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TMEM182 Gene

protein-coding   GIFtS: 42
GCID: GC02P103353

Transmembrane Protein 182

  See TMEM182-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 1821 2

External Ids:    HGNC: 263911   Entrez Gene: 1308272   Ensembl: ENSG000001704177   UniProtKB: Q6ZP803   
ORGUL members:         

Export aliases for TMEM182 gene to outside databases

Previous GC identifers: GC02P102744 GC02P097144


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM182 Gene:
TMEM182 (transmembrane protein 182) is a protein-coding gene. Diseases associated with TMEM182 include low tension glaucoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000002.11  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM182 gene promoter:
         Pbx1a   Tal-1   AP-4   Nkx2-5   GATA-1   GATA-2   E47   SRY   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM182 promoter sequence
   Search Chromatin IP Primers for TMEM182

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM182


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

TMEM182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM182 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103353:  view genomic region     (about GC identifiers)

Start:
103,353,367 bp from pter      End:
103,460,352 bp from pter
Size:
106,986 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: TM182_HUMAN, Q6ZP80 (See protein sequence)
Recommended Name: Transmembrane protein 182 precursor  
Size: 229 amino acids; 25879 Da
Sequence caution: Sequence=AAH73844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI07695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JML7 Q3B7B8 Q53TT9 Q6GMU0 Q8WW45 Q96NR4
Alternative splicing: 3 isoforms:  Q6ZP80-1   Q6ZP80-2   Q6ZP80-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM182: NX_Q6ZP80

Explore proteomics data for TMEM182 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn47, Asn102

  • See TMEM182 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_653233.3  
    ENSEMBL proteins: 
     ENSP00000392106   ENSP00000387258   ENSP00000387184   ENSP00000394178  

    TMEM182 Human Recombinant Protein Products:

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    antibodies-online peptides for TMEM182

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    antibodies-online antibodies for TMEM182 (2 products) 

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    antibodies-online kits for TMEM182 (6 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR026763 TMEM182
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q6ZP80

    ProtoNet protein and cluster: Q6ZP80

    UniProtKB/Swiss-Prot: TM182_HUMAN, Q6ZP80
    Similarity: Belongs to the TMEM182 family


    Find genes that share domains with TMEM182           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for TMEM182

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM182 (see all 30):
    hsa-miR-875-3p hsa-miR-4272 hsa-miR-3942-5p hsa-miR-944 hsa-miR-138-2* hsa-miR-340 hsa-miR-3167 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTMEM182 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM182

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    Browse Sino Biological Human cDNA Clones
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM182

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM182_HUMAN, Q6ZP80: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM182           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM182
    Interactions:

        Search GeneGlobe Interaction Network for TMEM182

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM182 (TM182)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM182 gene: 
    NM_144632.3  

    Unigene Cluster for TMEM182:

    Transmembrane protein 182
    Hs.436203  [show with all ESTs]
    Unigene Representative Sequence: NM_144632
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000454536 ENST00000409528 ENST00000409173 ENST00000469971 ENST00000488134
    ENST00000412401(uc002tcc.4 uc002tcd.4 uc010fjb.3 uc010ywe.2)
    ENST00000486293 ENST00000484094
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM182 (see all 30):
    hsa-miR-875-3p hsa-miR-4272 hsa-miR-3942-5p hsa-miR-944 hsa-miR-138-2* hsa-miR-340 hsa-miR-3167 hsa-miR-105
    SwitchGear 3'UTR luciferase reporter plasmidTMEM182 3' UTR sequence
    Inhib. RNA
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM182
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM182
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM182
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM182
      QuantiFast Probe-based Assays in human, mouse, rat TMEM182

    Additional mRNA sequence: 

    AK054856.1 AK129862.1 AL832688.1 AY358262.1 BC020898.1 BC073844.1 BC107694.1 BC130306.1 
    BC130308.1 CR936731.1 CR936732.1 CR936735.1 

    6 DOTS entries:

    DT.99933770  DT.207554  DT.99959273  DT.97770654  DT.97836781  DT.99986465 

    Selected AceView cDNA sequences (see all 50):

