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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM186 Gene

protein-coding   GIFtS: 41
GCID: GC16M008874

Transmembrane Protein 186

(Previous name: chromosome 16 open reading frame 51)
(Previous symbol: C16orf51)
  Search for TMEM186
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1861 2
C16orf511 2 3
Chromosome 16 Open Reading Frame 511

External Ids:    HGNC: 245301   Entrez Gene: 258802   Ensembl: ENSG000001848577   UniProtKB: Q96B773   

Export aliases for TMEM186 gene to outside databases

Previous GC identifers: GC16M008798 GC16M008889 GC16M008811


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM186 Gene:
This gene encodes a potential transmembrane protein. (provided by RefSeq, Dec 2012)

GeneCards Summary for TMEM186 Gene: 
TMEM186 (transmembrane protein 186) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010393.16  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM186 gene promoter:
         Pax-2   Pax-2a   C/EBPalpha   c-Ets-1   AREB6   HEN1   FOXJ2 (long isoform)   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM186 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM186

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM186


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.2

TMEM186 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM186 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M008874:  view genomic region     (about GC identifiers)

Start:
8,874,241 bp from pter      End:
8,891,505 bp from pter
Size:
17,265 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM186_HUMAN, Q96B77 (See protein sequence)
Recommended Name: Transmembrane protein 186  
Size: 213 amino acids; 24893 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2RAY0 Q9Y4T4

Explore the universe of human proteins at neXtProt for TMEM186: NX_Q96B77

Explore proteomics data for TMEM186 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q96B77

  • TMEM186 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM186 Protein Expression
    REFSEQ proteins: NP_056236.2  
    ENSEMBL proteins: 
     ENSP00000331640  

    Human Recombinant Protein Products for TMEM186: 
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    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0016021integral to membrane IEA--

    TMEM186 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR026571 Tmem186

    Graphical View of Domain Structure for InterPro Entry Q96B77

    ProtoNet protein and cluster: Q96B77

    UniProtKB/Swiss-Prot: TM186_HUMAN, Q96B77
    Similarity: Belongs to the TMEM186 family


    TMEM186 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM186:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM186 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM186

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM186 (TM186)

    Search CenterWatch for drugs/clinical trials and news about TMEM186 / TM186

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM186 gene: 
    NM_015421.3  

    Unigene Cluster for TMEM186:

    Transmembrane protein 186
    Hs.513330  [show with all ESTs]
    Unigene Representative Sequence: AK093383
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564869 ENST00000333050(uc002cze.3)
    miRNA
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM186
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM186
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    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM186
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM186

    Additional mRNA sequence: 

    AK093383.1 AK225638.1 AK314404.1 AL080088.1 BC015912.1 

    3 DOTS entries:

    DT.312086  DT.312087  DT.91745089 

    24/94 AceView cDNA sequences (see all 94):

    CD675781 BC015912 AA621611 CR603758 CA433910 AI870524 BP339316 BX279633 
    BU687159 BE645549 BM979870 AI824644 BE792162 BF793175 BE646278 BM470032 
    BG682191 BX389647 BE465201 CF147413 AI985342 BF002758 AL080088 AW294158 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM186 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGGGTGT
    TMEM186 Expression
    About this image


    See TMEM186 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM186

    SOURCE GeneReport for Unigene cluster: Hs.513330
        SABiosciences Custom PCR Arrays for TMEM186
    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM186

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM186 gene from 5/9 species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1861 , 5 transmembrane protein 1861, 5 74.96(n)1
    71.36(a)1
      16 (4.24 cM)5
    666901  NM_025708.41  NP_079984.21 
     86338845 
    chicken
    (Gallus gallus)
    Aves LOC4166411 transmembrane protein 186-like 51.36(n)
    42.35(a)
      416641  XM_003642109.1  XP_003642157.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1866
    transmembrane protein 186
    33(a)
    1 ↔ 1
    GL343263.1(907400-969610)
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1945391 zgc:194539 51.61(n)
    44.52(a)
      799142  NM_001135984.1  NP_001129456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46276
    --
    27(a)
    1 ↔ 1
    2R(9102211-9103265)


    ENSEMBL Gene Tree for TMEM186 (if available)
    TreeFam Gene Tree for TMEM186 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/34 SNPs in TMEM186 are shown (see all 34)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930831461,2
    --8810990(+) ATCTTG/TGTATG 1 -- int10--------
    rs133366731,2
    C--8811022(+) CACAAT/CAAAAA 1 -- int12Minor allele frequency- C:0.25NA 4
    rs133354841,2
    C--8811034(+) AAAATT/ATTTTT 1 -- int13Minor allele frequency- A:0.00NA WA 6
    rs1114758081,2
    C,F--8811180(+) TGCCAT/CCACGC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1469826301,2
    C--8811238(+) TTAGCA/GAGGAT 1 -- int10--------
    rs1380648991,2
    --8811274(+) CCGCCA/GCCTTG 1 -- int10--------
    rs1875277521,2
    --8811316(+) GCCACC/TGCCCC 1 -- int10--------
    rs133356131,2
    C,F,H--8811334(+) AAAACA/GTTCTT 1 -- int15Minor allele frequency- G:0.04NS EA WA 538
    rs1918203051,2
    --8811357(+) GTGGCA/GAAATA 1 -- int10--------
    rs169644791,2
    C,F,H--8811390(+) TCTTTA/GCTGTG 1 -- int112Minor allele frequency- G:0.21NA NS EA WA CSA 915

    HapMap Linkage Disequilibrium report for TMEM186 (8874241 - 8891505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMEM186:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv819097CNV Loss19587683
    nsv905320CNV Gain21882294
    nsv457394CNV Gain19166990
    dgv2597n71CNV Gain21882294
    nsv905307CNV Gain21882294
    dgv341n27CNV Gain19166990
    nsv457398CNV Gain19166990
    dgv2599n71CNV Gain21882294
    nsv905311CNV Gain21882294
    dgv2598n71CNV Gain21882294

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM186 for disorders           About MalaCards

    TMEM186 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM186
    Human Genome Epidemiology (HuGE) Navigator: TMEM186 (1 document)

    Export disorders for TMEM186 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM186 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM186)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (2001)
    2. Genetic variants in nuclear-encoded mitochondrial gen es influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (2000)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 25880 HGNC: 24530 AceView: DKFZP564K2062 Ensembl:ENSG00000184857 euGenes: HUgn25880
    ECgene: TMEM186 H-InvDB: TMEM186

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM186 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM186 gene:
    Search GeneIP for patents involving TMEM186

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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