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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM178A Gene

protein-coding   GIFtS: 36
GCID: GC02P039893

Transmembrane Protein 178A

(Previous name: transmembrane protein 178)
(Previous symbol: TMEM178)
  Search for TMEM178A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 178A1 2
TMEM1781 2 3
Transmembrane Protein 1781 2

External Ids:    HGNC: 285171   Entrez Gene: 1307332   Ensembl: ENSG000001521547   UniProtKB: Q8NBL33   

Export aliases for TMEM178A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM178A Gene: 
TMEM178A (transmembrane protein 178A) is a protein-coding gene. An important paralog of this gene is TMEM178B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_022184.15  NC_018913.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for TMEM178A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM178A promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM178A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM178A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

TMEM178A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM178A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P039893:  view genomic region     (about GC identifiers)

Start:
39,892,122 bp from pter      End:
39,945,103 bp from pter
Size:
52,982 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3 (See protein sequence)
Recommended Name: Transmembrane protein 178A precursor  
Size: 297 amino acids; 33019 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q6UWI6 Q8N6N4
Alternative splicing: 2 isoforms:  Q8NBL3-1   Q8NBL3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM178A: NX_Q8NBL3

Explore proteomics data for TMEM178A at MOPED 

TMEM178A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

TMEM178A Protein Expression

REFSEQ proteins (2 alternative transcripts): 
NP_001161431.1  NP_689603.2  

ENSEMBL proteins: 
 ENSP00000281961  

Human Recombinant Protein Products for TMEM178A: 
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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0016021integral to membrane IEA--

TMEM178A for ontologies           About GeneDecksing



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Browse CLIAs at Cloud-Clone Corp.


(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8NBL3

1 Blocks protein domain: IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3
Similarity: Belongs to the TMEM178 family


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

Phenotypes:
     1 MGI phenotypic allele for Tmem178 (no phenotypes)

TMEM178A for phenotypes           About GeneDecksing

Animal Models:
     MGI mouse knock-out Tmem178tm1Lex for TMEM178A

   inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM178A 
   inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM178A

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   genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM178A 

miRNA
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Inhib. RNA
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Gene Editing
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In Situ Assay
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM178A


(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM178A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM178A (T178A)

Search CenterWatch for drugs/clinical trials and news about TMEM178A / T178A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM178A gene (2 alternative transcripts): 
NM_001167959.1  NM_152390.2  

Unigene Cluster for TMEM178A:

Transmembrane protein 178A
Hs.40808  [show with all ESTs]
Unigene Representative Sequence: NM_152390
5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000437068 ENST00000482239 ENST00000281961(uc010fam.2 uc021vgg.1 uc002rrt.3)
ENST00000413011 ENST00000495402
miRNA
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Search QIAGEN for miScript miRNA Assays for microRNAs that regulate TMEM178A
SwitchGear 3'UTR luciferase reporter plasmidTMEM178A 3' UTR sequence
Inhib. RNA
Products:
     
Browse for Gene Knock-down Tools from EMD Millipore
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Clone
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Sirion Biotech Customized lentivirus for stable overexpression of TMEM178A 
                     Customized lentivirus expression plasmids for stable overexpression of TMEM178A 
Primer
Products:
    
OriGene qPCR primer pairs and template standards for TMEM178A
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM178A

Additional mRNA sequence: 

AK075440.1 AY358773.1 BC029530.1 

4 DOTS entries:

DT.414732  DT.101956309  DT.95113258  DT.100745218 

24/61 AceView cDNA sequences (see all 61):

AA995213 AW611569 CD678006 BX112047 AK075440 BQ188891 CR617129 CA395875 
CR597741 H86122 AA325374 BX334564 AA054237 BX382200 BM068722 NM_152390 
CD677792 AY358773 CK005078 BI597583 AI743984 AA324743 AI609358 CD676971 

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178A    About this scheme

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
SP1:              -     -                                       
SP2:                                                            
SP3:        -     -     -                                       
SP4:                                -     -                     


ECgene alternative splicing isoforms for TMEM178A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM178A expression in normal human tissues (normalized intensities)      TMEM178A embryonic expression: see
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: --
TMEM178A Expression
About this image


