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TMEM178A Gene

protein-coding   GIFtS: 38
GCID: GC02P039893

Transmembrane Protein 178A

(Previous name: transmembrane protein 178)
(Previous symbol: TMEM178)
  Search for TMEM178A
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 178A1 2
TMEM1781 2 3
Transmembrane Protein 1781 2

External Ids:    HGNC: 285171   Entrez Gene: 1307332   Ensembl: ENSG000001521547   UniProtKB: Q8NBL33   

Export aliases for TMEM178A gene to outside databases


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM178A Gene:
TMEM178A (transmembrane protein 178A) is a protein-coding gene. An important paralog of this gene is TMEM178B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_022184.16  NC_018913.2  
Regulatory elements:
   Search for regulatory transcription factor binding sites for TMEM178A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM178A promoter sequence
   Search Chromatin IP Primers for TMEM178A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM178A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2p22.1   Ensembl cytogenetic band:  2p22.1   HGNC cytogenetic band: 2p22.1

TMEM178A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM178A gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P039893:  view genomic region     (about GC identifiers)

Start:
39,892,122 bp from pter      End:
39,945,103 bp from pter
Size:
52,982 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3 (See protein sequence)
Recommended Name: Transmembrane protein 178A precursor  
Size: 297 amino acids; 33019 Da
Secondary accessions: Q6UWI6 Q8N6N4
Alternative splicing: 2 isoforms:  Q8NBL3-1   Q8NBL3-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM178A: NX_Q8NBL3

Explore proteomics data for TMEM178A at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn158

  • See TMEM178A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001161431.1  NP_689603.2  

    ENSEMBL proteins: 
     ENSP00000281961  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR004031 PMP22/EMP/MP20/Claudin

    Graphical View of Domain Structure for InterPro Entry Q8NBL3

    ProtoNet protein and cluster: Q8NBL3

    1 Blocks protein domain: IPB006187 Claudin family signature

    UniProtKB/Swiss-Prot: T178A_HUMAN, Q8NBL3
    Similarity: Belongs to the TMEM178 family


    Find genes that share domains with TMEM178A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Phenotypes:
         1 MGI phenotypic allele for Tmem178 (no phenotypes)

    Find genes that share phenotypes with TMEM178A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Tmem178tm1Lex for TMEM178A

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM178A
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    hsa-mir-335-5p (MIRT019194)

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T178A_HUMAN, Q8NBL3: Membrane; Multi-pass membrane protein (Potential)

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with TMEM178A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM178A
    Interactions:

        Search GeneGlobe Interaction Network for TMEM178A

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM178A (T178A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM178A gene (2 alternative transcripts): 
    NM_001167959.1  NM_152390.2  

    Unigene Cluster for TMEM178A:

    Transmembrane protein 178A
    Hs.40808  [show with all ESTs]
    Unigene Representative Sequence: NM_152390
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000437068 ENST00000482239 ENST00000281961(uc010fam.2 uc021vgg.1 uc002rrt.3)
    ENST00000413011 ENST00000495402
    miRNA
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      QuantiTect SYBR Green Assays in human, mouse, rat TMEM178A
      QuantiFast Probe-based Assays in human, mouse, rat TMEM178A

    Additional mRNA sequence: 

    AK075440.1 AY358773.1 BC029530.1 

    4 DOTS entries:

    DT.414732  DT.101956309  DT.95113258  DT.100745218 

    Selected AceView cDNA sequences (see all 61):

    H86122 CD678006 AA325374 CR597741 BX334564 CA395875 CR617129 AK075440 
    AA995213 BX112047 AW611569 BQ188891 BM068722 NM_152390 BX382200 AI609358 
    AA019053 AA324743 AA054237 CD677792 CD676971 BI597583 AI423612 H85013 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM178A    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c
    SP1:              -     -                                       
    SP2:                                                            
    SP3:        -     -     -                                       
    SP4:                                -     -                     