    T96636 AA332068 AA429380 BQ227357 AA991701 BQ081918 BU742874 AA428313 
    N73167 BM717675 BG500484 AI864861 CA772379 AI298041 AK129862 AL832688 
    BC073844 AA461200 CD637000 BC020898 AI553990 BM728345 CB047054 BG567617 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182    About this scheme

    ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
    SP1:                                    
    SP2:                    -               


    ECgene alternative splicing isoforms for TMEM182

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM182 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TCATCTGTAA
    TMEM182 Expression
    About this image

    TMEM182 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM182 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.436203
        Custom PCR Arrays for TMEM182
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM182
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM182

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM182 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1821 , 5 transmembrane protein 1821, 5 85.3(n)1
    89.08(a)1
      1 (20.01 cM)5
    3813391  NM_001081198.11  NP_001074667.11 
     408056015 
    chicken
    (Gallus gallus)
    Aves TMEM1821 transmembrane protein 182 73.68(n)
    73.25(a)
      418721  XM_416920.4  XP_416920.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1826
    transmembrane protein 182
    62(a)
    1 ↔ 1
    GL343243.1(1357691-1409141)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia Str.91072 Transcribed sequences 80.66(n)    BX742577.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1821 transmembrane protein 182 57.4(n)
    53.81(a)
      503742  NM_001013320.1  NP_001013338.1 


    ENSEMBL Gene Tree for TMEM182 (if available)
    TreeFam Gene Tree for TMEM182 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM182 (see all 1105)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1838283351,2
    --103032285(+) GAACAC/TTGTTG 1 -- us2k10--------
    rs25403031,2
    C,F,O,A,H--103376534(-) TAGCCG/ATTCTT 1 -- us2k115Minor allele frequency- A:0.33NS EA NA WA 930
    rs759562571,2
    C--103376540(+) GGCTAA/GAATAT 1 -- us2k10--------
    rs1885512771,2
    C--103376553(+) CCAGAA/TTATTT 1 -- us2k10--------
    rs1461977301,2
    C--103376612(+) AGAACA/GGAGAG 1 -- us2k10--------
    rs1160828611,2
    F--103376622(+) GGAGGA/CGGTCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
    rs1386125011,2
    --103376701(+) TCTATA/GTAGGG 1 -- us2k10--------
    rs1411691721,2
    C--103376888(+) TGGCT-/GGGG  
            
    GTTAC
    1 -- us2k10--------
    rs1815332221,2
    --103376927(+) ATGTCA/TTAGCT 1 -- us2k10--------
    rs728280871,2
    C,F--103377062(+) TCATGT/GTTTTT 1 -- us2k11Minor allele frequency- G:0.04NA 120

    HapMap Linkage Disequilibrium report for TMEM182 (103353367 - 103460352 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM182:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2720464CNV Deletion23290073
    nsv834319CNV Gain17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM182
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM182

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMEM182:    
    About MalaCards
    low tension glaucoma

    1 disease from the University of Copenhagen DISEASES database for TMEM182:
    Low tension glaucoma

    Find genes that share disorders with TMEM182           About GenesLikeMe

    Genetic Association Database (GAD): TMEM182

    Export disorders for TMEM182 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM182 gene, integrated from 10 sources (see all 15):
    (articles sorted by number of sources associating them with TMEM182)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (PLoS Genet. 2013)
    5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)4 Lingappa J.R....Goldstein D. (PLoS ONE 2011)
    6. Propensity score-based nonparametric test revealing genetic variants underlying bipolar disorder. (PubMed id 21254220)4 Jiang Y. and Zhang H. (Genet. Epidemiol. 2011)
    7. New sequence variants associated with bone mineral density. (PubMed id 19079262)4 Styrkarsdottir U....Stefansson K. (Nat. Genet. 2009)
    8. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (BMC Med. Genet. 2007)
    9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (BMC Med. Genet. 2007)
    10. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (BMC Med. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130827 HGNC: 26391 AceView: FLJ30294 Ensembl:ENSG00000170417 euGenes: HUgn130827
    ECgene: TMEM182 H-InvDB: TMEM182

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM182 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM182 gene:
    Search GeneIP for patents involving TMEM182

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from genOway)
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