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Aliases for TMEM181 Gene

Aliases for TMEM181 Gene

  • Transmembrane Protein 181 2 3 5
  • KIAA1423 2 3 4
  • G Protein-Coupled Receptor 178 2 3
  • GPR178 3 4

External Ids for TMEM181 Gene

Previous HGNC Symbols for TMEM181 Gene

  • KIAA1423
  • GPR178

Previous GeneCards Identifiers for TMEM181 Gene

  • GC06P158867
  • GC06P156428

Summaries for TMEM181 Gene

Entrez Gene Summary for TMEM181 Gene

  • The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

GeneCards Summary for TMEM181 Gene

TMEM181 (Transmembrane Protein 181) is a Protein Coding gene. GO annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot for TMEM181 Gene

  • Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM181 Gene

Genomics for TMEM181 Gene

Regulatory Elements for TMEM181 Gene

Promoters for TMEM181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM181 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM181 Gene

Chromosome:
6
Start:
158,536,432 bp from pter
End:
158,635,435 bp from pter
Size:
99,004 bases
Orientation:
Plus strand

Genomic View for TMEM181 Gene

Genes around TMEM181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM181 Gene

Proteins for TMEM181 Gene

  • Protein details for TMEM181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2C4-TM181_HUMAN
    Recommended name:
    Transmembrane protein 181
    Protein Accession:
    Q9P2C4
    Secondary Accessions:
    • Q5VTU1

    Protein attributes for TMEM181 Gene

    Size:
    612 amino acids
    Molecular mass:
    69325 Da
    Quaternary structure:
    • Interacts with cytolethal distending toxin.
    SequenceCaution:
    • Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM181 Gene

Proteomics data for TMEM181 Gene at MOPED

Post-translational modifications for TMEM181 Gene

  • Glycosylation at Asn 185 and Asn 299
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM181 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM181 Gene

Domains & Families for TMEM181 Gene

Protein Domains for TMEM181 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM181 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM181: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM181 Gene

Function for TMEM181 Gene

Molecular function for TMEM181 Gene

UniProtKB/Swiss-Prot Function:
Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
genes like me logo Genes that share phenotypes with TMEM181: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM181 Gene

Localization for TMEM181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM181 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM181 Gene COMPARTMENTS Subcellular localization image for TMEM181 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

No data available for Gene Ontology (GO) - Cellular Components for TMEM181 Gene

Pathways & Interactions for TMEM181 Gene

SuperPathways for TMEM181 Gene

No Data Available

Interacting Proteins for TMEM181 Gene

Gene Ontology (GO) - Biological Process for TMEM181 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM181 Gene

Drugs & Compounds for TMEM181 Gene

No Compound Related Data Available

Transcripts for TMEM181 Gene

mRNA/cDNA for TMEM181 Gene

Unigene Clusters for TMEM181 Gene

Transmembrane protein 181:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for TMEM181 Gene

GeneLoc Exon Structure for
TMEM181
ECgene alternative splicing isoforms for
TMEM181

Expression for TMEM181 Gene

mRNA expression in normal human tissues for TMEM181 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM181 Gene

This gene is overexpressed in Artery - Tibial (x10.1).

Protein differential expression in normal tissues from HIPED for TMEM181 Gene

This gene is overexpressed in Pancreas (22.3), Lung (11.2), Testis (11.1), Peripheral blood mononuclear cells (9.9), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM181 Gene



SOURCE GeneReport for Unigene cluster for TMEM181 Gene Hs.99145

genes like me logo Genes that share expression patterns with TMEM181: view

Protein tissue co-expression partners for TMEM181 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM181 Gene

Orthologs for TMEM181 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM181 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM181 35
  • 84.54 (n)
  • 88.14 (a)
TMEM181 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM181 35
  • 85.51 (n)
  • 89.33 (a)
TMEM181 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem181a 35
  • 84.71 (n)
  • 91.93 (a)
Tmem181a 16
Tmem181a 36
  • 91 (a)
OneToMany
Tmem181b-ps 36
  • 95 (a)
OneToMany
Tmem181b-ps 36
  • 85 (a)
OneToMany
Tmem181c-ps 36
  • 95 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia TMEM181 35
  • 99.13 (n)
  • 98.69 (a)
TMEM181 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem181 35
  • 87.22 (n)
  • 93.64 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM181 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM181 36
  • 85 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM181 35
  • 76.76 (n)
  • 84.27 (a)
TMEM181 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM181 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem181 35
  • 72.22 (n)
  • 78.88 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem181 35
  • 67.7 (n)
  • 71.51 (a)
tmem181 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000778 35
  • 56.27 (n)
  • 48.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13409 35
  • 54.32 (n)
  • 47.95 (a)
CG13409 36
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TMEM181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM181 Gene

ENSEMBL:
Gene Tree for TMEM181 (if available)
TreeFam:
Gene Tree for TMEM181 (if available)

Paralogs for TMEM181 Gene

No data available for Paralogs for TMEM181 Gene

Variants for TMEM181 Gene

Sequence variations from dbSNP and Humsavar for TMEM181 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1842 -- 158,634,609(+) CATTA(C/T)AGCAG utr-variant-3-prime
rs8036 -- 158,635,005(+) CGGTT(A/G)CCTTA utr-variant-3-prime
rs14759 -- 158,634,898(-) TGAGG(A/G)TCTGT utr-variant-3-prime
rs746284 -- 158,621,945(+) GCTCC(C/T)GCAGC intron-variant
rs750618 -- 158,561,889(+) GAGAA(A/G)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM181 Gene

Variant ID Type Subtype PubMed ID
esv2732998 CNV Deletion 23290073
esv2664518 CNV Deletion 23128226
nsv518771 CNV Loss 19592680
nsv349061 CNV Insertion 16902084
esv2732999 CNV Deletion 23290073
esv2733000 CNV Deletion 23290073
esv2672819 CNV Deletion 23128226

Variation tolerance for TMEM181 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM181 Gene

HapMap Linkage Disequilibrium report
TMEM181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM181 Gene

Disorders for TMEM181 Gene

Relevant External Links for TMEM181

Genetic Association Database (GAD)
TMEM181
Human Genome Epidemiology (HuGE) Navigator
TMEM181
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM181

No disorders were found for TMEM181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM181 Gene

Publications for TMEM181 Gene

  1. Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette J.E. … Brummelkamp T.R. (Science 2009) 3 4 67
  2. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PMID: 16452613) Wistrand M. … Sonnhammer E.L. (Protein Sci. 2006) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PMID: 19349973) Wollscheid B. … Watts J.D. (Nat. Biotechnol. 2009) 3
  5. Identification of host proteins required for HIV infection through a functional genomic screen. (PMID: 18187620) Brass A.L. … Elledge S.J. (Science 2008) 3

Products for TMEM181 Gene

Sources for TMEM181 Gene

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