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Aliases for TMEM184B Gene

Aliases for TMEM184B Gene

  • Transmembrane Protein 184B 2 3 5
  • Putative MAPK-Activating Protein FM08 3 4
  • C22orf5 3 4
  • Chromosome 22 Open Reading Frame 5 2
  • HSPC256 3
  • HS5O6A 3
  • FM08 3

External Ids for TMEM184B Gene

Previous HGNC Symbols for TMEM184B Gene

  • C22orf5

Previous GeneCards Identifiers for TMEM184B Gene

  • GC22M036945
  • GC22M038615
  • GC22M021581
  • GC22M038396
  • GC22M038520

Summaries for TMEM184B Gene

GeneCards Summary for TMEM184B Gene

TMEM184B (Transmembrane Protein 184B) is a Protein Coding gene. An important paralog of this gene is TMEM184C.

UniProtKB/Swiss-Prot for TMEM184B Gene

  • May activate the MAP kinase signaling pathway.

Gene Wiki entry for TMEM184B Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184B Gene

Genomics for TMEM184B Gene

Regulatory Elements for TMEM184B Gene

Enhancers for TMEM184B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM184B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM184B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM184B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM184B Gene

38,216,377 bp from pter
38,273,034 bp from pter
56,658 bases
Minus strand

Genomic View for TMEM184B Gene

Genes around TMEM184B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184B Gene

Proteins for TMEM184B Gene

  • Protein details for TMEM184B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 184B
    Protein Accession:
    Secondary Accessions:
    • A8K9D7
    • Q63HM8
    • Q7Z421
    • Q8NBM5
    • Q9UGT8
    • Q9UGT9
    • Q9UGV5

    Protein attributes for TMEM184B Gene

    407 amino acids
    Molecular mass:
    45562 Da
    Quaternary structure:
    No Data Available
    • Sequence=BAC11607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB51403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM184B Gene

Proteomics data for TMEM184B Gene at MOPED

Post-translational modifications for TMEM184B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM184B Gene

Antibody Products

No data available for DME Specific Peptides for TMEM184B Gene

Domains & Families for TMEM184B Gene

Protein Domains for TMEM184B Gene

Suggested Antigen Peptide Sequences for TMEM184B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM184 family.
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184B: view

No data available for Gene Families for TMEM184B Gene

Function for TMEM184B Gene

Molecular function for TMEM184B Gene

UniProtKB/Swiss-Prot Function:
May activate the MAP kinase signaling pathway.

Phenotypes for TMEM184B Gene

genes like me logo Genes that share phenotypes with TMEM184B: view

Animal Models for TMEM184B Gene

MGI Knock Outs for TMEM184B:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM184B

CRISPR Products

Inhibitory RNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM184B Gene

Localization for TMEM184B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM184B Gene COMPARTMENTS Subcellular localization image for TMEM184B gene
Compartment Confidence
plasma membrane 3
cytosol 2
golgi apparatus 2
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM184B Gene

Pathways & Interactions for TMEM184B Gene

SuperPathways for TMEM184B Gene

No Data Available

Interacting Proteins for TMEM184B Gene

Gene Ontology (GO) - Biological Process for TMEM184B Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM184B Gene

Drugs & Compounds for TMEM184B Gene

No Compound Related Data Available

Transcripts for TMEM184B Gene

Unigene Clusters for TMEM184B Gene

Transmembrane protein 184B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8: - - -
SP10: -

Relevant External Links for TMEM184B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM184B Gene

mRNA expression in normal human tissues for TMEM184B Gene

Protein differential expression in normal tissues from HIPED for TMEM184B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM184B Gene

SOURCE GeneReport for Unigene cluster for TMEM184B Gene Hs.182626

genes like me logo Genes that share expression patterns with TMEM184B: view

Protein tissue co-expression partners for TMEM184B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM184B Gene

Orthologs for TMEM184B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM184B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM184B 35
  • 94.51 (n)
  • 99.02 (a)
TMEM184B 36
  • 99 (a)
(Canis familiaris)
Mammalia TMEM184B 35
  • 92.79 (n)
  • 98.03 (a)
TMEM184B 36
  • 98 (a)
(Mus musculus)
Mammalia Tmem184b 35
  • 91.07 (n)
  • 96.07 (a)
Tmem184b 16
Tmem184b 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM184B 35
  • 99.43 (n)
  • 99.26 (a)
TMEM184B 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem184b 35
  • 90.83 (n)
  • 95.82 (a)
(Monodelphis domestica)
Mammalia TMEM184B 36
  • 91 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 95 (a)
-- 36
  • 90 (a)
(Gallus gallus)
Aves TMEM184B 35
  • 83.62 (n)
  • 91.65 (a)
TMEM184B 36
  • 87 (a)
(Anolis carolinensis)
Reptilia TMEM184B 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184b 35
  • 78.62 (n)
  • 88.13 (a)
Str.15225 35
(Danio rerio)
Actinopterygii tmem184ba 35
  • 77.84 (n)
  • 85.05 (a)
TMEM184B (2 of 3) 36
  • 75 (a)
tmem184ba 36
  • 78 (a)
tmem184bb 36
  • 78 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006101 35
  • 66.95 (n)
  • 67.32 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12004 35
  • 66.41 (n)
  • 66.33 (a)
CG12004 36
  • 50 (a)
(Caenorhabditis elegans)
Secernentea F40E10.6 35
  • 61.11 (n)
  • 62.57 (a)
F40E10.6 36
  • 56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 36
  • 21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 61 (a)
Species with no ortholog for TMEM184B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM184B Gene

Gene Tree for TMEM184B (if available)
Gene Tree for TMEM184B (if available)

Paralogs for TMEM184B Gene

Paralogs for TMEM184B Gene

(2) SIMAP similar genes for TMEM184B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM184B: view

Variants for TMEM184B Gene

Sequence variations from dbSNP and Humsavar for TMEM184B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs84308 -- 38,263,829(-) agact(C/G)catct intron-variant
rs2092076 -- 38,241,670(+) acaag(A/G)tcagg intron-variant
rs2092077 -- 38,241,802(+) tggcg(C/T)gaacc intron-variant
rs2235187 -- 38,226,591(+) CACTC(A/C)GGGGC intron-variant
rs2235265 -- 38,221,326(+) GGAAG(C/T)GACAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM184B Gene

Variant ID Type Subtype PubMed ID
nsv834194 CNV Loss 17160897
nsv915060 CNV Loss 21882294
esv2724225 CNV Deletion 23290073
esv2670091 CNV Deletion 23128226
esv2673581 CNV Deletion 23128226
esv2724226 CNV Deletion 23290073
esv2724227 CNV Deletion 23290073
nsv915061 CNV Loss 21882294
esv2659372 CNV Deletion 23128226

Variation tolerance for TMEM184B Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM184B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184B Gene

Disorders for TMEM184B Gene

Relevant External Links for TMEM184B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM184B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184B Gene

Publications for TMEM184B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. MicroRNA expression signature of oral squamous cell carcinoma: functional role of microRNA-26a/b in the modulation of novel cancer pathways. (PMID: 25668004) Fukumoto I. … Seki N. (Br. J. Cancer 2015) 3
  4. Genome-wide association study identifies multiple loci associated with both mammographic density and breast cancer risk. (PMID: 25342443) LindstrAPm S. … Tamimi R.M. (Nat Commun 2014) 3
  5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3

Products for TMEM184B Gene

Sources for TMEM184B Gene