMEM189 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM189 gene, integrated from 10 sources (see all 17):
    (articles sorted by number of sources associating them with TMEM189)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)1, 2, 3, 9 Thomson T.M.... Guigo R. (Genome Res. 2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (Cancer Res. 2001)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (Cell 2012)
    5. Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (Haematologica 2011)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (Cell 2011)
    9. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    10. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (J. Biol. Chem. 2011)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 387521 HGNC: 16735 AceView: Kua-UEV Ensembl:ENSG00000240849 euGenes: HUgn387521
    ECgene: TMEM189 H-InvDB: TMEM189

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM189 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM189 gene:
    Search GeneIP for patents involving TMEM189

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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