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TMEM181 Gene

protein-coding   GIFtS: 46
GCID: GC06P158867

Transmembrane Protein 181

(Previous names: G protein-coupled receptor 178, KIAA1423)
(Previous symbols: KIAA1423, GPR178)
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1811 2
GPR1781 2 3 5
KIAA14231 2 3 5
G Protein-Coupled Receptor 1781 2

External Ids:    HGNC: 209581   Entrez Gene: 575832   Ensembl: ENSG000001464337   OMIM: 6132095   UniProtKB: Q9P2C43   

Export aliases for TMEM181 gene to outside databases

Previous GC identifer: GC06P156428


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for TMEM181 Gene:
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009
(PubMed 19965467); Wollscheid et al., 2009 (PubMed 19349973)).(supplied by OMIM, Jan 2010)

GeneCards Summary for TMEM181 Gene:
TMEM181 (transmembrane protein 181) is a protein-coding gene. GO annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4
Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
Expression level of TMEM181 is rate-limiting for intoxication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NT_025741.16  NC_018917.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM181 gene promoter:
         MEF-2   Pax-6   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   Evi-1   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search Chromatin IP Primers for TMEM181

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM181


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

TMEM181 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM181 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P158867:  view genomic region     (about GC identifiers)

Start:
158,957,468 bp from pter      End:
159,056,467 bp from pter
Size:
99,000 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4 (See protein sequence)
Recommended Name: Transmembrane protein 181  
Size: 612 amino acids; 69325 Da
Subunit: Interacts with cytolethal distending toxin
Sequence caution: Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VTU1

Explore the universe of human proteins at neXtProt for TMEM181: NX_Q9P2C4

Explore proteomics data for TMEM181 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn185, Asn299
  • Modification sites at PhosphoSitePlus

  • See TMEM181 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065874.1  
    ENSEMBL proteins: 
     ENSP00000356057  

    TMEM181 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9P2C4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM181_HUMAN, Q9P2C4
    Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
    Expression level of TMEM181 is rate-limiting for intoxication

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015643toxic substance binding IDA19965467
         
    Find genes that share ontologies with TMEM181           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM181:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM181
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    miRNA
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    miRTarBase miRNAs that target TMEM181:
    hsa-mir-335-5p (MIRT018233), hsa-mir-935 (MIRT036698)

    Block miRNA regulation of human, mouse, rat TMEM181 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM181 (see all 44):
    hsa-miR-579 hsa-miR-607 hsa-miR-4328 hsa-miR-374a hsa-miR-624 hsa-miR-30d hsa-miR-183* hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
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    Browse Sino Biological Human cDNA Clones
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM181

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM181_HUMAN, Q9P2C4: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    golgi apparatus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM181           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM181
    Interactions:

        Search GeneGlobe Interaction Network for TMEM181

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009405pathogenesis IMP19965467

    Find genes that share ontologies with TMEM181           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM181 (TM181)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM181 gene: 
    NM_020823.1  

    Unigene Cluster for TMEM181:

    Transmembrane protein 181
    Hs.99145  [show with all ESTs]
    Unigene Representative Sequence: NM_020823
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367090(uc010kjr.1 uc003qrm.4 uc003qri.1 uc003qrj.1 uc003qrk.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM181 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate TMEM181 (see all 44):
    hsa-miR-579 hsa-miR-607 hsa-miR-4328 hsa-miR-374a hsa-miR-624 hsa-miR-30d hsa-miR-183* hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TMEM181 (NM_020823)
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM181
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM181
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM181
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM181
      QuantiFast Probe-based Assays in human, mouse, rat TMEM181

    Additional mRNA sequence: 

    AB037844.1 AJ420476.1 AJ420523.1 AK127866.1 AL359569.1 AY927470.1 AY927471.1 AY927472.1 
    AY927473.1 AY927585.1 BC033450.1 BC044210.1 BC046100.1 BC058328.1 BC067769.1 BC092402.1 
    BC108681.1 

    12 DOTS entries:

    DT.101972628  DT.446559  DT.121404377  DT.40288173  DT.92061914  DT.92022279  DT.99999541  DT.102842599 
    DT.102842600  DT.121404325  DT.92424563  DT.99966545 

    Selected AceView cDNA sequences (see all 206):

