Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM179B Gene

Aliases for TMEM179B Gene

  • Transmembrane Protein 179B 2 3

External Ids for TMEM179B Gene

Previous GeneCards Identifiers for TMEM179B Gene

  • GC11P062312
  • GC11P062554
  • GC11P058884

Summaries for TMEM179B Gene

GeneCards Summary for TMEM179B Gene

TMEM179B (Transmembrane Protein 179B) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM179B Gene

Genomics for TMEM179B Gene

Regulatory Elements for TMEM179B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM179B Gene

Chromosome:
11
Start:
62,787,399 bp from pter
End:
62,790,405 bp from pter
Size:
3,007 bases
Orientation:
Plus strand

Genomic View for TMEM179B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM179B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179B Gene

Proteins for TMEM179B Gene

  • Protein details for TMEM179B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q7Z7N9-T179B_HUMAN
    Recommended name:
    Transmembrane protein 179B
    Protein Accession:
    Q7Z7N9

    Protein attributes for TMEM179B Gene

    Size:
    219 amino acids
    Molecular mass:
    23550 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM179B Gene

Proteomics data for TMEM179B Gene at MOPED

Post-translational modifications for TMEM179B Gene

  • Glycosylation at Asn 48 and Asn 136
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM179B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM179B Gene

Domains & Families for TMEM179B Gene

Protein Domains for TMEM179B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q7Z7N9

UniProtKB/Swiss-Prot:

T179B_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179B: view

No data available for Gene Families for TMEM179B Gene

Function for TMEM179B Gene

Phenotypes for TMEM179B Gene

genes like me logo Genes that share phenotypes with TMEM179B: view

Animal Model Products

CRISPR Products

miRNA for TMEM179B Gene

miRTarBase miRNAs that target TMEM179B

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM179B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179B Gene

Localization for TMEM179B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM179B Gene COMPARTMENTS Subcellular localization image for TMEM179B gene
Compartment Confidence
nucleus 2

Gene Ontology (GO) - Cellular Components for TMEM179B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM179B: view

Pathways & Interactions for TMEM179B Gene

SuperPathways for TMEM179B Gene

No Data Available

Interacting Proteins for TMEM179B Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000333697%0d%0a9606.ENSP00000363745%0d%0a9606.ENSP00000375863%0d%0a
Selected Interacting proteins: Q7Z7N9-T179B_HUMAN ENSP00000333697 for TMEM179B Gene via MINT STRING

Gene Ontology (GO) - Biological Process for TMEM179B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM179B Gene

Drugs & Compounds for TMEM179B Gene

No Compound Related Data Available

Transcripts for TMEM179B Gene

mRNA/cDNA for TMEM179B Gene

Unigene Clusters for TMEM179B Gene

Transmembrane protein 179B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM179B

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b
SP1: -
SP2: - -
SP3:

Relevant External Links for TMEM179B Gene

GeneLoc Exon Structure for
TMEM179B
ECgene alternative splicing isoforms for
TMEM179B

Expression for TMEM179B Gene

mRNA expression in normal human tissues for TMEM179B Gene

Protein differential expression in normal tissues from HIPED for TMEM179B Gene

This gene is overexpressed in Peripheral blood mononuclear cells (22.5), Testis (8.7), and Skin (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM179B Gene



SOURCE GeneReport for Unigene cluster for TMEM179B Gene Hs.381134

genes like me logo Genes that share expression patterns with TMEM179B: view

Protein tissue co-expression partners for TMEM179B Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM179B Gene

Orthologs for TMEM179B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM179B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM179B 35
  • 88.07 (n)
  • 85.32 (a)
TMEM179B 36
  • 85 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM179B 35
  • 89.04 (n)
  • 88.13 (a)
TMEM179B 36
  • 88 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem179b 35
  • 85.24 (n)
  • 80.82 (a)
Tmem179b 16
Tmem179b 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM179B 35
  • 100 (n)
  • 100 (a)
TMEM179B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem179b 35
  • 84.48 (n)
  • 79.89 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM179B 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179B 36
  • 60 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem179b 36
  • 39 (a)
OneToMany
TMEM179B (1 of 2) 36
  • 37 (a)
OneToMany
Species with no ortholog for TMEM179B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM179B Gene

ENSEMBL:
Gene Tree for TMEM179B (if available)
TreeFam:
Gene Tree for TMEM179B (if available)

Paralogs for TMEM179B Gene

No data available for Paralogs for TMEM179B Gene

Variants for TMEM179B Gene

Sequence variations from dbSNP and Humsavar for TMEM179B Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs780622373 -- 62,787,339(+) CCCCG(-/GAAAT)GACGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM179B Gene

Variant ID Type Subtype PubMed ID
nsv897623 CNV Loss 21882294
nsv483055 CNV Loss 15286789
nsv508636 CNV Loss 20534489
nsv509416 CNV Insertion 20534489
nsv897624 CNV Loss 21882294

Variation tolerance for TMEM179B Gene

Residual Variation Intolerance Score: 28% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.51; 11.10% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM179B Gene

HapMap Linkage Disequilibrium report
TMEM179B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM179B Gene

Disorders for TMEM179B Gene

Relevant External Links for TMEM179B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM179B
genes like me logo Genes that share disorders with TMEM179B: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179B Gene

Publications for TMEM179B Gene

  1. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 67
  2. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 67
  3. Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. (PMID: 19690332) Mayya V. … Han D.K. (Sci. Signal. 2009) 67
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 67
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 67

Products for TMEM179B Gene

Sources for TMEM179B Gene

Back to Top

Content