TMEM187 Gene
protein-coding GIFtS: 39
GCID: GC0XP153237
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transmembrane protein 187(Previous name: chromosome X open reading frame 12 )
(Previous symbol: CXorf12)
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Aliases
for TMEM187 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1871 2 | | ITBA11 2 3 5 | | CXorf121 2 3 | | DXS9878E1 2 3 | | Chromosome X Open Reading Frame 121 | | Protein ITBA13 |
Export aliases for TMEM187 gene to outside databasesPrevious GC identifers: GC0XP152891 GC0XP141899 |
Summaries
for TMEM187 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMEM187:
This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variantencoding the same protein has been found, but its biological validity is not determined. (provided by RefSeq, May2010)
|
Genomic Views
for TMEM187 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000023.10 NC_018934.1 NT_167198.1
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM187 gene promoter:
AhR SRY Sp1 Arnt YY1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM187
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM187 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: Xq28 Ensembl cytogenetic band: Xq28 HGNC cytogenetic band: Xq28TMEM187 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome X GeneLoc Exon Structure GeneLoc location for GC0XP153237: view genomic region
(about GC identifiers)
Start:
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153,237,778 bp from pter |
End:
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153,248,646 bp from pter |
Size:
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10,869 bases |
Orientation:
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plus strand |
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Proteins
for TMEM187 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM187_HUMAN, Q14656 (See
protein sequence)Recommended Name: Transmembrane protein 187 Size: 261 amino acids; 29148 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RC47 Q6IAV7Explore the universe of human proteins at neXtProt for TMEM187: NX_Q14656
TMEM187 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_003483.1
ENSEMBL proteins: ENSP00000358999 ENSP00000390108 ENSP00000412872
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- | | GO:0030133 | transport vesicle |
IDA | -- |
TMEM187 for ontologies About GeneDecksing
TMEM187 Antibody Products:
Assay Products for TMEM187: |
Protein
Domains /
Families
for TMEM187 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q14656 |
Function
for TMEM187 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM187
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM187 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM187 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
TMEM187 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM187 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM187
1 Interacting protein for TMEM187 (Q146563) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
TMEM187 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM187 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM187
Search CenterWatch for drugs/clinical trials and news about TMEM187 / TM187
|
Transcripts
for TMEM187 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM187 gene: NM_003492.2 Unigene Cluster for TMEM187: Transmembrane protein 187 Hs.23119 [show with all ESTs]Unigene Representative Sequence: NM_0034923 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000369982(uc004fjq.2) ENST00000425274 ENST00000431598
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM187
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM187 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM187 (NM_003492) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM187 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM187 |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM187
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM187 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM187 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM187 |
Additional cDNA sequence: AK314938.1 BC008203.1 BC017026.1 CR457047.1 DQ655925.2 X92475.1 4 DOTS entries: DT.114597 DT.92423749 DT.95191131 DT.97808571 24/124 AceView cDNA sequences (see all 124): AL527481 Z41547 CA309349 X92475 CB054700 CR614641 CR598778 AA464991 CR613909 CR598856 R46273 BF437102 AI089546 CA436793 AA041521 AW951412 BM762410 AA563799 AW662939 AW161814 BC008203 BC017026 AA455272 CA487214
GeneLoc Exon Structure
|
Expression
for TMEM187 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM187 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GTTGGACAGA
About this image
See TMEM187 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM187
SOURCE GeneReport for Unigene cluster: Hs.23119
UniProtKB/Swiss-Prot: TM187_HUMAN, Q14656Tissue specificity: Ubiquitous
SABiosciences Custom PCR Arrays for TMEM187
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM187
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM187 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM187 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM187 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM187 |
Orthologs
for TMEM187 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM187 gene from 2/7 species (see all 7) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
TMEM1876 |
-- |
58(a) |
1 ↔ 1 |
2(88406699-88407890) |
zebrafish
(Danio rerio) |
Actinopterygii |
tmem1871 |
transmembrane protein 187 |
59.18(n)
54.69(a) |
|
100001485 XM_001341435.4 XP_001341471.1 |
Species with no ortholog for TMEM187
ENSEMBL Gene Tree for TMEM187 (if available)
TreeFam Gene Tree for TMEM187 (if available) |
Paralogs
for TMEM187 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM187 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr X pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM187 (153237778 - 153248646 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM187: --
Human Gene Mutation Database (HGMD): TMEM187
Locus Specific Mutation Databases (LSDB): TMEM187
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM187 |
|
Disorders
/ Diseases
for TMEM187 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM187 for disorders About MalaCards
TMEM187 for disorders About GeneDecksing
OMIM gene information: 300059
OMIM disorders: --
Export disorders for TMEM187 gene to outside databases
|
Publications
for TMEM187 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM187 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM187) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- The complete sequence of the host cell factor 1 (HCFC1) gene and its promoter: a role for YY1 transcription factor in the regulation of its expression. (PubMed id 8661027)1, 3 Zoppe M....Vezzoni P. (1996)
- Characterization and fine localization of two new genes in Xq28 using the genomic sequence/EST database screening approach. (PubMed id 8786131)1, 2 Faranda S.... Vezzoni P. (1996)
- Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions. (PubMed id 17567994)1 Denoeud F....Reymond A. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
|
External Searches for TMEM187 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM187 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM187 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM187 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM187 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM187 gene:
Search GeneIP for patents involving TMEM187
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM187 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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 | | | TMEM187 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM187 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM187 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM187 |
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