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Aliases for TMEM181 Gene

Aliases for TMEM181 Gene

  • Transmembrane Protein 181 2 3 5
  • KIAA1423 2 3 4
  • G Protein-Coupled Receptor 178 2 3
  • GPR178 3 4

External Ids for TMEM181 Gene

Previous HGNC Symbols for TMEM181 Gene

  • KIAA1423
  • GPR178

Previous GeneCards Identifiers for TMEM181 Gene

  • GC06P158867
  • GC06P156428

Summaries for TMEM181 Gene

Entrez Gene Summary for TMEM181 Gene

  • The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009 [PubMed 19965467]; Wollscheid et al., 2009 [PubMed 19349973]).[supplied by OMIM, Jan 2010]

GeneCards Summary for TMEM181 Gene

TMEM181 (Transmembrane Protein 181) is a Protein Coding gene. GO annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot for TMEM181 Gene

  • Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM181 Gene

Genomics for TMEM181 Gene

Regulatory Elements for TMEM181 Gene

Enhancers for TMEM181 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G158559 1.6 Ensembl ENCODE dbSUPER 23 +24.4 24359 3.3 HDGF FOXA2 MLX ARNT CREB3L1 AGO1 ARID4B SIN3A DMAP1 ZNF766 TMEM181 DYNLT1 SYTL3 PIR47640 PIR42837
GH06G158648 1.9 FANTOM5 Ensembl ENCODE dbSUPER 7.5 +115.9 115908 8.2 HDGF PKNOX1 MLX WRNIP1 SIN3A FEZF1 ZNF48 SLC30A9 GATA2 ZNF143 SYTL3 DYNLT1 TATDN2P2 TAGAP LOC442272 RNU6-293P TMEM181 AMZ2P2
GH06G158563 1.5 Ensembl ENCODE dbSUPER 9 +30.5 30469 7.0 HDGF FOXA2 ZFP64 ZNF133 ARID4B YBX1 GLI4 ZNF48 ZNF143 ZNF207 TMEM181 DYNLT1 SYTL3 PIR47640 PIR33029
GH06G158807 2.1 FANTOM5 Ensembl ENCODE dbSUPER 5.5 +277.6 277567 13.2 CREB3L1 AGO1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 MEF2D GLIS1 EZR LOC442272 RNU6-293P RSPH3 SYTL3 TMEM181 DYNLT1 TAGAP EZR-AS1 GC06M158798
GH06G158571 1.3 ENCODE dbSUPER 8.2 +36.2 36189 2.4 FOXA2 ATF1 MLX ZFP64 ARID4B DMAP1 ZNF48 TCF12 SLC30A9 PAF1 SYTL3 TMEM181 DYNLT1 PIR33029 PIR47640
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM181 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM181 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000206106 368 1201 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 SLC30A9 ZNF766 CBX5 ZNF143

Genomic Location for TMEM181 Gene

158,536,432 bp from pter
158,635,435 bp from pter
99,004 bases
Plus strand

Genomic View for TMEM181 Gene

Genes around TMEM181 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM181 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM181 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM181 Gene

Proteins for TMEM181 Gene

  • Protein details for TMEM181 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 181
    Protein Accession:
    Secondary Accessions:
    • Q5VTU1

    Protein attributes for TMEM181 Gene

    612 amino acids
    Molecular mass:
    69325 Da
    Quaternary structure:
    • Interacts with cytolethal distending toxin.
    • Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

neXtProt entry for TMEM181 Gene

Post-translational modifications for TMEM181 Gene

  • Glycosylation at Asn185 and Asn299
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM181 Gene

No data available for DME Specific Peptides for TMEM181 Gene

Domains & Families for TMEM181 Gene

Protein Domains for TMEM181 Gene


Suggested Antigen Peptide Sequences for TMEM181 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM181: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM181 Gene

Function for TMEM181 Gene

Molecular function for TMEM181 Gene

UniProtKB/Swiss-Prot Function:
Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria. Expression level of TMEM181 is rate-limiting for intoxication.

