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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM189 Gene

protein-coding   GIFtS: 39
GCID: GC20M048699

Transmembrane Protein 189

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1891 2
KUA2 3

External Ids:    HGNC: 167351   Entrez Gene: 3875212   Ensembl: ENSG000002408497   OMIM: 6109945   UniProtKB: A5PLL73   

Export aliases for TMEM189 gene to outside databases

Previous GC identifers: GC20M048134 GC20M048740 GC20M045488


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM189 Gene:
Co-transcription of this gene and the neighboring downstream gene (ubiquitin-conjugating enzyme E2 variant 1)
generates a rare read-through transcript, which encodes a fusion protein comprised of sequence sharing identity
with each individual gene product. The protein encoded by this individual gene lacks a UEV1 domain but includes
three transmembrane regions. Alternative splicing results in multiple transcript variants. (provided by RefSeq,
Jun 2009)

GeneCards Summary for TMEM189 Gene: 
TMEM189 (transmembrane protein 189) is a protein-coding gene. Diseases associated with TMEM189 include chronic lymphocytic leukemia, and pancreatic cancer. An important paralog of this gene is UBE2V1.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM189 gene promoter:
         AhR   AP-4   NF-kappaB   AP-2gamma   CREB   deltaCREB   ARP-1   NF-kappaB1   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM189

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM189


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 20q13.2   Ensembl cytogenetic band:  20q13.13   HGNC cytogenetic band: 20q13.13

TMEM189 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM189 gene location

GeneLoc information about chromosome 20         GeneLoc Exon Structure

GeneLoc location for GC20M048699:  view genomic region     (about GC identifiers)

Start:
48,697,663 bp from pter      End:
48,770,335 bp from pter
Size:
72,673 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM189_HUMAN, A5PLL7 (See protein sequence)
Recommended Name: Transmembrane protein 189  
Size: 270 amino acids; 31135 Da
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein
Miscellaneous: TMEM189/KUA and UBE2V1/UEV1 are adjacent genes which can produce independent proteins and can also
be fused to form a TMEM189-UBE2V1 hybrid protein

Explore the universe of human proteins at neXtProt for TMEM189: NX_A5PLL7

Explore proteomics data for TMEM189 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_A5PLL7

  • TMEM189 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM189 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001155977.1  NP_954580.1  

    ENSEMBL proteins: 
     ENSP00000360713   ENSP00000360719   ENSP00000360715   ENSP00000411045   ENSP00000360721  
     ENSP00000450635  

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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0016021integral to membrane IEA--

    TMEM189 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR019547 KuaUb-conj-enz_UEV1

    Graphical View of Domain Structure for InterPro Entry A5PLL7

    ProtoNet protein and cluster: A5PLL7


    TMEM189 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016881acid-amino acid ligase activity ----
         
    TMEM189 for ontologies           About GeneDecksing


    Phenotypes:
         8 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmem189):
     adipose tissue  growth/size  hematopoietic system  homeostasis/metabolism  immune system 
     pigmentation  skeleton  vision/eye 

    TMEM189 for phenotypes           About GeneDecksing

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM189 
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    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM189

    STRING Interaction Network Preview (showing 4 interactants - click image to see more details)

    5 Interacting proteins for TMEM189 (A5PLL73 ENSP000003607154) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2NP610883, ENSP000003161764I2D: score=2 STRING: ENSP00000316176
    TRAF6Q9Y4K33I2D: score=1 
    HGSENSP000003312014STRING: ENSP00000331201
    UBCENSP000003448184STRING: ENSP00000344818
    ELAVL1ENSP000003852694STRING: ENSP00000385269
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM189 (TM189)

    Search CenterWatch for drugs/clinical trials and news about TMEM189 / TM189

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM189 gene (2 alternative transcripts): 
    NM_001162505.1  NM_199129.2  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000371650(uc010zyq.1 uc002xvg.2 uc010gif.2) ENST00000371656(uc010zyp.1)
    ENST00000371652 ENST00000453505 ENST00000371658 ENST00000557021(uc002xvf.3)

    miRNA
    Products:
         
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    8/24 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM189 (see all 24):
    hsa-miR-21* hsa-miR-323-3p hsa-miR-411 hsa-miR-3660 hsa-miR-3605-3p hsa-miR-1271 hsa-miR-340 hsa-miR-1297
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
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    Clone
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM189
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM189

