Aliases for TMEM181 Gene
Aliases for TMEM181 Gene
External Ids for TMEM181 Gene
- HGNC: 20958
- Entrez Gene: 57583
- Ensembl: ENSG00000146433
- OMIM: 613209
- UniProtKB: Q9P2C4
Previous HGNC Symbols for TMEM181 Gene
- KIAA1423
- GPR178
Previous GeneCards Identifiers for TMEM181 Gene
- GC06P158867
- GC06P156428
Summaries for TMEM181 Gene
-
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]
GeneCards Summary for TMEM181 Gene
TMEM181 (Transmembrane Protein 181) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include toxic substance binding.
UniProtKB/Swiss-Prot for TMEM181 Gene
-
Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Additional gene information for TMEM181 Gene
No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM181 Gene
Genomics for TMEM181 Gene
GeneHancer (GH) Regulatory Elements for TMEM181 Gene
- Top Transcription factor binding sites by QIAGEN in the TMEM181 gene promoter:
Regulatory Element Products
Genomic Locations for TMEM181 Gene
- chr6:158,536,432-158,635,435
- (GRCh38/hg38)
- Size:
- 99,004 bases
- Orientation:
- Plus strand
- chr6:158,957,468-159,056,467
- (GRCh37/hg19)
Genomic View for TMEM181 Gene
- Cytogenetic band:
-
- 6q25.3 by Ensembl
- 6q25.3 by Entrez Gene
- 6q25.3 by HGNC


RefSeq DNA sequence for TMEM181 Gene
Proteins for TMEM181 Gene
-
Protein details for TMEM181 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9P2C4-TM181_HUMAN
- Recommended name:
- Transmembrane protein 181
- Protein Accession:
- Q9P2C4
- Q5VTU1
Protein attributes for TMEM181 Gene
- Size:
- 612 amino acids
- Molecular mass:
- 69325 Da
- Quaternary structure:
-
- Interacts with cytolethal distending toxin.
- SequenceCaution:
-
- Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for TMEM181 Gene
Post-translational modifications for TMEM181 Gene
- Glycosylation at posLast=185185 and posLast=299299
Other Protein References for TMEM181 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
-
Custom Antibody ServicesOriGene Antibodies for TMEM181
- Novus Biologicals Antibodies for TMEM181
- Invitrogen Antibodies for TMEM181
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Protein Products
-
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Assay Products
No data available for DME Specific Peptides for TMEM181 Gene
Domains & Families for TMEM181 Gene
Gene Families for TMEM181 Gene
- Human Protein Atlas (HPA):
-
- Predicted membrane proteins
Protein Domains for TMEM181 Gene
- ProtoNet:
Suggested Antigen Peptide Sequences for TMEM181 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
No data available for UniProtKB/Swiss-Prot for TMEM181 Gene
Function for TMEM181 Gene
Molecular function for TMEM181 Gene
- UniProtKB/Swiss-Prot Function:
- Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.
