TMEM185B Gene
protein-coding GIFtS: 37
GCID: GC02M120978
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transmembrane protein 185B(Previous names: family with sequence similarity 11, member B, transmembrane...)
(Previous symbol: FAM11B)
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Aliases
for TMEM185B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 185B1 2 | | FLJ209791 | | FAM11B1 2 3 | | Ee3_21 | | Family With Sequence Similarity 11, Member B1 2 | | Putative Transmembrane Protein 185B2 | | Transmembrane Protein 185B (Pseudogene)1 2 | | Protein FAM11B3 |
Export aliases for TMEM185B gene to outside databasesPrevious GC identifers: GC02M120696 GC02M113302 |
Summaries
for TMEM185B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM185B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM185B gene promoter:
Sox5 AML1a NRSF form 1 NRSF form 2 E47 C/EBPalpha Pax-3 E2F-1 E2F LyF-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM185B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM185B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2TMEM185B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M120978: view genomic region
(about GC identifiers)
Start:
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120,978,854 bp from pter |
End:
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120,980,984 bp from pter |
Size:
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2,131 bases |
Orientation:
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minus strand |
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Proteins
for TMEM185B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T185B_HUMAN, Q9H7F4 (See
protein sequence)Recommended Name: Putative transmembrane protein 185B Size: 350 amino acids; 40599 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Caution: Could be the product of a pseudogene
Sequence caution: Sequence=BAB14938.1; Type=Frameshift; Positions=13;
Secondary accessions: A8K1G5 Q53T33 Q66K44 Q8IZ77Explore the universe of human proteins at neXtProt for TMEM185B: NX_Q9H7F4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9H7F4
TMEM185B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_077026.2
ENSEMBL proteins: ENSP00000453399
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM185B for ontologies About GeneDecksing
TMEM185B Antibody Products:
Assay Products for TMEM185B: |
Protein
Domains /
Families
for TMEM185B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM185B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9H7F4ProtoNet protein and cluster: Q9H7F4 UniProtKB/Swiss-Prot: T185B_HUMAN, Q9H7F4Similarity: Belongs to the TMEM185 family |
Function
for TMEM185B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript Custom all cDNA clones Services for TMEM185B | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM185B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM185B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM185B |
|
Pathways & Interactions
for TMEM185B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM185B
1 Interacting protein for TMEM185B (Q9H7F43) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM185B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM185B
Search CenterWatch for drugs/clinical trials and news about TMEM185B / T185B
|
Transcripts
for TMEM185B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM185B gene: NM_024121.2 Unigene Cluster for TMEM185B: Transmembrane protein 185B Hs.376722 [show with all ESTs]Unigene Representative Sequence: NM_0241211 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000426077(uc002tmj.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript Custom all cDNA clones Services for TMEM185B | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM185B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM185B |
Additional cDNA sequence: AF530474.1 AK021716.1 AK024632.1 AK090980.1 AK289880.1 BC016849.1 BC068087.1 BC080607.1 4 DOTS entries: DT.211742 DT.97769564 DT.120990453 DT.92418709 24/151 AceView cDNA sequences (see all 151): AL119878 BM705087 AK021716 BI756067 AI359923 AX746715 CA489867 BQ721728 AW136349 AU118868 BE909235 BU839328 BI832883 BQ018036 BX483342 CR595954 BM556630 AK090980 AA844074 AA255439 AI858971 AI524024 AL597514 BX110007
GeneLoc Exon Structure
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Expression
for TMEM185B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM185B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TAATGGATGT
About this image
Genevestigator expression for TMEM185B
SOURCE GeneReport for Unigene cluster: Hs.376722
SABiosciences Custom PCR Arrays for TMEM185B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM185B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM185B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM185B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM185B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM185B |
Orthologs
for TMEM185B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM185B gene from 3/15 species (see all 15) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
zebrafish
(Danio rerio) |
Actinopterygii |
zgc:635726 |
zgc:63572 |
83(a) |
1 → many |
21(41866409-41879790) |
fruit fly
(Drosophila melanogaster) |
Insecta |
CG141941 |
CG14194 |
57.9(n)
49.68(a) |
|
32908 NM_133132.1 NP_573360.1 |
worm
(Caenorhabditis elegans) |
Secernentea |
Y116A8C.96 |
-- |
31(a) |
1 → many |
IV(16940411-16946821) |
ENSEMBL Gene Tree for TMEM185B (if available)
TreeFam Gene Tree for TMEM185B (if available) |
Paralogs
for TMEM185B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM185B gene
- TMEM185A2
2 SIMAP similar genes for TMEM185B using alignment to 1 protein entry: T185B_HUMAN:TMEM185A FAM11A
TMEM185B for paralogs About GeneDecksing
2 Pseudogenes.org Pseudogenes for TMEM185B
PGOHUM00000235422 PGOHUM00000257277
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Genomic Variants
for TMEM185B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM185B (120978854 - 120980984 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM185B
1 CNV: 4304 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM185B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM185B for disorders About GeneDecksing
1  disease for TMEM185B: About MalaCardsneuronitis
Export disorders for TMEM185B gene to outside databases
|
Publications
for TMEM185B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM185B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM185B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation. (PubMed id 12404111)1, 3 Shaw M.A.... Gecz J. (2002)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- A quantitative atlas of mitotic phosphorylation. (PubMed id 18669648)2 Dephoure N.... Gygi S.P. (2008)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. (PubMed id 15525354)1 Maurer M.H....Schneider A. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
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External Searches for TMEM185B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM185B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM185B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM185B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM185B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM185B gene:
Search GeneIP for patents involving TMEM185B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM185B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM185B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM185B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM185B | | | OriGene Protein Over-expression Lysate for TMEM185B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM185B | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM185B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM185B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM185B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM185B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM185B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM185B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM185B |
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 | | | TMEM185B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM185B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM185B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM185B |
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