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TMEM179 Gene

protein-coding   GIFtS: 38
GCID: GC14M104942

Transmembrane Protein 179

(Previous name: chromosome 14 open reading frame 90)
(Previous symbol: C14orf90)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1791 2
C14orf901 2 3
Transmembrane Protein 179A2 3
TMEM179A2 3
Chromosome 14 Open Reading Frame 901

External Ids:    HGNC: 201371   Entrez Gene: 3880212   Ensembl: ENSG000002589867   UniProtKB: Q6ZVK13   

Export aliases for TMEM179 gene to outside databases

Previous GC identifers: GC14M104132 GC14M105061 GC14M085256


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM179 Gene:
TMEM179 (transmembrane protein 179) is a protein-coding gene. Diseases associated with TMEM179 include malaria.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000014.9  NC_018925.2  NT_026437.13  NT_187599.1  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM179 gene promoter:
         AML1a   p300   NCX/Ncx   Brachyury   NRSF form 1   Nkx2-5   NRSF form 2   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM179 promoter sequence
   Search Chromatin IP Primers for TMEM179

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM179


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q32.33   Ensembl cytogenetic band:  14q32.33   HGNC cytogenetic band: 14q32.33

TMEM179 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM179 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14M104942:  view genomic region     (about GC identifiers)

Start:
104,941,015 bp from pter      End:
105,071,984 bp from pter
Size:
130,970 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: T179A_HUMAN, Q6ZVK1 (See protein sequence)
Recommended Name: Transmembrane protein 179  
Size: 233 amino acids; 26378 Da
Alternative splicing: 2 isoforms:  Q6ZVK1-1   Q6ZVK1-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM179: NX_Q6ZVK1

Explore proteomics data for TMEM179 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn51
  • Modification sites at PhosphoSitePlus

  • See TMEM179 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001273318.1  NP_001273319.1  

    ENSEMBL proteins: 
     ENSP00000397763   ENSP00000452113   ENSP00000450958   ENSP00000340477  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q6ZVK1

    UniProtKB/Swiss-Prot: T179A_HUMAN, Q6ZVK1
    Similarity: Belongs to the TMEM179 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM179
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T179A_HUMAN, Q6ZVK1: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular2
    plasma membrane2
    mitochondrion1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM179 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM179
    Interactions:

        Search GeneGlobe Interaction Network for TMEM179

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM179 (T179A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM179 gene (3 alternative transcripts): 
    NM_207379.1  NM_001286389.1  NM_001286390.1  

    Unigene Cluster for TMEM179:

    Transmembrane protein 179
    Hs.655004  [show with all ESTs]
    Unigene Representative Sequence: AK124477
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000415614 ENST00000556320 ENST00000556573 ENST00000341595(uc001yox.1)

    miRNA
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    Additional mRNA sequence: AK124477.1 

    3 DOTS entries:

    DT.75102061  DT.97794933  DT.423072 

    Selected AceView cDNA sequences (see all 47):

    BF530306 CK300060 AF462446 AI290819 AI290831 BM726911 AW026835 BX461969 
    BM702493 AI564904 BI090668 BE792466 AW205300 AI299168 BF196202 AW160386 
    AI290914 AK124477 BM725557 BM665210 BE671450 AI494391 AI632939 BF110793 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM179 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGGGGACACA
    TMEM179 Expression
    About this image


    TMEM179 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Neural Tube (Nervous System)
             Telencephalon
     
     Spinal Cord (Nervous System)
    TMEM179 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM179 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.655004
        Custom PCR Arrays for TMEM179
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM179

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for TMEM179 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1791 , 5 transmembrane protein 1791, 5 89.7(n)1
    93.56(a)1
      12 (61.20 cM)5
    1048851  NM_178915.31  NP_849246.21 
     1125001845 
    chicken
    (Gallus gallus)
    Aves TMEM1791 transmembrane protein 179 79.02(n)
    83.19(a)
      423491  NM_001277901.1  NP_001264830.1 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1796
    transmembrane protein 179
    61(a)
    1 ↔ 1
    1(4430189-4450423)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1791 transmembrane protein 179 73.13(n)
    76.29(a)
      100490211  XM_002940718.2  XP_002940764.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC1005373831 transmembrane protein 179-like 68.1(n)
    66.38(a)
      100537383  XM_003200379.2  XP_003200427.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG136031 CG13603 50.24(n)
    29.95(a)
      42838  NM_142943.2  NP_651200.1 


    ENSEMBL Gene Tree for TMEM179 (if available)
    TreeFam Gene Tree for TMEM179 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM179 (see all 262)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2018455041,2
    --86053610(+) GATGGC/GGGAGA 1 -- ut310--------
    rs2010121961,2
    C--86053644(+) ATGGCC/TCCCTC 2 S G mis10--------
    rs345725481,2
    C,F--86053719(+) GAAGGC/TGGAGT 2 T A mis13Minor allele frequency- T:0.00NA EU 5951
    rs1385563061,2
    C--86053818(+) CAGTGA/CGGGAC 1 -- int10--------
    rs1901121151,2
    --86053959(+) CCTTTA/GGGGAA 1 -- int10--------
    rs1831595081,2
    --86054172(+) ATGCCC/TCACAC 1 -- int10--------
    rs733618631,2
    C,F--86054190(+) GTCACA/GGGGTC 1 -- int16Minor allele frequency- G:0.16WA NA CSA EA 364
    rs1172241201,2
    F--86054311(+) TGGGCA/CTCAGA 1 -- int11Minor allele frequency- C:0.07EA 120
    rs1882916561,2
    --86054350(+) CCCGGC/TAGGTG 1 -- int10--------
    rs345277631,2
    C,F--86054378(+) AAAACG/ATGAAG 1 -- int112Minor allele frequency- A:0.38NA EA WA 730

    HapMap Linkage Disequilibrium report for TMEM179 (104941015 - 105071984 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for TMEM179:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv902373CNV Loss21882294
    nsv470676CNV Loss18288195
    nsv456445CNV Loss19166990
    nsv902372CNV Loss21882294
    dgv2007n71CNV Gain21882294
    nsv902376CNV Gain21882294
    nsv902377CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM179

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    1 disease for TMEM179:    
    About MalaCards
    malaria


    TMEM179 for disorders           About GeneDecksing


    Export disorders for TMEM179 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM179 gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM179)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    2. The DNA sequence and analysis of human chromosome 14. (PubMed id 12508121)1, 2 Heilig R.... Weissenbach J. (Nature 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 388021 HGNC: 20137 AceView: FLJ42486 Ensembl:ENSG00000258986 euGenes: HUgn388021
    ECgene: TMEM179 H-InvDB: TMEM179

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM179 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM179 gene:
    Search GeneIP for patents involving TMEM179

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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