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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM179 Gene

protein-coding   GIFtS: 35
GCID: GC14M105061

transmembrane protein 179

(Previous name: chromosome 14 open reading frame 90 )
(Previous symbol: C14orf90)
  Search for TMEM179
in
MalaCards
our new
 Human Malady Compendium 
Biological research products
for TMEM179    

Aliases
for TMEM179 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Transmembrane Protein 1791 2
C14orf901 2 3
TMEM179A1 2 3
Transmembrane Protein 179A2 3
FLJ424861
Chromosome 14 Open Reading Frame 901

External Ids:    HGNC: 201371   Entrez Gene: 3880212   Ensembl: ENSG000002589867   UniProtKB: Q6ZVK13   

Export aliases for TMEM179 gene to outside databases

Previous GC identifers: GC14M104132 GC14M085256


Summaries
for TMEM179 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
  --

Genomic Views
for TMEM179 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000014.8  NC_018925.1  NT_026437.12  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM179 gene promoter:
         AML1a   p300   NCX/Ncx   Brachyury   NRSF form 1   Nkx2-5   NRSF form 2   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM179 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM179

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM179


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

TMEM179 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM179 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M105061:  view genomic region     (about GC identifiers)

Start:
 105,057,201 bp from pter      End:
 105,071,984 bp from pter
Size:
 14,784 bases      Orientation:
 minus strand

Proteins
for TMEM179 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: T179A_HUMAN, Q6ZVK1 (See protein sequence)
Recommended Name: Transmembrane protein 179  
Size: 233 amino acids; 26378 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Alternative splicing: 2 isoforms:  Q6ZVK1-1   Q6ZVK1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM179: NX_Q6ZVK1

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q6ZVK1

    • TMEM179 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_997262.1  
    ENSEMBL proteins: 
     ENSP00000452113   ENSP00000450958   ENSP00000340477  

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    Uscn Proteins for TMEM179

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral to membrane IEA--


    TMEM179 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for TMEM179 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q6ZVK1

    UniProtKB/Swiss-Prot: T179A_HUMAN, Q6ZVK1
    Similarity: Belongs to the TMEM179 family


    Function
    for TMEM179 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat TMEM179
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    Inhib. RNA
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    Pathways & Interactions
    for TMEM179 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM179

    Drugs & Compounds
    for TMEM179 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM179
    Search CenterWatch for drugs/clinical trials and news about TMEM179 / T179A 

    Transcripts
    for TMEM179 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for TMEM179 gene: 
    NM_207379.1  

    Unigene Cluster for TMEM179:

    Transmembrane protein 179
    Hs.655004  [show with all ESTs]
    Unigene Representative Sequence: AK124477
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000556320 ENST00000556573 ENST00000341595(uc001yox.1)

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    Inhib. RNA
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    Primer
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    Additional cDNA sequence: AK124477.1 

    3 DOTS entries:

    DT.75102061  DT.97794933  DT.423072 

    24/47 AceView cDNA sequences (see all 47):

    BF530306 BM725557 BM726911 BM702493 BX461969 AW341777 BF196202 AW026835 
    CF455308 BC047917 CK300060 AI418219 BM665210 BI090668 AI290914 AI299168 
    AK124477 AI632939 AI290819 D80960 BE671450 BE792466 AI290831 AF462446 

    GeneLoc Exon Structure


    Expression
    for TMEM179 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM179 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGGGGACACA

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    TMEM179 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    4 LifeMap In Vivo Development Anatomical Compartments/Cells 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumCushion Mesenchymal CellsEndocardium
    Neural TubeNeural TubeSpinal Neural Tube CellsNeural Ectoderm
    Neural TubeTelencephalonNeural Tube
    Spinal CordPresumptive Spinal CordSpinal Cord
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization

