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Aliases for TMEM178B Gene

Aliases for TMEM178B Gene

  • Transmembrane Protein 178B 2 3 5

External Ids for TMEM178B Gene

Previous GeneCards Identifiers for TMEM178B Gene

  • GC07P140775

Summaries for TMEM178B Gene

GeneCards Summary for TMEM178B Gene

TMEM178B (Transmembrane Protein 178B) is a Protein Coding gene. An important paralog of this gene is TMEM178A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM178B Gene

Genomics for TMEM178B Gene

Regulatory Elements for TMEM178B Gene

Enhancers for TMEM178B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07G141071 1 ENCODE 23.1 -1.2 -1246 1.5 ARNT FEZF1 GLI4 ZNF2 GLIS2 KLF7 YY2 REST ZNF518A ZNF579 TMEM178B WEE2-AS1 LOC105375537
GH07G141074 0.9 ENCODE 20.6 +1.3 1255 0.7 ZSCAN4 SIN3A ZNF76 ZNF2 ZNF391 EGR2 YY2 ZEB2 ZNF398 ZNF645 TMEM178B RNU4-74P WEE2-AS1 ENSG00000261778
GH07G141013 1.2 ENCODE 12.9 -59.0 -58980 2.6 CREB3L1 FEZF1 DMAP1 YY1 ZNF143 SP3 NFYC TBX21 MEF2D GLIS1 TMEM178B BRAF NDUFB2-AS1 NDUFB2 MRPS33 CCT4P1
GH07G140972 1.1 ENCODE 12.8 -100.0 -100015 1.7 HDGF PKNOX1 FOXA2 MLX CREB3L1 ARNT ARID4B SIN3A DMAP1 FEZF1 BRAF TMEM178B TAS2R6P NDUFB2-AS1 NDUFB2 TAS2R5 CCT4P1 LOC105375536
GH07G141076 0.6 FANTOM5 22.6 +3.3 3282 0.0 MXI1 RFX1 BMI1 EP300 RFX3 SCRT2 PRDM10 PRDM1 TMEM178B RNU4-74P ENSG00000261778
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM178B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM178B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000328708 -11 201 CTCF FOXA2 SUZ12 SIN3A MNT CEBPG RBBP5 MIER2 REST HDAC2
ENSR00000219153 789 201 SUZ12 RBBP5 ZFHX2 POLR2A ZNF652 ZBTB20 EZH2 EGR2 MAZ YY2

Genomic Location for TMEM178B Gene

Chromosome:
7
Start:
141,073,311 bp from pter
End:
141,497,881 bp from pter
Size:
424,571 bases
Orientation:
Plus strand

Genomic View for TMEM178B Gene

Genes around TMEM178B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM178B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM178B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM178B Gene

Proteins for TMEM178B Gene

  • Protein details for TMEM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H3BS89-T178B_HUMAN
    Recommended name:
    Transmembrane protein 178B
    Protein Accession:
    H3BS89

    Protein attributes for TMEM178B Gene

    Size:
    294 amino acids
    Molecular mass:
    33409 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM178B Gene

Post-translational modifications for TMEM178B Gene

  • Glycosylation at Asn148 and Asn152
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM178B Gene

No data available for DME Specific Peptides for TMEM178B Gene

Domains & Families for TMEM178B Gene

Protein Domains for TMEM178B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

H3BS89

UniProtKB/Swiss-Prot:

T178B_HUMAN :
  • Belongs to the TMEM178 family.
Family:
  • Belongs to the TMEM178 family.
genes like me logo Genes that share domains with TMEM178B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM178B Gene

Function for TMEM178B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM178B Gene

Localization for TMEM178B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM178B Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM178B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM178B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM178B Gene

Pathways & Interactions for TMEM178B Gene

SuperPathways for TMEM178B Gene

No Data Available

Interacting Proteins for TMEM178B Gene

Gene Ontology (GO) - Biological Process for TMEM178B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM178B Gene

Transcripts for TMEM178B Gene

mRNA/cDNA for TMEM178B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM178B Gene

Transmembrane protein 178B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178B Gene

No ASD Table

Relevant External Links for TMEM178B Gene

GeneLoc Exon Structure for
TMEM178B
ECgene alternative splicing isoforms for
TMEM178B

Expression for TMEM178B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM178B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM178B Gene