    24/1050 AceView cDNA sequences (see all 1050):

    CA848223 BQ685274 AI077910 BG819344 AA948616 CK430145 AI342795 AY008273 
    BQ221327 AA632107 CR617021 BE295324 CA414658 BM799727 BQ441690 BG940023 
    CA393362 AI362120 BI909653 BM692858 BU618625 CR622665 AA370295 BQ045410 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM189 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM189 Expression
    About this image


    See TMEM189 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM189
        SABiosciences Expression via Pathway-Focused PCR Array including TMEM189: 
              Ubiquitination (Ubiquitylation) Pathway in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM189

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for TMEM189 gene from 7/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1891 , 5 transmembrane protein 1891, 5 88.52(n)1
    93.33(a)1
      2 (87.50 cM)5
    4072431  NM_145538.21  NP_663513.11 
     1676426085 
    chicken
    (Gallus gallus)
    Aves TMEM1891 transmembrane protein 189 72.4(n)
    81.25(a)
      100538348  NM_001205100.1  NP_001192029.1 
    lizard
    (Anolis carolinensis)
    Reptilia UBE2V16
    ubiquitin-conjugating enzyme E2 variant 1
    95(a)
    possible ortholog
    4(147633496-147637769)
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1891 transmembrane protein 189 69.7(n)
    73.12(a)
      450031  NM_001006052.1  NP_001006052.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta Uev1A6
    Uev1A
    64(a)
    1 → many
    3L(5355984-5359325)
    worm
    (Caenorhabditis elegans)
    Secernentea uev-16
    Protein UEV-1
    65(a)
    1 → many
    I(14790244-14790939)
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes MMS26
    Ubiquitin-conjugating enzyme variant involved in e...
    50(a)
    1 → many
    VII(346406-346904)


    ENSEMBL Gene Tree for TMEM189 (if available)
    TreeFam Gene Tree for TMEM189 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM189 gene
    UBE2V12  UBE2V22  TMEM189-UBE2V12  
    2 SIMAP similar genes for TMEM189 using alignment to 6 protein entries:     TM189_HUMAN (see all proteins):
    UBE2V1    UBE2V2

    TMEM189 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    1 SNPs in TMEM189 are shown    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 20 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0597324
    ----see VAR_0597322 W G mis40--------

    HapMap Linkage Disequilibrium report for TMEM189 (48697663 - 48770335 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM189:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv34129CNV Loss18971310
    nsv834000CNV Gain+Loss17160897

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM189
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM189

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 610994    OMIM disorders: --

    4 diseases for TMEM189:    About MalaCards
    chronic lymphocytic leukemia    pancreatic cancer    pancreatitis    leukemia


    TMEM189 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: TMEM189 (1 document)

    Export disorders for TMEM189 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM189 gene, integrated from 9 sources (see all 17):
    (articles sorted by number of sources associating them with TMEM189)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Fusion of the human gene for the polyubiquitination coeffector UEV1 with Kua, a newly identified gene. (PubMed id 11076860)1, 2, 3, 9 Thomson T.M.... Guigo R. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Molecular basis of T cell-mediated recognition of pancreatic cancer cells. (PubMed id 11280764)1, 2 Ito M....Itoh K. (2001)
    4. A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
    5. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. Mapping the NPHP-JBTS-MKS protein network reveals ciliopathy disease genes and pathways. (PubMed id 21565611)1 Sang L.... Jackson P.K. (2011)
    8. Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
    9. The BTB and CNC homology 1 (BACH1) target genes are i nvolved in the oxidative stress response and in control of the cell cycle. (PubMed id 21555518)1 Warnatz H.J....Yaspo M.L. (2011)
    10. Single nucleotide polymorphisms of matrix metalloprot einase 9 (MMP-9) and tumour protein 73 (TP73) interact with Epstein Barr virus in chronic lymphocytic leukemia: results from the European case-control study E piLymph. (PubMed id 21048031)1 Casabonne D....de Sanjose S. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 387521 HGNC: 16735 AceView: Kua-UEV Ensembl:ENSG00000240849 euGenes: HUgn387521
    ECgene: TMEM189 H-InvDB: TMEM189

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM189 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM189 gene:
    Search GeneIP for patents involving TMEM189

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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