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Aliases for TMEM185B Gene

Aliases for TMEM185B Gene

  • Transmembrane Protein 185B 2 3 5
  • Family With Sequence Similarity 11, Member B 2 3
  • Transmembrane Protein 185B (Pseudogene) 2 3
  • FAM11B 3 4
  • Putative Transmembrane Protein 185B 3
  • Protein FAM11B 4
  • Ee3_2 3

External Ids for TMEM185B Gene

Previous HGNC Symbols for TMEM185B Gene

  • FAM11B

Previous GeneCards Identifiers for TMEM185B Gene

  • GC02M120696
  • GC02M120978
  • GC02M113302

Summaries for TMEM185B Gene

GeneCards Summary for TMEM185B Gene

TMEM185B (Transmembrane Protein 185B) is a Protein Coding gene. An important paralog of this gene is TMEM185A.

Additional gene information for TMEM185B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM185B Gene

Genomics for TMEM185B Gene

GeneHancer (GH) Regulatory Elements for TMEM185B Gene

Promoters and enhancers for TMEM185B Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH02I120222 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 559.9 +0.1 51 2.2 HDGF CLOCK ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 CBX5 E2F8 TMEM185B PIR50435 RALB
GH02I119541 Promoter/Enhancer 2.2 EPDnew Ensembl ENCODE dbSUPER 10.2 +676.6 676618 10.8 PKNOX1 CLOCK ATF1 ARNT ARID4B SIN3A ZNF48 TCF12 ZNF213 GATA2 CFAP221 SCTR TMEM185B TMEM177 EPB41L5
GH02I120011 Promoter/Enhancer 2 EPDnew Ensembl ENCODE 7.6 +210.2 210163 3.2 PKNOX1 FOXA2 MLX ARID4B SIN3A FEZF1 DMAP1 YY1 ZNF766 ZNF143 EPB41L5 TMEM185B C2orf76 LOC105373582
GH02I120680 Enhancer 0.9 Ensembl ENCODE 10.2 -457.0 -456975 0.7 CTCF USF1 ZSCAN4 RAD21 ZNF143 SMC3 ZNF444 ZNF600 CREM ZNF654 TMEM185B GC02M120601 GC02P120694
GH02I120251 Promoter/Enhancer 2.5 EPDnew FANTOM5 Ensembl ENCODE dbSUPER 3.1 -29.8 -29814 3.4 HDGF PKNOX1 SMAD1 ZFP64 ARID4B SIN3A FEZF1 ZNF2 YY1 POLR2B RALB C2orf76 GLI2 MTND4P26 TMEM185B LOC105373583 PIR31138
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM185B on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM185B gene promoter:

Genomic Locations for TMEM185B Gene

Genomic Locations for TMEM185B Gene
5,938 bases
Minus strand

Genomic View for TMEM185B Gene

Genes around TMEM185B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM185B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM185B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM185B Gene

Proteins for TMEM185B Gene

  • Protein details for TMEM185B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 185B
    Protein Accession:
    Secondary Accessions:
    • A8K1G5
    • Q53T33
    • Q66K44
    • Q8IZ77

    Protein attributes for TMEM185B Gene

    350 amino acids
    Molecular mass:
    40599 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAB14938.1; Type=Frameshift; Positions=13; Evidence={ECO:0000305};

neXtProt entry for TMEM185B Gene

Post-translational modifications for TMEM185B Gene

No Post-translational modifications

Other Protein References for TMEM185B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM185B Gene

Domains & Families for TMEM185B Gene

Gene Families for TMEM185B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM185B Gene


Suggested Antigen Peptide Sequences for TMEM185B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM185 family.
  • Belongs to the TMEM185 family.
genes like me logo Genes that share domains with TMEM185B: view

Function for TMEM185B Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM185B Gene

Localization for TMEM185B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM185B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Endoplasmic reticulum (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM185B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM185B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM185B Gene

