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Aliases for TMEM189 Gene

Aliases for TMEM189 Gene

  • Transmembrane Protein 189 2 3
  • KUA 3 4

External Ids for TMEM189 Gene

Summaries for TMEM189 Gene

Entrez Gene Summary for TMEM189 Gene

  • Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes three transmembrane regions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2009]

GeneCards Summary for TMEM189 Gene

TMEM189 (Transmembrane Protein 189) is a Protein Coding gene. Among its related pathways are PI-3K cascade and Class I MHC mediated antigen processing and presentation. An important paralog of this gene is TMEM189-UBE2V1.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM189 Gene

Genomics for TMEM189 Gene

Genomic Location for TMEM189 Gene

Start:
50,118,254 bp from pter
End:
50,153,798 bp from pter
Size:
35,545 bases
Orientation:
Minus strand

Genomic View for TMEM189 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM189 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM189 Gene

Regulatory Elements for TMEM189 Gene

Proteins for TMEM189 Gene

  • Protein details for TMEM189 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A5PLL7-TM189_HUMAN
    Recommended name:
    Transmembrane protein 189
    Protein Accession:
    A5PLL7
    Secondary Accessions:

    Protein attributes for TMEM189 Gene

    Size:
    270 amino acids
    Molecular mass:
    31135 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also be fused to form a TMEM189-UBE2V1 hybrid protein

    Alternative splice isoforms for TMEM189 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM189 Gene

Proteomics data for TMEM189 Gene at MOPED

Post-translational modifications for TMEM189 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM189 Gene

No data available for DME Specific Peptides for TMEM189 Gene

Domains for TMEM189 Gene

Protein Domains for TMEM189 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM189: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM189 Gene

Function for TMEM189 Gene

Gene Ontology (GO) - Molecular Function for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0019787 ubiquitin-like protein transferase activity IBA --
GO:0031625 ubiquitin protein ligase binding IBA --
GO:0061630 ubiquitin protein ligase activity IBA --
genes like me logo Genes that share ontologies with TMEM189: view
genes like me logo Genes that share phenotypes with TMEM189: view

miRNA for TMEM189 Gene

miRTarBase miRNAs that target TMEM189

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM189 Gene

Localization for TMEM189 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM189 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM189 Gene COMPARTMENTS Subcellular localization image for TMEM189 gene
Compartment Confidence
nucleus 5
cytosol 4

Gene Ontology (GO) - Cellular Components for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IBA --
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM189: view

Pathways for TMEM189 Gene

genes like me logo Genes that share pathways with TMEM189: view

Interacting Proteins for TMEM189 Gene

Selected Interacting proteins: A5PLL7-TM189_HUMAN for TMEM189 Gene via I2D

Symbol External ID(s) Details
TRAF6
UBE2N

Gene Ontology (GO) - Biological Process for TMEM189 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016567 protein ubiquitination IBA --
genes like me logo Genes that share ontologies with TMEM189: view

Transcripts for TMEM189 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM189 Gene

No ASD Table

Relevant External Links for TMEM189 Gene

GeneLoc Exon Structure for
TMEM189
ECgene alternative splicing isoforms for
TMEM189

Expression for TMEM189 Gene

mRNA expression in normal human tissues for TMEM189 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM189 Gene

genes like me logo Genes that share expressions with TMEM189: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM189 Gene

Orthologs for TMEM189 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM189 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM189 35
  • 99.63 (n)
  • 99.63 (a)
TMEM189 36
  • 88 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM189 35
  • 90.74 (n)
  • 91.11 (a)
TMEM189 36
  • 82 (a)
OneToMany
dog
(Canis familiaris)
Mammalia -- 36
  • 83 (a)
OneToMany
TMEM189 35
  • 92.59 (n)
  • 94.44 (a)
mouse
(Mus musculus)
Mammalia Gm20431 36
  • 92 (a)
OneToMany
Tmem189 35
  • 88.52 (n)
  • 93.33 (a)
Tmem189 16
oppossum
(Monodelphis domestica)
Mammalia TMEM189 36
  • 66 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM189 36
  • 63 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem189 35
  • 89.51 (n)
  • 92.96 (a)
chicken
(Gallus gallus)
Aves TMEM189 35
  • 72.4 (n)
  • 81.25 (a)
TMEM189 36
  • 70 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 51 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem189 35
  • 70.16 (n)
  • 73.79 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem189 35
  • 69.42 (n)
  • 72.83 (a)
tmem189 36
  • 60 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta Kua 36
  • 43 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea Y53C10A.5 36
  • 37 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 47 (a)
OneToMany
Species with no ortholog for TMEM189:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM189 Gene

ENSEMBL:
Gene Tree for TMEM189 (if available)
TreeFam:
Gene Tree for TMEM189 (if available)

Paralogs for TMEM189 Gene

Paralogs for TMEM189 Gene

Selected SIMAP similar genes for TMEM189 Gene using alignment to 6 proteins:

genes like me logo Genes that share paralogs with TMEM189: view

Variants for TMEM189 Gene

Sequence variations from dbSNP and Humsavar for TMEM189 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
VAR_059732 -

Structural Variations from Database of Genomic Variants (DGV) for TMEM189 Gene

Variant ID Type Subtype PubMed ID
nsv834000 CNV Gain+Loss 17160897
esv34129 CNV Loss 18971310

Relevant External Links for TMEM189 Gene

HapMap Linkage Disequilibrium report
TMEM189

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM189 Gene

Disorders for TMEM189 Gene

Relevant External Links for TMEM189

Human Genome Epidemiology (HuGE) Navigator
TMEM189
genes like me logo Genes that share disorders with TMEM189: view

No data available for UniProtKB/Swiss-Prot for TMEM189 Gene

Publications for TMEM189 Gene

  1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PMID: 11076860) Thomson T.M. … Guigo R. (Genome Res. 2000) 2 3 4 23
  2. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PMID: 11280764) Ito M. … Itoh K. (Cancer Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. (PMID: 16129784) Andersen P.L. … Xiao W. (J. Cell Biol. 2005) 3
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3

Products for TMEM189 Gene

Sources for TMEM189 Gene

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