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Aliases for TMEM184A Gene

Aliases for TMEM184A Gene

  • Transmembrane Protein 184A 2 3 5
  • Sexually Dimorphic, Expressed In Male Gonads 1 2 3
  • SDMG1 3

External Ids for TMEM184A Gene

Previous GeneCards Identifiers for TMEM184A Gene

  • GC07M001551
  • GC07M001502
  • GC07M001581

Summaries for TMEM184A Gene

GeneCards Summary for TMEM184A Gene

TMEM184A (Transmembrane Protein 184A) is a Protein Coding gene. An important paralog of this gene is TMEM184B.

UniProtKB/Swiss-Prot for TMEM184A Gene

  • Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).

Additional gene information for TMEM184A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM184A Gene

Genomics for TMEM184A Gene

Regulatory Elements for TMEM184A Gene

Enhancers for TMEM184A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H001512 1.9 FANTOM5 Ensembl ENCODE dbSUPER 16.8 +45.5 45511 6 PKNOX1 ATF1 FOXA2 ARID4B ZNF121 FOS SP5 MIER2 REST PPARG INTS1 TMEM184A MAFK MICALL2 ZFAND2A ENSG00000231927
GH07H001529 1.8 FANTOM5 ENCODE dbSUPER 16.6 +26.0 26009 10 HDGF PKNOX1 FOXA2 ZFP64 ARID4B SIN3A DMAP1 ZBTB7B YY1 SLC30A9 INTS1 TMEM184A MAFK ZFAND2A PSMG3-AS1 LOC100128653
GH07H001553 1.6 Ensembl ENCODE dbSUPER 14.2 +3.3 3299 7 FOXA2 PKNOX1 MLX ARID4B SIN3A DMAP1 ZBTB7B YY1 ZNF143 FOS TMEM184A INTS1 PSMG3-AS1 MICALL2 PIR48186
GH07H001510 1.4 FANTOM5 Ensembl ENCODE dbSUPER 12.2 +49.7 49704 1 POLR2A MAX NR2F6 MYC GABPA INTS1 TMEM184A MRM2 ENSG00000231927 MAFK
GH07H001548 0.7 dbSUPER 17.9 +12.0 11995 1 CTCF MAX MNT REST PAX8 NR3C1 ZEB2 CC2D1A CTBP1 POLR2A TMEM184A PIR48186
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM184A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM184A Gene

Chromosome:
7
Start:
1,542,235 bp from pter
End:
1,560,821 bp from pter
Size:
18,587 bases
Orientation:
Minus strand

Genomic View for TMEM184A Gene

Genes around TMEM184A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM184A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM184A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM184A Gene

Proteins for TMEM184A Gene

  • Protein details for TMEM184A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZMB5-T184A_HUMAN
    Recommended name:
    Transmembrane protein 184A
    Protein Accession:
    Q6ZMB5
    Secondary Accessions:
    • Q8TBQ6

    Protein attributes for TMEM184A Gene

    Size:
    413 amino acids
    Molecular mass:
    45777 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAC86522.2; Type=Miscellaneous discrepancy; Note=Probable cloning artifact. Aberrant splice sites.; Evidence={ECO:0000305};

neXtProt entry for TMEM184A Gene

Post-translational modifications for TMEM184A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM184A Gene

Domains & Families for TMEM184A Gene

Gene Families for TMEM184A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM184A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM184A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZMB5

UniProtKB/Swiss-Prot:

T184A_HUMAN :
  • Belongs to the TMEM184 family.
Family:
  • Belongs to the TMEM184 family.
genes like me logo Genes that share domains with TMEM184A: view

Function for TMEM184A Gene

Molecular function for TMEM184A Gene

UniProtKB/Swiss-Prot Function:
Acts as a heparin receptor in vascular cells (By similarity). May be involved in vesicle transport in exocrine cells and Sertoli cells (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005215 transporter activity IBA --
GO:0008201 heparin binding ISS --
genes like me logo Genes that share ontologies with TMEM184A: view

Phenotypes for TMEM184A Gene

GenomeRNAi human phenotypes for TMEM184A:
genes like me logo Genes that share phenotypes with TMEM184A: view

Animal Model Products

CRISPR Products

miRNA for TMEM184A Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM184A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM184A Gene

Localization for TMEM184A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM184A Gene

Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cytoplasmic vesicle membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein. Endosome. Cytoplasmic vesicle, secretory vesicle membrane.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM184A gene
Compartment Confidence
plasma membrane 5
endosome 4
nucleus 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005768 endosome ISS --
GO:0005886 plasma membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IBA,IEA --
genes like me logo Genes that share ontologies with TMEM184A: view

Pathways & Interactions for TMEM184A Gene

SuperPathways for TMEM184A Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM184A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006810 transport IBA --
genes like me logo Genes that share ontologies with TMEM184A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM184A Gene

Drugs & Compounds for TMEM184A Gene

No Compound Related Data Available

Transcripts for TMEM184A Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM184A
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM184A Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8 ^ 9a · 9b ^ 10a · 10b ^ 11 ^ 12 ^ 13a · 13b ^ 14a · 14b ·
SP1: - - - - -
SP2: - - -
SP3: - - - - - - -
SP4: - - - - -
SP5: - -
SP6: -
SP7: -
SP8:
SP9:
SP10:
SP11: - -

