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Aliases for TMEM180 Gene

Aliases for TMEM180 Gene

  • Transmembrane Protein 180 2 3
  • C10orf77 3 4
  • BA18I14.8 3

External Ids for TMEM180 Gene

Previous HGNC Symbols for TMEM180 Gene

  • C10orf77

Previous GeneCards Identifiers for TMEM180 Gene

  • GC10P104212
  • GC10P097855
  • GC10P104223

Summaries for TMEM180 Gene

GeneCards Summary for TMEM180 Gene

TMEM180 (Transmembrane Protein 180) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM180 Gene

Genomics for TMEM180 Gene

Regulatory Elements for TMEM180 Gene

Genomic Location for TMEM180 Gene

Chromosome:
10
Start:
102,461,381 bp from pter
End:
102,480,118 bp from pter
Size:
18,738 bases
Orientation:
Plus strand

Genomic View for TMEM180 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM180 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM180 Gene

Proteins for TMEM180 Gene

  • Protein details for TMEM180 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q14CX5-TM180_HUMAN
    Recommended name:
    Transmembrane protein 180
    Protein Accession:
    Q14CX5
    Secondary Accessions:
    • Q6NWM8
    • Q6NWM9
    • Q6PEZ7
    • Q9H679

    Protein attributes for TMEM180 Gene

    Size:
    517 amino acids
    Molecular mass:
    57381 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH67530.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH67531.2; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=BAB15385.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAI12524.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

neXtProt entry for TMEM180 Gene

Proteomics data for TMEM180 Gene at MOPED

Post-translational modifications for TMEM180 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM180 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM180 Gene

Domains & Families for TMEM180 Gene

Protein Domains for TMEM180 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM180 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM180: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM180 Gene

Function for TMEM180 Gene

Phenotypes for TMEM180 Gene

genes like me logo Genes that share phenotypes with TMEM180: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM180

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM180 Gene

Localization for TMEM180 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM180 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM180 Gene COMPARTMENTS Subcellular localization image for TMEM180 gene
Compartment Confidence
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM180 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM180: view

Pathways & Interactions for TMEM180 Gene

SuperPathways for TMEM180 Gene

No Data Available

Interacting Proteins for TMEM180 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000238936%0d%0a9606.ENSP00000385269%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000238936 for TMEM180 Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM180 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM180 Gene

Drugs & Compounds for TMEM180 Gene

No Compound Related Data Available

Transcripts for TMEM180 Gene

Unigene Clusters for TMEM180 Gene

Transmembrane protein 180:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM180

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM180 Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b · 10c · 10d · 10e ^ 11 ^ 12 ^ 13a · 13b ^ 14 ^ 15 ^ 16a ·
SP1: -
SP2: - - - - - - - - - - - - -
SP3: - - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: -
SP7: - - -
SP8: - - - - -
SP9:
SP10: - -

ExUns: 16b
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:
SP10:

Relevant External Links for TMEM180 Gene

GeneLoc Exon Structure for
TMEM180
ECgene alternative splicing isoforms for
TMEM180

Expression for TMEM180 Gene

mRNA expression in normal human tissues for TMEM180 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for TMEM180 Gene Hs.309069

genes like me logo Genes that share expression patterns with TMEM180: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM180 Gene

Orthologs for TMEM180 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM180 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM180 35
  • 89.88 (n)
  • 91.1 (a)
TMEM180 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM180 35
  • 90.46 (n)
  • 91.49 (a)
TMEM180 36
  • 91 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem180 35
  • 86.59 (n)
  • 88.59 (a)
Tmem180 16
Tmem180 36
  • 89 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM180 35
  • 96.7 (n)
  • 96.14 (a)
TMEM180 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM180 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM180 36
  • 74 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM180 35
  • 70.44 (n)
  • 72.37 (a)
TMEM180 36
  • 73 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM180 36
  • 70 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.2014 35
tmem180 35
  • 65.87 (n)
  • 69.7 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem180 35
  • 69.24 (n)
  • 70.12 (a)
tmem180 36
  • 69 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea C27H5.4 35
  • 39.46 (n)
  • 27.98 (a)
C27H5.4 36
  • 20 (a)
OneToMany
F10E7.3 36
  • 20 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 54 (a)
OneToOne
Species with no ortholog for TMEM180:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM180 Gene

ENSEMBL:
Gene Tree for TMEM180 (if available)
TreeFam:
Gene Tree for TMEM180 (if available)

Paralogs for TMEM180 Gene

No data available for Paralogs for TMEM180 Gene

Variants for TMEM180 Gene

Sequence variations from dbSNP and Humsavar for TMEM180 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type MAF
rs727804 -- 102,459,830(+) CTGTA(G/T)CCCCT upstream-variant-2KB
rs913028 -- 102,471,477(-) tggcc(A/G)AGTTC intron-variant
rs1056738 -- 102,476,724(+) GAGGG(A/G)GCTGC utr-variant-3-prime, intron-variant
rs1056739 -- 102,476,785(+) CTGAC(C/T)GGAGC utr-variant-3-prime, intron-variant
rs1056740 -- 102,476,795(+) CTGGC(C/T)GCTGT utr-variant-3-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM180 Gene

Variant ID Type Subtype PubMed ID
nsv895970 CNV Loss 21882294

Variation tolerance for TMEM180 Gene

Residual Variation Intolerance Score: 11.93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.70; 32.40% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM180 Gene

HapMap Linkage Disequilibrium report
TMEM180

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM180 Gene

Disorders for TMEM180 Gene

Relevant External Links for TMEM180

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM180
genes like me logo Genes that share disorders with TMEM180: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM180 Gene

Publications for TMEM180 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  3. Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array. (PMID: 23535732) Eeles R.A. … Easton D.F. (Nat. Genet. 2013) 67
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 67
  5. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 67

Products for TMEM180 Gene

Sources for TMEM180 Gene

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