TMEM18 Gene
protein-coding GIFtS: 48
GCID: GC02M000660
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|
transmembrane protein 18
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Aliases
for TMEM18 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 181 2 | | DKFZp434C17141 |
Export aliases for TMEM18 gene to outside databasesPrevious GC identifers: GC02M000658 GC02M000659 |
Summaries
for TMEM18 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTGrepeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) andneural precursor cells (NPC)
Gene Wiki entry for TMEM18
|
Genomic Views
for TMEM18 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022221.13
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM18 gene promoter:
HOXA9B HOXA9 GATA-3 AML1a GATA-1 GATA-2 POU2F1 POU2F1a Meis-1a Meis-1
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM18
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM18 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p25.3 Ensembl cytogenetic band: 2p25.3 HGNC cytogenetic band: 2p25.3TMEM18 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M000660: view genomic region
(about GC identifiers)
Start:
|
667,335 bp from pter |
End:
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677,439 bp from pter |
Size:
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10,105 bases |
Orientation:
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minus strand |
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Proteins
for TMEM18 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42 (See
protein sequence)Recommended Name: Transmembrane protein 18 Size: 140 amino acids; 16265 Da
Subunit: Forms homooligomers, independently of the DNA-binding domain
Subcellular location: Cytoplasm. Nucleus membrane; Multi-pass membrane protein
Sequence caution: Sequence=CAB70668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W4X9 Q8N5H2 Q9NTH3Alternative splicing: 2 isoforms: Q96B42-1 Q96B42-2 Explore the universe of human proteins at neXtProt for TMEM18: NX_Q96B42
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96B42
TMEM18 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_690047.2
ENSEMBL proteins: ENSP00000281017 ENSP00000390474 ENSP00000384347 ENSP00000408658 ENSP00000347874
Human Recombinant Protein Products:
Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table
TMEM18 for ontologies About GeneDecksing
TMEM18 Antibody Products:
Assay Products for TMEM18: |
Protein
Domains /
Families
for TMEM18 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM18 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q96B42ProtoNet protein and cluster: Q96B42 UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42Similarity: Belongs to the TMEM18 family |
Function
for TMEM18 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTGrepeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) andneural precursor cells (NPC)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM18 (NM_003492) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM18 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM18 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM18 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003677 | DNA binding |
IEA | -- |
TMEM18 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM18 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM18
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM18 (ENSP000002810174) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table
TMEM18 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM18 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM18
Search CenterWatch for drugs/clinical trials and news about TMEM18 / TMM18
|
Transcripts
for TMEM18 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM18 gene: NM_152834.2 Unigene Cluster for TMEM18: Transmembrane protein 18 Hs.43899 [show with all ESTs]Unigene Representative Sequence: BC0323798 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000281017(uc002qwl.3) ENST00000432667(uc002qwk.3) ENST00000497508
ENST00000477202 ENST00000405941 ENST00000418447 ENST00000461640 ENST00000355654
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM18 (NM_003492) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM18 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM18 |
Additional cDNA sequence: AK125009.1 AL137269.1 BC016010.1 BC032379.1 BC040373.1 8 DOTS entries: DT.85105478 DT.101983725 DT.97810446 DT.91717515 DT.99962270 DT.100755004 DT.91855835 DT.121013724 24/159 AceView cDNA sequences (see all 159): AW300816 BX097325 AA363401 CB240644 AI285226 BQ637250 AI335865 AI090821 BF980829 AI027988 AI283879 AI074464 AL042559 AI656404 BQ689243 BM982791 BM544709 AA452396 BE612445 AA457464 AA233702 AI131313 AI937733 NM_152834
GeneLoc Exon Structure
5/6 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM18 (see all 6) About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | · | 2c | ^ | 3a | · | 3b | ^ | 4a | · | 4b | ^ | 5 | ^ | 6 | ^ | 7 |
|---|
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| SP1: | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM18
|
Expression
for TMEM18 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM18 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGGAACTGAG
About this image
See TMEM18 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM18
SOURCE GeneReport for Unigene cluster: Hs.43899
SABiosciences Custom PCR Arrays for TMEM18
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM18
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM18 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM18 |
Orthologs
for TMEM18 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for TMEM18 gene from 7/22 species (see all 22) About this table
ENSEMBL Gene Tree for TMEM18 (if available)
TreeFam Gene Tree for TMEM18 (if available) |
Paralogs
for TMEM18 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM18 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM18 (667335 - 677439 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 6 variations for TMEM18
6 CNVs: 5205 3341 30931 2361 5206 8356 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM18 |
|
Disorders
/ Diseases
for TMEM18 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM18 for disorders About GeneDecksing
OMIM gene information: 613220
OMIM disorders: --
4  diseases for TMEM18: About MalaCardsanorexia nervosa asthma obesity neuronitis
Human Genome Epidemiology (HuGE) Navigator: TMEM18 (28 documents)
Export disorders for TMEM18 gene to outside databases
|
Publications
for TMEM18 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM18 gene, integrated from 9 sources (see all 38):
(articles sorted by number of sources associating them with TMEM18) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. (PubMed id 21980424)1, 2 Jurvansuu J.M. and Goldman A. (2011)
- Transmembrane protein 18 enhances the tropism of neural stem cells for glioma cells. (PubMed id 18559506)1, 2 Jurvansuu J....Wang S. (2008)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Association between obesity and polymorphisms in SEC1 6B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 9 Hotta K....Nakamura Y. (2009)
- b2-adrenergic receptor Thr164Ile polymorphism, obesity , and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals. (PubMed id 22466342)1 Thomsen M....Nordestgaard B.G. (2012)
- Genome-wide association of serum uric acid concentrati on: replication of sequence variants in an island population of the Adriatic coa st of Croatia. (PubMed id 22229870)1 Karns R....Deka R. (2012)
- Common variants in FTO, MC4R, TMEM18, PRL, AIF1, and P CSK1 show evidence of association with adult obesity in the Greek population. (PubMed id 21720444)1 Rouskas K....Froguel P. (2012)
- Study of eight GWAS-identified common variants for ass ociation with obesity-related indices in Chinese children at puberty. (PubMed id 22083549)1 Wang J....Jiang F. (2012)
- Implication of European-derived adiposity loci in Afri can Americans. (PubMed id 21750520)1 Hester J.M....Ng M.C. (2012)
- Association of TMEM18 variants with BMI and waist circ umference in children and correlation of mRNA expression in the PFC with body we ight in rats. (PubMed id 21952719)1 Rask-Andersen M....Schioth H.B. (2012)
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External Searches for TMEM18 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM18 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM18 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM18 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM18 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM18 gene:
Search GeneIP for patents involving TMEM18
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM18 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | OriGene Antibodies for TMEM18 | | OriGene shRNA RFP for TMEM18 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM18 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM18 | | | OriGene Protein Over-expression Lysate for TMEM18 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM18 | | OriGene 3'-UTR Clone for TMEM18 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM18 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM18 | | OriGene Custom Protein Services for TMEM18 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM18 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM18 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM18 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM18 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM18 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM18 |
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| | | | Search Tocris compounds for TMEM18 |
| |  |  |  |  | | | | |
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 | | | TMEM18 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM18 |
|  |  |  | | | | ThermoFisher Antibodies for TMEM18 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM18 |
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