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TMEM18 Gene

protein-coding   GIFtS: 49
GCID: GC02M000660

Transmembrane Protein 18

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 181 2

External Ids:    HGNC: 252571   Entrez Gene: 1297872   Ensembl: ENSG000001513537   OMIM: 6132205   UniProtKB: Q96B423   

Export aliases for TMEM18 gene to outside databases

Previous GC identifers: GC02M000658 GC02M000659


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM18 Gene:
TMEM18 (transmembrane protein 18) is a protein-coding gene. Diseases associated with TMEM18 include anorexia nervosa, and obesity.

UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42
Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end
CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells
(NSC) and neural precursor cells (NPC)

Gene Wiki entry for TMEM18 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NC_018913.2  NT_005334.17  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM18 gene promoter:
         HOXA9B   HOXA9   GATA-3   AML1a   GATA-1   GATA-2   POU2F1   POU2F1a   Meis-1a   Meis-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM18 promoter sequence
   Search Chromatin IP Primers for TMEM18

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM18


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p25.3   Ensembl cytogenetic band:  2p25.3   HGNC cytogenetic band: 2p25.3

TMEM18 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM18 gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02M000660:  view genomic region     (about GC identifiers)

Start:
667,335 bp from pter      End:
677,439 bp from pter
Size:
10,105 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42 (See protein sequence)
Recommended Name: Transmembrane protein 18  
Size: 140 amino acids; 16265 Da
Subunit: Forms homooligomers, independently of the DNA-binding domain
Sequence caution: Sequence=CAB70668.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Secondary accessions: D6W4X9 Q8N5H2 Q9NTH3
Alternative splicing: 2 isoforms:  Q96B42-1   Q96B42-2   

Explore the universe of human proteins at neXtProt for TMEM18: NX_Q96B42

Explore proteomics data for TMEM18 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys82
  • Modification sites at PhosphoSitePlus

  • See TMEM18 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_690047.2  
    ENSEMBL proteins: 
     ENSP00000281017   ENSP00000390474   ENSP00000384347   ENSP00000408658   ENSP00000347874  

    TMEM18 Human Recombinant Protein Products:

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    Novus Biologicals TMEM18 Lysate
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    Cloud-Clone Corp. Proteins for TMEM18

    TMEM18 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of TMEM18
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    Search for Antibodies for TMEM18 at Abcam
    Cloud-Clone Corp. Antibodies for TMEM18
    ThermoFisher Antibodies for TMEM18
    LSBio Antibodies in human, mouse, rat for TMEM18

    TMEM18 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM18
    Cloud-Clone Corp. CLIAs for TMEM18


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR026721 TMEM18

    Graphical View of Domain Structure for InterPro Entry Q96B42

    ProtoNet protein and cluster: Q96B42

    UniProtKB/Swiss-Prot: TMM18_HUMAN, Q96B42
    Similarity: Belongs to the TMEM18 family


    TMEM18 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: TMM18_HUMAN, Q96B42
    Function: Transcription repressor. Sequence-specific ssDNA and dsDNA binding protein, with preference for GCT end
    CTG repeats. Cell migration modulator which enhances the glioma-specific migration ability of neural stem cells
    (NSC) and neural precursor cells (NPC)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003677DNA binding IEA--
         
    TMEM18 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM18
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM18

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM18
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM18

    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM18 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for TMEM18
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM18

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for TMEM18

    Clone
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    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM18 (NM_003492)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM18

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM18 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM18


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TMM18_HUMAN, Q96B42: Cytoplasm. Nucleus membrane; Multi-pass membrane protein
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3
    endoplasmic reticulum1
    extracellular1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IEA--
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IDA18559506

    TMEM18 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM18
    Interactions:

        Search GeneGlobe Interaction Network for TMEM18

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    1 Interacting protein for TMEM18 (ENSP000002810174) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBCENSP000003448184STRING: ENSP00000344818
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006351transcription, DNA-templated IEA--
    GO:0016477cell migration IDA18559506

    TMEM18 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM18 (TMM18)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM18 gene: 
    NM_152834.2  

    Unigene Cluster for TMEM18:

    Transmembrane protein 18
    Hs.43899  [show with all ESTs]
    Unigene Representative Sequence: BC032379
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000281017(uc002qwl.3) ENST00000432667(uc002qwk.3) ENST00000497508
    ENST00000477202 ENST00000405941 ENST00000418447 ENST00000461640 ENST00000355654

    miRNA
    Products:
         
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    Search for qRT-PCR Assays for microRNAs that regulate TMEM18
    SwitchGear 3'UTR luciferase reporter plasmidTMEM18 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM18
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM18
    Clone
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    OriGene clones in human, mouse for TMEM18 (see all 8)
    OriGene ORF clones in mouse, rat for TMEM18
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: TMEM18 (NM_003492)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM18
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM18
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM18
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM18
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM18
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM18
      QuantiFast Probe-based Assays in human, mouse, rat TMEM18

    Additional mRNA sequence: 

    AK125009.1 AL137269.1 BC016010.1 BC032379.1 BC040373.1 

    9 DOTS entries:

    DT.85105478  DT.101983725  DT.97810446  DT.91717515  DT.99962270  DT.100755004  DT.91855835  DT.121013724 
    DT.95297603 

    Selected AceView cDNA sequences (see all 159):

    AI131313 AL137269 AI335865 AA233702 AI097178 BF440032 AI283879 BE612445 
    AI285226 AA768470 AI656404 AI686402 BQ637250 NM_152834 BQ689243 AA457464 
    CB240644 AW300816 BX097325 BC032379 AI027988 AA385376 AA363401 BM722345 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM18 (see all 6)    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b · 2c ^ 3a · 3b ^ 4a · 4b ^ 5 ^ 6 ^ 7
    SP1:              -     -     -     -     -                                 
    SP2:              -     -     -                                             
    SP3:                                -     -                                 
    SP4:                                                                        
    SP5:                                                                        


