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Aliases for TMEM178B Gene

Aliases for TMEM178B Gene

  • Transmembrane Protein 178B 2 3 5

External Ids for TMEM178B Gene

Previous GeneCards Identifiers for TMEM178B Gene

  • GC07P140775

Summaries for TMEM178B Gene

GeneCards Summary for TMEM178B Gene

TMEM178B (Transmembrane Protein 178B) is a Protein Coding gene. An important paralog of this gene is TMEM178A.

Additional gene information for TMEM178B Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM178B Gene

Genomics for TMEM178B Gene

GeneHancer (GH) Regulatory Elements for TMEM178B Gene

Promoters and enhancers for TMEM178B Gene
GeneHancer (GH) Identifier GH Type GH
Score
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I141073 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE 570.6 +1.1 1095 1 ZSCAN4 SIN3A ZNF76 ZNF2 ZNF335 ZNF391 EGR2 YY2 ZBTB11 ZNF398 TMEM178B RNU4-74P WEE2-AS1 ENSG00000261778
GH07I141074 Promoter/Enhancer 1.1 Ensembl ENCODE 550.8 0.0 -10 0.2 CTCF SMARCE1 ZBTB11 BACH1 SIN3A MIER2 MNT REST ZNF335 RCOR1 TMEM178B LOC105375537
GH07I141071 Enhancer 0.9 ENCODE 573.2 -1.2 -1245 1.5 ARNT FEZF1 GLI4 ZNF2 GLIS2 ZNF213 ZNF143 KLF7 KLF13 YY2 TMEM178B WEE2-AS1 AGK TAS2R5 LOC105375537
GH07I141072 Enhancer 0.8 ENCODE 550.8 -0.3 -315 0.2 ZSCAN4 KLF17 ZNF2 ZNF335 KLF13 ZBTB11 ZNF398 ZEB2 ZFP69B KLF16 TMEM178B WEE2-AS1 LOC105375537
GH07I141075 Enhancer 0.6 ENCODE 550.8 -0.1 -143 0.1 SMARCE1 ZFP37 BACH1 SIN3A MIER2 MNT ZEB2 REST ZNF335 ZBTB26 TMEM178B LOC105375537
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM178B on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM178B Gene

Genomic Locations for TMEM178B Gene
chr7:141,073,311-141,497,881
(GRCh38/hg38)
Size:
424,571 bases
Orientation:
Plus strand
chr7:140,774,032-141,180,180
(GRCh37/hg19)

Genomic View for TMEM178B Gene

Genes around TMEM178B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM178B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM178B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM178B Gene

Proteins for TMEM178B Gene

  • Protein details for TMEM178B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    H3BS89-T178B_HUMAN
    Recommended name:
    Transmembrane protein 178B
    Protein Accession:
    H3BS89

    Protein attributes for TMEM178B Gene

    Size:
    294 amino acids
    Molecular mass:
    33409 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM178B Gene

Post-translational modifications for TMEM178B Gene

  • Glycosylation at posLast=148148 and posLast=152152

Other Protein References for TMEM178B Gene

No data available for DME Specific Peptides for TMEM178B Gene

Domains & Families for TMEM178B Gene

Gene Families for TMEM178B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM178B Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

H3BS89

UniProtKB/Swiss-Prot:

T178B_HUMAN :
  • Belongs to the TMEM178 family.
Family:
  • Belongs to the TMEM178 family.
genes like me logo Genes that share domains with TMEM178B: view

No data available for Suggested Antigen Peptide Sequences for TMEM178B Gene

Function for TMEM178B Gene

Phenotypes From GWAS Catalog for TMEM178B Gene

Animal Model Products

miRNA for TMEM178B Gene

miRTarBase miRNAs that target TMEM178B

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM178B Gene

Localization for TMEM178B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM178B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoli (1)
  • Vesicles (1)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM178B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM178B: view

No data available for Subcellular locations from COMPARTMENTS for TMEM178B Gene

Pathways & Interactions for TMEM178B Gene

SuperPathways for TMEM178B Gene

No Data Available

Interacting Proteins for TMEM178B Gene

Gene Ontology (GO) - Biological Process for TMEM178B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM178B Gene

Drugs & Compounds for TMEM178B Gene

No Compound Related Data Available

Transcripts for TMEM178B Gene

mRNA/cDNA for TMEM178B Gene

(3) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM178B Gene

Transmembrane protein 178B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178B Gene

No ASD Table

Relevant External Links for TMEM178B Gene

GeneLoc Exon Structure for
TMEM178B
ECgene alternative splicing isoforms for
TMEM178B

Expression for TMEM178B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM178B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM178B Gene

This gene is overexpressed in Heart - Left Ventricle (x5.5), Brain - Frontal Cortex (BA9) (x4.8), Brain - Cortex (x4.6), and Heart - Atrial Appendage (x4.1).