Phenotypes From GWAS Catalog for TMEM181 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0015643 | toxic substance binding | IDA | 19965467 |
Phenotypes for TMEM181 Gene
- MGI mutant phenotypes for TMEM181:
- inferred from 1 alleles
- GenomeRNAi human phenotypes for TMEM181:
Animal Models for TMEM181 Gene
- MGI Knock Outs for TMEM181:
-
- Tmem181a tm1b(EUCOMM)Wtsi
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM181
-
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM181 gene
-
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CRISPR Products
-
OriGene CRISPR knockouts for TMEM181
- genomics-online: gRNA clones - Search results for 57 available TMEM181 gene related products
- Overview of 57 available TMEM181 gene related products
- Applied Biological Materials CRISPR for TMEM181
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Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM181
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miRNA for TMEM181 Gene
- miRTarBase miRNAs that target TMEM181
-
- hsa-mir-335-5p (MIRT018233)
- hsa-mir-935 (MIRT036698)
- hsa-mir-3714 (MIRT218108)
- hsa-mir-6878-3p (MIRT652466)
- hsa-mir-6783-3p (MIRT652467)
- hsa-mir-1343-3p (MIRT652468)
- hsa-mir-6749-3p (MIRT652469)
- hsa-mir-1260b (MIRT652470)
- hsa-mir-1260a (MIRT652471)
- hsa-mir-6744-3p (MIRT652472)
- hsa-mir-4757-5p (MIRT652473)
- hsa-mir-378g (MIRT652474)
- hsa-mir-371a-5p (MIRT652475)
- hsa-mir-212-5p (MIRT652476)
- hsa-mir-6742-3p (MIRT652477)
- hsa-mir-6852-5p (MIRT652478)
- hsa-mir-939-3p (MIRT652479)
- hsa-mir-1224-3p (MIRT652480)
- hsa-mir-6513-3p (MIRT652481)
- hsa-mir-8079 (MIRT652482)
- hsa-mir-1245a (MIRT652483)
- hsa-mir-6813-3p (MIRT652484)
- hsa-mir-6875-3p (MIRT665780)
- hsa-mir-676-5p (MIRT665781)
- hsa-mir-4742-3p (MIRT665782)
- hsa-mir-4521 (MIRT665783)
- hsa-mir-3910 (MIRT665784)
- hsa-mir-3150b-5p (MIRT665785)
- hsa-mir-3150a-5p (MIRT665786)
- hsa-mir-124-3p (MIRT665787)
- hsa-mir-506-3p (MIRT665788)
miRNA Products
- Search ViGene Biosciences for TMEM181
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for TMEM181
- Browse OriGene Inhibitory RNA Products For TMEM181
- genomics-online: shRNA clones - Search results for 57 available TMEM181 gene related products
- Overview of 57 available TMEM181 gene related products
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ViGene Biosciences ready-to-package AAV shRNAs for TMEM181 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TMEM181
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM181
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TMEM181
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
Cell Line Products
-
Horizon Cell Lines for TMEM181
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM181 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM181 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM181 gene
No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM181 Gene
Localization for TMEM181 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM181 Gene
- Membrane; Multi-pass membrane protein.
- Golgi apparatus (2)
- Vesicles (2)
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0016020 | membrane | IEA | -- |
GO:0016021 | integral component of membrane | IEA | -- |
Pathways & Interactions for TMEM181 Gene
Interacting Proteins for TMEM181 Gene
GO ID | Qualified GO term | Evidence | PubMed IDs |
---|---|---|---|
GO:0009405 | pathogenesis | IMP | 19965467 |
No data available for Pathways by source and SIGNOR curated interactions for TMEM181 Gene
Transcripts for TMEM181 Gene
mRNA/cDNA for TMEM181 Gene
- (7) REFSEQ mRNAs :
- (17) Additional mRNA sequences :
- (1) Selected AceView cDNA sequences:
- (1) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM181 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM181
- genomics-online: gRNA clones - Search results for 57 available TMEM181 gene related products
- Overview of 57 available TMEM181 gene related products
- Applied Biological Materials CRISPR for TMEM181
-
Vectors and viruses for KO, Activation, Repression, and more
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM181
- GenScript: Design CRISPR guide RNA sequences for TMEM181
miRNA Products
- Search ViGene Biosciences for TMEM181
Inhibitory RNA Products
- Origene RNAi and shrna products in human, mouse, rat for TMEM181
- Browse OriGene Inhibitory RNA Products For TMEM181
- genomics-online: shRNA clones - Search results for 57 available TMEM181 gene related products
- Overview of 57 available TMEM181 gene related products
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM181 gene
Clone Products
- VectorBuilder custom plasmid, inducible vectors for TMEM181
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM181
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- Applied Biological Materials Clones for TMEM181
-
Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more
ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
SP1: | - | - | - | ||||||||||||||||||||||||||||||||||||||||
SP2: | - | - | - | - | |||||||||||||||||||||||||||||||||||||||
SP3: | - | ||||||||||||||||||||||||||||||||||||||||||
SP4: | - |
Expression for TMEM181 Gene
mRNA differential expression in normal tissues according to GTEx for TMEM181 Gene
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM181 Gene
NURSA nuclear receptor signaling pathways regulating expression of TMEM181 Gene:
TMEM181SOURCE GeneReport for Unigene cluster for TMEM181 Gene:
Hs.99145Evidence on tissue expression from TISSUES for TMEM181 Gene
- Nervous system(4.3)
Primer Products
-
OriGene qPCR primer pairs for TMEM181
- genomics-online: primer clones - Search results for 57 available TMEM181 gene related products
- Overview of 57 available TMEM181 gene related products
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM181 Gene
Orthologs for TMEM181 Gene
This gene was present in the common ancestor of animals.