This gene is overexpressed in Heart - Left Ventricle (x5.5), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.6), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM178B Gene

This gene is overexpressed in Frontal cortex (37.1), Fetal Brain (20.4), and Retina (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM178B Gene



Protein tissue co-expression partners for TMEM178B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM178B Gene:

TMEM178B

SOURCE GeneReport for Unigene cluster for TMEM178B Gene:

Hs.283851

Evidence on tissue expression from TISSUES for TMEM178B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM178B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM178B Gene

Orthologs for TMEM178B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM178B 34
  • 100 (n)
cow
(Bos Taurus)
Mammalia -- 35
  • 98 (a)
ManyToMany
TMEM178B 34
  • 94.56 (n)
dog
(Canis familiaris)
Mammalia -- 35
  • 98 (a)
ManyToMany
TMEM178B 34
  • 96.15 (n)
-- 35
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem178b 34
  • 94.44 (n)
mouse
(Mus musculus)
Mammalia Tmem178b 34 16 35
  • 94.32 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 84 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM178B 34 35
  • 83.9 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM178B 35
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem178b 34 35
  • 78.34 (n)
zgc:194665 35
  • 75 (a)
ManyToMany
AL929252.1 35
  • 69 (a)
ManyToMany
si:ch211-87j1.4 35
  • 65 (a)
ManyToMany
Species where no ortholog for TMEM178B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM178B Gene

ENSEMBL:
Gene Tree for TMEM178B (if available)
TreeFam:
Gene Tree for TMEM178B (if available)

Paralogs for TMEM178B Gene

Paralogs for TMEM178B Gene

(1) SIMAP similar genes for TMEM178B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM178B: view

Variants for TMEM178B Gene

Sequence variations from dbSNP and Humsavar for TMEM178B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000002701 -- 141,179,733(+) GAGCA(A/G)GCCAT intron-variant
rs1000032254 -- 141,401,358(+) AATTG(G/T)TTCAG intron-variant
rs1000036374 -- 141,480,293(+) GACTT(A/G)TTCAT intron-variant, utr-variant-3-prime
rs1000041331 -- 141,310,150(+) AGACA(A/G)CCTAC intron-variant
rs1000046686 -- 141,370,343(+) GGCAA(A/G)AGGGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM178B Gene

Variant ID Type Subtype PubMed ID
dgv246n111 CNV duplication 26073780
dgv247n111 CNV duplication 26073780
dgv3679n106 CNV deletion 24896259
esv1753264 CNV deletion 17803354
esv2264887 CNV deletion 18987734
esv2435946 CNV insertion 19546169
esv2580388 CNV deletion 19546169
esv2672376 CNV deletion 23128226
esv2678484 CNV deletion 23128226
esv2735246 CNV deletion 23290073
esv2735247 CNV deletion 23290073
esv3307580 CNV mobile element insertion 20981092
esv3309483 CNV mobile element insertion 20981092
esv34135 CNV loss 18971310
esv3433902 CNV insertion 20981092
esv3438644 CNV insertion 20981092
esv3542532 CNV deletion 23714750
esv3572174 CNV loss 25503493
esv3615247 CNV loss 21293372
esv3615248 CNV loss 21293372
esv3615249 CNV loss 21293372
esv3615252 CNV loss 21293372
esv3615253 CNV loss 21293372
esv4171 CNV loss 18987735
esv8962 CNV loss 19470904
nsv1149570 CNV deletion 26484159
nsv1152918 CNV deletion 26484159
nsv366438 CNV deletion 16902084
nsv437577 CNV loss 16327808
nsv507423 OTHER sequence alteration 20534489
nsv512929 CNV insertion 21212237
nsv519080 CNV loss 19592680
nsv527529 CNV loss 19592680
nsv831160 CNV loss 17160897
nsv955983 CNV deletion 24416366

Variation tolerance for TMEM178B Gene

Gene Damage Index Score: 1.57; 30.33% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM178B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM178B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM178B Gene

Disorders for TMEM178B Gene

Relevant External Links for TMEM178B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM178B

No disorders were found for TMEM178B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM178B Gene

Publications for TMEM178B Gene

  1. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. (PMID: 28092667) Kim H.S. … Cho B.C. (Oncogene 2017) 3 64
  2. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3 64
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3 64

Products for TMEM178B Gene

Sources for TMEM178B Gene

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