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Aliases for TMEM179 Gene

Aliases for TMEM179 Gene

  • Transmembrane Protein 179 2 3 5
  • Transmembrane Protein 179A 3 4
  • C14orf90 3 4
  • TMEM179A 3 4
  • Chromosome 14 Open Reading Frame 90 2

External Ids for TMEM179 Gene

Previous HGNC Symbols for TMEM179 Gene

  • C14orf90

Previous GeneCards Identifiers for TMEM179 Gene

  • GC14M104132
  • GC14M105061
  • GC14M085256
  • GC14M104942

Summaries for TMEM179 Gene

GeneCards Summary for TMEM179 Gene

TMEM179 (Transmembrane Protein 179) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM179 Gene

Genomics for TMEM179 Gene

Regulatory Elements for TMEM179 Gene

Enhancers for TMEM179 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14F104603 0.8 Ensembl ENCODE 7.8 +1.1 1102 1.7 HDGF PKNOX1 ARID4B BMI1 ZNF48 ZSCAN9 ZNF143 ZNF207 ETV6 FOS C14orf180 TMEM179 GC14P104604 GC14P104592
GH14F104656 0.9 FANTOM5 Ensembl ENCODE 6.3 -53.7 -53741 6.8 HDGF BMI1 RAD21 RARA ZNF121 EGR1 ETV6 CREM EGR2 ZNF623 C14orf180 TMEM179 PLD4 INF2 ENSG00000258736 LOC101929634
GH14F104642 0.9 Ensembl 5.9 -36.7 -36654 0.2 ZBTB11 ZNF24 TMEM179 ENSG00000258736 GC14P104606
GH14F103711 1 Ensembl ENCODE 5.1 +893.5 893494 2.1 CTCF KLF1 KLF17 DPF2 KLF4 ZIC2 ZFP69B ZFHX2 ZNF692 POLR2A XRCC3 TMEM179 GC14P103713 PIR57408
GH14F104293 0.9 FANTOM5 ENCODE 2 +309.9 309907 4.3 CTCF JUN KLF17 BRCA1 ZIC2 RAD21 RFX5 HIC1 GLIS2 ZBTB48 XRCC3 C14orf180 APOPT1 TMEM179 LOC105370694 LOC105370693
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM179 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM179 Gene

Chromosome:
14
Start:
104,474,678 bp from pter
End:
104,605,647 bp from pter
Size:
130,970 bases
Orientation:
Minus strand

Genomic View for TMEM179 Gene

Genes around TMEM179 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM179 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM179 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM179 Gene

Proteins for TMEM179 Gene

  • Protein details for TMEM179 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZVK1-T179A_HUMAN
    Recommended name:
    Transmembrane protein 179
    Protein Accession:
    Q6ZVK1

    Protein attributes for TMEM179 Gene

    Size:
    233 amino acids
    Molecular mass:
    26378 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM179 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM179 Gene

Post-translational modifications for TMEM179 Gene

  • Glycosylation at Asn 51
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM179 Gene

Domains & Families for TMEM179 Gene

Protein Domains for TMEM179 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM179 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6ZVK1

UniProtKB/Swiss-Prot:

T179A_HUMAN :
  • Belongs to the TMEM179 family.
Family:
  • Belongs to the TMEM179 family.
genes like me logo Genes that share domains with TMEM179: view

No data available for Gene Families for TMEM179 Gene

Function for TMEM179 Gene

Phenotypes for TMEM179 Gene

GenomeRNAi human phenotypes for TMEM179:
genes like me logo Genes that share phenotypes with TMEM179: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM179 Gene

Localization for TMEM179 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM179 Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM179 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM179: view

No data available for Subcellular locations from COMPARTMENTS for TMEM179 Gene

Pathways & Interactions for TMEM179 Gene

SuperPathways for TMEM179 Gene

No Data Available

Interacting Proteins for TMEM179 Gene

Gene Ontology (GO) - Biological Process for TMEM179 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM179 Gene

Transcripts for TMEM179 Gene

Unigene Clusters for TMEM179 Gene

Transmembrane protein 179:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM179 Gene

No ASD Table

Relevant External Links for TMEM179 Gene

GeneLoc Exon Structure for
TMEM179
ECgene alternative splicing isoforms for
TMEM179

Expression for TMEM179 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM179 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM179 Gene

This gene is overexpressed in Pituitary (x7.9), Brain - Cortex (x4.5), Brain - Putamen (basal ganglia) (x4.4), Brain - Hypothalamus (x4.3), and Brain - Frontal Cortex (BA9) (x4.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MaxQB, and MOPED for TMEM179 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM179 Gene:

TMEM179

SOURCE GeneReport for Unigene cluster for TMEM179 Gene:

Hs.655004
genes like me logo Genes that share expression patterns with TMEM179: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM179 Gene

Orthologs for TMEM179 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM179 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM179 34 35
  • 99.24 (n)
cow
(Bos Taurus)
Mammalia TMEM179 34 35
  • 93.53 (n)
dog
(Canis familiaris)
Mammalia TMEM179 34 35
  • 92.74 (n)
mouse
(Mus musculus)
Mammalia Tmem179 34 16 35
  • 89.7 (n)
rat
(Rattus norvegicus)
Mammalia Tmem179 34
  • 89.56 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM179 35
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM179 35
  • 50 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM179 34 35
  • 79.02 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM179 35
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem179 34
  • 73.13 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100537383 34
  • 68.1 (n)
CABZ01084273.1 35
  • 50 (a)
OneToMany
tmem179 35
  • 50 (a)
OneToMany
TMEM179 (2 of 3) 35
  • 33 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG13603 34 35
  • 50.24 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP004210 34
  • 46.94 (n)
Species where no ortholog for TMEM179 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM179 Gene

ENSEMBL:
Gene Tree for TMEM179 (if available)
TreeFam:
Gene Tree for TMEM179 (if available)

Paralogs for TMEM179 Gene

No data available for Paralogs for TMEM179 Gene

Variants for TMEM179 Gene

Sequence variations from dbSNP and Humsavar for TMEM179 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs10144804 -- 104,601,869(+) CCCTC(C/G)ACAAC intron-variant, utr-variant-3-prime
rs10145420 -- 104,603,148(+) TCTCA(C/T)TCCTC intron-variant, utr-variant-3-prime
rs10220597 -- 104,603,809(+) TGGGC(C/T)CCAGT intron-variant, utr-variant-3-prime
rs10873548 -- 104,602,163(+) GTTAC(A/G)GCATC intron-variant, utr-variant-3-prime
rs111274571 -- 104,598,348(+) AGGCT(C/T)GATGT intron-variant, upstream-variant-2KB, reference, synonymous-codon

Structural Variations from Database of Genomic Variants (DGV) for TMEM179 Gene

Variant ID Type Subtype PubMed ID
esv2761599 CNV gain 21179565
esv3635623 CNV gain 21293372
nsv1054574 CNV loss 25217958
nsv1134408 CNV deletion 24896259
nsv456445 CNV loss 19166990
nsv470676 CNV loss 18288195
nsv566047 CNV loss 21841781
nsv952271 CNV deletion 24416366

Variation tolerance for TMEM179 Gene

Residual Variation Intolerance Score: 49.7% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.89; 18.55% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM179 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM179

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM179 Gene

Disorders for TMEM179 Gene

Relevant External Links for TMEM179

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM179

No disorders were found for TMEM179 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM179 Gene

Publications for TMEM179 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and analysis of human chromosome 14. (PMID: 12508121) Heilig R. … Weissenbach J. (Nature 2003) 3 4 64

Products for TMEM179 Gene

Sources for TMEM179 Gene

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