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Aliases for TMEM18 Gene

Aliases for TMEM18 Gene

  • Transmembrane Protein 18 2 3 5
  • LncND 3

External Ids for TMEM18 Gene

Previous GeneCards Identifiers for TMEM18 Gene

  • GC02M000658
  • GC02M000659

Summaries for TMEM18 Gene

GeneCards Summary for TMEM18 Gene

TMEM18 (Transmembrane Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM18 Gene

  • Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Gene Wiki entry for TMEM18 Gene

Additional gene information for TMEM18 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM18 Gene

Genomics for TMEM18 Gene

Regulatory Elements for TMEM18 Gene

Enhancers for TMEM18 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H000672 1.4 ENCODE dbSUPER 25.8 +1.9 1894 6 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2 LOC105373354 TMEM18 LOC101060391 LOC105373479 LOC105373352 PIR44996
GH02H000260 1.4 ENCODE dbSUPER 14.1 +414.0 414046 6 PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 SH3YL1 ALKAL2 TMEM18 LOC101927262 ENSG00000227061 ACP1 GC02M000255
GH02H001652 1.5 FANTOM5 Ensembl ENCODE dbSUPER 12.4 -976.7 -976737 4 MAZ SOX6 HLF MNT YBX1 BMI1 RAD21 FOXA1 NONO TARDBP TMEM18 ENSG00000228613 GC02M001555 GC02P001702
GH02H000662 0.6 dbSUPER 21.7 +13.7 13714 3 CTCF SUZ12 SMC3 MNT RUNX3 RAD21 TMEM18 LOC105373354 LOC101060391 GC02P000663 GC02P000636
GH02H000246 0.8 ENCODE 10.8 +430.6 430592 0 ELF3 CTCF FOXA2 SAP130 MAX RAD21 SMC3 ZNF143 RUNX3 HOMEZ LOC101927262 ALKAL2 LOC105373354 TMEM18 GC02M000239 GC02M000255
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM18 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM18 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000111944 139 2201 HDGF PKNOX1 FOXA2 MLX ARNT ZFP64 ARID4B SIN3A DMAP1 ZNF2

Genomic Location for TMEM18 Gene

Chromosome:
2
Start:
667,335 bp from pter
End:
677,439 bp from pter
Size:
10,105 bases
Orientation:
Minus strand

Genomic View for TMEM18 Gene

Genes around TMEM18 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM18 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM18 Gene

Proteins for TMEM18 Gene

  • Protein details for TMEM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B42-TMM18_HUMAN
    Recommended name:
    Transmembrane protein 18
    Protein Accession:
    Q96B42
    Secondary Accessions:
    • D6W4X9
    • Q8N5H2
    • Q9NTH3

    Protein attributes for TMEM18 Gene

    Size:
    140 amino acids
    Molecular mass:
    16265 Da
    Quaternary structure:
    • Forms homooligomers, independently of the DNA-binding domain.
    SequenceCaution:
    • Sequence=CAB70668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM18 Gene

Post-translational modifications for TMEM18 Gene

  • Ubiquitination at Lys82
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM18 Gene

No data available for DME Specific Peptides for TMEM18 Gene

Domains & Families for TMEM18 Gene

Gene Families for TMEM18 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B42

UniProtKB/Swiss-Prot:

TMM18_HUMAN :
  • Belongs to the TMEM18 family.
Family:
  • Belongs to the TMEM18 family.
genes like me logo Genes that share domains with TMEM18: view

Function for TMEM18 Gene

Molecular function for TMEM18 Gene

UniProtKB/Swiss-Prot Function:
Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Phenotypes From GWAS Catalog for TMEM18 Gene

Gene Ontology (GO) - Molecular Function for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TMEM18: view

Phenotypes for TMEM18 Gene

GenomeRNAi human phenotypes for TMEM18:
genes like me logo Genes that share phenotypes with TMEM18: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM18 Gene

Localization for TMEM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM18 Gene

Cytoplasm. Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM18 gene
Compartment Confidence
nucleus 5
plasma membrane 3
mitochondrion 3
extracellular 1
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA,IEA 18559506
genes like me logo Genes that share ontologies with TMEM18: view

