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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM182 Gene

protein-coding   GIFtS: 40
GCID: GC02P103353

Transmembrane Protein 182

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1821 2

External Ids:    HGNC: 263911   Entrez Gene: 1308272   Ensembl: ENSG000001704177   UniProtKB: Q6ZP803   

Export aliases for TMEM182 gene to outside databases

Previous GC identifers: GC02P102744 GC02P097144


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM182 Gene: 
TMEM182 (transmembrane protein 182) is a protein-coding gene. Diseases associated with TMEM182 include low tension glaucoma, and glaucoma.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022171.15  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM182 gene promoter:
         Pbx1a   Tal-1   AP-4   Nkx2-5   GATA-1   GATA-2   E47   SRY   FOXJ2 (long isoform)   FOXJ2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM182 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM182

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM182


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q12.1   Ensembl cytogenetic band:  2q12.1   HGNC cytogenetic band: 2q12.1

TMEM182 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM182 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P103353:  view genomic region     (about GC identifiers)

Start:
103,353,367 bp from pter      End:
103,460,352 bp from pter
Size:
106,986 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM182_HUMAN, Q6ZP80 (See protein sequence)
Recommended Name: Transmembrane protein 182 precursor  
Size: 229 amino acids; 25879 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=AAH73844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAI07695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: C9JML7 Q3B7B8 Q53TT9 Q6GMU0 Q8WW45 Q96NR4
Alternative splicing: 3 isoforms:  Q6ZP80-1   Q6ZP80-2   Q6ZP80-3   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM182: NX_Q6ZP80

Explore proteomics data for TMEM182 at MOPED 

TMEM182 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM182 Protein Expression

REFSEQ proteins: NP_653233.3  
ENSEMBL proteins: 
 ENSP00000392106   ENSP00000387258   ENSP00000387184   ENSP00000394178  

Human Recombinant Protein Products for TMEM182: 
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Cloud-Clone Corp. Proteins for TMEM182 

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM182 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
1 InterPro protein domain:
 IPR026763 TMEM182

Graphical View of Domain Structure for InterPro Entry Q6ZP80

ProtoNet protein and cluster: Q6ZP80

UniProtKB/Swiss-Prot: TM182_HUMAN, Q6ZP80
Similarity: Belongs to the TMEM182 family


TMEM182 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Animal Models:
   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM182 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM182

   genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM182 
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SwitchGear 3'UTR luciferase reporter plasmidTMEM182 3' UTR sequence
Inhib. RNA
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Clone
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GenScript: all cDNA clones in your preferred vector: TMEM182 (NM_144632)
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                     Customized lentivirus expression plasmids for stable overexpression of TMEM182 

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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM182


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM182

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM182 (TM182)

Search CenterWatch for drugs/clinical trials and news about TMEM182 / TM182

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM182 gene: 
NM_144632.3  

Unigene Cluster for TMEM182:

Transmembrane protein 182
Hs.436203  [show with all ESTs]
Unigene Representative Sequence: NM_144632
8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000454536 ENST00000409528 ENST00000409173 ENST00000469971 ENST00000488134
ENST00000412401(uc002tcc.4 uc002tcd.4 uc010fjb.3 uc010ywe.2)
ENST00000486293 ENST00000484094
miRNA
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hsa-miR-875-3p hsa-miR-4272 hsa-miR-3942-5p hsa-miR-944 hsa-miR-138-2* hsa-miR-340 hsa-miR-3167 hsa-miR-105
SwitchGear 3'UTR luciferase reporter plasmidTMEM182 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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OriGene ORF clones in mouse, rat for TMEM182
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GenScript: all cDNA clones in your preferred vector: TMEM182 (NM_144632)
DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM182
Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM182
Sirion Biotech Customized lentivirus for stable overexpression of TMEM182 
                     Customized lentivirus expression plasmids for stable overexpression of TMEM182 
Primer
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OriGene qPCR primer pairs and template standards for TMEM182
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM182
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM182
  QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM182
  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM182

Additional mRNA sequence: 

AK054856.1 AK129862.1 AL832688.1 AY358262.1 BC020898.1 BC073844.1 BC107694.1 BC130306.1 
BC130308.1 CR936731.1 CR936732.1 CR936735.1 

6 DOTS entries:

DT.99933770  DT.207554  DT.99959273  DT.97770654  DT.97836781  DT.99986465 

24/50 AceView cDNA sequences (see all 50):

AA332068 AA429380 BM717675 BQ227357 AA991701 T96636 BQ081918 BU742874 
AA428313 N73167 AK129862 AL832688 AI275001 AI864861 AI298041 BC073844 
AI553990 BC020898 BG500484 AA461200 CD637000 BM728345 CB047054 BG567617 

GeneLoc Exon Structure

2 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182    About this scheme

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:                                    
SP2:                    -               


ECgene alternative splicing isoforms for TMEM182

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM182 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TCATCTGTAA
TMEM182 Expression
About this image


