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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM178A Gene

protein-coding GIFtS: 37
GCID: GC02P039893

transmembrane protein 178A

(Previous name: transmembrane protein 178 )
(Previous symbol: TMEM178)

Explore 2 diseases affiliated with
TMEM178A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 178A¹ ²
TMEM178¹ ² ³
Transmembrane Protein 178¹ ²
MGC33926¹

External Ids:	HGNC: 28517¹	Entrez Gene: 130733²	Ensembl: ENSG00000152154⁷	UniProtKB: Q8NBL3³

Export aliases for TMEM178A gene to outside databases

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022184.15

Regulatory elements:

Search SABiosciences Regulatory transcription factor binding sites for TMEM178A
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM178A promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM178A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM178A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1 Ensembl cytogenetic band: 2p22.1 HGNC cytogenetic band: 2p22.1

TMEM178A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM178A gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P039893: view genomic region (about GC identifiers)

Start:	39,892,122 bp from pter	End:	39,945,103 bp from pter
Size:	52,982 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3 (See protein sequence)

Recommended Name: Transmembrane protein 178A precursor

Size: 297 amino acids; 33019 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: Q6UWI6 Q8N6N4

Alternative splicing: 2 isoforms: Q8NBL3-1 Q8NBL3-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM178A: NX_Q8NBL3

TMEM178A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001161431.1 NP_689603.2

ENSEMBL proteins:

ENSP00000281961

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	Uscn Proteins for TMEM178A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM178A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

ProtoNet protein and cluster: Q8NBL3

1 Blocks protein family: IPB006187 Claudin family signature

UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3

Similarity: Belongs to the TMEM178 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Animal Models:
Mouse knock-out Tmem178^tm1Lex for TMEM178A
1 MGI phenotypic allele

for Tmem178 (no phenotypes)

TMEM178A for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM178A

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Search CenterWatch for drugs/clinical trials and news about TMEM178A / T178A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for TMEM178A gene (2 alternative transcripts):

NM_001167959.1 NM_152390.2

Unigene Cluster for TMEM178A:

Transmembrane protein 178A

Hs.40808 [show with all ESTs]

Unigene Representative Sequence: NM_152390

5 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000437068 ENST00000482239 ENST00000281961(uc010fam.2 uc021vgg.1 uc002rrt.3)

ENST00000413011 ENST00000495402

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Additional cDNA sequence:

AK075440.1 AY358773.1 BC029530.1

4 DOTS entries:

DT.414732 DT.101956309 DT.95113258 DT.100745218

24/61 AceView cDNA sequences (see all 61):

BX334564 CR617129 CA395875 CR597741 BX112047 AA325374 AK075440 BQ188891

AA995213 AW611569 CD678006 H86122 BX382199 AA324743 BM023477 AW058591

CD677792 BC029530 BQ186651 BQ188919 AI248700 BM929644 H85013 AI743984

GeneLoc Exon Structure

4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178A About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	·	6c
SP1:					-		-
SP2:
SP3:			-		-		-
SP4:											-		-

ECgene alternative splicing isoforms for TMEM178A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --

TMEM178A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Heart

Endocardium

Cushion Mesenchymal Cells

Endocardium

Bone

Zeugopod Epiphyseal End

Bone

Kidney

Renal Vesicle

Kidney

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 7 LifeMap Cells

Name

Category

Sclerotome cells (Primary Cell)

Bone, Cartilage, Somite

PureStem™ myogenic progenitor Z11 (Embryonic Progenitor Cell)

Heart, Myocardium, Smooth Muscle

PureStem™ progenitor EN2 (Embryonic Progenitor Cell)

PureStem™ progenitor RASMO12 (Embryonic Progenitor Cell)

PureStem™ progenitor SK17 (Embryonic Progenitor Cell)

PureStem™ progenitor W10 (Embryonic Progenitor Cell)

Posterior foregut-like cells (A scalable, suspensi...)

See TMEM178A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM178A

SOURCE GeneReport for Unigene cluster: Hs.40808

SABiosciences Custom PCR Arrays for TMEM178A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM178A gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem178^{1 , 5}	transmembrane protein 178^{1, 5}	92.7(n)¹ 98.32(a)¹		17 (50.97 cM)⁵ 68027¹ NM_026516.2¹ NP_080792.2¹ 80944632⁵
lizard (Anolis carolinensis)	Reptilia	TMEM178⁶	--	87(a)	1 ↔ 1	1(253739906-253745040)
African clawed frog (Xenopus laevis)	Amphibia	Xl.30299²	Xenopus laevis transcribed sequences	71.95(n)		48050572
zebrafish (Danio rerio)	Actinopterygii	BI708852.1²	--	76.51(n)		BI708852.1

ENSEMBL Gene Tree for TMEM178A (if available)
TreeFam Gene Tree for TMEM178A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM178A gene

TMEM178B²

1 SIMAP similar gene for TMEM178A using alignment to 1 protein entry: T178A_HUMAN:

TMEM178B

TMEM178A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs2716732^1,2	C,F,A,	--	39890661(+)	`TGAGAC/ATGGTC`	1	--	us2k¹		12		NA WA CSA EA	373
rs184656351^1,2		--	39890673(+)	`TAAACA/GTAGAC`	1	--	us2k¹		0	--	--	--	--
rs189328981^1,2		--	39890738(+)	`TCTAGA/CTAGGA`	1	--	us2k¹		0	--	--	--	--
rs115548518^1,2	F,	--	39890813(+)	`TGTCTA/GGCTCC`	1	--	us2k¹		1		WA	118
rs114574604^1,2	F,	--	39890840(+)	`ATTGTG/ATGAAG`	1	--	us2k¹		1		WA	118
rs114020111^1,2	F,	--	39891021(+)	`ACTTGA/CGTGAA`	1	--	us2k¹		1		NA	120
rs148596412^1,2		--	39891097(+)	`ATTTTA/GTACAT`	2	--	us2k¹		0	--	--	--	--
rs181987010^1,2		--	39891226(+)	`ACACTA/GAAATT`	2	--	us2k¹		0	--	--	--	--
rs1861244^1,2	C,F,A,H,	--	39891339(-)	`CCCGCG/ATTCCC`	2	--	us2k¹ tfbs³		25		MN NS EA NA WA CSA	2538
rs142755838^1,2		--	39891350(+)	`TCTGAC/TATAAC`	2	--	us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM178A (39892122 - 39945103 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM178A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM178A for disorders About GeneDecksing

2 diseases for TMEM178A: About MalaCards

prostate cancer prostatitis

Export disorders for TMEM178A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM178A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM178A)

Utopia: connect your pdf to the dynamic
world of online information

The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2, 3} Clark H.F.... Gray A.M. (2003)
Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)^{1, 2} Otsuki T....Isogai T. (2005)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (2006)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 130733	HGNC: 28517	AceView: MGC33926	Ensembl:ENSG00000152154	euGenes: HUgn130733
ECgene: TMEM178A	H-InvDB: TMEM178A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM178A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM178A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM178A gene:
Search GeneIP for patents involving TMEM178A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM178A Gene

transmembrane protein 178A

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TMEM178A Gene

transmembrane protein 178A

Aliasesfor TMEM178A gene

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for TMEM178A gene

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