Protein differential expression in normal tissues from HIPED for TMEM178B Gene

This gene is overexpressed in Frontal cortex (37.1), Fetal Brain (20.4), and Retina (11.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM178B Gene



Protein tissue co-expression partners for TMEM178B Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM178B Gene:

TMEM178B

SOURCE GeneReport for Unigene cluster for TMEM178B Gene:

Hs.283851

Evidence on tissue expression from TISSUES for TMEM178B Gene

  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM178B: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM178B Gene

Orthologs for TMEM178B Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM178B 33
  • 100 (n)
cow
(Bos Taurus)
Mammalia -- 34
  • 98 (a)
ManyToMany
TMEM178B 33
  • 94.56 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 98 (a)
ManyToMany
TMEM178B 33
  • 96.15 (n)
-- 34
  • 93 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Tmem178b 33
  • 94.44 (n)
mouse
(Mus musculus)
Mammalia Tmem178b 33 16 34
  • 94.32 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 34
  • 84 (a)
ManyToMany
chicken
(Gallus gallus)
Aves TMEM178B 33 34
  • 83.9 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM178B 34
  • 85 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem178b 33 34
  • 78.34 (n)
zgc:194665 34
  • 75 (a)
ManyToMany
AL929252.1 34
  • 69 (a)
ManyToMany
si:ch211-87j1.4 34
  • 65 (a)
ManyToMany
Species where no ortholog for TMEM178B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM178B Gene

ENSEMBL:
Gene Tree for TMEM178B (if available)
TreeFam:
Gene Tree for TMEM178B (if available)

Paralogs for TMEM178B Gene

Paralogs for TMEM178B Gene

(1) SIMAP similar genes for TMEM178B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM178B: view

Variants for TMEM178B Gene

Sequence variations from dbSNP and Humsavar for TMEM178B Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000002701 -- 141,179,733(+) G/A intron_variant
rs1000032254 -- 141,401,358(+) G/T intron_variant
rs1000036374 -- 141,480,293(+) G/A 3_prime_UTR_variant, genic_downstream_transcript_variant, intron_variant
rs1000041331 -- 141,310,150(+) A/G intron_variant
rs1000046686 -- 141,370,343(+) G/A intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM178B Gene

Variant ID Type Subtype PubMed ID
dgv246n111 CNV duplication 26073780
dgv247n111 CNV duplication 26073780
dgv3679n106 CNV deletion 24896259
esv1753264 CNV deletion 17803354
esv2264887 CNV deletion 18987734
esv2435946 CNV insertion 19546169
esv2580388 CNV deletion 19546169
esv2672376 CNV deletion 23128226
esv2678484 CNV deletion 23128226
esv2735246 CNV deletion 23290073
esv2735247 CNV deletion 23290073
esv3307580 CNV mobile element insertion 20981092
esv3309483 CNV mobile element insertion 20981092
esv34135 CNV loss 18971310
esv3433902 CNV insertion 20981092
esv3438644 CNV insertion 20981092
esv3542532 CNV deletion 23714750
esv3572174 CNV loss 25503493
esv3615247 CNV loss 21293372
esv3615248 CNV loss 21293372
esv3615249 CNV loss 21293372
esv3615252 CNV loss 21293372
esv3615253 CNV loss 21293372
esv4171 CNV loss 18987735
esv8962 CNV loss 19470904
nsv1149570 CNV deletion 26484159
nsv1152918 CNV deletion 26484159
nsv366438 CNV deletion 16902084
nsv437577 CNV loss 16327808
nsv507423 OTHER sequence alteration 20534489
nsv512929 CNV insertion 21212237
nsv519080 CNV loss 19592680
nsv527529 CNV loss 19592680
nsv831160 CNV loss 17160897
nsv955983 CNV deletion 24416366

Variation tolerance for TMEM178B Gene

Gene Damage Index Score: 1.57; 30.33% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM178B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM178B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM178B Gene

Disorders for TMEM178B Gene

Additional Disease Information for TMEM178B

No disorders were found for TMEM178B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM178B Gene

Publications for TMEM178B Gene

  1. Oncogenic BRAF fusions in mucosal melanomas activate the MAPK pathway and are sensitive to MEK/PI3K inhibition or MEK/CDK4/6 inhibition. (PMID: 28092667) Kim HS … Cho BC (Oncogene 2017) 3 58
  2. Genome-wide association study of primary dentition pit-and-fissure and smooth surface caries. (PMID: 24556642) Zeng Z … Shaffer JR (Caries research 2014) 3 58
  3. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose JE … Uhl GR (Molecular medicine (Cambridge, Mass.) 2010) 3 58
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 58
  5. Human chromosome 7: DNA sequence and biology. (PMID: 12690205) Scherer SW … Tsui LC (Science (New York, N.Y.) 2003) 3 58

Products for TMEM178B Gene

Sources for TMEM178B Gene

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