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Aliases for TMEM184B Gene

Aliases for TMEM184B Gene

  • Transmembrane Protein 184B 2 3
  • Putative MAPK-Activating Protein FM08 3 4
  • C22orf5 3 4
  • Chromosome 22 Open Reading Frame 5 2
  • HS5O6A 3
  • FM08 3

External Ids for TMEM184B Gene

Previous Symbols for TMEM184B Gene

  • C22orf5

Summaries for TMEM184B Gene

GeneCards Summary for TMEM184B Gene

TMEM184B (Transmembrane Protein 184B) is a Protein Coding gene. An important paralog of this gene is TMEM184C.

UniProtKB/Swiss-Prot for TMEM184B Gene

  • May activate the MAP kinase signaling pathway.

Gene Wiki entry for TMEM184B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184B Gene

Genomics for TMEM184B Gene

Genomic Location for TMEM184B Gene

Start:
38,216,597 bp from pter
End:
38,273,034 bp from pter
Size:
56,438 bases
Orientation:
Minus strand

Genomic View for TMEM184B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM184B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184B Gene

Regulatory Elements for TMEM184B Gene

Proteins for TMEM184B Gene

  • Protein details for TMEM184B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y519-T184B_HUMAN
    Recommended name:
    Transmembrane protein 184B
    Protein Accession:
    Q9Y519
    Secondary Accessions:
    • A8K9D7
    • Q63HM8
    • Q7Z421
    • Q8NBM5
    • Q9UGT8
    • Q9UGT9
    • Q9UGV5

    Protein attributes for TMEM184B Gene

    Size:
    407 amino acids
    Molecular mass:
    45562 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB51403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM184B Gene

Proteomics data for TMEM184B Gene at MOPED

Post-translational modifications for TMEM184B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM184B Gene

No data available for DME Specific Peptides for TMEM184B Gene

Domains for TMEM184B Gene

Protein Domains for TMEM184B Gene

UniProtKB/Swiss-Prot:

T184B_HUMAN
Family:
  • Belongs to the TMEM184 family.:
    • Q9Y519
genes like me logo Genes that share domains with TMEM184B: view

No data available for Gene Families for TMEM184B Gene

Function for TMEM184B Gene

Molecular function for TMEM184B Gene

UniProtKB/Swiss-Prot Function: May activate the MAP kinase signaling pathway.

Phenotypes for TMEM184B Gene

GenomeRNAi human phenotypes for TMEM184B:
genes like me logo Genes that share phenotypes with TMEM184B: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM184B Gene

Localization for TMEM184B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM184B Gene COMPARTMENTS Subcellular localization image for TMEM184B gene
Compartment Confidence
plasma membrane 3
cytosol 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM184B: view

Pathways for TMEM184B Gene

SuperPathways for TMEM184B Gene

No Data Available

Interacting Proteins for TMEM184B Gene

Gene Ontology (GO) - Biological Process for TMEM184B Gene

None

No data available for Pathways by source for TMEM184B Gene

Transcripts for TMEM184B Gene

Unigene Clusters for TMEM184B Gene

Transmembrane protein 184B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8: - - -
SP9:
SP10: -
SP11:

Relevant External Links for TMEM184B Gene

GeneLoc Exon Structure for
TMEM184B
ECgene alternative splicing isoforms for
TMEM184B

Expression for TMEM184B Gene

mRNA expression in normal human tissues for TMEM184B Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM184B Gene

SOURCE GeneReport for Unigene cluster for TMEM184B Gene Hs.182626

genes like me logo Genes that share expressions with TMEM184B: view

Orthologs for TMEM184B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM184B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM184B 36
  • 99.43 (n)
  • 99.26 (a)
TMEM184B 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM184B 36
  • 94.51 (n)
  • 99.02 (a)
TMEM184B 37
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM184B 36
  • 92.79 (n)
  • 98.03 (a)
TMEM184B 37
  • 98 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem184b 36
  • 91.07 (n)
  • 96.07 (a)
Tmem184b 16
Tmem184b 37
  • 96 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM184B 37
  • 91 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 37
  • 95 (a)
OneToMany
-- 37
  • 90 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem184b 36
  • 90.83 (n)
  • 95.82 (a)
chicken
(Gallus gallus)
Aves TMEM184B 36
  • 83.62 (n)
  • 91.65 (a)
TMEM184B 37
  • 87 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM184B 37
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.15225 36
tmem184b 36
  • 78.62 (n)
  • 88.13 (a)
zebrafish
(Danio rerio)
Actinopterygii TMEM184B (2 of 3) 37
  • 75 (a)
OneToMany
tmem184ba 36
  • 77.84 (n)
  • 85.05 (a)
tmem184ba 37
  • 78 (a)
OneToMany
tmem184bb 37
  • 78 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006101 36
  • 66.95 (n)
  • 67.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12004 36
  • 66.41 (n)
  • 66.33 (a)
CG12004 37
  • 50 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F40E10.6 36
  • 61.11 (n)
  • 62.57 (a)
F40E10.6 37
  • 56 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 61 (a)
OneToMany
Species with no ortholog for TMEM184B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM184B Gene

ENSEMBL:
Gene Tree for TMEM184B (if available)
TreeFam:
Gene Tree for TMEM184B (if available)

Paralogs for TMEM184B Gene

Paralogs for TMEM184B Gene

Selected SIMAP similar genes for TMEM184B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM184B: view

Variants for TMEM184B Gene

Sequence variations from dbSNP and Humsavar for TMEM184B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type MAF
rs84308 -- 38,263,829(-) agact(C/G)catct intron-variant
rs135704 -- 38,225,312(+) GCTGA(-/G)GCCCC intron-variant
rs135705 -- 38,228,504(+) ggctg(-/G)acatc intron-variant
rs135706 -- 38,229,398(+) TCTCT(A/C)GAGAG intron-variant
rs135707 -- 38,231,076(+) GGCCC(-/C)TCCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM184B Gene

Variant ID Type Subtype PubMed ID
nsv834194 CNV Loss 17160897
nsv915060 CNV Loss 21882294
esv2724225 CNV Deletion 23290073
esv2670091 CNV Deletion 23128226
esv2673581 CNV Deletion 23128226
esv2724226 CNV Deletion 23290073
esv2724227 CNV Deletion 23290073
nsv915061 CNV Loss 21882294
esv2659372 CNV Deletion 23128226

Relevant External Links for TMEM184B Gene

HapMap Linkage Disequilibrium report
TMEM184B

Disorders for TMEM184B Gene

No disorders were found for TMEM184B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM184B Gene

Publications for TMEM184B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4
  2. Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways. (PMID: 12761501) Matsuda A. … Sugano S. (Oncogene 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4

Products for TMEM184B Gene

Sources for TMEM184B Gene

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