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Aliases for TMEM185B Gene

Aliases for TMEM185B Gene

  • Transmembrane Protein 185B 2 3
  • Family With Sequence Similarity 11, Member B 2 3
  • Transmembrane Protein 185B (Pseudogene) 2 3
  • FAM11B 3 4
  • Putative Transmembrane Protein 185B 3
  • Protein FAM11B 4
  • Ee3_2 3

External Ids for TMEM185B Gene

Previous HGNC Symbols for TMEM185B Gene

  • FAM11B

Previous GeneCards Identifiers for TMEM185B Gene

  • GC02M120696
  • GC02M120978
  • GC02M113302

Summaries for TMEM185B Gene

GeneCards Summary for TMEM185B Gene

TMEM185B (Transmembrane Protein 185B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM185B Gene

Genomics for TMEM185B Gene

Regulatory Elements for TMEM185B Gene

Genomic Location for TMEM185B Gene

Start:
120,217,471 bp from pter
End:
120,223,408 bp from pter
Size:
5,938 bases
Orientation:
Minus strand

Genomic View for TMEM185B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM185B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM185B Gene

Proteins for TMEM185B Gene

  • Protein details for TMEM185B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9H7F4-T185B_HUMAN
    Recommended name:
    Transmembrane protein 185B
    Protein Accession:
    Q9H7F4
    Secondary Accessions:
    • A8K1G5
    • Q53T33
    • Q66K44
    • Q8IZ77

    Protein attributes for TMEM185B Gene

    Size:
    350 amino acids
    Molecular mass:
    40599 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB14938.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305};

neXtProt entry for TMEM185B Gene

Proteomics data for TMEM185B Gene at MOPED

Post-translational modifications for TMEM185B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM185B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM185B Gene

Domains for TMEM185B Gene

Protein Domains for TMEM185B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM185B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9H7F4

UniProtKB/Swiss-Prot:

T185B_HUMAN :
  • Q9H7F4
Family:
  • Belongs to the TMEM185 family.
genes like me logo Genes that share domains with TMEM185B: view

No data available for Gene Families for TMEM185B Gene

Function for TMEM185B Gene

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM185B Gene

Localization for TMEM185B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM185B Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM185B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM185B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM185B Gene

Pathways for TMEM185B Gene

SuperPathways for TMEM185B Gene

No Data Available

Interacting Proteins for TMEM185B Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000453399%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000453399 Q9H7F4-T185B_HUMAN for TMEM185B Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM185B Gene

None

No data available for Pathways by source for TMEM185B Gene

Transcripts for TMEM185B Gene

mRNA/cDNA for TMEM185B Gene

(151) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM185B Gene

Transmembrane protein 185B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM185B

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM185B Gene

No ASD Table

Relevant External Links for TMEM185B Gene

GeneLoc Exon Structure for
TMEM185B
ECgene alternative splicing isoforms for
TMEM185B

Expression for TMEM185B Gene

mRNA expression in normal human tissues for TMEM185B Gene

SOURCE GeneReport for Unigene cluster for TMEM185B Gene Hs.376722

genes like me logo Genes that share expressions with TMEM185B: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Expression partners for TMEM185B Gene

Orthologs for TMEM185B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM185B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM185B 35
  • 90.29 (n)
  • 96.86 (a)
TMEM185B 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM185B 35
  • 93.14 (n)
  • 97.14 (a)
TMEM185B 36
  • 97 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem185b 35
  • 88.76 (n)
  • 96 (a)
Tmem185b 16
TMEM185B 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM185B 35
  • 99.81 (n)
  • 100 (a)
rat
(Rattus norvegicus)
Mammalia Tmem185b 35
  • 88.76 (n)
  • 96.29 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 89 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 88 (a)
OneToMany
chicken
(Gallus gallus)
Aves -- 36
  • 88 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 88 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii TMEM185A 36
  • 83 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001144 35
  • 55.49 (n)
  • 48.98 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG14194 35
  • 54.6 (n)
  • 46.26 (a)
CG14194 36
  • 44 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.9 35
  • 49.67 (n)
  • 41.83 (a)
Y116A8C.9 36
  • 31 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.679 36
  • 52 (a)
OneToMany
Species with no ortholog for TMEM185B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM185B Gene

ENSEMBL:
Gene Tree for TMEM185B (if available)
TreeFam:
Gene Tree for TMEM185B (if available)

Paralogs for TMEM185B Gene

Selected SIMAP similar genes for TMEM185B Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for TMEM185B Gene

genes like me logo Genes that share paralogs with TMEM185B: view

No data available for Paralogs for TMEM185B Gene

Variants for TMEM185B Gene

Sequence variations from dbSNP and Humsavar for TMEM185B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs9644 -- 120,221,746(-) GTGTG(A/G)TGTGT utr-variant-3-prime
rs1437421 -- 120,218,255(+) CATGG(A/C)AGACA utr-variant-3-prime
rs1965781 -- 120,220,624(-) gcctc(C/G)cgagt utr-variant-3-prime
rs2018962 -- 120,217,026(+) AGTAT(A/C)TTTGC downstream-variant-500B
rs3820768 -- 120,220,792(+) CACTG(G/T)TCTTA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM185B Gene

Variant ID Type Subtype PubMed ID
nsv834346 CNV Gain 17160897
nsv508164 CNV Loss 20534489

Relevant External Links for TMEM185B Gene

HapMap Linkage Disequilibrium report
TMEM185B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM185B Gene

Disorders for TMEM185B Gene

No disorders were found for TMEM185B Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM185B Gene

Publications for TMEM185B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation. (PMID: 12404111) Shaw M.A. … Gecz J. (Eur. J. Hum. Genet. 2002) 2 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Cloning of a novel neuronally expressed orphan G-protein-coupled receptor which is up-regulated by erythropoietin, interacts with microtubule-associated protein 1b and colocalizes with the 5-hydroxytryptamine 2a receptor. (PMID: 15525354) Maurer M.H. … Schneider A. (J. Neurochem. 2004) 3

Products for TMEM185B Gene

Sources for TMEM185B Gene

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