    See TMEM179 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM179

    SOURCE GeneReport for Unigene cluster: Hs.655004
        SABiosciences Custom PCR Arrays for TMEM179
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    In Situ
    Assay Products:     
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    Orthologs
    for TMEM179 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for TMEM179 gene from 5/15 species (see all 15)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Tmem1791 , 5 transmembrane protein 1791, 5 89.96(n)1
    93.18(a)1    		   12 (61.20 cM)5
    1048851  NM_178915.31  NP_849246.21 
     1125001845 
    chicken
    (Gallus gallus)    		 Aves TMEM1791 transmembrane protein 179 79.43(n)
    83.43(a)    		   423491  XM_421395.3  XP_421395.1 
    lizard
    (Anolis carolinensis)    		 Reptilia TMEM1796
    		 --
    		 61(a)
    		 1 ↔ 1
    		 1(4430521-4446022)
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC1005373831 transmembrane protein 179-like 66.86(n)
    64.57(a)    		   100537383  XM_003200379.1  XP_003200427.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta CG136031 CG13603 50(n)
    30.95(a)    		   42838  NM_142943.2  NP_651200.1 


    ENSEMBL Gene Tree for TMEM179 (if available)
    TreeFam Gene Tree for TMEM179 (if available) 

    Paralogs
    for TMEM179 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for TMEM179 gene
    ENSG000001892032  

    TMEM179 for paralogs           About GeneDecksing



    Genomic Variants
    for TMEM179 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/244 NCBI SNPs in TMEM179 are shown (see all 244)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 14 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs128793301,2
    		C,A,--105060024(+) TCAGAG/AGCCGT 2 -- ds5001 us2k112Minor allele frequency- A:0.36NA WA CSA EA 373
    rs128806511,2
    		C,F,--105060029(+) AGCCGT/CTGGGG 2 -- ds5001 us2k19Minor allele frequency- C:0.38NA CSA WA EA 370
    rs1158529021,2
    		F,--105060222(+) CTCCCG/AGAACC 2 -- us2k1 ds50011Minor allele frequency- A:0.07WA 118
    rs758336731,2
    		C,--105060269(+) CCTCAC/TTCCAG 2 -- us2k1 ds50012Minor allele frequency- T:0.14NA 122
    rs1480539751,2
    		--105060348(+) TGTCGA/GCTCTA 2 -- us2k1 ds50010--------
    rs768179671,2
    		C,F,--105060361(+) GAGGGC/TGGGTA 2 -- us2k1 ds50015Minor allele frequency- T:0.22WA NA CSA 244
    rs38033161,2
    		C,F,--105060368(-) CGCTGT/GTTACC 2 -- us2k1 ds500110Minor allele frequency- G:0.45EA NA CSA WA 1288
    rs1862569241,2
    		--105060391(+) ACCACC/TGGAAT 2 -- ds5001 us2k10--------
    rs1908285351,2
    		--105060440(+) AGAAAA/CAATTT 2 -- us2k1 ut310--------
    rs1417515911,2
    		--105060497(+) GTATTC/TGCCAT 2 -- us2k1 ut310--------

    HapMap Linkage Disequilibrium report for TMEM179 (105057201 - 105071984 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for TMEM179: --

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    Disorders / Diseases
    for TMEM179 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    		   --

    Publications
    for TMEM179 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM179 gene integrated from 9 sources:
    (articles sorted by number of sources associating them with TMEM179)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    2. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (2003)

    External Searches for TMEM179 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing TMEM179 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 388021 HGNC: 20137 AceView: FLJ42486 Ensembl:ENSG00000258986 euGenes: HUgn388021
    ECgene: TMEM179 H-InvDB: TMEM179

    Other Databases showing TMEM179 gene

    (According to HUGE)
    About This Section
    		   --

    Specialized Databases showing TMEM179 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM179 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for TMEM179 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for TMEM179 gene:
    Search GeneIP for patents involving TMEM179

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    Products
    for TMEM179 gene

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    About This Section

     
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