TMEM178A expression in embryonic tissues and stem cells    About this table
Data from LifeMap, the Embryonic Development and Stem Cells Database 
 5/8 selected tissues (see all 8) fully expand
 
 Brain (Nervous System)    fully expand to see all 12 entries
         Thalamus
         Septum   
 
 Uncategorized (Uncategorized)    fully expand to see all 3 entries
         PureStem Progenitor ES-154
 
 Bone (Muscoskeletal System)    fully expand to see all 2 entries
         Zeugopod Epiphyseal End
 
 Spinal Cord (Nervous System)    fully expand to see all 2 entries
         Dorsal Horn   
 
 Mesoderm (Gastrulation Derivatives)
         PureStem Z11, Meso Progenitor

See TMEM178A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM178A

SOURCE GeneReport for Unigene cluster: Hs.40808
    SABiosciences Custom PCR Arrays for TMEM178A
Primer
Products:
OriGene qPCR primer pairs and template standards for TMEM178A
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM178A
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QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM178A
In Situ
Assay Products:
 

 
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM178A

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178A gene from 4/10 species (see all 10)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
mouse
(Mus musculus)
Mammalia Tmem1781 , 5 transmembrane protein 1781, 5 92.7(n)1
98.32(a)1
  17 (50.97 cM)5
680271  NM_026516.21  NP_080792.21 
 809446325 
lizard
(Anolis carolinensis)
Reptilia TMEM178A6
Uncharacterized protein
87(a)
1 ↔ 1
1(253739903-253745040)
African clawed frog
(Xenopus laevis)
Amphibia Xl.302992 Xenopus laevis transcribed sequences 71.95(n)    48050572 
zebrafish
(Danio rerio)
Actinopterygii BI708852.12   -- 76.51(n)    BI708852.1 


ENSEMBL Gene Tree for TMEM178A (if available)
TreeFam Gene Tree for TMEM178A (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for TMEM178A gene
TMEM178B2  
1 SIMAP similar gene for TMEM178A using alignment to 1 protein entry:     T178A_HUMAN:
TMEM178B

TMEM178A for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/1135 SNPs in TMEM178A are shown (see all 1135)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 2 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
rs1140201111,2
C,F--39630591(+) ACTTGA/CGTGAA 1 -- us2k11Minor allele frequency- C:0.04NA 120
rs27167321,2
C,F,A--39890661(+) TGAGAC/ATGGTC 1 -- us2k112Minor allele frequency- A:0.30NA WA CSA EA 373
rs1846563511,2
--39890673(+) TAAACA/GTAGAC 1 -- us2k10--------
rs1893289811,2
--39890738(+) TCTAGA/CTAGGA 1 -- us2k10--------
rs1155485181,2
F--39890813(+) TGTCTA/GGCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
rs1145746041,2
F--39890840(+) ATTGTG/ATGAAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
rs1485964121,2
C--39891097(+) ATTTTA/GTACAT 2 -- us2k10--------
rs1819870101,2
--39891226(+) ACACTA/GAAATT 2 -- us2k10--------
rs18612441,2
C,F,A,H--39891339(-) CCCGCG/ATTCCC 2 -- us2k1 tfbs325Minor allele frequency- A:0.39MN NS EA NA WA CSA 2538
rs1427558381,2
--39891350(+) TCTGAC/TATAAC 2 -- us2k10--------

HapMap Linkage Disequilibrium report for TMEM178A (39892122 - 39945103 bp)

Structural Variations
      Database of Genomic Variants (DGV) variations for TMEM178A: --
SABiosciences Cancer Mutation PCR Assays
Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM178A
DNA2.0 Custom Variant and Variant Library Synthesis for TMEM178A

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section
  --

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for TMEM178A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM178A)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (2003)
  2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (2005)
  3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (2012)
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
  5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
  6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 130733 HGNC: 28517 AceView: MGC33926 Ensembl:ENSG00000152154 euGenes: HUgn130733
ECgene: TMEM178A H-InvDB: TMEM178A

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for TMEM178A Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for TMEM178A gene:
Search GeneIP for patents involving TMEM178A

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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