    ECgene alternative splicing isoforms for TMEM178A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM178A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM178A Expression
    About this image


    TMEM178A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Brain (Nervous System)    fully expand to see all 8 entries
             Thalamus
     
     Bone (Muscoskeletal System)    fully expand to see all 2 entries
             Zeugopod Epiphyseal End
     
     Heart (Cardiovascular System)
             Cushion Mesenchymal Cells Endocardium
     
     Blood (Hematopoietic System)
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Eye (Sensory Organs)
    TMEM178A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM178A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.40808
        Custom PCR Arrays for TMEM178A
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM178A gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1781 , 5 transmembrane protein 1781, 5 92.7(n)1
    98.32(a)1
      17 (50.97 cM)5
    680271  NM_026516.21  NP_080792.21 
     809446325 
    chicken
    (Gallus gallus)
    Aves gga-mir-17256
    gga-mir-1725
    43(a)
    1 ↔ 1
    5(22181527-22185061)
    lizard
    (Anolis carolinensis)
    Reptilia TMEM178A6
    transmembrane protein 178A
    87(a)
    1 ↔ 1
    1(253739903-253745040)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.302992 Xenopus laevis transcribed sequences 71.95(n)    48050572 
    zebrafish
    (Danio rerio)
    Actinopterygii BI708852.12   -- 76.51(n)    BI708852.1 


    ENSEMBL Gene Tree for TMEM178A (if available)
    TreeFam Gene Tree for TMEM178A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM178A gene
    TMEM178B2  
    1 SIMAP similar gene for TMEM178A using alignment to 1 protein entry:     T178A_HUMAN:
    TMEM178B

    Find genes that share paralogs with TMEM178A           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM178A (see all 1135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1140201111,2
    C,F--39630591(+) ACTTGA/CGTGAA 1 -- us2k11Minor allele frequency- C:0.04NA 120
    rs27167321,2
    C,F,A--39890661(+) TGAGAC/ATGGTC 1 -- us2k112Minor allele frequency- A:0.30NA WA CSA EA 373
    rs1846563511,2
    --39890673(+) TAAACA/GTAGAC 1 -- us2k10--------
    rs1893289811,2
    --39890738(+) TCTAGA/CTAGGA 1 -- us2k10--------
    rs1155485181,2
    F--39890813(+) TGTCTA/GGCTCC 1 -- us2k11Minor allele frequency- G:0.05WA 118
    rs1145746041,2
    F--39890840(+) ATTGTG/ATGAAG 1 -- us2k11Minor allele frequency- A:0.03WA 118
    rs1485964121,2
    C--39891097(+) ATTTTA/GTACAT 2 -- us2k10--------
    rs1819870101,2
    --39891226(+) ACACTA/GAAATT 2 -- us2k10--------
    rs18612441,2
    C,F,A,H--39891339(-) CCCGCG/ATTCCC 2 -- us2k1 tfbs325Minor allele frequency- A:0.39MN NS EA NA WA CSA 2538
    rs1427558381,2
    --39891350(+) TCTGAC/TATAAC 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for TMEM178A (39892122 - 39945103 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for TMEM178A: --
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM178A
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM178A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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      --

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM178A gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM178A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2, 3 Clark H.F.... Gray A.M. (Genome Res. 2003)
    2. Signal sequence and keyword trap in silico for selection of full- length human cDNAs encoding secretion or membrane proteins from oligo- capped cDNA libraries. (PubMed id 16303743)1, 2 Otsuki T....Isogai T. (DNA Res. 2005)
    3. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PubMed id 23251661)1 Comuzzie A.G....Butte N.F. (PLoS ONE 2012)
    4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    5. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W.... Wilson R.K. (Nature 2005)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 130733 HGNC: 28517 AceView: MGC33926 Ensembl:ENSG00000152154 euGenes: HUgn130733
    ECgene: TMEM178A H-InvDB: TMEM178A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM178A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM178A gene:
    Search GeneIP for patents involving TMEM178A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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