ExUns: 14c
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:
SP11:

Relevant External Links for TMEM184A Gene

GeneLoc Exon Structure for
TMEM184A
ECgene alternative splicing isoforms for
TMEM184A

Expression for TMEM184A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM184A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM184A Gene

This gene is overexpressed in Esophagus - Mucosa (x11.7), Vagina (x4.4), and Skin - Not Sun Exposed (Suprapubic) (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM184A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM184A Gene



Protein tissue co-expression partners for TMEM184A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM184A Gene:

TMEM184A

SOURCE GeneReport for Unigene cluster for TMEM184A Gene:

Hs.592174

mRNA Expression by UniProt/SwissProt for TMEM184A Gene:

Q6ZMB5-T184A_HUMAN
Tissue specificity: Expressed in vascular cells (at protein level).

Evidence on tissue expression from TISSUES for TMEM184A Gene

  • Intestine(4.3)
genes like me logo Genes that share expression patterns with TMEM184A: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM184A Gene

Orthologs for TMEM184A Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for TMEM184A Gene

Organism Taxonomy Gene Similarity Type Details
dog
(Canis familiaris)
Mammalia TMEM184A 33 34
  • 87.73 (n)
cow
(Bos Taurus)
Mammalia TMEM184A 33 34
  • 85.53 (n)
mouse
(Mus musculus)
Mammalia Tmem184a 33 16
  • 81.47 (n)
Gm26938 34
  • 54 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem184a 33
  • 81.15 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM184A 34
  • 68 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM184A 34
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM184A 33 34
  • 79.18 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM184A 34
  • 65 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem184a 33
  • 70.15 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem184a 33 34
  • 72.6 (n)
wufi16g03 33
fruit fly
(Drosophila melanogaster)
Insecta CG12004 34
  • 46 (a)
OneToMany
worm
(Caenorhabditis elegans)
Secernentea F40E10.6 34
  • 51 (a)
OneToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 34
  • 21 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons AT5G26740 33
  • 50.77 (n)
rice
(Oryza sativa)
Liliopsida Os07g0244300 33
  • 50.83 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 58 (a)
OneToMany
Species where no ortholog for TMEM184A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM184A Gene

ENSEMBL:
Gene Tree for TMEM184A (if available)
TreeFam:
Gene Tree for TMEM184A (if available)

Paralogs for TMEM184A Gene

Paralogs for TMEM184A Gene

(3) SIMAP similar genes for TMEM184A Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with TMEM184A: view

Variants for TMEM184A Gene

Sequence variations from dbSNP and Humsavar for TMEM184A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000028094 -- 1,552,429(+) GAGGA(C/T)ATGTA intron-variant
rs1000036040 -- 1,544,148(+) CCCAC(C/T)CTGCG nc-transcript-variant, utr-variant-3-prime
rs1000142168 -- 1,558,410(+) ATGTC(A/G)CCCTC intron-variant, upstream-variant-2KB
rs1000162679 -- 1,555,513(+) ACCGG(A/G)AGGAG intron-variant
rs1000278337 -- 1,555,673(+) GCCAT(C/T)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM184A Gene

Variant ID Type Subtype PubMed ID
dgv11135n54 CNV loss 21841781
dgv11136n54 CNV loss 21841781
esv2733773 CNV deletion 23290073
esv2759499 CNV loss 17122850
esv3891010 CNV loss 25118596
nsv464247 CNV loss 19166990
nsv471182 CNV loss 18288195
nsv482100 CNV gain 20164927
nsv5615 CNV deletion 18451855
nsv605819 CNV loss 21841781
nsv605820 CNV loss 21841781
nsv605824 CNV loss 21841781
nsv823970 CNV gain 20364138
nsv823974 CNV loss 20364138
nsv823975 CNV loss 20364138
nsv823977 CNV gain 20364138
nsv830879 CNV gain+loss 17160897
nsv830880 CNV loss 17160897
nsv950786 CNV deletion 24416366

Variation tolerance for TMEM184A Gene

Residual Variation Intolerance Score: 98.2% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 5.14; 69.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM184A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM184A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM184A Gene

Disorders for TMEM184A Gene

Relevant External Links for TMEM184A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM184A

No disorders were found for TMEM184A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM184A Gene

Publications for TMEM184A Gene

  1. Sdmg1 is a conserved transmembrane protein associated with germ cell sex determination and germline-soma interactions in mice. (PMID: 18321981) Best D … Adams IR (Development (Cambridge, England) 2008) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  4. Transmembrane Protein 184A Is a Receptor Required for Vascular Smooth Muscle Cell Responses to Heparin. (PMID: 26769966) Pugh RJ … Lowe-Krentz LJ (The Journal of biological chemistry 2016) 4 60
  5. Heparin Decreases in Tumor Necrosis Factor α (TNFα)-induced Endothelial Stress Responses Require Transmembrane Protein 184A and Induction of Dual Specificity Phosphatase 1. (PMID: 26769965) Farwell SL … Lowe-Krentz LJ (The Journal of biological chemistry 2016) 3 60

Products for TMEM184A Gene

Sources for TMEM184A Gene

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