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Aliases for TMEM182 Gene

Aliases for TMEM182 Gene

  • Transmembrane Protein 182 2 3

External Ids for TMEM182 Gene

Summaries for TMEM182 Gene

GeneCards Summary for TMEM182 Gene

TMEM182 (Transmembrane Protein 182) is a Protein Coding gene. Diseases associated with TMEM182 include low tension glaucoma.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM182 Gene

Genomics for TMEM182 Gene

Genomic Location for TMEM182 Gene

102,736,908 bp from pter
102,843,893 bp from pter
106,986 bases
Plus strand

Genomic View for TMEM182 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM182 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM182 Gene

Regulatory Elements for TMEM182 Gene

Proteins for TMEM182 Gene

  • Protein details for TMEM182 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 182
    Protein Accession:
    Secondary Accessions:
    • C9JML7
    • Q3B7B8
    • Q53TT9
    • Q6GMU0
    • Q8WW45
    • Q96NR4

    Protein attributes for TMEM182 Gene

    229 amino acids
    Molecular mass:
    25879 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH73844.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAI07695.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM182 Gene


neXtProt entry for TMEM182 Gene

Proteomics data for TMEM182 Gene at MOPED

Post-translational modifications for TMEM182 Gene

  • Glycosylation at Asn47 and Asn102

Other Protein References for TMEM182 Gene

No data available for DME Specific Peptides for TMEM182 Gene

Domains for TMEM182 Gene

Protein Domains for TMEM182 Gene



  • Belongs to the TMEM182 family.:
    • Q6ZP80
genes like me logo Genes that share domains with TMEM182: view

No data available for Gene Families for TMEM182 Gene

Function for TMEM182 Gene

Gene Ontology (GO) - Molecular Function for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM182: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM182 Gene

Localization for TMEM182 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM182 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM182 Gene COMPARTMENTS Subcellular localization image for TMEM182 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM182 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM182: view

Pathways for TMEM182 Gene

SuperPathways for TMEM182 Gene

No Data Available

Interacting Proteins for TMEM182 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000394178 Q6ZP80-TM182_HUMAN for TMEM182 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM182 Gene


No data available for Pathways by source for TMEM182 Gene

Transcripts for TMEM182 Gene

Unigene Clusters for TMEM182 Gene

Transmembrane protein 182:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM182 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5a · 5b
SP2: -

Relevant External Links for TMEM182 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM182 Gene

mRNA expression in normal human tissues for TMEM182 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM182 Gene

This gene is overexpressed in Heart - Left Ventricle (15.9), Heart - Atrial Appendage (13.5), and Muscle - Skeletal (9.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM182 Gene

SOURCE GeneReport for Unigene cluster for TMEM182 Gene Hs.436203

genes like me logo Genes that share expressions with TMEM182: view

Orthologs for TMEM182 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM182 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM182 36
  • 99.27 (n)
  • 99.13 (a)
TMEM182 37
  • 99 (a)
(Bos Taurus)
Mammalia TMEM182 36
  • 87.05 (n)
  • 91.27 (a)
TMEM182 37
  • 91 (a)
(Canis familiaris)
Mammalia TMEM182 36
  • 89.81 (n)
  • 93.45 (a)
TMEM182 37
  • 93 (a)
(Mus musculus)
Mammalia Tmem182 36
  • 85.3 (n)
  • 89.08 (a)
Tmem182 16
Tmem182 37
  • 89 (a)
(Monodelphis domestica)
Mammalia TMEM182 37
  • 84 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM182 37
  • 83 (a)
(Rattus norvegicus)
Mammalia Tmem182 36
  • 85.74 (n)
  • 89.96 (a)
(Gallus gallus)
Aves TMEM182 36
  • 73.68 (n)
  • 73.25 (a)
TMEM182 37
  • 71 (a)
(Anolis carolinensis)
Reptilia TMEM182 37
  • 62 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.9107 36
tmem182 36
  • 65.79 (n)
  • 61.84 (a)
(Danio rerio)
Actinopterygii tmem182 36
  • 57.4 (n)
  • 53.81 (a)
tmem182 37
  • 46 (a)
TMEM182 (2 of 2) 37
  • 33 (a)
Species with no ortholog for TMEM182:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM182 Gene

Gene Tree for TMEM182 (if available)
Gene Tree for TMEM182 (if available)

Paralogs for TMEM182 Gene

No data available for Paralogs for TMEM182 Gene

Variants for TMEM182 Gene

Sequence variations from dbSNP and Humsavar for TMEM182 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs869833 -- 102,766,672(-) TATAC(A/G)TAGTC intron-variant
rs878802 -- 102,815,859(-) CTAAA(A/G)AATAT utr-variant-3-prime, intron-variant
rs887987 - 102,814,945(-) ATGCC(A/G)TCCAA missense, reference, intron-variant
rs887988 -- 102,789,070(-) TATGT(C/T)GCCTC intron-variant
rs887989 -- 102,783,482(+) CACAG(C/T)AAATA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM182 Gene

Variant ID Type Subtype PubMed ID
esv2720464 CNV Deletion 23290073
nsv834319 CNV Gain 17160897

Relevant External Links for TMEM182 Gene

HapMap Linkage Disequilibrium report

Disorders for TMEM182 Gene

(1) MalaCards Diseases for TMEM182 Gene

Search for TMEM182 Gene in MalaCards »

(1) University of Copenhagen DISEASES for TMEM182 Gene

Relevant External Links for TMEM182

Genetic Association Database (GAD)
genes like me logo Genes that share disorders with TMEM182: view

No data available for UniProtKB/Swiss-Prot for TMEM182 Gene

Publications for TMEM182 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 3 4
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  4. Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers. (PMID: 23382691) Lauc G. … Rudan I. (PLoS Genet. 2013) 3
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3

Products for TMEM182 Gene

Sources for TMEM182 Gene

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