Gene Ontology (GO) - Molecular Function for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0015643 toxic substance binding IDA 19965467
genes like me logo Genes that share ontologies with TMEM181: view
genes like me logo Genes that share phenotypes with TMEM181: view

Animal Models for TMEM181 Gene

MGI Knock Outs for TMEM181:

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM181 Gene

Localization for TMEM181 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM181 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM181 gene
Compartment Confidence
plasma membrane 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM181: view

Pathways & Interactions for TMEM181 Gene

SuperPathways for TMEM181 Gene

No Data Available

Interacting Proteins for TMEM181 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
Selected Interacting proteins: ENSP00000356057 Q9P2C4-TM181_HUMAN for TMEM181 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM181 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009405 pathogenesis IMP 19965467
genes like me logo Genes that share ontologies with TMEM181: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM181 Gene

Drugs & Compounds for TMEM181 Gene

No Compound Related Data Available

Transcripts for TMEM181 Gene

mRNA/cDNA for TMEM181 Gene

(7) REFSEQ mRNAs :
(17) Additional mRNA sequences :
(1) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM181 Gene

Transmembrane protein 181:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
SP1: - - -
SP2: - - - -
SP3: -
SP4: -

Relevant External Links for TMEM181 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM181 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM181 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM181 Gene

This gene is overexpressed in Artery - Tibial (x10.1).

Protein differential expression in normal tissues from HIPED for TMEM181 Gene

This gene is overexpressed in Pancreas (22.3), Lung (11.2), Testis (11.1), Peripheral blood mononuclear cells (9.9), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM181 Gene

Protein tissue co-expression partners for TMEM181 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM181 Gene:


SOURCE GeneReport for Unigene cluster for TMEM181 Gene:


Evidence on tissue expression from TISSUES for TMEM181 Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM181: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM181 Gene

Orthologs for TMEM181 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM181 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM181 34 35
  • 99.13 (n)
(Mus musculus)
Mammalia Tmem181b-ps 35 35
  • 95 (a)
Tmem181c-ps 35
  • 95 (a)
Tmem181a 34 16 35
  • 84.71 (n)
(Rattus norvegicus)
Mammalia Tmem181 34
  • 87.22 (n)
(Canis familiaris)
Mammalia TMEM181 34 35
  • 85.51 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM181 35
  • 85 (a)
(Bos Taurus)
Mammalia TMEM181 34 35
  • 84.54 (n)
(Monodelphis domestica)
Mammalia TMEM181 35
  • 84 (a)
(Gallus gallus)
Aves TMEM181 34 35
  • 76.76 (n)
(Anolis carolinensis)
Reptilia TMEM181 35
  • 75 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem181 34
  • 72.22 (n)
(Danio rerio)
Actinopterygii tmem181 34 35
  • 67.7 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP000778 34
  • 56.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG13409 34 35
  • 54.32 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 43 (a)
Species where no ortholog for TMEM181 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM181 Gene

Gene Tree for TMEM181 (if available)
Gene Tree for TMEM181 (if available)

Paralogs for TMEM181 Gene

No data available for Paralogs for TMEM181 Gene

Variants for TMEM181 Gene

Sequence variations from dbSNP and Humsavar for TMEM181 Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000044765 -- 158,585,151(+) CTGGG(A/C)AATTA intron-variant
rs1000082599 -- 158,543,029(+) TGCCA(A/C)CACGC intron-variant
rs1000091114 -- 158,620,564(+) CCCAT(C/T)GCTGG intron-variant
rs1000096705 -- 158,584,905(+) TTTTT(A/T)AAAAT intron-variant
rs1000123494 -- 158,633,199(+) AAAAC(-/G)TATTT utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM181 Gene

Variant ID Type Subtype PubMed ID
dgv3422n106 CNV deletion 24896259
esv2664518 CNV deletion 23128226
esv2672819 CNV deletion 23128226
esv2732998 CNV deletion 23290073
esv2732999 CNV deletion 23290073
esv2733000 CNV deletion 23290073
esv3540742 CNV deletion 23714750
esv3540743 CNV deletion 23714750
esv3611399 CNV loss 21293372
nsv1074972 CNV deletion 25765185
nsv1152744 CNV deletion 26484159
nsv349061 CNV insertion 16902084
nsv518771 CNV loss 19592680
nsv955906 CNV deletion 24416366

Variation tolerance for TMEM181 Gene

Residual Variation Intolerance Score: 69.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.52; 44.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM181 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM181 Gene

Disorders for TMEM181 Gene

Relevant External Links for TMEM181

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM181 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM181 Gene

Publications for TMEM181 Gene

  1. Haploid genetic screens in human cells identify host factors used by pathogens. (PMID: 19965467) Carette J.E. … Brummelkamp T.R. (Science 2009) 3 4 64
  2. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PMID: 16452613) Wistrand M. … Sonnhammer E.L. (Protein Sci. 2006) 2 3 64
  3. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PMID: 17081983) Olsen J.V. … Mann M. (Cell 2006) 3 4 64
  4. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 3 4 64
  5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 3 4 64

Products for TMEM181 Gene

Sources for TMEM181 Gene

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