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Aliases for TMEM179 Gene

Aliases for TMEM179 Gene

  • Transmembrane Protein 179 2 3 5
  • Transmembrane Protein 179A 3 4
  • C14orf90 3 4
  • TMEM179A 3 4
  • Chromosome 14 Open Reading Frame 90 2

External Ids for TMEM179 Gene

Previous HGNC Symbols for TMEM179 Gene

  • C14orf90

Previous GeneCards Identifiers for TMEM179 Gene

  • GC14M104132
  • GC14M105061
  • GC14M085256
  • GC14M104942

Summaries for TMEM179 Gene

GeneCards Summary for TMEM179 Gene

TMEM179 (Transmembrane Protein 179) is a Protein Coding gene.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM179 Gene

Genomics for TMEM179 Gene

Regulatory Elements for TMEM179 Gene

Enhancers for TMEM179 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14G104656 1.7 FANTOM5 Ensembl ENCODE dbSUPER 6.3 -53.7 -53741 6.8 HDGF BMI1 RAD21 RARA ZNF121 EGR1 RELB ETV6 IKZF2 CREM C14orf180 TMEM179 PLD4 INF2 ENSG00000258736 LINC02280
GH14G104603 1.2 Ensembl ENCODE 7.8 +1.1 1080 1.7 HDGF PKNOX1 ARID4B SIN3A ZNF48 ZNF207 ZNF143 FOS CEBPZ MXD4 C14orf180 TMEM179 GC14P104604 GC14P104592
GH14G104222 1.8 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +381.0 381022 4.3 PKNOX1 ARID4B SIN3A GLIS2 ZNF207 SP3 SP5 REST PPARG ZNF592 LOC105370693 KIF26A PPP1R13B TMEM179 LOC105370694
GH14G104665 1.9 FANTOM5 Ensembl ENCODE dbSUPER 1.6 -60.9 -60864 2.9 HDGF YBX1 DMAP1 ZBTB7B ZNF302 ZNF207 FOS SP5 ZHX2 ZNF662 ENSG00000257270 XRCC3 TMEM121 RPS20P33 ENSG00000269940 PACS2 LINC00638 ENSG00000256050 INF2 TMEM179
GH14G104642 0.4 Ensembl 5.9 -36.7 -36654 0.2 ZBTB11 ZNF24 TMEM179 ENSG00000258736 GC14P104606
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM179 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM179 Gene

Chromosome:
14
Start:
104,474,678 bp from pter
End:
104,605,647 bp from pter
Size:
130,970 bases
Orientation:
Minus strand

Genomic View for TMEM179 Gene

Genes around TMEM179 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM179 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM179 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179 Gene

Proteins for TMEM179 Gene

  • Protein details for TMEM179 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK1-T179A_HUMAN
    Recommended name:
    Transmembrane protein 179
    Protein Accession:
    Q6ZVK1

    Protein attributes for TMEM179 Gene

    Size:
    233 amino acids
    Molecular mass:
    26378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM179 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM179 Gene

Post-translational modifications for TMEM179 Gene

  • Glycosylation at posLast=5151
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM179 Gene

Domains & Families for TMEM179 Gene

Protein Domains for TMEM179 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVK1

UniProtKB/Swiss-Prot:

T179A_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179: view

No data available for Gene Families for TMEM179 Gene

Function for TMEM179 Gene

Phenotypes for TMEM179 Gene

GenomeRNAi human phenotypes for TMEM179:
genes like me logo Genes that share phenotypes with TMEM179: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179 Gene

Localization for TMEM179 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM179 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM179: view

No data available for Subcellular locations from COMPARTMENTS for TMEM179 Gene

Pathways & Interactions for TMEM179 Gene

SuperPathways for TMEM179 Gene

No Data Available

Interacting Proteins for TMEM179 Gene

Gene Ontology (GO) - Biological Process for TMEM179 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM179 Gene

Drugs & Compounds for TMEM179 Gene

No Compound Related Data Available

Transcripts for TMEM179 Gene

Unigene Clusters for TMEM179 Gene

Transmembrane protein 179:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179 Gene

No ASD Table

Relevant External Links for TMEM179 Gene

GeneLoc Exon Structure for
TMEM179
ECgene alternative splicing isoforms for
TMEM179

Expression for TMEM179 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM179 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM179 Gene

This gene is overexpressed in Pituitary (x7.9), Brain - Cortex (x4.5), Brain - Putamen (basal ganglia) (x4.4), Brain - Hypothalamus (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM179 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM179 Gene:

TMEM179

SOURCE GeneReport for Unigene cluster for TMEM179 Gene:

Hs.655004

Evidence on tissue expression from TISSUES for TMEM179 Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM179: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM179 Gene

Orthologs for TMEM179 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM179 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM179 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia TMEM179 34 35
  • 93.53 (n)
dog
(Canis familiaris)
Mammalia TMEM179 34 35
  • 92.74 (n)
mouse
(Mus musculus)
Mammalia Tmem179 34 16 35
  • 89.7 (n)
rat
(Rattus norvegicus)
Mammalia Tmem179 34
  • 89.56 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM179 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM179 34 35
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM179 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem179 34
  • 73.13 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537383 34
  • 68.1 (n)
CABZ01084273.1 35
  • 50 (a)
OneToMany
tmem179 35
  • 50 (a)
OneToMany
TMEM179 (2 of 3) 35
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13603 34 35
  • 50.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004210 34
  • 46.94 (n)
Species where no ortholog for TMEM179 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM179 Gene

ENSEMBL:
Gene Tree for TMEM179 (if available)
TreeFam:
Gene Tree for TMEM179 (if available)

Paralogs for TMEM179 Gene

No data available for Paralogs for TMEM179 Gene

Variants for TMEM179 Gene

Sequence variations from dbSNP and Humsavar for TMEM179 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000041353 -- 104,603,303(+) CTGCC(A/G)CCCAC intron-variant, utr-variant-3-prime
rs1000280815 -- 104,597,981(+) GCCAC(A/G)CTGCC intron-variant, upstream-variant-2KB
rs1000455392 -- 104,606,453(+) TTGGG(C/T)GACAG upstream-variant-2KB
rs1000487995 -- 104,593,124(+) AGCAT(C/T)CGGCC downstream-variant-500B, utr-variant-3-prime
rs1000503109 -- 104,599,208(+) CTCCC(A/G)CCTGC intron-variant, downstream-variant-500B, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM179 Gene

Variant ID Type Subtype PubMed ID
esv2761599 CNV gain 21179565
esv3635623 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv1134408 CNV deletion 24896259
nsv456445 CNV loss 19166990
nsv470676 CNV loss 18288195
nsv566047 CNV loss 21841781
nsv952271 CNV deletion 24416366

Variation tolerance for TMEM179 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM179 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM179

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM179 Gene

Disorders for TMEM179 Gene

Relevant External Links for TMEM179

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM179

No disorders were found for TMEM179 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179 Gene

Publications for TMEM179 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64

Products for TMEM179 Gene

Sources for TMEM179 Gene

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