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Aliases for TMEM186 Gene

Aliases for TMEM186 Gene

  • Transmembrane Protein 186 2 3 5
  • C16orf51 3 4
  • Chromosome 16 Open Reading Frame 51 2

External Ids for TMEM186 Gene

Previous HGNC Symbols for TMEM186 Gene

  • C16orf51

Previous GeneCards Identifiers for TMEM186 Gene

  • GC16M008798
  • GC16M008889
  • GC16M008811
  • GC16M008874

Summaries for TMEM186 Gene

Entrez Gene Summary for TMEM186 Gene

  • This gene encodes a potential transmembrane protein. [provided by RefSeq, Dec 2012]

GeneCards Summary for TMEM186 Gene

TMEM186 (Transmembrane Protein 186) is a Protein Coding gene.

No data available for UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM186 Gene

Genomics for TMEM186 Gene

Regulatory Elements for TMEM186 Gene

Enhancers for TMEM186 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM186 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM186 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM186 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM186 Gene

8,780,384 bp from pter
8,797,648 bp from pter
17,265 bases
Minus strand

Genomic View for TMEM186 Gene

Genes around TMEM186 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM186 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM186 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM186 Gene

Proteins for TMEM186 Gene

  • Protein details for TMEM186 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 186
    Protein Accession:
    Secondary Accessions:
    • B2RAY0
    • Q9Y4T4

    Protein attributes for TMEM186 Gene

    213 amino acids
    Molecular mass:
    24893 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM186 Gene

Proteomics data for TMEM186 Gene at MOPED

Post-translational modifications for TMEM186 Gene

  • Ubiquitination at Lys 55
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM186 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM186 Gene

Domains & Families for TMEM186 Gene

Protein Domains for TMEM186 Gene


Suggested Antigen Peptide Sequences for TMEM186 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM186 family.
  • Belongs to the TMEM186 family.
genes like me logo Genes that share domains with TMEM186: view

No data available for Gene Families for TMEM186 Gene

Function for TMEM186 Gene

genes like me logo Genes that share phenotypes with TMEM186: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM186 Gene

Localization for TMEM186 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM186 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM186 Gene COMPARTMENTS Subcellular localization image for TMEM186 gene
Compartment Confidence
mitochondrion 5
cytoskeleton 2
cytosol 2
plasma membrane 2

Gene Ontology (GO) - Cellular Components for TMEM186 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005739 mitochondrion IDA --
genes like me logo Genes that share ontologies with TMEM186: view

Pathways & Interactions for TMEM186 Gene

SuperPathways for TMEM186 Gene

No Data Available

Interacting Proteins for TMEM186 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000331640 for TMEM186 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM186 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM186 Gene

Drugs & Compounds for TMEM186 Gene

No Compound Related Data Available

Transcripts for TMEM186 Gene

mRNA/cDNA for TMEM186 Gene

Unigene Clusters for TMEM186 Gene

Transmembrane protein 186:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM186 Gene

No ASD Table

Relevant External Links for TMEM186 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM186 Gene

mRNA expression in normal human tissues for TMEM186 Gene

Protein differential expression in normal tissues from HIPED for TMEM186 Gene

This gene is overexpressed in Liver (14.8), Rectum (14.3), Frontal cortex (11.3), Testis (10.5), and Pancreas (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM186 Gene

SOURCE GeneReport for Unigene cluster for TMEM186 Gene Hs.513330

genes like me logo Genes that share expression patterns with TMEM186: view

Protein tissue co-expression partners for TMEM186 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM186 Gene

Orthologs for TMEM186 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM186 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM186 35
  • 77.99 (n)
  • 72.64 (a)
TMEM186 36
  • 72 (a)
(Mus musculus)
Mammalia Tmem186 35
  • 74.96 (n)
  • 71.36 (a)
Tmem186 16
Tmem186 36
  • 70 (a)
(Pan troglodytes)
Mammalia TMEM186 35
  • 99.37 (n)
  • 99.53 (a)
TMEM186 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem186 35
  • 77.31 (n)
  • 71.36 (a)
(Monodelphis domestica)
Mammalia TMEM186 36
  • 50 (a)
(Gallus gallus)
Aves TMEM186 35
  • 51.36 (n)
  • 42.35 (a)
TMEM186 36
  • 39 (a)
(Anolis carolinensis)
Reptilia TMEM186 36
  • 33 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem186 35
  • 51.1 (n)
  • 47.9 (a)
(Danio rerio)
Actinopterygii zgc:194539 35
  • 51.27 (n)
  • 43.67 (a)
TMEM186 36
  • 32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG4627 36
  • 27 (a)
Species with no ortholog for TMEM186:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM186 Gene

Gene Tree for TMEM186 (if available)
Gene Tree for TMEM186 (if available)

Paralogs for TMEM186 Gene

No data available for Paralogs for TMEM186 Gene

Variants for TMEM186 Gene

Sequence variations from dbSNP and Humsavar for TMEM186 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1864 -- 8,795,676(+) TGGCA(C/T)AGGTT utr-variant-3-prime
rs12049 -- 8,795,771(-) AGGAA(A/G)AAGGC utr-variant-3-prime
rs13335484 -- 8,794,732(+) AAAAT(A/T)TTTTT downstream-variant-500B
rs13335613 -- 8,795,032(+) AAAAC(A/G)TTCTT downstream-variant-500B
rs13336673 -- 8,794,721(+) CACAA(C/T)AAAAA downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM186 Gene

Variant ID Type Subtype PubMed ID
nsv905307 CNV Gain 21882294
nsv457394 CNV Gain 19166990
dgv341n27 CNV Gain 19166990
dgv2597n71 CNV Gain 21882294
dgv2598n71 CNV Gain 21882294
nsv457398 CNV Gain 19166990
nsv905311 CNV Gain 21882294
dgv2599n71 CNV Gain 21882294
nsv819097 CNV Loss 19587683
nsv905320 CNV Gain 21882294

Variation tolerance for TMEM186 Gene

Residual Variation Intolerance Score: 86.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.94; 19.49% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM186 Gene

Disorders for TMEM186 Gene

Relevant External Links for TMEM186

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM186 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM186 Gene

Publications for TMEM186 Gene

  1. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. TIMMDC1/C3orf1 functions as a membrane-embedded mitochondrial complex I assembly factor through association with the MCIA complex. (PMID: 24344204) Guarani V. … Harper J.W. (Mol. Cell. Biol. 2014) 3
  4. The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease. (PMID: 24705354) Butland S.L. … Hayden M.R. (Hum. Mol. Genet. 2014) 3
  5. Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression. (PMID: 20877624) Hendrickson S.L. … O'Brien S.J. (PLoS ONE 2010) 3

Products for TMEM186 Gene

Sources for TMEM186 Gene