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TMEM186 Gene

protein-coding   GIFtS: 43
GCID: GC16M008874

Transmembrane Protein 186

(Previous name: chromosome 16 open reading frame 51)
(Previous symbol: C16orf51)
  Search for TMEM186
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 1861 2
C16orf511 2 3
Chromosome 16 Open Reading Frame 511

External Ids:    HGNC: 245301   Entrez Gene: 258802   Ensembl: ENSG000001848577   UniProtKB: Q96B773   
ORGUL members:         

Export aliases for TMEM186 gene to outside databases

Previous GC identifers: GC16M008798 GC16M008889 GC16M008811


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM186 Gene:
This gene encodes a potential transmembrane protein. (provided by RefSeq, Dec 2012)

GeneCards Summary for TMEM186 Gene:
TMEM186 (transmembrane protein 186) is a protein-coding gene.




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010393.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM186 gene promoter:
         Pax-2   Pax-2a   C/EBPalpha   c-Ets-1   AREB6   HEN1   FOXJ2 (long isoform)   STAT3   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM186 promoter sequence
   Search Chromatin IP Primers for TMEM186

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM186


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16p13.2   Ensembl cytogenetic band:  16p13.2   HGNC cytogenetic band: 16p13.2

TMEM186 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM186 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M008874:  view genomic region     (about GC identifiers)

Start:
8,874,241 bp from pter      End:
8,891,505 bp from pter
Size:
17,265 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TM186_HUMAN, Q96B77 (See protein sequence)
Recommended Name: Transmembrane protein 186  
Size: 213 amino acids; 24893 Da
Secondary accessions: B2RAY0 Q9Y4T4

Explore the universe of human proteins at neXtProt for TMEM186: NX_Q96B77

Explore proteomics data for TMEM186 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys55
  • Modification sites at PhosphoSitePlus

  • See TMEM186 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_056236.2  
    ENSEMBL proteins: 
     ENSP00000331640  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026571 Tmem186

    Graphical View of Domain Structure for InterPro Entry Q96B77

    ProtoNet protein and cluster: Q96B77

    UniProtKB/Swiss-Prot: TM186_HUMAN, Q96B77
    Similarity: Belongs to the TMEM186 family


    TMEM186 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM186:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM186
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM186_HUMAN, Q96B77: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    mitochondrion4
    cytosol2
    cytoskeleton1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005739mitochondrion IDA--
    GO:0016021integral component of membrane IEA--

    TMEM186 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM186
    Interactions:

        Search GeneGlobe Interaction Network for TMEM186

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM186 (TM186)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM186 gene: 
    NM_015421.3  

    Unigene Cluster for TMEM186:

    Transmembrane protein 186
    Hs.513330  [show with all ESTs]
    Unigene Representative Sequence: AK093383
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000564869 ENST00000333050(uc002cze.3)
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    Additional mRNA sequence: 

    AK093383.1 AK225638.1 AK314404.1 AL080088.1 BC015912.1 

    3 DOTS entries:

    DT.312086  DT.312087  DT.91745089 

    Selected AceView cDNA sequences (see all 94):

    BE792162 CD675781 BM979870 BE645549 BP339316 BC015912 AI824644 BF793175 
    AI870524 AA621611 BX279633 BM470032 BE646278 BG682191 CR603758 CA433910 
    BU687159 AI985342 AA883089 BE465201 AI538473 AW003145 AA706193 CF147413 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM186 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGATGGGTGT
    TMEM186 Expression
    About this image

    TMEM186 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM186 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.513330
        Custom PCR Arrays for TMEM186
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM186

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM186 gene from Selected species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1861 , 5 transmembrane protein 1861, 5 74.96(n)1
    71.36(a)1
      16 (4.24 cM)5
    666901  NM_025708.41  NP_079984.21 
     86338845 
    chicken
    (Gallus gallus)
    Aves TMEM1861 transmembrane protein 186 51.36(n)
    42.35(a)
      416641  XM_003642109.2  XP_003642157.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1866
    transmembrane protein 186
    33(a)
    1 ↔ 1
    GL343263.1(907400-969610)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1861 transmembrane protein 186 51.1(n)
    47.9(a)
      100497442  XM_002939439.2  XP_002939485.1 
    zebrafish
    (Danio rerio)
    Actinopterygii zgc:1945391 zgc:194539 51.27(n)
    43.67(a)
      799142  NM_001135984.1  NP_001129456.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG46276
    --
    27(a)
    1 ↔ 1
    2R(9102211-9103265)


    ENSEMBL Gene Tree for TMEM186 (if available)
    TreeFam Gene Tree for TMEM186 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM186 (see all 34)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1930831461,2
    --8810990(+) ATCTTG/TGTATG 1 -- int10--------
    rs133366731,2
    C--8811022(+) CACAAT/CAAAAA 1 -- int12Minor allele frequency- C:0.25NA 4
    rs133354841,2
    C--8811034(+) AAAATT/ATTTTT 1 -- int13Minor allele frequency- A:0.00NA WA 6
    rs1114758081,2
    C,F--8811180(+) TGCCAT/CCACGC 1 -- int11Minor allele frequency- C:0.00WA 2
    rs1469826301,2
    C--8811238(+) TTAGCA/GAGGAT 1 -- int10--------
    rs1380648991,2
    --8811274(+) CCGCCA/GCCTTG 1 -- int10--------
    rs1875277521,2
    --8811316(+) GCCACC/TGCCCC 1 -- int10--------
    rs133356131,2
    C,F,H--8811334(+) AAAACA/GTTCTT 1 -- int15Minor allele frequency- G:0.04NS EA WA 538
    rs1918203051,2
    --8811357(+) GTGGCA/GAAATA 1 -- int10--------
    rs169644791,2
    C,F,H--8811390(+) TCTTTA/GCTGTG 1 -- int112Minor allele frequency- G:0.21NA NS EA WA CSA 915

    HapMap Linkage Disequilibrium report for TMEM186 (8874241 - 8891505 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for TMEM186:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv819097CNV Loss19587683
    nsv905320CNV Gain21882294
    nsv457394CNV Gain19166990
    dgv2597n71CNV Gain21882294
    nsv905307CNV Gain21882294
    dgv341n27CNV Gain19166990
    nsv457398CNV Gain19166990
    dgv2599n71CNV Gain21882294
    nsv905311CNV Gain21882294
    dgv2598n71CNV Gain21882294

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    TMEM186 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM186
    Human Genome Epidemiology (HuGE) Navigator: TMEM186 (1 document)

    Export disorders for TMEM186 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM186 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM186)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)1, 2, 3 Wiemann S.... Poustka A. (Genome Res. 2001)
    2. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PubMed id 20877624)1, 4 Hendrickson S.L....O'Brien S.J. (PLoS ONE 2010)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    6. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    7. Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing. (PubMed id 11256614)1 Simpson J.C.... Wiemann S. (EMBO Rep. 2000)
    8. Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. (PubMed id 8125298)1 Maruyama K. and Sugano S. (Gene 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 25880 HGNC: 24530 AceView: DKFZP564K2062 Ensembl:ENSG00000184857 euGenes: HUgn25880
    ECgene: TMEM186 H-InvDB: TMEM186

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM186 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM186 gene:
    Search GeneIP for patents involving TMEM186

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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