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Aliases for TMEM178A Gene

Aliases for TMEM178A Gene

  • Transmembrane Protein 178A 2 3 5
  • Transmembrane Protein 178 2 3
  • TMEM178 3 4

External Ids for TMEM178A Gene

Previous HGNC Symbols for TMEM178A Gene

  • TMEM178

Previous GeneCards Identifiers for TMEM178A Gene

  • GC02P039893

Summaries for TMEM178A Gene

GeneCards Summary for TMEM178A Gene

TMEM178A (Transmembrane Protein 178A) is a Protein Coding gene. An important paralog of this gene is TMEM178B.

UniProtKB/Swiss-Prot for TMEM178A Gene

  • Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.

Additional gene information for TMEM178A Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM178A Gene

Genomics for TMEM178A Gene

Regulatory Elements for TMEM178A Gene

Enhancers for TMEM178A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H039666 0.7 FANTOM5 42.6 +2.1 2111 0.5 MXI1 CBX8 L3MBTL2 SUZ12 ZNF366 ZNF341 EZH2 TMEM178A THUMPD2
GH02H039641 0.9 Ensembl ENCODE 18.4 -22.6 -22587 1.3 SOX5 SOX13 FOXA2 JUN ZFP64 RARA TEAD3 ZNF217 CTBP1 JUND TMEM178A GC02P039595
GH02H039695 0.9 Ensembl ENCODE 12.1 +31.6 31635 3 CTCF ZNF654 JUN FEZF1 REST RAD21 OSR2 ZFP69B NFIC SCRT2 TMEM178A THUMPD2
GH02H039692 0.4 FANTOM5 25.3 +27.6 27619 0.1 ZMYM3 TMEM178A THUMPD2
GH02H039630 0.8 ENCODE 11.7 -32.6 -32624 3.2 HDAC1 TAL1 CEBPG FOSL1 TCF12 ZNF766 CTBP1 NCOR1 FOS TRIM24 TMEM178A LOC728730 GALM GC02P039595
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM178A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM178A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000115721 1118 1001 MXI1 L3MBTL2 SUZ12 MNT ZNF398 ZNF366 ZNF341 PRDM1 ZBTB26 EZH2

Genomic Locations for TMEM178A Gene

Genomic Locations for TMEM178A Gene
52,982 bases
Plus strand

Genomic View for TMEM178A Gene

Genes around TMEM178A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM178A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM178A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM178A Gene

Proteins for TMEM178A Gene

  • Protein details for TMEM178A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 178A
    Protein Accession:
    Secondary Accessions:
    • Q6UWI6
    • Q8N6N4

    Protein attributes for TMEM178A Gene

    297 amino acids
    Molecular mass:
    33019 Da
    Quaternary structure:
    • Interacts with STIM1.

    Alternative splice isoforms for TMEM178A Gene


neXtProt entry for TMEM178A Gene

Post-translational modifications for TMEM178A Gene

Other Protein References for TMEM178A Gene

No data available for DME Specific Peptides for TMEM178A Gene

Domains & Families for TMEM178A Gene

Gene Families for TMEM178A Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins
  • Predicted secreted proteins
  • Transporters

Protein Domains for TMEM178A Gene

Suggested Antigen Peptide Sequences for TMEM178A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM178 family.
  • Belongs to the TMEM178 family.
genes like me logo Genes that share domains with TMEM178A: view

Function for TMEM178A Gene

Molecular function for TMEM178A Gene

UniProtKB/Swiss-Prot Function:
Acts as a negative regulator of osteoclast differentiation in basal and inflammatory conditions by regulating TNFSF11-induced Ca (2+) fluxes, thereby controlling the induction of NFATC1.

