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Aliases for TMEM184C Gene

Aliases for TMEM184C Gene

  • Transmembrane Protein 184C 2 3 5
  • Transmembrane Protein 34 2 3 4
  • TMEM34 3 4

External Ids for TMEM184C Gene

Previous HGNC Symbols for TMEM184C Gene

  • TMEM34

Previous GeneCards Identifiers for TMEM184C Gene

  • GC04P148760
  • GC04P148538
  • GC04P144265

Summaries for TMEM184C Gene

GeneCards Summary for TMEM184C Gene

TMEM184C (Transmembrane Protein 184C) is a Protein Coding gene. An important paralog of this gene is TMEM184B.

UniProtKB/Swiss-Prot for TMEM184C Gene

  • Possible tumor suppressor which may play a role in cell growth.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184C Gene

Genomics for TMEM184C Gene

Regulatory Elements for TMEM184C Gene

Enhancers for TMEM184C Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04G147590 0.9 Ensembl ENCODE 20.8 -27.0 -26971 0.4 CTCF ZNF654 TEAD4 TRIM22 ZNF384 REST RAD21 FOXK2 SMC3 TMEM184C LINC02507 ENSG00000251298
GH04G147596 0.7 ENCODE 22.5 -19.9 -19932 1.2 BHLHE40 MAX CEBPB MNT EP300 JUND ZNF316 ELK1 RCOR1 FOS TMEM184C ENSG00000251298 LINC02507
GH04G148006 1.2 Ensembl ENCODE 11.9 +390.5 390515 2.0 PKNOX1 INSM2 KLF17 SIN3A GATA2 ZNF366 SMARCC2 RCOR1 FOS CREM TMEM184C GC04M148018 RFPL4AP4
GH04G147581 0.6 ENCODE 13.7 -35.3 -35290 1.8 ELK4 SRF TAF1 TAL1 CEBPB EP300 TCF12 NCOR1 NFE2L2 TMEM184C LINC02507 ENSG00000251298
GH04G147599 0.6 ENCODE 8.9 -17.4 -17372 1.0 BHLHE40 MAFG CEBPB MNT NFE2 MAFK NFE2L2 TMEM184C ENSG00000251298 LINC02507
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM184C on UCSC Golden Path with GeneCards custom track

Promoters for TMEM184C Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000174441 330 1800 HDGF PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 FOS SP3 NFYC

Genomic Location for TMEM184C Gene

Chromosome:
4
Start:
147,617,371 bp from pter
End:
147,672,044 bp from pter
Size:
54,674 bases
Orientation:
Plus strand

Genomic View for TMEM184C Gene

Genes around TMEM184C on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184C Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184C Gene

Proteins for TMEM184C Gene

  • Protein details for TMEM184C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVA4-T184C_HUMAN
    Recommended name:
    Transmembrane protein 184C
    Protein Accession:
    Q9NVA4
    Secondary Accessions:
    • D3DP04
    • Q86X84
    • Q969I7
    • Q9NXM2

    Protein attributes for TMEM184C Gene

    Size:
    438 amino acids
    Molecular mass:
    50142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK55526.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM184C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM184C Gene

Post-translational modifications for TMEM184C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM184C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM184C Gene

Domains & Families for TMEM184C Gene

Protein Domains for TMEM184C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM184C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVA4

UniProtKB/Swiss-Prot:

T184C_HUMAN :
  • Belongs to the TMEM184 family.
Family:
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184C: view

No data available for Gene Families for TMEM184C Gene

Function for TMEM184C Gene

Molecular function for TMEM184C Gene

UniProtKB/Swiss-Prot Function:
Possible tumor suppressor which may play a role in cell growth.

