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Aliases for TMEM179B Gene

Aliases for TMEM179B Gene

  • Transmembrane Protein 179B 2 3 5

External Ids for TMEM179B Gene

Previous GeneCards Identifiers for TMEM179B Gene

  • GC11P062312
  • GC11P062554
  • GC11P058884

Summaries for TMEM179B Gene

GeneCards Summary for TMEM179B Gene

TMEM179B (Transmembrane Protein 179B) is a Protein Coding gene. Among its related pathways are Innate Immune System.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM179B Gene

Genomics for TMEM179B Gene

Regulatory Elements for TMEM179B Gene

Enhancers for TMEM179B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11G062651 1.2 ENCODE 20.7 -134.6 -134569 2.3 MLX CREB3L1 DMAP1 YY1 ZNF143 ZNF263 SP3 NFYC TBX21 SSRP1 EML3 INTS5 MTA2 NXF1 METTL12 STX5 SNHG1 LOC105369332 TMEM179B TAF6L
GH11G061826 2 FANTOM5 Ensembl ENCODE dbSUPER 11.8 -955.0 -955030 12.6 HDGF PKNOX1 FOXA2 CREB3L1 ARNT AGO1 WRNIP1 SIN3A ARID4B YY1 FADS2 MTA2 FADS1 TMEM138 EML3 STX5 NXF1 TMEM179B INTS5 CYB561A3
GH11G062669 1.1 ENCODE 20.7 -115.9 -115911 4.2 HNRNPUL1 HDGF FOXA2 PKNOX1 CREB3L1 MLX ARNT AGO1 ARID4B SIN3A EML3 STX5 LOC105369332 INTS5 MTA2 NXF1 METTL12 SNHG1 TAF6L TMEM179B
GH11G062852 1.8 FANTOM5 ENCODE dbSUPER 12 +68.4 68439 5.9 CREB3L1 MLX AGO1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 SNHG1 MTA2 EML3 STX5 NXF1 TMEM179B INTS5 METTL12 LOC105369332 TTC9C
GH11G061960 1.8 FANTOM5 ENCODE dbSUPER 11.8 -818.5 -818476 16.4 MLX CREB3L1 AGO1 ZFP64 DMAP1 YBX1 YY1 SLC30A9 ZNF143 SP3 UBXN1 INTS5 MTA2 TMEM138 EML3 STX5 NXF1 BEST1 TMEM179B RAB3IL1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM179B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM179B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000040474 101 1801 CREB3L1 AGO1 ZFP64 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 SSRP1

Genomic Location for TMEM179B Gene

Chromosome:
11
Start:
62,787,399 bp from pter
End:
62,790,405 bp from pter
Size:
3,007 bases
Orientation:
Plus strand

Genomic View for TMEM179B Gene

Genes around TMEM179B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM179B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM179B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179B Gene

Proteins for TMEM179B Gene

  • Protein details for TMEM179B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7N9-T179B_HUMAN
    Recommended name:
    Transmembrane protein 179B
    Protein Accession:
    Q7Z7N9

    Protein attributes for TMEM179B Gene

    Size:
    219 amino acids
    Molecular mass:
    23550 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM179B Gene

Post-translational modifications for TMEM179B Gene

  • Glycosylation at Asn48 and posLast=136136
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM179B Gene

No data available for DME Specific Peptides for TMEM179B Gene

Domains & Families for TMEM179B Gene

Protein Domains for TMEM179B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7N9

UniProtKB/Swiss-Prot:

T179B_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179B: view

No data available for Gene Families for TMEM179B Gene

Function for TMEM179B Gene

genes like me logo Genes that share phenotypes with TMEM179B: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM179B

CRISPR Products

miRNA for TMEM179B Gene

miRTarBase miRNAs that target TMEM179B

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179B Gene

Localization for TMEM179B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM179B gene
Compartment Confidence
plasma membrane 5
nucleus 5
lysosome 4

Gene Ontology (GO) - Cellular Components for TMEM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
GO:0005886 plasma membrane TAS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0016607 nuclear speck IDA --
genes like me logo Genes that share ontologies with TMEM179B: view

Pathways & Interactions for TMEM179B Gene

genes like me logo Genes that share pathways with TMEM179B: view

Pathways by source for TMEM179B Gene

3 Reactome pathways for TMEM179B Gene

Gene Ontology (GO) - Biological Process for TMEM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0043312 neutrophil degranulation TAS --
genes like me logo Genes that share ontologies with TMEM179B: view

No data available for SIGNOR curated interactions for TMEM179B Gene

Drugs & Compounds for TMEM179B Gene

No Compound Related Data Available

Transcripts for TMEM179B Gene

Unigene Clusters for TMEM179B Gene

Transmembrane protein 179B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM179B Gene

GeneLoc Exon Structure for
TMEM179B
ECgene alternative splicing isoforms for
TMEM179B

Expression for TMEM179B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM179B Gene

Protein differential expression in normal tissues from HIPED for TMEM179B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Testis (8.7), and Skin (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM179B Gene



Protein tissue co-expression partners for TMEM179B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM179B Gene:

TMEM179B

SOURCE GeneReport for Unigene cluster for TMEM179B Gene:

Hs.381134
genes like me logo Genes that share expression patterns with TMEM179B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM179B Gene

Orthologs for TMEM179B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM179B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM179B 34 35
  • 100 (n)
dog
(Canis familiaris)
Mammalia TMEM179B 34 35
  • 89.04 (n)
cow
(Bos Taurus)
Mammalia TMEM179B 34 35
  • 88.07 (n)
mouse
(Mus musculus)
Mammalia Tmem179b 34 16 35
  • 85.24 (n)
rat
(Rattus norvegicus)
Mammalia Tmem179b 34
  • 84.48 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM179B 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179B 35
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem179b 35
  • 39 (a)
OneToMany
TMEM179B (1 of 2) 35
  • 37 (a)
OneToMany
Species where no ortholog for TMEM179B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM179B Gene

ENSEMBL:
Gene Tree for TMEM179B (if available)
TreeFam:
Gene Tree for TMEM179B (if available)

Paralogs for TMEM179B Gene

No data available for Paralogs for TMEM179B Gene

Variants for TMEM179B Gene

Sequence variations from dbSNP and Humsavar for TMEM179B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1000067794 -- 62,786,746(+) CGACA(C/T)CTACC upstream-variant-2KB, reference, missense
rs1000081793 -- 62,786,984(+) GCCTC(C/T)GAGAG upstream-variant-2KB, reference, synonymous-codon
rs1001085217 -- 62,787,648(+) GGCAC(A/G)GCTGG intron-variant, downstream-variant-500B
rs1001272030 -- 62,787,085(+) TTTCG(C/T)CCCGC upstream-variant-2KB, reference, missense
rs1002308087 -- 62,787,940(+) GATTG(A/T)AGCAC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM179B Gene

Variant ID Type Subtype PubMed ID
nsv508636 CNV deletion 20534489
nsv509416 CNV insertion 20534489
nsv555175 CNV loss 21841781

Variation tolerance for TMEM179B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM179B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM179B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM179B Gene

Disorders for TMEM179B Gene

Relevant External Links for TMEM179B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM179B

No disorders were found for TMEM179B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179B Gene

Publications for TMEM179B Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  2. Toward a comprehensive characterization of a human cancer cell phosphoproteome. (PMID: 23186163) Zhou H. … Mohammed S. (J. Proteome Res. 2013) 4 64
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3 64
  4. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for TMEM179B Gene

Sources for TMEM179B Gene

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