Organism | Taxonomy | Gene | Similarity | Type | Details |
---|---|---|---|---|---|
chimpanzee (Pan troglodytes) |
Mammalia | TMEM181 33 34 |
|
||
mouse (Mus musculus) |
Mammalia | Tmem181b-ps 34 34 |
|
OneToMany | |
Tmem181c-ps 34 |
|
OneToMany | |||
Tmem181a 33 16 34 |
|
||||
rat (Rattus norvegicus) |
Mammalia | Tmem181 33 |
|
||
dog (Canis familiaris) |
Mammalia | TMEM181 33 34 |
|
||
platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM181 34 |
|
OneToOne | |
cow (Bos Taurus) |
Mammalia | TMEM181 33 34 |
|
||
oppossum (Monodelphis domestica) |
Mammalia | TMEM181 34 |
|
OneToOne | |
chicken (Gallus gallus) |
Aves | TMEM181 33 34 |
|
||
lizard (Anolis carolinensis) |
Reptilia | TMEM181 34 |
|
OneToOne | |
tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem181 33 |
|
||
zebrafish (Danio rerio) |
Actinopterygii | tmem181 33 34 |
|
||
African malaria mosquito (Anopheles gambiae) |
Insecta | AgaP_AGAP000778 33 |
|
||
fruit fly (Drosophila melanogaster) |
Insecta | CG13409 33 34 |
|
||
sea squirt (Ciona savignyi) |
Ascidiacea | -- 34 |
|
OneToOne |
- Species where no ortholog for TMEM181 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TMEM181 Gene
No data available for Paralogs for TMEM181 Gene
Variants for TMEM181 Gene
SNP ID | Clin | Chr 06 pos | Variation | AA Info | Type |
---|---|---|---|---|---|
rs1000044765 | -- | 158,585,151(+) | C/A | intron_variant | |
rs1000082599 | -- | 158,543,029(+) | C/A | genic_upstream_transcript_variant, intron_variant | |
rs1000091114 | -- | 158,620,564(+) | C/T | genic_downstream_transcript_variant, intron_variant | |
rs1000096705 | -- | 158,584,905(+) | T/A | intron_variant | |
rs1000123494 | -- | 158,633,199(+) | G/ | 3_prime_UTR_variant, genic_downstream_transcript_variant |
Variant ID | Type | Subtype | PubMed ID |
---|---|---|---|
dgv3422n106 | CNV | deletion | 24896259 |
esv2664518 | CNV | deletion | 23128226 |
esv2672819 | CNV | deletion | 23128226 |
esv2732998 | CNV | deletion | 23290073 |
esv2732999 | CNV | deletion | 23290073 |
esv2733000 | CNV | deletion | 23290073 |
esv3540742 | CNV | deletion | 23714750 |
esv3540743 | CNV | deletion | 23714750 |
esv3611399 | CNV | loss | 21293372 |
nsv1074972 | CNV | deletion | 25765185 |
nsv1152744 | CNV | deletion | 26484159 |
nsv349061 | CNV | insertion | 16902084 |
nsv518771 | CNV | loss | 19592680 |
nsv955906 | CNV | deletion | 24416366 |
Additional Variant Information for TMEM181 Gene
- SNPedia medical, phenotypic, and genealogical associations of SNPs for
- TMEM181
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM181 Gene
Disorders for TMEM181 Gene
Additional Disease Information for TMEM181
- Genetic Association Database
- (GAD)
- Human Genome Epidemiology Navigator
- (HuGE)
- ATLAS of Genetics and Cytogenetics in Oncology and Haematology
No disorders were found for TMEM181 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM181 Gene
Publications for TMEM181 Gene
- Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette JE … Brummelkamp TR (Science (New York, N.Y.) 2009) 3 4 58
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen JV … Mann M (Cell 2006) 3 4 58
- A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PMID: 16452613) Wistrand M … Sonnhammer EL (Protein science : a publication of the Protein Society 2006) 2 3 58