    CB069266 BF115637 AA969015 F09857 BQ705894 BQ879425 CA314232 BU078905 
    BM980713 BC067769 AI218115 BQ029321 BC044210 AI623562 AI379035 F12228 
    AI636528 BX503578 BM550702 BM995064 BX494829 AA976851 AI273493 AW594108 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:                                                                                      -           -           -                     
    SP2:              -                                                                       -           -           -                     
    SP3:                                                                                                              -                     
    SP4:                                                                                                  -                                 


    ECgene alternative splicing isoforms for TMEM181

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM181 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCAGTTG
    TMEM181 Expression
    About this image

    TMEM181 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM181 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.99145
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM181 gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem181a1 , 5 transmembrane protein 181A1, 5 84.71(n)1
    91.93(a)1
      17 (3.85 cM)5
    771061  NM_001033178.31  NP_001028350.11 
     62704755 
    chicken
    (Gallus gallus)
    Aves TMEM1811 transmembrane protein 181 76.76(n)
    84.27(a)
      421659  XM_419698.3  XP_419698.3 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1816
    transmembrane protein 181
    75(a)
    1 ↔ 1
    1(212790875-212829492)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1811 transmembrane protein 181 72.22(n)
    78.88(a)
      733940  NM_001045654.2  NP_001039119.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1811 transmembrane protein 181 67.7(n)
    71.51(a)
      557799  NM_001044840.2  NP_001038305.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG134091 CG13409 54.32(n)
    47.95(a)
      42592  NM_142747.4  NP_651004.1 


    ENSEMBL Gene Tree for TMEM181 (if available)
    TreeFam Gene Tree for TMEM181 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM181 (see all 2574)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710301821,2
    C--156518830(-) GGGTG-/AGAA  
            
    TGAGG
    1 -- int11Minor allele frequency- AGAA:0.00NA 2
    rs677383431,2
    C--156526052(-) ACTTT-/CTAA  
            
    CTTTT
    1 -- ut312Minor allele frequency- CTAA:0.25NA 4
    rs1137936151,2
    C,F--158955575(+) TTCACG/ACCATT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1494661331,2
    C--158955635(+) CGCCCA/GGCTAA 1 -- us2k10--------
    rs1920297171,2
    --158955656(+) TTTTAC/GTAGAG 1 -- us2k10--------
    rs1837067941,2
    --158955710(+) CCTCGC/TGACCT 1 -- us2k10--------
    rs1438795001,2
    C--158955737(+) CAAAGA/TGCTGG 1 -- us2k10--------
    rs2000075521,2
    --158955741(+) TGCTG-/GGA   
       TTACA
    GGATT
    1 -- us2k10--------
    rs1879848411,2
    --158955755(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1912404281,2
    --158955756(+) GCATGA/GGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM181 (158957468 - 159056467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM181:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2732999CNV Deletion23290073
    esv2733000CNV Deletion23290073
    esv2664518CNV Deletion23128226
    esv2672819CNV Deletion23128226
    esv2732998CNV Deletion23290073
    nsv349061CNV Insertion16902084
    nsv518771CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM181
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM181

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613209    OMIM disorders: --


    Find genes that share disorders with TMEM181           About GenesLikeMe

    Genetic Association Database (GAD): TMEM181
    Human Genome Epidemiology (HuGE) Navigator: TMEM181 (1 document)

    Export disorders for TMEM181 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM181 gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TMEM181)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Haploid genetic screens in human cells identify host factors used by pathogens. (PubMed id 19965467)1, 2 Carette J.E....Brummelkamp T.R. (Science 2009)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    3. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PubMed id 16452613)1, 3 Wistrand M....Sonnhammer E.L. (Protein Sci. 2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (Nature 2003)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (BMC Syst. Biol. 2011)
    7. Genetic associations of variants in genes encoding HIV-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (J. Infect. Dis. 2010)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (Sci. Signal. 2010)
    9. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)1 Wollscheid B.... Watts J.D. (Nat. Biotechnol. 2009)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (Mol. Cell 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    NCBI Bookshelf
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57583 HGNC: 20958 AceView: KIAA1423 Ensembl:ENSG00000146433 euGenes: HUgn57583
    ECgene: TMEM181 H-InvDB: TMEM181

    (According to HUGE)
    About This Section

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    HUGE: KIAA1423

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM181 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for TMEM181 gene:
    Search GeneIP for patents involving TMEM181

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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