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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM181 Gene

protein-coding   GIFtS: 42
GCID: GC06P158867

Transmembrane Protein 181

(Previous names: G protein-coupled receptor 178, KIAA1423)
(Previous symbols: KIAA1423, GPR178)
Microbiology & Infectious Diseases Congress
  Search for TMEM181
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1811 2
GPR1781 2 3 5
KIAA14231 2 3 5
G Protein-Coupled Receptor 1781 2

External Ids:    HGNC: 209581   Entrez Gene: 575832   Ensembl: ENSG000001464337   OMIM: 6132095   UniProtKB: Q9P2C43   

Export aliases for TMEM181 gene to outside databases

Previous GC identifer: GC06P156428


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for TMEM181 Gene:
The TMEM181 gene encodes a putative G protein-coupled receptor expressed on the cell surface (Carette et al., 2009
(PubMed 19965467); Wollscheid et al., 2009 (PubMed 19349973)).(supplied by OMIM, Jan 2010)

GeneCards Summary for TMEM181 Gene: 
TMEM181 (transmembrane protein 181) is a protein-coding gene. GO annotations related to this gene include toxic substance binding.

UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4
Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
Expression level of TMEM181 is rate-limiting for intoxication




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000006.11  NT_025741.15  NC_018917.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM181 gene promoter:
         MEF-2   Pax-6   NRSF form 1   Pax-2   Pax-2a   NRSF form 2   Evi-1   MEF-2A   aMEF-2   Hlf   
         Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids
   Search SABiosciences Chromatin IP Primers for TMEM181

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM181


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q25.3   Ensembl cytogenetic band:  6q25.3   HGNC cytogenetic band: 6q25.3

TMEM181 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM181 gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06P158867:  view genomic region     (about GC identifiers)

Start:
158,957,468 bp from pter      End:
159,056,467 bp from pter
Size:
99,000 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: TM181_HUMAN, Q9P2C4 (See protein sequence)
Recommended Name: Transmembrane protein 181  
Size: 612 amino acids; 69325 Da
Subunit: Interacts with cytolethal distending toxin
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Sequence caution: Sequence=BAA92661.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q5VTU1

Explore the universe of human proteins at neXtProt for TMEM181: NX_Q9P2C4

Explore proteomics data for TMEM181 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2C4

  • TMEM181 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM181 Protein Expression
    REFSEQ proteins: NP_065874.1  
    ENSEMBL proteins: 
     ENSP00000356057  

    Human Recombinant Protein Products for TMEM181: 
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    Cloud-Clone Corp. Proteins for TMEM181 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--

    TMEM181 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q9P2C4


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TM181_HUMAN, Q9P2C4
    Function: Mediates action of cytolethal distending toxins (CDT), which are secreted by many pathogenic bacteria.
    Expression level of TMEM181 is rate-limiting for intoxication

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0015643toxic substance binding IDA19965467
         
    TMEM181 for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for TMEM181:
     Decreased p24 protein expressi 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM181 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM181 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM181

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009405pathogenesis IMP19965467

    TMEM181 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM181 (TM181)

    Search CenterWatch for drugs/clinical trials and news about TMEM181 / TM181

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM181 gene: 
    NM_020823.1  

    Unigene Cluster for TMEM181:

    Transmembrane protein 181
    Hs.99145  [show with all ESTs]
    Unigene Representative Sequence: NM_020823
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000367090(uc010kjr.1 uc003qrm.4 uc003qri.1 uc003qrj.1 uc003qrk.1)

    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM181
    8/44 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM181 (see all 44):
    hsa-miR-579 hsa-miR-607 hsa-miR-4328 hsa-miR-374a hsa-miR-624 hsa-miR-30d hsa-miR-183* hsa-miR-124
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for TMEM181
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM181
    Clone
    Products:
         
    OriGene clones in human, mouse for TMEM181 (see all 7)
    OriGene ORF clones in mouse, rat for TMEM181
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    Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat TMEM181
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                         Customized lentivirus expression plasmids for stable overexpression of TMEM181 
    Primer
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM181
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM181

    Additional mRNA sequence: 

    AB037844.1 AJ420476.1 AJ420523.1 AK127866.1 AL359569.1 AY927470.1 AY927471.1 AY927472.1 
    AY927473.1 AY927585.1 BC033450.1 BC044210.1 BC046100.1 BC058328.1 BC067769.1 BC092402.1 
    BC108681.1 

    12 DOTS entries:

    DT.101972628  DT.446559  DT.121404377  DT.40288173  DT.92061914  DT.92022279  DT.99999541  DT.102842599 
    DT.102842600  DT.121404325  DT.92424563  DT.99966545 

    24/206 AceView cDNA sequences (see all 206):