Phenotypes From GWAS Catalog for TMEM178A Gene

genes like me logo Genes that share phenotypes with TMEM178A: view

Animal Models for TMEM178A Gene

MGI Knock Outs for TMEM178A:

Animal Model Products

CRISPR Products

miRNA for TMEM178A Gene

miRTarBase miRNAs that target TMEM178A

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM178A Gene

Localization for TMEM178A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM178A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM178A gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleus (2)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM178A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane ISS --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM178A: view

Pathways & Interactions for TMEM178A Gene

SuperPathways for TMEM178A Gene

No Data Available

Interacting Proteins for TMEM178A Gene

Gene Ontology (GO) - Biological Process for TMEM178A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0045671 negative regulation of osteoclast differentiation ISS --
GO:0051480 regulation of cytosolic calcium ion concentration ISS --
genes like me logo Genes that share ontologies with TMEM178A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM178A Gene

Drugs & Compounds for TMEM178A Gene

No Compound Related Data Available

Transcripts for TMEM178A Gene

Unigene Clusters for TMEM178A Gene

Transmembrane protein 178A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP3: - - -
SP4: - -

Relevant External Links for TMEM178A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM178A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM178A Gene

mRNA differential expression in normal tissues according to GTEx for TMEM178A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x11.8) and Brain - Cerebellum (x11.1).

Protein differential expression in normal tissues from HIPED for TMEM178A Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM178A Gene

Protein tissue co-expression partners for TMEM178A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM178A Gene:


SOURCE GeneReport for Unigene cluster for TMEM178A Gene:


Evidence on tissue expression from TISSUES for TMEM178A Gene

  • Nervous system(4.8)
  • Eye(2.2)
genes like me logo Genes that share expression patterns with TMEM178A: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM178A Gene

Orthologs for TMEM178A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM178A 33
  • 100 (n)
TMEM178 34
  • 100 (a)
(Canis familiaris)
Mammalia TMEM178A 33 34
  • 96.3 (n)
(Bos Taurus)
Mammalia TMEM178 33 34
  • 93.94 (n)
(Monodelphis domestica)
Mammalia TMEM178A 34
  • 93 (a)
(Mus musculus)
Mammalia Tmem178 33 16 34
  • 92.7 (n)
(Rattus norvegicus)
Mammalia Tmem178a 33
  • 92.37 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM178A 34
  • 86 (a)
(Gallus gallus)
Aves gga-mir-1725 34
  • 43 (a)
(Anolis carolinensis)
Reptilia TMEM178A 34
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem178a 33
  • 74.35 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30299 33
(Danio rerio)
Actinopterygii tmem178 33 34
  • 68.36 (n)
Species where no ortholog for TMEM178A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM178A Gene

Gene Tree for TMEM178A (if available)
Gene Tree for TMEM178A (if available)

Paralogs for TMEM178A Gene

Paralogs for TMEM178A Gene

(1) SIMAP similar genes for TMEM178A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM178A: view

Variants for TMEM178A Gene

Sequence variations from dbSNP and Humsavar for TMEM178A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000021123 -- 39,680,811(+) CATGA(C/G)AGTAT intron-variant
rs1000027330 -- 39,679,492(+) ACTAA(C/T)AAAGA intron-variant
rs1000033617 -- 39,697,878(+) GACCA(C/T)ACATT intron-variant, utr-variant-5-prime
rs1000117719 -- 39,669,067(+) TATGA(C/G)TTACC intron-variant
rs1000276779 -- 39,702,736(+) AAAAT(-/A)AAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM178A Gene

Variant ID Type Subtype PubMed ID
nsv833881 CNV loss 17160897
nsv833870 CNV gain 17160897
esv3590433 CNV gain 21293372
dgv1894n106 CNV deletion 24896259

Variation tolerance for TMEM178A Gene

Residual Variation Intolerance Score: 30.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.59; 12.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM178A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM178A Gene

Disorders for TMEM178A Gene

Relevant External Links for TMEM178A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM178A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM178A Gene

Publications for TMEM178A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark HF … Gray A (Genome research 2003) 2 3 4 60
  2. Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries. (PMID: 16303743) Otsuki T … Isogai T (DNA research : an international journal for rapid publication of reports on genes and genomes 2005) 3 4 60
  3. Tmem178 acts in a novel negative feedback loop targeting NFATc1 to regulate bone mass. (PMID: 26644563) Decker CE … Faccio R (Proceedings of the National Academy of Sciences of the United States of America 2015) 3 60
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie AG … Butte NF (PloS one 2012) 3 60
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K … Sugano S (Genome research 2006) 3 60

Products for TMEM178A Gene

Sources for TMEM178A Gene

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