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Aliases for TMEM18 Gene

Aliases for TMEM18 Gene

  • Transmembrane Protein 18 2 3

External Ids for TMEM18 Gene

Previous GeneCards Identifiers for TMEM18 Gene

  • GC02M000658
  • GC02M000659

Summaries for TMEM18 Gene

GeneCards Summary for TMEM18 Gene

TMEM18 (Transmembrane Protein 18) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM18 Gene

  • Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Gene Wiki entry for TMEM18 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM18 Gene

Genomics for TMEM18 Gene

Regulatory Elements for TMEM18 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM18 Gene

Start:
667,335 bp from pter
End:
677,439 bp from pter
Size:
10,105 bases
Orientation:
Minus strand

Genomic View for TMEM18 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM18 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM18 Gene

Proteins for TMEM18 Gene

  • Protein details for TMEM18 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96B42-TMM18_HUMAN
    Recommended name:
    Transmembrane protein 18
    Protein Accession:
    Q96B42
    Secondary Accessions:
    • D6W4X9
    • Q8N5H2
    • Q9NTH3

    Protein attributes for TMEM18 Gene

    Size:
    140 amino acids
    Molecular mass:
    16265 Da
    Quaternary structure:
    • Forms homooligomers, independently of the DNA-binding domain.
    SequenceCaution:
    • Sequence=CAB70668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM18 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM18 Gene

Proteomics data for TMEM18 Gene at MOPED

Post-translational modifications for TMEM18 Gene

  • Ubiquitination at Lys82
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM18 Gene

No data available for DME Specific Peptides for TMEM18 Gene

Domains for TMEM18 Gene

Protein Domains for TMEM18 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM18 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96B42

UniProtKB/Swiss-Prot:

TMM18_HUMAN :
  • Q96B42
Family:
  • Belongs to the TMEM18 family.
genes like me logo Genes that share domains with TMEM18: view

No data available for Gene Families for TMEM18 Gene

Function for TMEM18 Gene

Molecular function for TMEM18 Gene

UniProtKB/Swiss-Prot Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells (NSC) and neural precursor cells (NPC).

Gene Ontology (GO) - Molecular Function for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003677 DNA binding IEA --
genes like me logo Genes that share ontologies with TMEM18: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM18

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM18 Gene

Localization for TMEM18 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM18 Gene

Cytoplasm. Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM18 Gene COMPARTMENTS Subcellular localization image for TMEM18 gene
Compartment Confidence
nucleus 5
plasma membrane 3
endoplasmic reticulum 1
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IDA 18559506
genes like me logo Genes that share ontologies with TMEM18: view

Pathways for TMEM18 Gene

SuperPathways for TMEM18 Gene

No Data Available

Interacting Proteins for TMEM18 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000281017%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000281017 for TMEM18 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM18 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006351 transcription, DNA-templated IEA --
GO:0016477 cell migration IDA 18559506
genes like me logo Genes that share ontologies with TMEM18: view

No data available for Pathways by source for TMEM18 Gene

Transcripts for TMEM18 Gene

Unigene Clusters for TMEM18 Gene

Transmembrane protein 18:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM18

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM18 Gene

ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
SP1: - - - - -
SP2: - - -
SP3: - -
SP4:
SP5:
SP6:

Relevant External Links for TMEM18 Gene

GeneLoc Exon Structure for
TMEM18
ECgene alternative splicing isoforms for
TMEM18

Expression for TMEM18 Gene

mRNA expression in normal human tissues for TMEM18 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM18 Gene

SOURCE GeneReport for Unigene cluster for TMEM18 Gene Hs.43899

genes like me logo Genes that share expressions with TMEM18: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM18 Gene

Orthologs for TMEM18 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM18 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM18 35
  • 99.72 (n)
  • 100 (a)
TMEM18 36
  • 87 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM18 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem18 16
Tmem18 36
  • 78 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM18 36
  • 74 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM18 36
  • 63 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM18 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM18 36
  • 58 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.20321 35
zebrafish
(Danio rerio)
Actinopterygii tmem18 36
  • 47 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG30051 36
  • 38 (a)
OneToOne
Species with no ortholog for TMEM18:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM18 Gene

ENSEMBL:
Gene Tree for TMEM18 (if available)
TreeFam:
Gene Tree for TMEM18 (if available)

Paralogs for TMEM18 Gene

No data available for Paralogs for TMEM18 Gene

Variants for TMEM18 Gene

Sequence variations from dbSNP and Humsavar for TMEM18 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1047647 -- 669,253(-) AATAC(A/C)CAATA utr-variant-3-prime
rs1317961 -- 678,969(+) TGTAA(C/T)TTCTG upstream-variant-2KB
rs1320333 -- 679,179(-) GGGAG(A/G)AATGT upstream-variant-2KB
rs2293082 -- 676,457(-) TGTGC(C/G)GGGCT intron-variant
rs2293083 -- 676,177(-) GTTCA(C/G)TGTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM18 Gene

Variant ID Type Subtype PubMed ID
dgv1137e1 CNV Complex 17122850
esv34786 CNV Gain 17911159
dgv4035n71 CNV Gain 21882294
dgv4036n71 CNV Gain 21882294
nsv9258 CNV Gain+Loss 18304495
nsv873543 CNV Gain 21882294
esv2422306 CNV Duplication 17116639
nsv873544 CNV Gain 21882294
esv2422321 CNV Duplication 17116639
nsv833192 CNV Gain 17160897
nsv873550 CNV Loss 21882294
nsv468883 CNV Gain 19166990
esv2719114 CNV Deletion 23290073

Relevant External Links for TMEM18 Gene

HapMap Linkage Disequilibrium report
TMEM18
Human Gene Mutation Database (HGMD)
TMEM18

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM18 Gene

Disorders for TMEM18 Gene

Relevant External Links for TMEM18

Genetic Association Database (GAD)
TMEM18
Human Genome Epidemiology (HuGE) Navigator
TMEM18
genes like me logo Genes that share disorders with TMEM18: view

No data available for UniProtKB/Swiss-Prot for TMEM18 Gene

Publications for TMEM18 Gene

  1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PMID: 19851340) Hotta K. … Nakamura Y. (J. Hum. Genet. 2009) 3 23 48
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Obesity and diabetes genes are associated with being born small for gestational age: results from the Auckland Birthweight Collaborative study. (PMID: 20712903) Morgan A.R. … Mitchell E.A. (BMC Med. Genet. 2010) 3 48
  4. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PMID: 20724581) den Hoed M. … Loos R.J. (Diabetes 2010) 3 48
  5. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PMID: 21102462) Elks C.E. … Murray A. (Nat. Genet. 2010) 3 48

Products for TMEM18 Gene

Sources for TMEM18 Gene

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