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Aliases for TMEM184B Gene

Aliases for TMEM184B Gene

  • Transmembrane Protein 184B 2 3 5
  • Putative MAPK-Activating Protein FM08 3 4
  • C22orf5 3 4
  • Chromosome 22 Open Reading Frame 5 2
  • HSPC256 3
  • HS5O6A 3
  • FM08 3

External Ids for TMEM184B Gene

Previous HGNC Symbols for TMEM184B Gene

  • C22orf5

Previous GeneCards Identifiers for TMEM184B Gene

  • GC22M036945
  • GC22M038615
  • GC22M021581
  • GC22M038396
  • GC22M038520
  • GC22M038830
  • GC22M039968
  • GC22M040658

Summaries for TMEM184B Gene

GeneCards Summary for TMEM184B Gene

TMEM184B (Transmembrane Protein 184B) is a Protein Coding gene. An important paralog of this gene is TMEM184A.

UniProtKB/Swiss-Prot for TMEM184B Gene

  • May activate the MAP kinase signaling pathway.

Gene Wiki entry for TMEM184B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184B Gene

Genomics for TMEM184B Gene

Regulatory Elements for TMEM184B Gene

Enhancers for TMEM184B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G038174 1.8 FANTOM5 ENCODE dbSUPER 23.6 +94.2 94226 8.7 MLX CREB3L1 DMAP1 YBX1 YY1 SLC30A9 ZNF143 ZNF263 SP3 MCM3 MAFF TMEM184B PLA2G6 ENSG00000230149 CBX6 ENSG00000273076 NPTXR ENSG00000272669 ENSG00000225450 APOBEC3D
GH22G038227 1.6 FANTOM5 Ensembl ENCODE dbSUPER 24.4 +43.5 43496 4.2 FOXA2 ZNF48 RAD21 RARA GATA2 FOS ZNF654 REST ETV4 RCOR2 TMEM184B MAFF PICK1 GTPBP1 JOSD1 CSNK1E ENSG00000235246 GC22P038220
GH22G038217 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.2 +53.6 53563 3.8 FOXA2 AGO1 ZFP64 ARID4B DMAP1 ZNF2 ZNF48 GATA2 FOS ZNF263 TMEM184B BAIAP2L2 MAFF CSNK1E MICALL1 GC22P038220 PLA2G6
GH22G038147 1.3 FANTOM5 Ensembl ENCODE 22.7 +125.0 124992 1.5 JUN ZMYM3 MAX RAD21 YY1 EED FOS ETV6 JUND PRDM6 PLA2G6 TMEM184B MAFF BAIAP2L2 DDX17 ENSG00000279080 GC22P038194
GH22G038309 1.8 FANTOM5 ENCODE dbSUPER 12.7 -41.2 -41203 11.9 MLX CREB3L1 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TMEM184B PICK1 MAFF KCNJ4 KDELR3 SOX10 POLR2F PDXP GGA1 SUN2
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM184B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM184B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000146155 234 1201 CREB3L1 SIN3A ZNF2 ZBTB40 ZNF121 GLIS2 EGR1 EGR2 SP3 YY2

Genomic Location for TMEM184B Gene

Chromosome:
22
Start:
38,216,377 bp from pter
End:
38,273,034 bp from pter
Size:
56,658 bases
Orientation:
Minus strand

Genomic View for TMEM184B Gene

Genes around TMEM184B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184B Gene

Proteins for TMEM184B Gene

  • Protein details for TMEM184B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9Y519-T184B_HUMAN
    Recommended name:
    Transmembrane protein 184B
    Protein Accession:
    Q9Y519
    Secondary Accessions:
    • A8K9D7
    • Q63HM8
    • Q7Z421
    • Q8NBM5
    • Q9UGT8
    • Q9UGT9
    • Q9UGV5

    Protein attributes for TMEM184B Gene

    Size:
    407 amino acids
    Molecular mass:
    45562 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC11607.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAB51403.1; Type=Erroneous initiation; Evidence={ECO:0000305};

neXtProt entry for TMEM184B Gene

Post-translational modifications for TMEM184B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM184B Gene

Domains & Families for TMEM184B Gene

Protein Domains for TMEM184B Gene

Suggested Antigen Peptide Sequences for TMEM184B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9Y519

UniProtKB/Swiss-Prot:

T184B_HUMAN :
  • Belongs to the TMEM184 family.
Family:
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184B: view

No data available for Gene Families for TMEM184B Gene

Function for TMEM184B Gene

Molecular function for TMEM184B Gene

UniProtKB/Swiss-Prot Function:
May activate the MAP kinase signaling pathway.