See TMEM182 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM182

SOURCE GeneReport for Unigene cluster: Hs.436203
    SABiosciences Custom PCR Arrays for TMEM182
Primer
Products:
OriGene qPCR primer pairs and template standards for TMEM182
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM182
SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM182
QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM182
QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM182
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM182

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM182 gene from 5/11 species (see all 11)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1821 , 5 transmembrane protein 1821, 5 85.3(n)1
89.08(a)1
  1 (20.01 cM)5
3813391  NM_001081198.11  NP_001074667.11 
 408056015 
chicken
(Gallus gallus)
Aves TMEM1821 transmembrane protein 182 73.68(n)
73.25(a)
  418721  XM_416920.3  XP_416920.1 
lizard
(Anolis carolinensis)
Reptilia TMEM1826
transmembrane protein 182
64(a)
1 ↔ 1
GL343243.1(1357691-1409141)
tropical clawed frog
(Xenopus tropicalis)
Amphibia Str.91072 Transcribed sequences 80.66(n)    BX742577.1 
zebrafish
(Danio rerio)
Actinopterygii tmem1821 transmembrane protein 182 57.25(n)
53.81(a)
  503742  NM_001013320.1  NP_001013338.1 


ENSEMBL Gene Tree for TMEM182 (if available)
TreeFam Gene Tree for TMEM182 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
  --

(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1105 SNPs in TMEM182 are shown (see all 1105)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1838283351,2
--103032285(+) GAACAC/TTGTTG 1 -- us2k10--------
rs25403031,2
C,F,O,A,H--103376534(-) TAGCCG/ATTCTT 1 -- us2k115Minor allele frequency- A:0.33NS EA NA WA 930
rs759562571,2
C--103376540(+) GGCTAA/GAATAT 1 -- us2k10--------
rs1885512771,2
C--103376553(+) CCAGAA/TTATTT 1 -- us2k10--------
rs1461977301,2
C--103376612(+) AGAACA/GGAGAG 1 -- us2k10--------
rs1160828611,2
F--103376622(+) GGAGGA/CGGTCT 1 -- us2k11Minor allele frequency- C:0.03WA 118
rs1386125011,2
--103376701(+) TCTATA/GTAGGG 1 -- us2k10--------
rs1411691721,2
C--103376888(+) TGGCT-/GGGG  
        
GTTAC
1 -- us2k10--------
rs1815332221,2
--103376927(+) ATGTCA/TTAGCT 1 -- us2k10--------
rs728280871,2
C,F--103377062(+) TCATGT/GTTTTT 1 -- us2k11Minor allele frequency- G:0.04NA 120

HapMap Linkage Disequilibrium report for TMEM182 (103353367 - 103460352 bp)

Structural Variations
     Database of Genomic Variants (DGV) 2 variations for TMEM182:    About this table     
Variant IDTypeSubtypePubMed ID
esv2720464CNV Deletion23290073
nsv834319CNV Gain17160897

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
2 diseases for TMEM182:    About MalaCards
low tension glaucoma    glaucoma

1 disease from the University of Copenhagen DISEASES database for TMEM182:
Low tension glaucoma

TMEM182 for disorders           About GeneDecksing

Genetic Association Database (GAD): TMEM182

Export disorders for TMEM182 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM182 gene, integrated from 9 sources (see all 15):
(articles sorted by number of sources associating them with TMEM182)
    Utopia: connect your pdf to the dynamic
world of online information

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
  4. Loci associated with N-glycosylation of human immunogl obulin G show pleiotropy with autoimmune diseases and haematological cancers. (PubMed id 23382691)1 Lauc G....Rudan I. (2013)
  5. Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure. (PubMed id 22174851)4 Lingappa J.R....Goldstein D. (2011)
  6. Propensity score-based nonparametric test revealing ge netic variants underlying bipolar disorder. (PubMed id 21254220)4 Jiang Y. and Zhang H. (2011)
  7. New sequence variants associated with bone mineral density. (PubMed id 19079262)4 Styrkarsdottir U....Stefansson K. (2009)
  8. Genome-wide association study of electrocardiographic and heart rate variability traits: the Framingham Heart Study. (PubMed id 17903306)4 Newton-Cheh C....Larson M.G. (2007)
  9. Framingham Heart Study 100K Project: genome-wide associations for blood pressure and arterial stiffness. (PubMed id 17903302)4 Levy D....Mitchell G.F. (2007)
  10. A genome-wide association for kidney function and endocrine-related traits in the NHLBI's Framingham Heart Study. (PubMed id 17903292)4 Hwang S.J....Fox C.S. (2007)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 130827 HGNC: 26391 AceView: FLJ30294 Ensembl:ENSG00000170417 euGenes: HUgn130827
ECgene: TMEM182 H-InvDB: TMEM182

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM182 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM182 gene:
Search GeneIP for patents involving TMEM182

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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