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Aliases for TMEM184C Gene

Aliases for TMEM184C Gene

  • Transmembrane Protein 184C 2 3
  • Transmembrane Protein 34 2 3 4
  • TMEM34 3 4 6

External Ids for TMEM184C Gene

Previous Symbols for TMEM184C Gene

  • TMEM34

Summaries for TMEM184C Gene

GeneCards Summary for TMEM184C Gene

TMEM184C (Transmembrane Protein 184C) is a Protein Coding gene. An important paralog of this gene is TMEM184B.

UniProtKB/Swiss-Prot for TMEM184C Gene

  • Possible tumor suppressor which may play a role in cell growth.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184C Gene

Genomics for TMEM184C Gene

Genomic Location for TMEM184C Gene

Start:
147,617,383 bp from pter
End:
147,672,044 bp from pter
Size:
54,662 bases
Orientation:
Plus strand

Genomic View for TMEM184C Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM184C Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184C Gene

Regulatory Elements for TMEM184C Gene

Proteins for TMEM184C Gene

  • Protein details for TMEM184C Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NVA4-T184C_HUMAN
    Recommended name:
    Transmembrane protein 184C
    Protein Accession:
    Q9NVA4
    Secondary Accessions:
    • D3DP04
    • Q86X84
    • Q969I7
    • Q9NXM2

    Protein attributes for TMEM184C Gene

    Size:
    438 amino acids
    Molecular mass:
    50142 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAK55526.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAA90988.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM184C Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM184C Gene

Proteomics data for TMEM184C Gene at MOPED

Post-translational modifications for TMEM184C Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM184C Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM184C Gene

Domains for TMEM184C Gene

Protein Domains for TMEM184C Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM184C Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NVA4

UniProtKB/Swiss-Prot:

T184C_HUMAN
Family:
  • Belongs to the TMEM184 family.:
    • Q9NVA4
genes like me logo Genes that share domains with TMEM184C: view

No data available for Gene Families for TMEM184C Gene

Function for TMEM184C Gene

Molecular function for TMEM184C Gene

UniProtKB/Swiss-Prot Function: Possible tumor suppressor which may play a role in cell growth.

miRNA for TMEM184C Gene

miRTarBase miRNAs that target TMEM184C

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM184C Gene

Localization for TMEM184C Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184C Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM184C Gene COMPARTMENTS Subcellular localization image for TMEM184C gene
Compartment Confidence
plasma membrane 3
cytosol 1

Gene Ontology (GO) - Cellular Components for TMEM184C Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM184C: view

Pathways for TMEM184C Gene

SuperPathways for TMEM184C Gene

No Data Available

Interacting Proteins for TMEM184C Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 11)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296582%0d%0a9606.ENSP00000297290%0d%0a9606.ENSP00000175091%0d%0a9606.ENSP00000366306%0d%0a9606.ENSP00000288670%0d%0a9606.ENSP00000335655%0d%0a
Selected Interacting proteins: ENSP00000296582 Q9NVA4-T184C_HUMAN for TMEM184C Gene via STRING I2D

Gene Ontology (GO) - Biological Process for TMEM184C Gene

None

No data available for Pathways by source for TMEM184C Gene

Transcripts for TMEM184C Gene

mRNA/cDNA for TMEM184C Gene

Unigene Clusters for TMEM184C Gene

Transmembrane protein 184C:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184C Gene

No ASD Table

Relevant External Links for TMEM184C Gene

GeneLoc Exon Structure for
TMEM184C
ECgene alternative splicing isoforms for
TMEM184C

Expression for TMEM184C Gene

mRNA expression in normal human tissues for TMEM184C Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM184C Gene

SOURCE GeneReport for Unigene cluster for TMEM184C Gene Hs.203896

mRNA Expression by UniProt/SwissProt for TMEM184C Gene

Q9NVA4-T184C_HUMAN
Tissue specificity: Widely expressed with higher expression in lung, kidney, spleen, pancreas, thymus, prostate, testis, ovary, small intestine and thyroid.
genes like me logo Genes that share expressions with TMEM184C: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for TMEM184C Gene

Orthologs for TMEM184C Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM184C Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM184C 35
  • 97.49 (n)
  • 96.58 (a)
TMEM184C 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM184C 35
  • 90.87 (n)
  • 93.15 (a)
TMEM34 36
  • 87 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM184C 35
  • 92.77 (n)
  • 95.89 (a)
TMEM184C 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem184c 35
  • 75.84 (n)
  • 79.25 (a)
Tmem184c 16
Tmem184c 36
  • 55 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM184C 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM184C 36
  • 75 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem184c 35
  • 76.31 (n)
  • 80 (a)
chicken
(Gallus gallus)
Aves TMEM184C 35
  • 78.29 (n)
  • 85.58 (a)
TMEM184C 36
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM184C 36
  • 82 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.14637 35
tmem184c 35
  • 73.47 (n)
  • 78.65 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem184c 35
  • 70.99 (n)
  • 79.3 (a)
tmem184c 36
  • 72 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP008048 35
  • 51.52 (n)
  • 49.72 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5850 35
  • 51 (n)
  • 45.45 (a)
CG5850 36
  • 34 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 23 (a)
OneToMany
-- 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G23070 35
  • 46.78 (n)
  • 34.8 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 44 (a)
OneToOne
Species with no ortholog for TMEM184C:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM184C Gene

ENSEMBL:
Gene Tree for TMEM184C (if available)
TreeFam:
Gene Tree for TMEM184C (if available)

Paralogs for TMEM184C Gene

Paralogs for TMEM184C Gene

Selected SIMAP similar genes for TMEM184C Gene using alignment to 2 proteins:

Pseudogenes.org Pseudogenes for TMEM184C Gene

genes like me logo Genes that share paralogs with TMEM184C: view

Variants for TMEM184C Gene

Sequence variations from dbSNP and Humsavar for TMEM184C Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs1129239 -- 147,634,996(+) gaatt(A/G)caggc utr-variant-3-prime
rs1503862 -- 147,624,460(-) ACTCA(C/T)ATTAG intron-variant
rs1503863 -- 147,624,274(-) AATAT(A/C)ACATT intron-variant
rs2036499 -- 147,616,159(-) tgcag(G/T)ggctc upstream-variant-2KB
rs2036500 -- 147,616,040(-) aaaaa(A/T)ttagc upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM184C Gene

Variant ID Type Subtype PubMed ID
nsv830110 CNV Loss 17160897

Relevant External Links for TMEM184C Gene

HapMap Linkage Disequilibrium report
TMEM184C

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184C Gene

Disorders for TMEM184C Gene

(1) University of Copenhagen DISEASES for TMEM184C Gene

genes like me logo Genes that share disorders with TMEM184C: view

No data available for UniProtKB/Swiss-Prot for TMEM184C Gene

Publications for TMEM184C Gene

  1. Down-regulation of an inhibitor of cell growth, transmembrane protein 34 (TMEM34), in anaplastic thyroid cancer. (PMID: 17072649) Akaishi J. … Shimizu K. (J. Cancer Res. Clin. Oncol. 2007) 3 4 23
  2. Gene expression profiling in human fetal liver and identification of tissue- and developmental-stage-specific genes through compiled expression profiles and efficient cloning of full-length cDNAs. (PMID: 11483580) Yu Y. … He F. (Genome Res. 2001) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Toward an understanding of the protein interaction network of the human liver. (PMID: 21988832) Wang J. … Yang X. (Mol. Syst. Biol. 2011) 3

Products for TMEM184C Gene

Sources for TMEM184C Gene

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