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Aliases for TMEM183A Gene

Aliases for TMEM183A Gene

  • Transmembrane Protein 183A 2 3 5
  • C1orf37 3 4
  • Chromosome 1 Open Reading Frame 37 2

External Ids for TMEM183A Gene

Previous HGNC Symbols for TMEM183A Gene

  • C1orf37

Previous GeneCards Identifiers for TMEM183A Gene

  • GC01P201245

Summaries for TMEM183A Gene

GeneCards Summary for TMEM183A Gene

TMEM183A (Transmembrane Protein 183A) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM183A Gene

Genomics for TMEM183A Gene

Regulatory Elements for TMEM183A Gene

Enhancers for TMEM183A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G203025 1.4 ENCODE dbSUPER 12 +20.4 20414 4.0 HDGF CREB3L1 ARNT AGO1 SIN3A FEZF1 YY1 ZNF766 CBX5 ZNF143 TMEM183A PPFIA4 LOC105371687
GH01G203319 2.1 FANTOM5 Ensembl ENCODE dbSUPER 2.5 +317.0 317011 9.8 HDGF FOXA2 PKNOX1 CREB3L1 ARNT ZFP64 WRNIP1 SIN3A FEZF1 YBX1 FMOD LOC100131747 BTG2 TMEM183A RABIF KLHL12 LAX1 ZBED6 RNU6-487P GC01M203320
GH01G203276 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.3 +273.0 273005 7.9 HDGF PKNOX1 FOXA2 FEZF1 ZNF48 ZNF121 GLIS2 TSHZ1 ZNF518A ZNF579 BTG2 LINC01136 RNU6-487P FMOD LOC100131747 OPTC PRELP LINC01353 RABIF TMEM183A
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM183A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM183A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000018370 117 2201 PKNOX1 CREB3L1 ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 ZBTB7B YY1

Genomic Location for TMEM183A Gene

Chromosome:
1
Start:
203,007,383 bp from pter
End:
203,024,848 bp from pter
Size:
17,466 bases
Orientation:
Plus strand

Genomic View for TMEM183A Gene

Genes around TMEM183A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM183A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM183A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM183A Gene

Proteins for TMEM183A Gene

  • Protein details for TMEM183A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8IXX5-T183A_HUMAN
    Recommended name:
    Transmembrane protein 183A
    Protein Accession:
    Q8IXX5
    Secondary Accessions:
    • A8K5W1
    • Q6NW15
    • Q96E06

    Protein attributes for TMEM183A Gene

    Size:
    376 amino acids
    Molecular mass:
    42826 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM183A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM183A Gene

Post-translational modifications for TMEM183A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM183A Gene

No data available for DME Specific Peptides for TMEM183A Gene

Domains & Families for TMEM183A Gene

Protein Domains for TMEM183A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM183A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8IXX5

UniProtKB/Swiss-Prot:

T183A_HUMAN :
  • Belongs to the TMEM183 family.
Family:
  • Belongs to the TMEM183 family.
genes like me logo Genes that share domains with TMEM183A: view

No data available for Gene Families for TMEM183A Gene

Function for TMEM183A Gene

Gene Ontology (GO) - Molecular Function for TMEM183A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM183A: view
genes like me logo Genes that share phenotypes with TMEM183A: view

Animal Model Products

CRISPR Products

miRNA for TMEM183A Gene

miRTarBase miRNAs that target TMEM183A

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM183A Gene

Localization for TMEM183A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM183A Gene

Membrane; Single-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM183A gene
Compartment Confidence
nucleus 3
cytosol 3
plasma membrane 1
mitochondrion 1
peroxisome 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM183A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM183A: view

Pathways & Interactions for TMEM183A Gene

SuperPathways for TMEM183A Gene

No Data Available

Interacting Proteins for TMEM183A Gene

Gene Ontology (GO) - Biological Process for TMEM183A Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM183A Gene

Drugs & Compounds for TMEM183A Gene

No Compound Related Data Available

Transcripts for TMEM183A Gene

Unigene Clusters for TMEM183A Gene

Transmembrane protein 183A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM183A Gene

No ASD Table

Relevant External Links for TMEM183A Gene

GeneLoc Exon Structure for
TMEM183A
ECgene alternative splicing isoforms for
TMEM183A

Expression for TMEM183A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM183A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of TMEM183A Gene:

TMEM183A

SOURCE GeneReport for Unigene cluster for TMEM183A Gene:

Hs.497443

Evidence on tissue expression from TISSUES for TMEM183A Gene

  • Nervous system(4.7)
  • Intestine(4.3)
genes like me logo Genes that share expression patterns with TMEM183A: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM183A Gene

Orthologs for TMEM183A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM183A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM183A 34 35
  • 99.82 (n)
cow
(Bos Taurus)
Mammalia TMEM183 35
  • 95 (a)
OneToOne
LOC534797 34
  • 94.5 (n)
dog
(Canis familiaris)
Mammalia TMEM183A 34 35
  • 94.15 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM183A 35
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem183a 34
  • 92.11 (n)
mouse
(Mus musculus)
Mammalia Tmem183a 34 16 35
  • 91.11 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM183A 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM183A 34 35
  • 78.97 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM183A 35
  • 67 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem183a 34
  • 64.04 (n)
Str.10764 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.18610 34
zebrafish
(Danio rerio)
Actinopterygii tmem183a 34 35
  • 65.83 (n)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13905 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004102 34
  • 43.91 (n)
fruit fly
(Drosophila melanogaster)
Insecta fsd 35
  • 21 (a)
OneToOne
Species where no ortholog for TMEM183A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM183A Gene

ENSEMBL:
Gene Tree for TMEM183A (if available)
TreeFam:
Gene Tree for TMEM183A (if available)

Paralogs for TMEM183A Gene

(1) SIMAP similar genes for TMEM183A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM183A: view

No data available for Paralogs for TMEM183A Gene

Variants for TMEM183A Gene

Sequence variations from dbSNP and Humsavar for TMEM183A Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs193920903 Uncertain significance 203,016,141(+) CCAAA(A/G)TAAGT splice-donor-variant
rs1000190081 -- 203,011,962(+) TTTTT(A/G)ATGAA intron-variant
rs1000315857 -- 203,019,260(+) GGATA(C/T)TCAAT intron-variant
rs1000412421 -- 203,019,197(+) ATGCA(A/G)ATATT intron-variant
rs1000527530 -- 203,013,558(+) CCAGG(C/G)TGGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM183A Gene

Variant ID Type Subtype PubMed ID
nsv1110666 CNV insertion 24896259
nsv4132 CNV insertion 18451855
nsv832370 CNV loss 17160897
nsv946592 CNV duplication 23825009

Variation tolerance for TMEM183A Gene

Residual Variation Intolerance Score: 44.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.20; 75.99% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM183A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM183A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM183A Gene

Disorders for TMEM183A Gene

Relevant External Links for TMEM183A

Genetic Association Database (GAD)
TMEM183A
Human Genome Epidemiology (HuGE) Navigator
TMEM183A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM183A

No disorders were found for TMEM183A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM183A Gene

Publications for TMEM183A Gene

  1. Follow-up of a major linkage peak on chromosome 1 reveals suggestive QTLs associated with essential hypertension: GenNet study. (PMID: 19536175) Ehret G.B. … Chakravarti A. (Eur. J. Hum. Genet. 2009) 3 46 64
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3 64
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3 64

Products for TMEM183A Gene

Sources for TMEM183A Gene

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