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Aliases for TMEM178B Gene

Aliases for TMEM178B Gene

  • Transmembrane Protein 178B 2 3 5

External Ids for TMEM178B Gene

Previous GeneCards Identifiers for TMEM178B Gene

  • GC07P140775

Summaries for TMEM178B Gene

GeneCards Summary for TMEM178B Gene

TMEM178B (Transmembrane Protein 178B) is a Protein Coding gene. An important paralog of this gene is TMEM178A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM178B Gene

Genomics for TMEM178B Gene

Regulatory Elements for TMEM178B Gene

Enhancers for TMEM178B Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM178B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM178B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM178B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM178B Gene

141,073,311 bp from pter
141,497,881 bp from pter
424,571 bases
Plus strand

Genomic View for TMEM178B Gene

Genes around TMEM178B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM178B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM178B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM178B Gene

Proteins for TMEM178B Gene

  • Protein details for TMEM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 178B
    Protein Accession:

    Protein attributes for TMEM178B Gene

    294 amino acids
    Molecular mass:
    33409 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM178B Gene

Proteomics data for TMEM178B Gene at MOPED

Post-translational modifications for TMEM178B Gene

  • Glycosylation at Asn 148 and Asn 152
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM178B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM178B Gene

Domains & Families for TMEM178B Gene

Protein Domains for TMEM178B Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM178 family.
  • Belongs to the TMEM178 family.
genes like me logo Genes that share domains with TMEM178B: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM178B Gene

Function for TMEM178B Gene

Animal Model Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM178B Gene

Localization for TMEM178B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM178B Gene

Membrane; Multi-pass membrane protein.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for TMEM178B Gene

Pathways & Interactions for TMEM178B Gene

SuperPathways for TMEM178B Gene

No Data Available

Interacting Proteins for TMEM178B Gene

Gene Ontology (GO) - Biological Process for TMEM178B Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM178B Gene

Drugs & Compounds for TMEM178B Gene

No Compound Related Data Available

Transcripts for TMEM178B Gene

mRNA/cDNA for TMEM178B Gene

(2) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM178B Gene

Transmembrane protein 178B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178B Gene

No ASD Table

Relevant External Links for TMEM178B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM178B Gene

mRNA expression in normal human tissues for TMEM178B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM178B Gene

This gene is overexpressed in Heart - Left Ventricle (x5.5), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.6), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM178B Gene

This gene is overexpressed in Frontal cortex (37.1), Fetal Brain (20.4), and Retina (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM178B Gene

SOURCE GeneReport for Unigene cluster for TMEM178B Gene Hs.283851

genes like me logo Genes that share expression patterns with TMEM178B: view

Protein tissue co-expression partners for TMEM178B Gene

- Elite partner

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for TMEM178B Gene

Orthologs for TMEM178B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178B Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM178B 35
  • 94.56 (n)
  • 99.32 (a)
-- 36
  • 98 (a)
(Canis familiaris)
Mammalia TMEM178B 35
  • 96.15 (n)
  • 99.32 (a)
-- 36
  • 93 (a)
-- 36
  • 98 (a)
(Mus musculus)
Mammalia Tmem178b 35
  • 94.32 (n)
  • 98.45 (a)
Tmem178b 16
Tmem178b 36
  • 93 (a)
(Pan troglodytes)
Mammalia TMEM178B 35
  • 100 (n)
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem178b 35
  • 94.44 (n)
  • 99.66 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 84 (a)
(Gallus gallus)
Aves TMEM178B 35
  • 83.9 (n)
  • 92.18 (a)
TMEM178B 36
  • 92 (a)
(Anolis carolinensis)
Reptilia TMEM178B 36
  • 85 (a)
(Danio rerio)
Actinopterygii tmem178b 35
  • 78.34 (n)
  • 85.71 (a)
AL929252.1 36
  • 69 (a)
si:ch211-87j1.4 36
  • 65 (a)
tmem178b 36
  • 86 (a)
zgc:194665 36
  • 75 (a)
Species with no ortholog for TMEM178B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM178B Gene

Gene Tree for TMEM178B (if available)
Gene Tree for TMEM178B (if available)

Paralogs for TMEM178B Gene

Paralogs for TMEM178B Gene

(1) SIMAP similar genes for TMEM178B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM178B: view

Variants for TMEM178B Gene

Sequence variations from dbSNP and Humsavar for TMEM178B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs801157 -- 141,081,108(+) ggagg(G/T)attcc intron-variant
rs801158 -- 141,081,155(+) tgtgc(A/G)ccatt intron-variant
rs801159 -- 141,081,188(+) gctaa(A/G)atgtg intron-variant
rs801160 -- 141,081,701(+) taaaa(A/T)gtata intron-variant
rs876422 -- 141,251,079(-) GATGC(C/T)TAAAA intron-variant

Variation tolerance for TMEM178B Gene

Gene Damage Index Score: 1.57; 30.33% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for TMEM178B Gene

Disorders for TMEM178B Gene

Relevant External Links for TMEM178B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM178B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM178B Gene

Publications for TMEM178B Gene

  1. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z. … Shaffer J.R. (Caries Res. 2014) 3 67
  2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  4. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer S.W. … Tsui L.-C. (Science 2003) 3
  5. Toward a complete human genome sequence. (PMID: 9847074) Sulston J.E. … Waterston R. (Genome Res. 1998) 3

Products for TMEM178B Gene

Sources for TMEM178B Gene