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Aliases for TMEM182 Gene

Aliases for TMEM182 Gene

  • Transmembrane Protein 182 2 3 5

External Ids for TMEM182 Gene

Previous GeneCards Identifiers for TMEM182 Gene

  • GC02P103353
  • GC02P097144

Summaries for TMEM182 Gene

GeneCards Summary for TMEM182 Gene

TMEM182 (Transmembrane Protein 182) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM182 Gene

Genomics for TMEM182 Gene

Regulatory Elements for TMEM182 Gene

Promoters for TMEM182 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM182 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM182 Gene

Chromosome:
2
Start:
102,736,908 bp from pter
End:
102,843,893 bp from pter
Size:
106,986 bases
Orientation:
Plus strand

Genomic View for TMEM182 Gene

Genes around TMEM182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM182 Gene

Proteins for TMEM182 Gene

  • Protein details for TMEM182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP80-TM182_HUMAN
    Recommended name:
    Transmembrane protein 182
    Protein Accession:
    Q6ZP80
    Secondary Accessions:
    • C9JML7
    • Q3B7B8
    • Q53TT9
    • Q6GMU0
    • Q8WW45
    • Q96NR4

    Protein attributes for TMEM182 Gene

    Size:
    229 amino acids
    Molecular mass:
    25879 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI07695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM182 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM182 Gene

Proteomics data for TMEM182 Gene at MOPED

Post-translational modifications for TMEM182 Gene

  • Glycosylation at Asn 47 and Asn 102

Other Protein References for TMEM182 Gene

No data available for DME Specific Peptides for TMEM182 Gene

Domains & Families for TMEM182 Gene

Protein Domains for TMEM182 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM182 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZP80

UniProtKB/Swiss-Prot:

TM182_HUMAN :
  • Belongs to the TMEM182 family.
Family:
  • Belongs to the TMEM182 family.
genes like me logo Genes that share domains with TMEM182: view

No data available for Gene Families for TMEM182 Gene

Function for TMEM182 Gene

genes like me logo Genes that share phenotypes with TMEM182: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM182 Gene

Localization for TMEM182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM182 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM182 Gene COMPARTMENTS Subcellular localization image for TMEM182 gene
Compartment Confidence
plasma membrane 3
nucleus 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM182 Gene

Pathways & Interactions for TMEM182 Gene

SuperPathways for TMEM182 Gene

No Data Available

Interacting Proteins for TMEM182 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000394178%0d%0a9606.ENSP00000316130%0d%0a
Selected Interacting proteins: Q6ZP80-TM182_HUMAN ENSP00000394178 for TMEM182 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMEM182 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM182 Gene

Drugs & Compounds for TMEM182 Gene

No Compound Related Data Available

Transcripts for TMEM182 Gene

Unigene Clusters for TMEM182 Gene

Transmembrane protein 182:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for TMEM182 Gene

GeneLoc Exon Structure for
TMEM182
ECgene alternative splicing isoforms for
TMEM182

Expression for TMEM182 Gene

mRNA expression in normal human tissues for TMEM182 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM182 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.9), Heart - Atrial Appendage (x13.5), and Muscle - Skeletal (x9.0).

Protein differential expression in normal tissues from HIPED for TMEM182 Gene

This gene is overexpressed in Heart (49.4) and Tonsil (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM182 Gene



SOURCE GeneReport for Unigene cluster for TMEM182 Gene Hs.436203

genes like me logo Genes that share expression patterns with TMEM182: view

Protein tissue co-expression partners for TMEM182 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM182 Gene

Orthologs for TMEM182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM182 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM182 35
  • 87.05 (n)
  • 91.27 (a)
TMEM182 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM182 35
  • 89.81 (n)
  • 93.45 (a)
TMEM182 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem182 35
  • 85.3 (n)
  • 89.08 (a)
Tmem182 16
Tmem182 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM182 35
  • 99.27 (n)
  • 99.13 (a)
TMEM182 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem182 35
  • 85.74 (n)
  • 89.96 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM182 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM182 36
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM182 35
  • 73.68 (n)
  • 73.25 (a)
TMEM182 36
  • 71 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM182 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9107 35
tmem182 35
  • 65.79 (n)
  • 61.84 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem182 35
  • 57.4 (n)
  • 53.81 (a)
tmem182 36
  • 46 (a)
OneToMany
TMEM182 (2 of 2) 36
  • 33 (a)
OneToMany
Species with no ortholog for TMEM182:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM182 Gene

ENSEMBL:
Gene Tree for TMEM182 (if available)
TreeFam:
Gene Tree for TMEM182 (if available)

Paralogs for TMEM182 Gene

No data available for Paralogs for TMEM182 Gene

Variants for TMEM182 Gene

Sequence variations from dbSNP and Humsavar for TMEM182 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs887987 - 102,814,945(-) ATGCC(A/G)TCCAA intron-variant, reference, missense
rs887988 -- 102,789,070(-) TATGT(C/T)GCCTC intron-variant
rs887989 -- 102,783,482(+) CACAG(C/T)AAATA intron-variant
rs887990 -- 102,784,014(+) TACGC(A/C)GGACC intron-variant
rs887991 -- 102,771,066(-) CCATA(C/T)ATGAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM182 Gene

Variant ID Type Subtype PubMed ID
esv2720464 CNV Deletion 23290073
nsv834319 CNV Gain 17160897

Variation tolerance for TMEM182 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM182 Gene

HapMap Linkage Disequilibrium report
TMEM182

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM182 Gene

Disorders for TMEM182 Gene

Relevant External Links for TMEM182

Genetic Association Database (GAD)
TMEM182
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM182

No disorders were found for TMEM182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM182 Gene

Publications for TMEM182 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Identification of a genetic variant at 2q12.1 associated with blood pressure in East Asians by genome-wide scan including gene-environment interactions. (PMID: 24903457) Kim Y.K. … Kim B.J. (BMC Med. Genet. 2014) 3
  4. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  5. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3

Products for TMEM182 Gene

Sources for TMEM182 Gene

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