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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM184A Gene

protein-coding GIFtS: 43
GCID: GC07M001581

transmembrane protein 184A

Search for TMEM184A
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 184A¹ ²
MGC9712¹

External Ids:	HGNC: 28797¹	Entrez Gene: 202915²	Ensembl: ENSG00000164855⁷	UniProtKB: Q6ZMB5³

Export aliases for TMEM184A gene to outside databases

Previous GC identifers: GC07M001551 GC07M001502

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007819.17 NT_079592.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM184A gene promoter:
NF-1 NF-1/L RP58 AML1a Lmo2 LUN-1 GATA-1 E47 C/EBPalpha HEN1
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

Search SABiosciences Chromatin IP Primers for TMEM184A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM184A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7p22.3 Ensembl cytogenetic band: 7p22.3 HGNC cytogenetic band: 7p22.3

TMEM184A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM184A gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M001581: view genomic region (about GC identifiers)

Start:	1,581,871 bp from pter	End:	1,600,457 bp from pter
Size:	18,587 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 1,634,279-1,648,474

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T184A_HUMAN, Q6ZMB5 (See protein sequence)

Recommended Name: Transmembrane protein 184A

Size: 413 amino acids; 45777 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Sequence caution: Sequence=BAC86522.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice

sites;

Secondary accessions: Q8TBQ6

Explore the universe of human proteins at neXtProt for TMEM184A: NX_Q6ZMB5

TMEM184A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001091089.1

ENSEMBL proteins:

ENSP00000297477 ENSP00000326348 ENSP00000325945 ENSP00000413955 ENSP00000398382

ENSP00000389092 ENSP00000403499

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	Uscn Proteins for TMEM184A

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0031901	early endosome membrane	IEA	--

TMEM184A for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for TMEM184A

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM184A for domains About GeneDecksing

1 InterPro domain/family:

IPR005178 Ost-alpha

Graphical View of Domain Structure for InterPro Entry Q6ZMB5

ProtoNet protein and cluster: Q6ZMB5

UniProtKB/Swiss-Prot: T184A_HUMAN, Q6ZMB5

Similarity: Belongs to the TMEM184 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Phenotypes:
1 GenomeRNAi human phenotype for TMEM184A:

Synthetic lethal with Ras

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM184A

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM184A

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM184A

STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

2 Interacting proteins for TMEM184A (ENSP00000297477⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
RCHY1	ENSP00000321239⁴	STRING: ENSP00000321239
BRI3	ENSP00000297290⁴	STRING: ENSP00000297290

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0018992	germ-line sex determination	IEA	--
GO:0032880	regulation of protein localization	IEA	--
GO:0051046	regulation of secretion	IEA	--

TMEM184A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM184A
Search CenterWatch for drugs/clinical trials and news about TMEM184A / T184A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM184A gene (2 alternative transcripts):

NM_152689.2 NM_001097620.1

Unigene Clusters for TMEM184A:

Transmembrane protein 184A

Hs.592174 [show with all ESTs], Hs.707784 [show with all ESTs]

Unigene Representative Sequences: NM_001097620, AK096817

9 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000297477(uc021zyr.1 uc003skv.4) ENST00000319018 ENST00000468535(uc003skt.4)

ENST00000319010 ENST00000474813 ENST00000421923 ENST00000414730 ENST00000441933

ENST00000431208

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM184A
		8/26 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM184A (see all 26):
		hsa-miR-3164 hsa-miR-3607-3p hsa-miR-361-5p hsa-miR-137 hsa-miR-139-5p hsa-miR-134 hsa-miR-944 hsa-miR-218

		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM184A (see all 4) OriGene shRNA RFP: TMEM184A OriGene siRNA: TMEM184A
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM184A
		Sirion Biotech Custom design and validation of potent shRNA sequences against TMEM184A

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Additional cDNA sequence: AK096817.1

10 DOTS entries:

DT.205124 DT.95111972 DT.92018390 DT.100778227 DT.100021884 DT.100778226 DT.97804110 DT.121047911

DT.121047933 DT.121047953

24/92 AceView cDNA sequences (see all 92):

AK172850 AI433334 BX400812 BE463570 AA401191 BX356596 AK096790 CR625853

AW007808 BU860188 AI700369 AI655084 BU542430 BG742913 BM792078 BQ900132

CA488237 BM981655 BM706421 BE910472 AK075043 AI742321 BU680045 BU538554

GeneLoc Exon Structure

5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184A (see all 11) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	·	7c	^	8	^	9a	·	9b	^	10a	·	10b	^	11	^	12	^	13a	·	13b	^	14a	·	14b	·
SP1:							-		-																				-		-		-
SP2:							-		-																				-
SP3:							-		-												-		-						-		-		-
SP4:																					-		-						-		-		-
SP5:							-		-

