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Aliases for TMEM182 Gene

Aliases for TMEM182 Gene

  • Transmembrane Protein 182 2 3 5

External Ids for TMEM182 Gene

Previous GeneCards Identifiers for TMEM182 Gene

  • GC02P103353
  • GC02P097144

Summaries for TMEM182 Gene

GeneCards Summary for TMEM182 Gene

TMEM182 (Transmembrane Protein 182) is a Protein Coding gene.

Additional gene information for TMEM182 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM182 Gene

Genomics for TMEM182 Gene

Regulatory Elements for TMEM182 Gene

Enhancers for TMEM182 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H102806 1.2 Ensembl ENCODE dbSUPER 0.2 +69.4 69442 0 CTCF KLF11 ZNF654 TFE3 TRIM22 MAX REST RAD21 TEAD3 MITF TMEM182 LINC01796
GH02H102827 1.1 Ensembl ENCODE dbSUPER 0.2 +90.2 90196 0 MXI1 L3MBTL2 MAX MEF2D ZBTB48 POLR2A PRDM10 TRIM28 LINC01796 TMEM182
GH02H102801 1.1 ENCODE dbSUPER 0.2 +65.6 65582 2 ATF1 FOXA2 RAD21 CHAMP1 YY1 TCF12 GATA2 ZNF143 ATF7 RUNX3 MFSD9 TMEM182 LINC01796
GH02H102754 0.4 dbSUPER 0.4 +18.4 18383 1 CEBPG HNF4A MFSD9 TMEM182 LINC01796
GH02H102766 0.5 dbSUPER 0.3 +30.5 30528 2 ATF3 HNF4A ZBTB33 YY1 MFSD9 TMEM182 LINC01796
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM182 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM182 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000121062 -205 1801 ATF1 MLX ARID4B SIN3A DMAP1 YY1 GTF3C2 SLC30A9 GLIS2 RUNX3

Genomic Location for TMEM182 Gene

Chromosome:
2
Start:
102,736,905 bp from pter
End:
103,019,900 bp from pter
Size:
282,996 bases
Orientation:
Plus strand

Genomic View for TMEM182 Gene

Genes around TMEM182 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM182 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM182 Gene

Proteins for TMEM182 Gene

  • Protein details for TMEM182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZP80-TM182_HUMAN
    Recommended name:
    Transmembrane protein 182
    Protein Accession:
    Q6ZP80
    Secondary Accessions:
    • C9JML7
    • Q3B7B8
    • Q53TT9
    • Q6GMU0
    • Q8WW45
    • Q96NR4

    Protein attributes for TMEM182 Gene

    Size:
    229 amino acids
    Molecular mass:
    25879 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH73844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI07695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM182 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM182 Gene

Post-translational modifications for TMEM182 Gene

  • Glycosylation at posLast=4747 and posLast=102102

No data available for DME Specific Peptides for TMEM182 Gene

Domains & Families for TMEM182 Gene

Gene Families for TMEM182 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM182 Gene

Suggested Antigen Peptide Sequences for TMEM182 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZP80

UniProtKB/Swiss-Prot:

TM182_HUMAN :
  • Belongs to the TMEM182 family.
Family:
  • Belongs to the TMEM182 family.
genes like me logo Genes that share domains with TMEM182: view

Function for TMEM182 Gene

Phenotypes From GWAS Catalog for TMEM182 Gene

Gene Ontology (GO) - Molecular Function for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM182: view
genes like me logo Genes that share phenotypes with TMEM182: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM182
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM182 Gene

Localization for TMEM182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM182 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM182 gene
Compartment Confidence
plasma membrane 3
nucleus 2

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM182: view

Pathways & Interactions for TMEM182 Gene

SuperPathways for TMEM182 Gene

No Data Available

Interacting Proteins for TMEM182 Gene

Selected Interacting proteins: Q6ZP80-TM182_HUMAN for TMEM182 Gene via IID UniProtKB

Symbol External ID(s) Details
SYNE4

Gene Ontology (GO) - Biological Process for TMEM182 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM182 Gene

Drugs & Compounds for TMEM182 Gene

No Compound Related Data Available

Transcripts for TMEM182 Gene

Unigene Clusters for TMEM182 Gene

Transmembrane protein 182:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM182
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP1:
SP2: -

Relevant External Links for TMEM182 Gene

GeneLoc Exon Structure for
TMEM182
ECgene alternative splicing isoforms for
TMEM182

Expression for TMEM182 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM182 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM182 Gene

This gene is overexpressed in Heart - Left Ventricle (x15.9), Heart - Atrial Appendage (x13.5), and Muscle - Skeletal (x9.0).

Protein differential expression in normal tissues from HIPED for TMEM182 Gene

This gene is overexpressed in Heart (49.4) and Tonsil (19.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM182 Gene



Protein tissue co-expression partners for TMEM182 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM182 Gene:

TMEM182

SOURCE GeneReport for Unigene cluster for TMEM182 Gene:

Hs.436203

Evidence on tissue expression from TISSUES for TMEM182 Gene

  • Heart(4.4)
  • Nervous system(4.2)
  • Liver(4)
genes like me logo Genes that share expression patterns with TMEM182: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM182 Gene

Orthologs for TMEM182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM182 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM182 33 34
  • 99.27 (n)
dog
(Canis familiaris)
Mammalia TMEM182 33 34
  • 89.81 (n)
cow
(Bos Taurus)
Mammalia TMEM182 33 34
  • 87.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem182 33
  • 85.74 (n)
mouse
(Mus musculus)
Mammalia Tmem182 33 16 34
  • 85.3 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM182 34
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM182 34
  • 83 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM182 33 34
  • 73.68 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM182 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem182 33
  • 65.79 (n)
Str.9107 33
zebrafish
(Danio rerio)
Actinopterygii tmem182 33 34
  • 57.4 (n)
TMEM182 (2 of 2) 34
  • 33 (a)
OneToMany
Species where no ortholog for TMEM182 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM182 Gene

ENSEMBL:
Gene Tree for TMEM182 (if available)
TreeFam:
Gene Tree for TMEM182 (if available)

Paralogs for TMEM182 Gene

No data available for Paralogs for TMEM182 Gene

Variants for TMEM182 Gene

Sequence variations from dbSNP and Humsavar for TMEM182 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000088219 -- 102,840,635(+) AAAAA(G/T)AACAT intron-variant
rs1000118395 -- 102,844,124(+) TCCCA(A/G)AGCCT downstream-variant-500B
rs1000180796 -- 102,765,578(+) CACAG(A/G)ACTCA intron-variant
rs1000194982 -- 102,760,963(+) CTTTA(G/T)TGAGA intron-variant, upstream-variant-2KB
rs1000236733 -- 102,814,261(+) AAAGA(C/T)CCGGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM182 Gene

Variant ID Type Subtype PubMed ID
esv2720464 CNV deletion 23290073
nsv834319 CNV gain 17160897

Variation tolerance for TMEM182 Gene

Residual Variation Intolerance Score: 57.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.90; 18.62% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM182 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM182

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM182 Gene

Disorders for TMEM182 Gene

Relevant External Links for TMEM182

Genetic Association Database (GAD)
TMEM182
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM182

No disorders were found for TMEM182 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM182 Gene

Publications for TMEM182 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T … Vidal M (Cell 2014) 3 60

Products for TMEM182 Gene

Sources for TMEM182 Gene

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