TMEM183A Gene
protein-coding GIFtS: 40
GCID: GC01P202976
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transmembrane protein 183A(Previous name: chromosome 1 open reading frame 37 )
(Previous symbol: C1orf37)
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Aliases
for TMEM183A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 183A1 2 | | C1orf371 2 3 | | Chromosome 1 Open Reading Frame 371 |
Export aliases for TMEM183A gene to outside databasesPrevious GC identifer: GC01P201245 |
Summaries
for TMEM183A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM183A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM183A gene promoter:
SRF p53 SRF (504 AA) CUTL1 Nkx2-5 E2F E2F-1 IRF-7A
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM183A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM183A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q32.1 Ensembl cytogenetic band: 1q32.1 HGNC cytogenetic band: 1q31.1TMEM183A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P202976: view genomic region
(about GC identifiers)
Start:
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202,976,514 bp from pter |
End:
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202,993,976 bp from pter |
Size:
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17,463 bases |
Orientation:
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plus strand |
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Proteins
for TMEM183A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T183A_HUMAN, Q8IXX5 (See
protein sequence)Recommended Name: Transmembrane protein 183A Size: 376 amino acids; 42826 Da
Subcellular location: Membrane; Single-pass membrane protein (Potential)
Secondary accessions: A8K5W1 Q6NW15 Q96E06Alternative splicing: 2 isoforms: Q8IXX5-1 Q8IXX5-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for TMEM183A: NX_Q8IXX5
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8IXX5
TMEM183A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612400.3
ENSEMBL proteins: ENSP00000356211
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0016021 | integral to membrane |
IEA | -- |
TMEM183A for ontologies About GeneDecksing
TMEM183A Antibody Products:
Assay Products for TMEM183A: |
Protein
Domains /
Families
for TMEM183A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM183A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8IXX5ProtoNet protein and cluster: Q8IXX5 UniProtKB/Swiss-Prot: T183A_HUMAN, Q8IXX5Similarity: Belongs to the TMEM183 family |
Function
for TMEM183A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM183A (NM_138391) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM183A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM183A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183A |
|
Pathways & Interactions
for TMEM183A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM183A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM183A (ENSP000003562114) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TMEM183A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM183A
Search CenterWatch for drugs/clinical trials and news about TMEM183A / T183A
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Transcripts
for TMEM183A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM183A gene: NM_138391.4 Unigene Cluster for TMEM183A: Transmembrane protein 183A Hs.497443 [show with all ESTs]Unigene Representative Sequence: NM_1383915 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367242(uc009xai.1 uc001gyu.1 uc001gyv.1 uc001gyw.1)
ENST00000543891 ENST00000468449 ENST00000463015 ENST00000488097
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A (see all 4)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A (see all 3)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM183A (NM_138391) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM183A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM183A |
Additional cDNA sequence: AF070537.1 AK291426.1 AK309745.1 AK312985.1 AL133052.1 BC013073.1 BC038952.2 BC067775.1 BC150647.1 14 DOTS entries: DT.91765304 DT.95244466 DT.100826132 DT.95251238 DT.102827191 DT.100826126 DT.100826135 DT.100826124 DT.121417564 DT.100764324 DT.100826123 DT.100826120 DT.120882372 DT.121417567 24/378 AceView cDNA sequences (see all 378): BM792668 BE395608 CR609677 BM423855 BQ021238 AW173019 CA944947 BE392654 T32525 AF070537 BQ898753 AA305187 BQ653460 BM461784 BI253318 BI762513 BU684860 CB215758 BE868129 AA337264 AA722341 BG491589 AA287464 BQ184689
GeneLoc Exon Structure
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Expression
for TMEM183A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM183A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM183A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM183A
SOURCE GeneReport for Unigene cluster: Hs.497443
SABiosciences Custom PCR Arrays for TMEM183A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM183A
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat TMEM183A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM183A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM183A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183A |
Orthologs
for TMEM183A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
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This gene was present in the common ancestor of animals.
Orthologs for TMEM183A gene from 6/19 species (see all 19) About this table
ENSEMBL Gene Tree for TMEM183A (if available)
TreeFam Gene Tree for TMEM183A (if available) |
Paralogs
for TMEM183A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM183A gene
1 SIMAP similar gene for TMEM183A using alignment to 1 protein entry: T183A_HUMAN:TMEM183B
TMEM183A for paralogs About GeneDecksing
5/7 Pseudogenes.org Pseudogenes for TMEM183A (see all 7)
PGOHUM00000247848 PGOHUM00000246717 PGOHUM00000237671 PGOHUM00000235549 PGOHUM00000235730
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Genomic Variants
for TMEM183A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM183A (202976514 - 202993976 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM183A: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM183A |
|
Disorders
/ Diseases
for TMEM183A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM183A for disorders About GeneDecksing
6  diseases for TMEM183A: About MalaCardsacute lymphoblastic leukemia lymphoblastic leukemia burkitt's lymphoma essential hypertension
hypertension leukemia
Human Genome Epidemiology (HuGE) Navigator: TMEM183A (1 document)
Export disorders for TMEM183A gene to outside databases
|
Publications
for TMEM183A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM183A gene, integrated from 9 sources (see all 11):
(articles sorted by number of sources associating them with TMEM183A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Follow-up of a major linkage peak on chromosome 1 rev eals suggestive QTLs associated with essential hypertension: GenNet study. (PubMed id 19536175)1 Ehret G.B....Chakravarti A. (2009)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Tiling resolution array comparative genomic hybridization, expression and methylation analyses of dup(1q) in Burkitt lymphomas and pediatric high hyperdiploid acute lymphoblastic leukemias reveal clustered near-centromeric breakpoints and overexpression of genes in 1q22-32.3. (PubMed id 17613536)1 Davidsson J....Johansson B. (2007)
- Origination and evolution of a human-specific transmembrane protein gene, c1orf37-dup. (PubMed id 16644869)1 Yu H.... Wang W. (2006)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Large-scale concatenation cDNA sequencing. (PubMed id 9110174)1 Yu W.... Gibbs R.A. (1997)
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External Searches for TMEM183A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
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Genome Databases showing TMEM183A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM183A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM183A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM183A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM183A gene:
Search GeneIP for patents involving TMEM183A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM183A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
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 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM183A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM183A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM183A | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM183A | | OriGene 3'-UTR Clone for TMEM183A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM183A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM183A | | OriGene Custom Protein Services for TMEM183A | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM183A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM183A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM183A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM183A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM183A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM183A |
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 | | | TMEM183A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM183A |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM183A |
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