TMEM183B Gene
protein-coding GIFtS: 33
GCID: GC03M149700
|
|
transmembrane protein 183B
| |
Aliases
for TMEM183B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 183B1 2 | | C1orf37-DUP1 2 | | C1orf37-Dup1 |
Export aliases for TMEM183B gene to outside databasesPrevious GC identifers: GC03M151184 GC03M147072 |
Summaries
for TMEM183B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMEM183B:
This locus was thought to represent a pseudogene of chromosome 1 open reading frame 37 because it is intronless andretains a polyA tail at the 3' end. It does however contain a complete open reading frame that subsequent research hasdemonstrated to be transcribed in a limited number of human tissues. The encoded protein may represent a transmembraneprotein associated with cell membranes and be involved in cell-cell or cell-environment interactions. (provided byRefSeq, Jul 2010)
|
Genomic Views
for TMEM183B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000003.11 NC_018914.1 NT_005612.16
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM183B gene promoter:
SRF Sox5 AML1a p53 SRF (504 AA) HNF-4alpha2 Nkx2-5 HNF-4alpha1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM183B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM183B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 3q25.1 Ensembl cytogenetic band: 3q25.1 HGNC cytogenetic band: 3q25.1TMEM183B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 3 GeneLoc Exon Structure GeneLoc location for GC03M149700: view genomic region
(about GC identifiers)
Start:
|
149,699,448 bp from pter |
End:
|
149,701,153 bp from pter |
Size:
|
1,706 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM183B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T183B_HUMAN, Q1AE95 (See
protein sequence)Recommended Name: Transmembrane protein 183B Size: 376 amino acids; 42940 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Miscellaneous: The chimpanzee orthologous protein does not exist, this gene was derived from TMEM183A throughretroposition after the divergence of human and chimpanzee
Secondary accessions: Q1AE97Explore the universe of human proteins at neXtProt for TMEM183B: NX_Q1AE95
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q1AE95
TMEM183B Protein expression data from MOPED and PaxDb: --
REFSEQ proteins: NP_001073277.1
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM183B for ontologies About GeneDecksing
TMEM183B Antibody Products:
Assay Products for TMEM183B: |
Protein
Domains /
Families
for TMEM183B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM183B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q1AE95ProtoNet protein and cluster: Q1AE95 UniProtKB/Swiss-Prot: T183B_HUMAN, Q1AE95Similarity: Belongs to the TMEM183 family |
Function
for TMEM183B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM183B (NM_001079809) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM183B | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM183B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183B |
|
Pathways & Interactions
for TMEM183B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM183B
|
Drugs & Compounds
for TMEM183B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM183B
Search CenterWatch for drugs/clinical trials and news about TMEM183B / T183B
|
Transcripts
for TMEM183B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM183B gene: NM_001079809.1 Unigene Cluster for TMEM183B: Transmembrane protein 183B Hs.652908 [show with all ESTs]Unigene Representative Sequence: NM_0010798092 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000463122 ENST00000438359
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM183B (NM_001079809) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM183B | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM183B |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM183B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM183B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM183B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM183B |
Additional cDNA sequence: AK297222.1 7 DOTS entries: DT.95244466 DT.91765304 DT.95251238 DT.100826132 DT.102827191 DT.100826123 DT.121417567
GeneLoc Exon Structure
|
Expression
for TMEM183B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM183B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTCAGGT
About this image
Genevestigator expression for TMEM183B
SOURCE GeneReport for Unigene cluster: Hs.652908
UniProtKB/Swiss-Prot: T183B_HUMAN, Q1AE95Tissue specificity: Expressed in brain, lung, pancreas, thymus, intestine and blood. Not detected in heart, placenta,liver, muscle, kidney, spleen, prostate, testis, ovary and colon
SABiosciences Custom PCR Arrays for TMEM183B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM183B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse / rat TMEM183B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM183B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM183B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183B |
Orthologs
for TMEM183B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
--
ENSEMBL Gene Tree for TMEM183B (if available)
TreeFam Gene Tree for TMEM183B (if available) |
Paralogs
for TMEM183B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM183B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 3 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM183B (149699448 - 149701153 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM183B: -- | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM183B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM183B for disorders About GeneDecksing
OMIM gene information: 611365
OMIM disorders: --
1  disease for TMEM183B: About MalaCardsprostatitis
Export disorders for TMEM183B gene to outside databases
|
Publications
for TMEM183B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM183B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM183B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. (PubMed id 16644869)1, 2, 3 Yu H.... Wang W. (2006)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
|
External Searches for TMEM183B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM183B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM183B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM183B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM183B | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM183B gene:
Search GeneIP for patents involving TMEM183B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM183B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM183B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM183B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM183B | | | OriGene Protein Over-expression Lysate for TMEM183B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM183B | | OriGene 3'-UTR Clone for TMEM183B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM183B | | OriGene Custom Protein Services for TMEM183B | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM183B | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM183B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM183B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM183B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM183B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM183B |
| |
 |  |  |  | |
| | | |  |  |  |  | | | | |
 |
 |
 |
 | | | TMEM183B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM183B |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM183B |
|
|
|
|