Pathways & Interactions for TMEM18 Gene

SuperPathways for TMEM18 Gene

No Data Available

Interacting Proteins for TMEM18 Gene

Gene Ontology (GO) - Biological Process for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016477 cell migration IDA 18559506
genes like me logo Genes that share ontologies with TMEM18: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM18 Gene

Drugs & Compounds for TMEM18 Gene

No Compound Related Data Available

Transcripts for TMEM18 Gene

Unigene Clusters for TMEM18 Gene

Transmembrane protein 18:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM18
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM18 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for TMEM18 Gene

GeneLoc Exon Structure for
TMEM18
ECgene alternative splicing isoforms for
TMEM18

Expression for TMEM18 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM18 Gene

Protein differential expression in normal tissues from HIPED for TMEM18 Gene

This gene is overexpressed in Bone (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM18 Gene



Protein tissue co-expression partners for TMEM18 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM18 Gene:

TMEM18

SOURCE GeneReport for Unigene cluster for TMEM18 Gene:

Hs.43899

Evidence on tissue expression from TISSUES for TMEM18 Gene

  • Lung(4.3)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with TMEM18: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM18 Gene

Orthologs for TMEM18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM18 33 34
  • 99.72 (n)
mouse
(Mus musculus)
Mammalia Tmem18 34
  • 78 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM18 34
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM18 34
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM18 34
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM18 34
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM18 34
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20321 33
zebrafish
(Danio rerio)
Actinopterygii tmem18 34
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30051 34
  • 38 (a)
OneToOne
Species where no ortholog for TMEM18 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM18 Gene

ENSEMBL:
Gene Tree for TMEM18 (if available)
TreeFam:
Gene Tree for TMEM18 (if available)

Paralogs for TMEM18 Gene

No data available for Paralogs for TMEM18 Gene

Variants for TMEM18 Gene

Sequence variations from dbSNP and Humsavar for TMEM18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000022969 -- 675,482(+) TCTGA(G/T)TTGTG intron-variant, upstream-variant-2KB
rs1000150745 -- 673,558(+) GTGAT(A/G)CTTCA intron-variant
rs1000215867 -- 675,811(+) AAAGG(A/G)AGAAG intron-variant, upstream-variant-2KB
rs1000305451 -- 668,056(+) AGGGA(C/G)AAACA utr-variant-3-prime
rs1000654482 -- 679,344(+) TTTGC(C/T)TACAT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM18 Gene

Variant ID Type Subtype PubMed ID
dgv6598n54 CNV gain 21841781
dgv674e214 CNV gain 21293372
esv2422306 CNV duplication 17116639
esv2422321 CNV duplication 17116639
esv2719114 CNV deletion 23290073
esv2759016 CNV gain 17122850
esv2763522 CNV gain 21179565
esv34786 CNV gain 17911159
esv3550754 CNV deletion 23714750
esv3891448 CNV gain 25118596
nsv468883 CNV gain 19166990
nsv580447 CNV gain 21841781
nsv580454 CNV gain 21841781
nsv580455 CNV gain 21841781
nsv833192 CNV gain 17160897
nsv9258 CNV gain+loss 18304495
nsv999707 CNV gain 25217958

Variation tolerance for TMEM18 Gene

Residual Variation Intolerance Score: 64% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.60; 12.88% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM18 Gene

Human Gene Mutation Database (HGMD)
TMEM18
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM18 Gene

Disorders for TMEM18 Gene

Relevant External Links for TMEM18

Genetic Association Database (GAD)
TMEM18
Human Genome Epidemiology (HuGE) Navigator
TMEM18
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM18

No disorders were found for TMEM18 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM18 Gene

Publications for TMEM18 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K … Nakamura Y (Journal of human genetics 2009) 3 22 45 60
  2. The Drosophila ortholog of TMEM18 regulates insulin and glucagon-like signaling. (PMID: 27029472) Wiemerslage L … Schiöth HB (The Journal of endocrinology 2016) 2 3 60
  3. Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. (PMID: 21980424) Jurvansuu JM … Goldman A (PloS one 2011) 3 4 60
  4. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PMID: 20571754) Fontaine-Bisson B … Franks PW (Diabetologia 2010) 3 45 60
  5. Analyses of shared genetic factors between asthma and obesity in children. (PMID: 20816195) Melén E … Lasky-Su J (The Journal of allergy and clinical immunology 2010) 3 45 60

Products for TMEM18 Gene

Sources for TMEM18 Gene

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