Gene Ontology (GO) - Molecular Function for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

Phenotypes for TMEM184C Gene

GenomeRNAi human phenotypes for TMEM184C:
genes like me logo Genes that share phenotypes with TMEM184C: view

Animal Model Products

CRISPR Products

miRNA for TMEM184C Gene

miRTarBase miRNAs that target TMEM184C

Inhibitory RNA Products

Clone Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM184C Gene

Localization for TMEM184C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184C gene
Compartment Confidence
plasma membrane 3
nucleus 2
endosome 1

Gene Ontology (GO) - Cellular Components for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA,IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

Pathways & Interactions for TMEM184C Gene

SuperPathways for TMEM184C Gene

No Data Available

Interacting Proteins for TMEM184C Gene

Gene Ontology (GO) - Biological Process for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with TMEM184C: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184C Gene

Drugs & Compounds for TMEM184C Gene

No Compound Related Data Available

Transcripts for TMEM184C Gene

mRNA/cDNA for TMEM184C Gene

Unigene Clusters for TMEM184C Gene

Transmembrane protein 184C:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184C Gene

No ASD Table

Relevant External Links for TMEM184C Gene

GeneLoc Exon Structure for
TMEM184C
ECgene alternative splicing isoforms for
TMEM184C

Expression for TMEM184C Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM184C Gene

Protein differential expression in normal tissues from HIPED for TMEM184C Gene

This gene is overexpressed in Kidney (21.0), Liver (16.6), and Fetal Brain (6.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM184C Gene



Protein tissue co-expression partners for TMEM184C Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM184C Gene:

TMEM184C

SOURCE GeneReport for Unigene cluster for TMEM184C Gene:

Hs.203896

mRNA Expression by UniProt/SwissProt for TMEM184C Gene:

Q9NVA4-T184C_HUMAN
Tissue specificity: Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.

Evidence on tissue expression from TISSUES for TMEM184C Gene

  • Intestine(4.2)
  • Lung(4.2)
  • Thyroid gland(2)
  • Nervous system(2)
genes like me logo Genes that share expression patterns with TMEM184C: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184C Gene

Orthologs for TMEM184C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM184C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM184C 34 35
  • 97.49 (n)
dog
(Canis familiaris)
Mammalia TMEM184C 34 35
  • 92.77 (n)
cow
(Bos Taurus)
Mammalia TMEM184C 34
  • 90.87 (n)
TMEM34 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM184C 35
  • 83 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem184c 34
  • 76.31 (n)
mouse
(Mus musculus)
Mammalia Tmem184c 34 16 35
  • 75.84 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM184C 35
  • 75 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM184C 34 35
  • 78.29 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM184C 35
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184c 34
  • 73.47 (n)
Str.14637 34
zebrafish
(Danio rerio)
Actinopterygii tmem184c 34 35
  • 70.99 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008048 34
  • 51.52 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5850 34 35
  • 51 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 23 (a)
OneToMany
-- 37
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23070 34
  • 46.78 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 44 (a)
OneToOne
Species where no ortholog for TMEM184C was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM184C Gene

ENSEMBL:
Gene Tree for TMEM184C (if available)
TreeFam:
Gene Tree for TMEM184C (if available)

Paralogs for TMEM184C Gene

Paralogs for TMEM184C Gene

(2) SIMAP similar genes for TMEM184C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMEM184C Gene

genes like me logo Genes that share paralogs with TMEM184C: view

Variants for TMEM184C Gene

Sequence variations from dbSNP and Humsavar for TMEM184C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000551635 -- 147,632,079(+) AAGGC(-/AGG)AGAAT intron-variant
rs1000622543 -- 147,630,103(+) AAAAA(C/T)GTGAG intron-variant
rs1000883621 -- 147,636,543(+) GAAAA(G/T)TTCCT nc-transcript-variant, utr-variant-3-prime
rs1000899940 -- 147,632,401(+) TCAGT(A/G)GTATA intron-variant
rs1000938354 -- 147,637,633(+) GGATA(C/T)GTTAA intron-variant, downstream-variant-500B, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM184C Gene

Variant ID Type Subtype PubMed ID
nsv1019205 CNV loss 25217958
nsv1146650 CNV deletion 26484159
nsv830110 CNV loss 17160897

Variation tolerance for TMEM184C Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.25; 5.49% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM184C Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM184C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184C Gene

Disorders for TMEM184C Gene

Relevant External Links for TMEM184C

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM184C

No disorders were found for TMEM184C Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184C Gene

Publications for TMEM184C Gene

  1. Down-regulation of an inhibitor of cell growth, transmembrane protein 34 (TMEM34), in anaplastic thyroid cancer. (PMID: 17072649) Akaishi J. … Shimizu K. (J. Cancer Res. Clin. Oncol. 2007) 3 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 3 4 64
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3 64
  5. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64

Products for TMEM184C Gene

Sources for TMEM184C Gene

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