    ECgene alternative splicing isoforms for TMEM18

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM18 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGAACTGAG
    TMEM18 Expression
    About this image

    TMEM18 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM18 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.43899
        Custom PCR Arrays for TMEM18
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM18

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM18 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem185 transmembrane protein 18   --   12 (13.00 cM) 30584443 
    chicken
    (Gallus gallus)
    Aves TMEM186
    Gallus gallus transmembrane protein 18 (TMEM18), m...
    58(a)
    1 ↔ 1
    3(91720289-91726599)
    lizard
    (Anolis carolinensis)
    Reptilia TMEM186
    transmembrane protein 18
    58(a)
    1 ↔ 1
    1(160337528-160344826)
    African clawed frog
    (Xenopus laevis)
    Amphibia CA981979.12   -- 72.79(n)    CA981979.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem186
    transmembrane protein 18
    47(a)
    1 ↔ 1
    23(35693605-35700544) ENSDARG00000036704
    fruit fly
    (Drosophila melanogaster)
    Insecta CG300516
    --
    38(a)
    1 ↔ 1
    2R(8323602-8324495)


    ENSEMBL Gene Tree for TMEM18 (if available)
    TreeFam Gene Tree for TMEM18 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM18 (see all 314)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1483231041,2
    --667475(+) TAAACA/TGATGA 1 -- ds50010--------
    rs782601511,2
    --667593(+) ACTGCC/TGATCA 1 -- ds50010--------
    rs727609391,2
    --667672(+) AGGCAC/TTGAAT 1 -- ds50010--------
    rs1462370441,2
    --667734(+) AAAATA/GTAACT 1 -- ds50010--------
    rs1848893501,2
    --667757(+) AGACAC/GACACA 1 -- ds50010--------
    rs1164526151,2
    F--667801(+) TTTCAC/AACTGA 1 -- ds50011Minor allele frequency- A:0.04WA 118
    rs1393403931,2
    C--667916(+) ACATAC/TAGATG 1 -- ds50010--------
    rs2001507781,2
    C--667923(+) GATGT-/TTAA  
            
    TTAGT
    1 -- ds50010--------
    rs766602551,2
    C,F--667974(+) TGGATT/CACTTT 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs1452074601,2
    C--668216(+) GTCCC-/TCCCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM18 (667335 - 677439 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for TMEM18 (see all 13):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2719114CNV Deletion23290073
    esv2422321CNV Duplication17116639
    esv2422306CNV Duplication17116639
    nsv873550CNV Loss21882294
    nsv873544CNV Gain21882294
    dgv4036n71CNV Gain21882294
    nsv833192CNV Gain17160897
    dgv4035n71CNV Gain21882294
    nsv873543CNV Gain21882294
    nsv468883CNV Gain19166990

    Human Gene Mutation Database (HGMD): TMEM18
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing TMEM18
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM18

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 613220    OMIM disorders: --

    5 diseases for TMEM18:    
    About MalaCards
    anorexia nervosa    obesity    asthma    malaria
    neuronitis


    TMEM18 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM18
    Human Genome Epidemiology (HuGE) Navigator: TMEM18 (28 documents)

    Export disorders for TMEM18 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM18 gene, integrated from 10 sources (see all 49):
    (articles sorted by number of sources associating them with TMEM18)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association between obesity and polymorphisms in SEC16B, TMEM18, GNPDA2, BDNF, FAIM2 and MC4R in a Japanese population. (PubMed id 19851340)1, 4, 9 Hotta K....Nakamura Y. (J. Hum. Genet. 2009)
    2. Obesity risk gene TMEM18 encodes a sequence-specific DNA-binding protein. (PubMed id 21980424)1, 2 Jurvansuu J.M. and Goldman A. (PLoS ONE 2011)
    3. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. (PubMed id 20724581)1, 4 den Hoed M....Loos R.J. (Diabetes 2010)
    4. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. (PubMed id 20520848)1, 4 Elks C.E....Ong K.K. (PLoS Med. 2010)
    5. Evaluating the discriminative power of multi-trait genetic risk scores for type 2 diabetes in a northern Swedish population. (PubMed id 20571754)1, 4 Fontaine-Bisson B....Franks P.W. (Diabetologia 2010)
    6. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. (PubMed id 20215397)1, 4 Ng M.C....Ma R.C. (J. Clin. Endocrinol. Metab. 2010)
    7. Are recently identified genetic variants regulating BMI in the general population associated with anorexia nervosa? (PubMed id 19746409)1, 4 Brandys M.K....Adan R.A. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2010)
    8. Analyses of shared genetic factors between asthma and obesity in children. (PubMed id 20816195)1, 4 MelAcn E....Lasky-Su J. (J. Allergy Clin. Immunol. 2010)
    9. Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies. (PubMed id 21102462)1, 4 Elks C.E....Murray A. (Nat. Genet. 2010)
    10. Obesity and diabetes genetic variants associated with gestational weight gain. (PubMed id 20816152)1, 4 Stuebe A.M....Siega-Riz A.M. (Am. J. Obstet. Gynecol. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 129787 HGNC: 25257 AceView: TMEM18 Ensembl:ENSG00000151353 euGenes: HUgn129787
    ECgene: TMEM18 H-InvDB: TMEM18

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM18 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM18 gene:
    Search GeneIP for patents involving TMEM18

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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