ExUns:	14c
SP1:
SP2:
SP3:
SP4:
SP5:

ECgene alternative splicing isoforms for TMEM184A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM184A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ATAAAAAGCA

About this image

TMEM184A expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

4 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Ovary

Ovary

Testis

Testis

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM184A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM184A

SOURCE GeneReport for Unigene clusters: Hs.592174 Hs.707784

SABiosciences Custom PCR Arrays for TMEM184A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM184A gene from 7/24 species (see all 24) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	TMEM184A¹	transmembrane protein 184A	77.13(n) 75.77(a)		769655 XM_001232942.2 XP_001232943.2
lizard (Anolis carolinensis)	Reptilia	TMEM184A⁶	--	72(a)	1 ↔ 1	GL343327.1(899323-907087)
zebrafish (Danio rerio)	Actinopterygii	wufi16g03²	Danio rerio cDNA clone MGC66481 IMAGE2601364, complete cds less	78.19(n)		BC057539.1
fruit fly (Drosophila melanogaster)	Insecta	CG12004⁶	--	47(a)	1 → many	3L(1569181-1575620)
worm (Caenorhabditis elegans)	Secernentea	F40E10.6⁶	--	51(a)	1 → many	X(14703645-14706789)
thale cress (Arabidopsis thaliana)	eudicotyledons	AT5G26740¹	hypothetical protein	51.12(n) 46.01(a)		832714 NM_203107.2 NP_974836.1
rice (Oryza sativa)	Liliopsida	Os07g0244300¹	hypothetical protein	50.6(n) 41.64(a)		4342821 NM_001065813.1 NP_001059278.1

ENSEMBL Gene Tree for TMEM184A (if available)
TreeFam Gene Tree for TMEM184A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM184A gene

TMEM184C² TMEM184B²

3 SIMAP similar genes for TMEM184A using alignment to 7 protein entries: T184A_HUMAN (see all proteins):

TMEM184B DKFZp686N1150 TMEM184C

TMEM184A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs138639771^1,2		--	1583273(+)	`CAACTC/GGAGTT`	1	--	ut3¹		0	--	--	--	--
rs892523^1,2	C,F,A,H	--	1583288(+)	`GAGACG/AGTATC`	1	--	ut3¹		22		NS EA NA WA CSA	2348
rs185132635^1,2		--	1583340(+)	`GTTCAC/GTGCAG`	1	--	ut3¹		0	--	--	--	--
rs190782142^1,2		--	1583469(+)	`TCACCA/GTGTTG`	1	--	ut3¹		0	--	--	--	--
rs149197894^1,2		--	1583562(+)	`CTGCA-/CCCGAT`	1	--	ut3¹		0	--	--	--	--
rs181863199^1,2		--	1583564(+)	`GCACCC/TGATCA`	1	--	ut3¹		0	--	--	--	--
rs114619432^1,2		--	1583583(+)	`ACTCGC/AAGCAT`	1	--	ut3¹		1		WA	118
rs112718544^1,2	C	--	1583606(+)	`GGGCCA/C/GGTTCC`	2	--	ut3¹		2		CSA NA	121
rs4268033^1,2	C,F,A,H	--	1583673(+)	`GGCACG/ATAGCG`	1	--	ut3¹		21		NS EA NA WA CSA	2338
rs76082160^1,2	C,F	--	1583788(+)	`CCCTGC/TGGCTC`	1	--	ut3¹		1		WA	118

HapMap Linkage Disequilibrium report for TMEM184A (1581871 - 1600457 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TMEM184A
5 CNVs: 4521 3660 30251 4522 30252

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM184A

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM184A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM184A)

Utopia: connect your pdf to the dynamic
world of online information

Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (2002)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (2003)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 202915	HGNC: 28797	AceView: MGC9712	Ensembl:ENSG00000164855	euGenes: HUgn202915
ECgene: TMEM184A	H-InvDB: TMEM184A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM184A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM184A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM184A gene:
Search GeneIP for patents involving TMEM184A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section


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	OriGene Antibodies for TMEM184A		OriGene shRNA RFP for TMEM184A
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	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM184A
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ThermoFisher Antibodies for TMEM184A

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM184A

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for TMEM184A

Sirion Biotech Customized:

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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 13 May 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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TMEM184A Gene

transmembrane protein 184A

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TMEM184A Gene

transmembrane protein 184A

Aliasesfor TMEM184A gene

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Genomic Viewsfor TMEM184A gene

Proteinsfor TMEM184A gene

Protein Domains /Familiesfor TMEM184A gene

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for TMEM184A gene

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for TMEM184A gene

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for TMEM184A gene

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for TMEM184A gene

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for TMEM184A gene

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