TMEM189 Gene
protein-coding GIFtS: 40
GCID: GC20M048699
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transmembrane protein 189
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Aliases
for TMEM189 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1891 2 | | KUA2 3 | | Kua1 |
Export aliases for TMEM189 gene to outside databasesPrevious GC identifers: GC20M048134 GC20M048740 GC20M045488 |
Summaries
for TMEM189 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMEM189:
Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1) generatesa rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity with eachindividual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes threetransmembrane regions. Alternative splicing results in multiple transcript variants. (provided by RefSeq, Jun 2009)
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Genomic Views
for TMEM189 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM189 gene promoter:
AhR AP-4 NF-kappaB AP-2gamma CREB deltaCREB ARP-1 NF-kappaB1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM189
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM189 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 20q13.2 Ensembl cytogenetic band: 20q13.13 HGNC cytogenetic band: 20q13.13TMEM189 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 20 GeneLoc Exon Structure GeneLoc location for GC20M048699: view genomic region
(about GC identifiers)
Start:
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48,697,663 bp from pter |
End:
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48,770,335 bp from pter |
Size:
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72,673 bases |
Orientation:
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minus strand |
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Proteins
for TMEM189 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM189_HUMAN, A5PLL7 (See
protein sequence)Recommended Name: Transmembrane protein 189 Size: 270 amino acids; 31135 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also befused to form a TMEM189-UBE2V1 hybrid proteinExplore the universe of human proteins at neXtProt for TMEM189: NX_A5PLL7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_A5PLL7
TMEM189 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (2 alternative transcripts):
NP_001155977.1 NP_954580.1
ENSEMBL proteins: ENSP00000360713 ENSP00000360719 ENSP00000360715 ENSP00000411045 ENSP00000360721 ENSP00000450635
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005789 | endoplasmic reticulum membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM189 for ontologies About GeneDecksing
TMEM189 Antibody Products:
Assay Products for TMEM189: |
Protein
Domains /
Families
for TMEM189 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM189 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry A5PLL7ProtoNet protein and cluster: A5PLL7 |
Function
for TMEM189 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM189 (NM_199129) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM189 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016881 | acid-amino acid ligase activity |
-- | -- |
TMEM189 for ontologies About GeneDecksing
Animal Models:
8 MGI mutant phenotypes (inferred from 1 allele ) (MGI details for Tmem189):
TMEM189 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM189 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM189
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5 Interacting proteins for TMEM189 (A5PLL73 ENSP000003607154) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM189 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM189
Search CenterWatch for drugs/clinical trials and news about TMEM189 / TM189
|
Transcripts
for TMEM189 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM189 gene (2 alternative transcripts): NM_001162505.1 NM_199129.2 6 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000371650(uc010zyq.1 uc002xvg.2 uc010gif.2) ENST00000371656(uc010zyp.1)
ENST00000371652 ENST00000453505 ENST00000371658 ENST00000557021(uc002xvf.3)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 2): TMEM189 (NM_199129) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM189 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189 |
24/1050 AceView cDNA sequences (see all 1050): CR610565 AA948616 BQ685274 AI077910 BG819344 CK430145 AY008273 AI342795 BQ221327 AA632107 CR617021 CA414658 BM799727 BE295324 BQ441690 BG940023 CA393362 AI362120 BI909653 CB528660 AI989384 BM561707 BG943775 BQ652458
GeneLoc Exon Structure
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Expression
for TMEM189 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM189 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM189 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM189
SABiosciences Expression via Pathway-Focused PCR Array including TMEM189:
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM189
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM189 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM189 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM189 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189 |
Orthologs
for TMEM189 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM189 gene from 7/21 species (see all 21) About this table
ENSEMBL Gene Tree for TMEM189 (if available)
TreeFam Gene Tree for TMEM189 (if available) |
Paralogs
for TMEM189 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM189 gene
- UBE2V12 UBE2V22 TMEM189-UBE2V12
2 SIMAP similar genes for TMEM189 using alignment to 6 protein entries: TM189_HUMAN (see all proteins):UBE2V1 UBE2V2
TMEM189 for paralogs About GeneDecksing
|
Genomic Variants
for TMEM189 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 20 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM189 (48697663 - 48770335 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for TMEM189
2 CNVs: 47899 5140 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM189 |
|
Disorders
/ Diseases
for TMEM189 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM189 for disorders About GeneDecksing
OMIM gene information: 610994
OMIM disorders: --
5  diseases for TMEM189: About MalaCardschronic lymphocytic leukemia lymphocytic leukemia pancreatic cancer leukemia
pancreatitis
Human Genome Epidemiology (HuGE) Navigator: TMEM189 (1 document)
Export disorders for TMEM189 gene to outside databases
|
Publications
for TMEM189 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM189 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with TMEM189) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)1, 2, 3, 9 Thomson T.M.... Guigo R. (2000)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (2001)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)
- Recruitment of Uev1B to Hrs-containing endosomes and its effect on endosomal trafficking. (PubMed id 20420830)1 Duex J.E....Sorkin A. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Distinct regulation of Ubc13 functions by the two ubiquitin-conjugating enzyme variants Mms2 and Uev1A. (PubMed id 16129784)1 Andersen P.L....Xiao W. (2005)
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External Searches for TMEM189 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM189 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM189 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM189 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM189 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM189 gene:
Search GeneIP for patents involving TMEM189
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM189 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM189 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM189 | | | OriGene Protein Over-expression Lysate for TMEM189 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM189 | | OriGene 3'-UTR Clone for TMEM189 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM189 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM189 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM189 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM189 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM189 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM189 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM189 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM189 |
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| | | | Search Tocris compounds for TMEM189 |
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 | | | TMEM189 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM189 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189 |
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