Pathways & Interactions for TMEM185B Gene

SuperPathways for TMEM185B Gene

No Data Available

Interacting Proteins for TMEM185B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: Q9H7F4-T185B_HUMAN ENSP00000453399 for TMEM185B Gene via IID STRING

Gene Ontology (GO) - Biological Process for TMEM185B Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM185B Gene

Drugs & Compounds for TMEM185B Gene

No Compound Related Data Available

Transcripts for TMEM185B Gene

mRNA/cDNA for TMEM185B Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(151) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM185B Gene

Transmembrane protein 185B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM185B Gene

No ASD Table

Relevant External Links for TMEM185B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM185B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM185B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM185B Gene:


SOURCE GeneReport for Unigene cluster for TMEM185B Gene:


Evidence on tissue expression from TISSUES for TMEM185B Gene

  • Intestine(4)
  • Skin(4)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM185B: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM185B Gene

Orthologs for TMEM185B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM185B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM185B 33
  • 99.81 (n)
(Mus musculus)
Mammalia TMEM185B 34
  • 96 (a)
Tmem185b 33 16
  • 88.76 (n)
(Canis familiaris)
Mammalia TMEM185B 33 34
  • 93.14 (n)
(Bos Taurus)
Mammalia TMEM185B 33 34
  • 90.29 (n)
(Monodelphis domestica)
Mammalia -- 34
  • 89 (a)
(Rattus norvegicus)
Mammalia Tmem185b 33
  • 88.76 (n)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 88 (a)
(Gallus gallus)
Aves -- 34
  • 88 (a)
(Anolis carolinensis)
Reptilia -- 34
  • 88 (a)
(Danio rerio)
Actinopterygii TMEM185A 34
  • 83 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001144 33
  • 55.49 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG14194 33 34
  • 54.6 (n)
(Caenorhabditis elegans)
Secernentea CELE_Y116A8C.9 33
  • 49.67 (n)
Y116A8C.9 34
  • 31 (a)
sea squirt
(Ciona savignyi)
Ascidiacea CSA.679 34
  • 52 (a)
Species where no ortholog for TMEM185B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for TMEM185B Gene

Gene Tree for TMEM185B (if available)
Gene Tree for TMEM185B (if available)

Paralogs for TMEM185B Gene

Paralogs for TMEM185B Gene

(2) SIMAP similar genes for TMEM185B Gene using alignment to 1 proteins: Pseudogenes for TMEM185B Gene

genes like me logo Genes that share paralogs with TMEM185B: view

Variants for TMEM185B Gene

Sequence variations from dbSNP and Humsavar for TMEM185B Gene

SNP ID Clin Chr 02 pos Variation AA Info Type
rs1000077232 -- 120,217,557(-) A/G/T 3_prime_UTR_variant
rs1000362276 -- 120,222,706(-) G/A coding_sequence_variant, missense_variant
rs1000921415 -- 120,220,969(-) A/C 3_prime_UTR_variant
rs1001340313 -- 120,223,436(-) T/C upstream_transcript_variant
rs1001871285 -- 120,218,970(-) A/G 3_prime_UTR_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM185B Gene

Variant ID Type Subtype PubMed ID
nsv1000477 CNV gain 25217958
nsv508164 CNV deletion 20534489
nsv834346 CNV gain 17160897

Variation tolerance for TMEM185B Gene

Gene Damage Index Score: 1.40; 27.63% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM185B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM185B Gene

Disorders for TMEM185B Gene

Additional Disease Information for TMEM185B

No disorders were found for TMEM185B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM185B Gene

Publications for TMEM185B Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. A novel gene, FAM11A, associated with the FRAXF CpG island is transcriptionally silent in FRAXF full mutation. (PMID: 12404111) Shaw MA … Gécz J (European journal of human genetics : EJHG 2002) 2 3 58
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 58
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 58

Products for TMEM185B Gene

Sources for TMEM185B Gene

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