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Aliases for TMEM178A Gene

Aliases for TMEM178A Gene

  • Transmembrane Protein 178A 2 3
  • Transmembrane Protein 178 2 3
  • TMEM178 3 4

External Ids for TMEM178A Gene

Previous HGNC Symbols for TMEM178A Gene

  • TMEM178

Previous GeneCards Identifiers for TMEM178A Gene

  • GC02P039893

Summaries for TMEM178A Gene

GeneCards Summary for TMEM178A Gene

TMEM178A (Transmembrane Protein 178A) is a Protein Coding gene. An important paralog of this gene is TMEM178B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM178A Gene

Genomics for TMEM178A Gene

Genomic Location for TMEM178A Gene

39,664,982 bp from pter
39,717,963 bp from pter
52,982 bases
Plus strand

Genomic View for TMEM178A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM178A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM178A Gene

No data available for Regulatory Elements for TMEM178A Gene

Proteins for TMEM178A Gene

  • Protein details for TMEM178A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 178A
    Protein Accession:
    Secondary Accessions:
    • Q6UWI6
    • Q8N6N4

    Protein attributes for TMEM178A Gene

    297 amino acids
    Molecular mass:
    33019 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM178A Gene


neXtProt entry for TMEM178A Gene

Proteomics data for TMEM178A Gene at MOPED

Post-translational modifications for TMEM178A Gene

Other Protein References for TMEM178A Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM178A Gene

Domains for TMEM178A Gene

Protein Domains for TMEM178A Gene

Graphical View of Domain Structure for InterPro Entry



  • Q8NBL3
  • Belongs to the TMEM178 family.
genes like me logo Genes that share domains with TMEM178A: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for TMEM178A Gene

Function for TMEM178A Gene

Animal Model Products

CRISPR Products

miRNA for TMEM178A Gene

miRTarBase miRNAs that target TMEM178A

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM178A

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM178A Gene

Localization for TMEM178A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM178A Gene

Membrane; Multi-pass membrane protein.

Gene Ontology (GO) - Cellular Components for TMEM178A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM178A: view

No data available for Subcellular locations from COMPARTMENTS for TMEM178A Gene

Pathways for TMEM178A Gene

SuperPathways for TMEM178A Gene

No Data Available

Interacting Proteins for TMEM178A Gene

Gene Ontology (GO) - Biological Process for TMEM178A Gene


No data available for Pathways by source for TMEM178A Gene

Transcripts for TMEM178A Gene

Unigene Clusters for TMEM178A Gene

Transmembrane protein 178A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM178A

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1: - -
SP3: - - -
SP4: - -

Relevant External Links for TMEM178A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM178A Gene

mRNA expression in normal human tissues for TMEM178A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM178A Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (11.8) and Brain - Cerebellum (11.1).

Protein differential expression in normal tissues for TMEM178A Gene

This gene is overexpressed in Pancreas (69.0).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM178A Gene

SOURCE GeneReport for Unigene cluster for TMEM178A Gene Hs.40808

genes like me logo Genes that share expressions with TMEM178A: view

Expression partners for TMEM178A Gene

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for TMEM178A Gene

Orthologs for TMEM178A Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM178 35
  • 93.94 (n)
  • 99.33 (a)
TMEM178 36
  • 99 (a)
(Canis familiaris)
Mammalia TMEM178A 35
  • 96.3 (n)
  • 98.99 (a)
TMEM178A 36
  • 99 (a)
(Mus musculus)
Mammalia Tmem178 35
  • 92.7 (n)
  • 98.32 (a)
Tmem178 16
Tmem178 36
  • 98 (a)
(Pan troglodytes)
Mammalia TMEM178A 35
  • 100 (n)
  • 100 (a)
TMEM178 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Tmem178a 35
  • 92.37 (n)
  • 97.64 (a)
(Monodelphis domestica)
Mammalia TMEM178A 36
  • 93 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM178A 36
  • 86 (a)
(Gallus gallus)
Aves gga-mir-1725 36
  • 43 (a)
(Anolis carolinensis)
Reptilia TMEM178A 36
  • 87 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem178a 35
  • 74.35 (n)
  • 79.66 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.30299 35
(Danio rerio)
Actinopterygii tmem178 35
  • 68.36 (n)
  • 72.2 (a)
tmem178 36
  • 68 (a)
Species with no ortholog for TMEM178A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM178A Gene

Gene Tree for TMEM178A (if available)
Gene Tree for TMEM178A (if available)

Paralogs for TMEM178A Gene

Paralogs for TMEM178A Gene

Selected SIMAP similar genes for TMEM178A Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM178A: view

Variants for TMEM178A Gene

Sequence variations from dbSNP and Humsavar for TMEM178A Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs917964 -- 39,672,295(-) GGCAA(C/T)TTTGA intron-variant
rs954559 -- 39,695,669(-) ACACT(A/T)ACCTG intron-variant
rs955556 -- 39,703,685(+) CACTT(C/T)TTAAT intron-variant
rs955557 -- 39,703,686(+) ACTTC(C/T)TAATG intron-variant
rs988285 -- 39,713,178(-) CACAA(C/T)TGGAC intron-variant

Relevant External Links for TMEM178A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for TMEM178A Gene

Disorders for TMEM178A Gene

No disorders were found for TMEM178A Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for TMEM178A Gene

Publications for TMEM178A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PMID: 16303743) Otsuki T. … Isogai T. (DNA Res. 2005) 3 4
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for TMEM178A Gene

Sources for TMEM178A Gene

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