- The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall AJ … Beck S (Nature 2003) 3 4 58
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 3 4 58
Products for TMEM181 Gene
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- Invitrogen Antibodies for TMEM181
- Cyagen custom Knockout/knockin (KOKI) mouse models for TMEM181
- VectorBuilder custom plasmid, inducible vectors for TMEM181
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for TMEM181
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
- antibodies-online: Search results for 10 available TMEM181 Antibodies ranked by validation data
- Compare Top TMEM181 Antibodies
- antibodies-online: Search results for available TMEM181 related products ranked by validation data
- antibodies-online: Search results for available TMEM181 related products ranked by validation data
- Search GeneTex for Antibodies for TMEM181
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- ViGene Biosciences adenoviral particle packaged cDNA for TMEM181 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM181 gene
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- genomics-online: cdna clones - Search results for 57 available TMEM181 gene related products
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- Overview of 57 available TMEM181 gene related products
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- Overview of 57 available TMEM181 gene related products
Sources for TMEM181 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) IntAct
- (22) Novoseek
- (23) PharmGKB
- (24) DrugBank
- (25) HMDB
- (26) UniGene
- (27) AceView
- (28) ASD
- (29) ECgene
- (30) GeneAnnot
- (31) CGAP SAGE
- (32) SOURCE
- (33) HomoloGene
- (34) PanEnsembl
- (35) euGenes
- (36) SGD
- (37) FlyBase
- (38) WormBase
- (39) Pseudogene
- (40) DGV
- (41) dbSNP
- (42) GenAtlas
- (43) HGMD
- (44) GAD
- (45) BGMUT
- (46) HuGE
- (47) Atlas
- (48) Cell Signaling Technology
- (49) GenBank
- (50) H-invDB
- (51) HORDE
- (52) HUGE
- (53) IMGT
- (54) Leiden
- (55) miRBase
- (56) DME
- (57) OriGene
- (58) PubMed
- (59) R&D Systems
- (60) TGDB
- (61) Tocris
- (62) Abcam
- (63) Novus Biologicals
- (64) ProSpec
- (65) Sino Biological
- (66) GenScript
- (67) Qiagen
- (68) Cloud-Clone Corp.
- (69) OCA
- (70) Proteopedia
- (71) MOPED
- (72) neXtProt
- (73) Reactome
- (74) GeneGo (Thomson Reuters)
- (75) fRNAdb
- (76) DISEASES
- (77) SIMAP
- (78) GenomeRNAi
- (79) LifeMap
- (80) miRTarBase
- (81) MalaCards
- (82) Invitrogen
- (83) BitterDB
- (84) Vector BioLabs
- (85) ESI-BIO
- (86) RefSeq
- (87) BioSystems
- (88) MaxQB
- (89) IUPHAR
- (90) BioGPS
- (91) Illumina
- (92) COMPARTMENTS
- (93) HOMER
- (94) PaxDb
- (95) ApexBio
- (96) Addgene
- (97) antibodies-online
- (98) CYP
- (99) NONCODE
- (100) SwitchGear Genomics
- (101) TreeFam
- (102) PathCards
- (103) GeneReviews
- (104) GeneTex
- (105) Taconic Biosciences
- (106) GTEx
- (107) ProteomicsDB
- (108) SCBT
- (109) DGIdb
- (110) ClinicalTrials
- (111) FDA Approved Drugs
- (112) RVIS
- (113) SIGNOR
- (114) diseasecard
- (115) NIH Rare Diseases
- (116) Orphanet
- (117) UMLS
- (118) GTR
- (119) Disease Ontology
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