TMEM181 Gene
protein-coding GIFtS: 42
GCID: GC06P158867
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|
Transmembrane Protein 181(Previous names: G protein-coupled receptor 178, KIAA1423)
(Previous symbols: KIAA1423, GPR178)
| |
Aliases
for TMEM181 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1811 2 | | GPR1781 2 3 5 | | KIAA14231 2 3 5 | | G Protein-Coupled Receptor 1781 2 |
Export aliases for TMEM181 gene to outside databasesPrevious GC identifer: GC06P156428 |
Summaries
for TMEM181 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for TMEM181 Gene:
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009
(PubMed 19965467); Wollscheid et al., 2009 (PubMed 19349973)).(supplied by OMIM, Jan 2010)
GeneCards Summary for TMEM181 Gene: 
TMEM181 (transmembrane protein 181) is a protein-coding gene. GO annotations related to this gene include toxic substance binding.
UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
Expression level of TMEM181 is rate-limiting for intoxication
|
Genomic Views
for TMEM181 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 73),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000006.11 NT_025741.15 NC_018917.2
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM181 gene promoter:
MEF-2 Pax-6 NRSF form 1 Pax-2 Pax-2a NRSF form 2 Evi-1 MEF-2A aMEF-2 Hlf
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM181
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM181 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 6q25.3 Ensembl cytogenetic band: 6q25.3 HGNC cytogenetic band: 6q25.3TMEM181 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 6 GeneLoc Exon Structure GeneLoc location for GC06P158867: view genomic region
(about GC identifiers)
Start:
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158,957,468 bp from pter |
End:
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159,056,467 bp from pter |
Size:
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99,000 bases |
Orientation:
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plus strand |
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Proteins
for TMEM181 gene
(According to
UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MAXQB
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Ontologies according to Gene
Ontology Consortium 01 Oct 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
About This Section
|
UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4 (See
protein sequence)Recommended Name: Transmembrane protein 181 Size: 612 amino acids; 69325 Da
Subunit: Interacts with cytolethal distending toxin
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VTU1Explore the universe of human proteins at neXtProt for TMEM181: NX_Q9P2C4
Explore proteomics data for TMEM181 at MOPED
Post-translational modifications:
View modification sites using PhosphoSitePlusView neXtProt modification sites for NX_Q9P2C4
TMEM181 Protein expression data from MOPED1, PaxDb2 and
MAXQB3 : About this image 
REFSEQ proteins: NP_065874.1
ENSEMBL proteins: ENSP00000356057
Human Recombinant Protein Products for TMEM181:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM181 for ontologies About GeneDecksing
TMEM181 Antibody Products:
Assay Products for TMEM181: |
Protein
Domains /
Families
for TMEM181 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q9P2C4 |
Function
for TMEM181 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
Vector BioLabs,
and Sirion Biotech,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene.)
About This Section
|
Molecular Function:
UniProtKB/Swiss-Prot Summary: TM181_HUMAN, Q9P2C4Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
Expression level of TMEM181 is rate-limiting for intoxication Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table
TMEM181 for ontologies About GeneDecksing
Phenotypes:
1 GenomeRNAi human phenotype for TMEM181:
Animal Models:
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TMEM181 | |  | Search LifeMap BioReagents cell lines for TMEM181 | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181 |
Pathways & Interactions
for TMEM181 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Oct 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM181
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table
TMEM181 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM181 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM181 (TM181)
Search CenterWatch for drugs/clinical trials and news about TMEM181 / TM181
|
Transcripts
for TMEM181 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Sirion Biotech,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM181 gene: NM_020823.1 Unigene Cluster for TMEM181: Transmembrane protein 181 Hs.99145 [show with all ESTs]Unigene Representative Sequence: NM_0208231 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000367090(uc010kjr.1 uc003qrm.4 uc003qri.1 uc003qrj.1 uc003qrk.1)
Congresses - knowledge worth sharing: 
European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014
Primer
Products: |  | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM181
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM181 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM181 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM181 |
Additional mRNA sequence: AB037844.1 AJ420476.1 AJ420523.1 AK127866.1 AL359569.1 AY927470.1 AY927471.1 AY927472.1 AY927473.1 AY927585.1 BC033450.1 BC044210.1 BC046100.1 BC058328.1 BC067769.1 BC092402.1 BC108681.1 12 DOTS entries: DT.101972628 DT.446559 DT.121404377 DT.40288173 DT.92061914 DT.92022279 DT.99999541 DT.102842599 DT.102842600 DT.121404325 DT.92424563 DT.99966545 24/206 AceView cDNA sequences (see all 206): CB069266 BF115637 AA969015 F09857 BQ705894 BQ879425 CA314232 BU078905 BM980713 BC067769 AI218115 BQ029321 BC044210 AI623562 AI379035 F12228 AI636528 BX503578 BM550702 BM995064 BX494829 AA976851 AI273493 AW594108
GeneLoc Exon Structure
4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14a | · | 14b | ^ | 15 | ^ | 16a | · | 16b | ^ | 17 | ^ | 18a | · | 18b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | | | | | | | | | - | | | | - | | | | - | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM181
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Expression
for TMEM181 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM181 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TGTTCAGTTG
About this image
See TMEM181 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM181
SOURCE GeneReport for Unigene cluster: Hs.99145
SABiosciences Custom PCR Arrays for TMEM181
Primer
Products: | | OriGene qSTAR qPCR primer pairs in human, mouse for TMEM181
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM181 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM181 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM181 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181 |
Orthologs
for TMEM181 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM181 gene from 5/13 species (see all 13) About this table
ENSEMBL Gene Tree for TMEM181 (if available)
TreeFam Gene Tree for TMEM181 (if available) |
Paralogs
for TMEM181 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM181 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 6 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM181 (158957468 - 159056467 bp)
Structural Variations
Database of Genomic Variants (DGV) 7 variations for TMEM181: About this table
| | SABiosciences Cancer Mutation PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TMEM181 |
|
Disorders
/ Diseases
for TMEM181 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM181 for disorders About MalaCards
OMIM gene information: 613209
OMIM disorders: --
TMEM181 for disorders About GeneDecksing
Genetic Association Database (GAD): TMEM181
Human Genome Epidemiology (HuGE) Navigator: TMEM181 (1 document)
Export disorders for TMEM181 gene to outside databases
|
Publications
for TMEM181 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM181 gene, integrated from 9 sources (see all 12):
(articles sorted by number of sources associating them with TMEM181) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Haploid genetic screens in human cells identify host factors used by pathogens. (PubMed id 19965467)1, 2 Carette J.E....Brummelkamp T.R. (2009)
- Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
- A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PubMed id 16452613)1, 3 Wistrand M....Sonnhammer E.L. (2006)
- The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
- Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
- Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
- Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
- Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
- Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)1 Wollscheid B.... Watts J.D. (2009)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
|
External Searches for TMEM181 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM181 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM181 gene
(According to HUGE)
About This Section
| |
Specialized Databases showing TMEM181 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM181 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM181 gene:
Search GeneIP for patents involving TMEM181
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM181 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
|
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 |
| | | | |
 |
 |
|  | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM181 | | | QIAGEN SeqTarget long-range PCR primers for resequencing TMEM181 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM181 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM181 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM181 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM181 |
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 |
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 | | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM181 |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM181 |
| |  |  |  | | | | LSBio Antibodies in human, mouse, rat for TMEM181 |
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