    CB069266 BF115637 AA969015 F09857 BQ705894 BQ879425 CA314232 BU078905 
    BM980713 BC067769 AI218115 BQ029321 BC044210 AI623562 AI379035 F12228 
    AI636528 BX503578 BM550702 BM995064 BX494829 AA976851 AI273493 AW594108 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM181    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15 ^ 16a · 16b ^ 17 ^ 18a · 18b
    SP1:                                                                                      -           -           -                     
    SP2:              -                                                                       -           -           -                     
    SP3:                                                                                                              -                     
    SP4:                                                                                                  -                                 


    ECgene alternative splicing isoforms for TMEM181

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM181 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTTCAGTTG
    TMEM181 Expression
    About this image


    See TMEM181 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM181

    SOURCE GeneReport for Unigene cluster: Hs.99145
        SABiosciences Custom PCR Arrays for TMEM181
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM181

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for TMEM181 gene from 5/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem181a1 , 5 transmembrane protein 181A1, 5 84.71(n)1
    91.93(a)1
      17 (3.85 cM)5
    771061  NM_001033178.21  NP_001028350.11 
     62704755 
    chicken
    (Gallus gallus)
    Aves TMEM1811 transmembrane protein 181 76.68(n)
    84.3(a)
      421659  XM_419698.2  XP_419698.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1816
    Uncharacterized protein
    75(a)
    1 ↔ 1
    1(212790875-212829492)
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1811 transmembrane protein 181 67.77(n)
    71.93(a)
      557799  NM_001044840.2  NP_001038305.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG134091 CG13409 55.13(n)
    48.79(a)
      42592  NM_142747.3  NP_651004.1 


    ENSEMBL Gene Tree for TMEM181 (if available)
    TreeFam Gene Tree for TMEM181 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2574 SNPs in TMEM181 are shown (see all 2574)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs710301821,2
    C--156518830(-) GGGTG-/AGAA  
            
    TGAGG
    1 -- int11Minor allele frequency- AGAA:0.00NA 2
    rs677383431,2
    C--156526052(-) ACTTT-/CTAA  
            
    CTTTT
    1 -- ut312Minor allele frequency- CTAA:0.25NA 4
    rs1137936151,2
    C,F--158955575(+) TTCACG/ACCATT 1 -- us2k11Minor allele frequency- A:0.50NA 2
    rs1494661331,2
    C--158955635(+) CGCCCA/GGCTAA 1 -- us2k10--------
    rs1920297171,2
    --158955656(+) TTTTAC/GTAGAG 1 -- us2k10--------
    rs1837067941,2
    --158955710(+) CCTCGC/TGACCT 1 -- us2k10--------
    rs1438795001,2
    C--158955737(+) CAAAGA/TGCTGG 1 -- us2k10--------
    rs2000075521,2
    --158955741(+) TGCTG-/GGA   
       TTACA
    GGATT
    1 -- us2k10--------
    rs1879848411,2
    --158955755(+) GGCATA/GAGCCA 1 -- us2k10--------
    rs1912404281,2
    --158955756(+) GCATGA/GGCCAC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM181 (158957468 - 159056467 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM181:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2732999CNV Deletion23290073
    esv2733000CNV Deletion23290073
    esv2664518CNV Deletion23128226
    esv2672819CNV Deletion23128226
    esv2732998CNV Deletion23290073
    nsv349061CNV Insertion16902084
    nsv518771CNV Loss19592680

    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM181
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TMEM181 for disorders           About MalaCards
    OMIM gene information: 613209    OMIM disorders: --


    TMEM181 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM181
    Human Genome Epidemiology (HuGE) Navigator: TMEM181 (1 document)

    Export disorders for TMEM181 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM181 gene, integrated from 9 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM181)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Haploid genetic screens in human cells identify host factors used by pathogens. (PubMed id 19965467)1, 2 Carette J.E....Brummelkamp T.R. (2009)
    2. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (2006)
    3. A general model of G protein-coupled receptor sequences and its application to detect remote homologs. (PubMed id 16452613)1, 3 Wistrand M....Sonnhammer E.L. (2006)
    4. The DNA sequence and analysis of human chromosome 6. (PubMed id 14574404)1, 2 Mungall A.J.... Beck S. (2003)
    5. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    6. Initial characterization of the human central proteome. (PubMed id 21269460)2 Burkard T.R.... Colinge J. (2011)
    7. Genetic associations of variants in genes encoding HI V-dependency factors required for HIV-1 infection. (PubMed id 21083371)4 Chinn L.W....O'Brien S.J. (2010)
    8. Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis. (PubMed id 20068231)2 Olsen J.V....Mann M. (2010)
    9. Mass-spectrometric identification and relative quantification of N- linked cell surface glycoproteins. (PubMed id 19349973)1 Wollscheid B.... Watts J.D. (2009)
    10. Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57583 HGNC: 20958 AceView: KIAA1423 Ensembl:ENSG00000146433 euGenes: HUgn57583
    ECgene: TMEM181 H-InvDB: TMEM181

    (According to HUGE)
    About This Section
    HUGE: KIAA1423

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM181 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM181 gene:
    Search GeneIP for patents involving TMEM181

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

     
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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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