Gene Ontology (GO) - Molecular Function for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
genes like me logo Genes that share ontologies with TMEM184B: view
genes like me logo Genes that share phenotypes with TMEM184B: view

Animal Models for TMEM184B Gene

MGI Knock Outs for TMEM184B:

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM184B

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM184B Gene

Localization for TMEM184B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184B gene
Compartment Confidence
plasma membrane 3
nucleus 2
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with TMEM184B: view

Pathways & Interactions for TMEM184B Gene

SuperPathways for TMEM184B Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM184B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with TMEM184B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184B Gene

Drugs & Compounds for TMEM184B Gene

No Compound Related Data Available

Transcripts for TMEM184B Gene

Unigene Clusters for TMEM184B Gene

Transmembrane protein 184B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184B Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6 ^ 7a · 7b · 7c · 7d ^ 8 ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b · 13c
SP1: - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - -
SP4: - -
SP5: - - -
SP6: -
SP7: - - - - - - - -
SP8: - - -
SP9:
SP10: -
SP11:

Relevant External Links for TMEM184B Gene

GeneLoc Exon Structure for
TMEM184B
ECgene alternative splicing isoforms for
TMEM184B

Expression for TMEM184B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM184B Gene

Protein differential expression in normal tissues from HIPED for TMEM184B Gene

This gene is overexpressed in Retina (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM184B Gene



Protein tissue co-expression partners for TMEM184B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM184B Gene:

TMEM184B

SOURCE GeneReport for Unigene cluster for TMEM184B Gene:

Hs.182626

Evidence on tissue expression from TISSUES for TMEM184B Gene

  • Lung(4.5)
  • Pancreas(4.5)
  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM184B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184B Gene

Orthologs for TMEM184B Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for TMEM184B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM184B 34 35
  • 99.43 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 95 (a)
OneToMany
-- 35
  • 90 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM184B 34 35
  • 94.51 (n)
dog
(Canis familiaris)
Mammalia TMEM184B 34 35
  • 92.79 (n)
mouse
(Mus musculus)
Mammalia Tmem184b 34 16 35
  • 91.07 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM184B 35
  • 91 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem184b 34
  • 90.83 (n)
chicken
(Gallus gallus)
Aves TMEM184B 34 35
  • 83.62 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM184B 35
  • 87 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184b 34
  • 78.62 (n)
Str.15225 34
zebrafish
(Danio rerio)
Actinopterygii tmem184bb 35
  • 78 (a)
OneToMany
tmem184ba 34 35
  • 77.84 (n)
TMEM184B (2 of 3) 35
  • 75 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006101 34
  • 66.95 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12004 34 35
  • 66.41 (n)
worm
(Caenorhabditis elegans)
Secernentea F40E10.6 34 35
  • 61.11 (n)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 35
  • 21 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 61 (a)
OneToMany
Species where no ortholog for TMEM184B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM184B Gene

ENSEMBL:
Gene Tree for TMEM184B (if available)
TreeFam:
Gene Tree for TMEM184B (if available)

Paralogs for TMEM184B Gene

Paralogs for TMEM184B Gene

(2) SIMAP similar genes for TMEM184B Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM184B: view

Variants for TMEM184B Gene

Sequence variations from dbSNP and Humsavar for TMEM184B Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000024834 -- 38,262,727(+) GGGTC(A/G)TATTT intron-variant
rs1000031938 -- 38,268,858(+) CGGCT(C/T)CCCGC intron-variant
rs1000055199 -- 38,267,534(+) TTCAG(A/G)CAATT intron-variant
rs1000066553 -- 38,240,524(+) TCCAG(A/G)AAGGG intron-variant
rs1000083960 -- 38,268,585(+) GAGAT(A/G)GCATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM184B Gene

Variant ID Type Subtype PubMed ID
esv2659372 CNV deletion 23128226
esv2670091 CNV deletion 23128226
esv2673581 CNV deletion 23128226
esv2724225 CNV deletion 23290073
esv2724226 CNV deletion 23290073
esv2724227 CNV deletion 23290073
esv3647725 CNV loss 21293372
nsv1136676 CNV deletion 24896259
nsv1136677 CNV deletion 24896259
nsv834194 CNV loss 17160897

Variation tolerance for TMEM184B Gene

Residual Variation Intolerance Score: 14.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.81; 17.08% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM184B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM184B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184B Gene

Disorders for TMEM184B Gene

Relevant External Links for TMEM184B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM184B

No disorders were found for TMEM184B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184B Gene

Publications for TMEM184B Gene

  1. The DNA sequence of human chromosome 22. (PMID: 10591208) Dunham I. … Wright H. (Nature 1999) 2 3 4 64
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. A genome annotation-driven approach to cloning the human ORFeome. (PMID: 15461802) Collins J.E. … Dunham I. (Genome Biol. 2004) 3 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64

Products for TMEM184B Gene

Sources for TMEM184B Gene

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