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Aliases for TMEM181 Gene

Aliases for TMEM181 Gene

  • Transmembrane Protein 181 2 3
  • KIAA1423 2 3 4 6
  • GPR178 3 4 6
  • G Protein-Coupled Receptor 178 2 3

External Ids for TMEM181 Gene

Previous HGNC Symbols for TMEM181 Gene

  • KIAA1423
  • GPR178

Previous GeneCards Identifiers for TMEM181 Gene

  • GC06P158867
  • GC06P156428

Summaries for TMEM181 Gene

Entrez Gene Summary for TMEM181 Gene

  • The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

GeneCards Summary for TMEM181 Gene

TMEM181 (Transmembrane Protein 181) is a Protein Coding gene. GO annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot for TMEM181 Gene

  • Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM181 Gene

Genomics for TMEM181 Gene

Regulatory Elements for TMEM181 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM181 Gene

Start:
158,536,436 bp from pter
End:
158,635,435 bp from pter
Size:
99,000 bases
Orientation:
Plus strand

Genomic View for TMEM181 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM181 Gene

Proteins for TMEM181 Gene

  • Protein details for TMEM181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2C4-TM181_HUMAN
    Recommended name:
    Transmembrane protein 181
    Protein Accession:
    Q9P2C4
    Secondary Accessions:
    • Q5VTU1

    Protein attributes for TMEM181 Gene

    Size:
    612 amino acids
    Molecular mass:
    69325 Da
    Quaternary structure:
    • Interacts with cytolethal distending toxin.
    SequenceCaution:
    • Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM181 Gene

Proteomics data for TMEM181 Gene at MOPED

Post-translational modifications for TMEM181 Gene

  • Glycosylation at Asn185 and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM181 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM181 Gene

Domains for TMEM181 Gene

Protein Domains for TMEM181 Gene

ProtoNet:

Suggested Antigen Peptide Sequences for TMEM181 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM181: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM181 Gene

Function for TMEM181 Gene

Molecular function for TMEM181 Gene

UniProtKB/Swiss-Prot Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

Gene Ontology (GO) - Molecular Function for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015643 toxic substance binding IDA 19965467
genes like me logo Genes that share ontologies with TMEM181: view

Phenotypes for TMEM181 Gene

GenomeRNAi human phenotypes for TMEM181:
genes like me logo Genes that share phenotypes with TMEM181: view

Animal Model Products

CRISPR Products

miRNA for TMEM181 Gene

miRTarBase miRNAs that target TMEM181

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM181

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM181 Gene

Localization for TMEM181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM181 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM181 Gene COMPARTMENTS Subcellular localization image for TMEM181 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM181: view

Pathways for TMEM181 Gene

SuperPathways for TMEM181 Gene

No Data Available

Interacting Proteins for TMEM181 Gene

Gene Ontology (GO) - Biological Process for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009405 pathogenesis IMP 19965467
genes like me logo Genes that share ontologies with TMEM181: view

No data available for Pathways by source for TMEM181 Gene

Transcripts for TMEM181 Gene

Unigene Clusters for TMEM181 Gene

Transmembrane protein 181:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM181

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM181

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for TMEM181 Gene

GeneLoc Exon Structure for
TMEM181
ECgene alternative splicing isoforms for
TMEM181

Expression for TMEM181 Gene

mRNA expression in normal human tissues for TMEM181 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM181 Gene

This gene is overexpressed in Artery - Tibial (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM181 Gene

SOURCE GeneReport for Unigene cluster for TMEM181 Gene Hs.99145

genes like me logo Genes that share expressions with TMEM181: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM181 Gene

Orthologs for TMEM181 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM181 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM181 35
  • 99.13 (n)
  • 98.69 (a)
TMEM181 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM181 35
  • 84.54 (n)
  • 88.14 (a)
TMEM181 36
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM181 35
  • 85.51 (n)
  • 89.33 (a)
TMEM181 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem181a 35
  • 84.71 (n)
  • 91.93 (a)
Tmem181a 16
Tmem181a 36
  • 91 (a)
OneToMany
Tmem181b-ps 36
  • 95 (a)
OneToMany
Tmem181b-ps 36
  • 85 (a)
OneToMany
Tmem181c-ps 36
  • 95 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia TMEM181 36
  • 84 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM181 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem181 35
  • 87.22 (n)
  • 93.64 (a)
chicken
(Gallus gallus)
Aves TMEM181 35
  • 76.76 (n)
  • 84.27 (a)
TMEM181 36
  • 82 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM181 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem181 35
  • 72.22 (n)
  • 78.88 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem181 35
  • 67.7 (n)
  • 71.51 (a)
tmem181 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000778 35
  • 56.27 (n)
  • 48.6 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG13409 35
  • 54.32 (n)
  • 47.95 (a)
CG13409 36
  • 45 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for TMEM181:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM181 Gene

ENSEMBL:
Gene Tree for TMEM181 (if available)
TreeFam:
Gene Tree for TMEM181 (if available)

Paralogs for TMEM181 Gene

No data available for Paralogs for TMEM181 Gene

Variants for TMEM181 Gene

Sequence variations from dbSNP and Humsavar for TMEM181 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs1842 -- 158,634,609(+) CATTA(C/T)AGCAG utr-variant-3-prime
rs8036 -- 158,635,005(+) CGGTT(A/G)CCTTA utr-variant-3-prime
rs14759 -- 158,634,898(-) TGAGG(A/G)TCTGT utr-variant-3-prime
rs746284 -- 158,621,945(+) GCTCC(C/T)GCAGC intron-variant
rs750618 -- 158,561,889(+) GAGAA(A/G)AGTTT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM181 Gene

Variant ID Type Subtype PubMed ID
esv2732998 CNV Deletion 23290073
esv2664518 CNV Deletion 23128226
nsv518771 CNV Loss 19592680
nsv349061 CNV Insertion 16902084
esv2732999 CNV Deletion 23290073
esv2733000 CNV Deletion 23290073
esv2672819 CNV Deletion 23128226

Relevant External Links for TMEM181 Gene

HapMap Linkage Disequilibrium report
TMEM181

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM181 Gene

Disorders for TMEM181 Gene

Relevant External Links for TMEM181

Genetic Association Database (GAD)
TMEM181
Human Genome Epidemiology (HuGE) Navigator
TMEM181
genes like me logo Genes that share disorders with TMEM181: view

No data available for UniProtKB/Swiss-Prot for TMEM181 Gene

Publications for TMEM181 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  2. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4
  3. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PMID: 16452613) Wistrand M. … Sonnhammer E.L. (Protein Sci. 2006) 2 3
  4. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4
  5. Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette J.E. … Brummelkamp T.R. (Science 2009) 3 4

Products for TMEM181 Gene

Sources for TMEM181 Gene

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