TMEM177 Gene
protein-coding GIFtS: 40
GCID: GC02P120436
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transmembrane protein 177
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Aliases for TMEM177 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb) About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1771 2 | | MGC109931 |
Export aliases for TMEM177 gene to outside databasesPrevious GC identifers: GC02P120153 GC02P112761 |
Summaries for TMEM177 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| -- |
Genomic Views for TMEM177 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics) About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022135.16
Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the TMEM177 gene promoter: AhR GR AML1a GR-beta HSF1 (long) PPAR-alpha COMP1 HSF1short GR-alpha Pax-4a Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM177
Epigenetics:
|  | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM177 |
Genomic Location: Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q14.2 Ensembl cytogenetic band: 2q14.2 HGNC cytogenetic band: 2q14.2TMEM177 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)

GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P120436: view genomic region
(about GC identifiers)
Start:
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120,436,743 bp from pter |
End:
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120,444,083 bp from pter |
Size:
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7,341 bases |
Orientation:
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plus strand |
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Proteins for TMEM177 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
| UniProtKB/Swiss-Prot: TM177_HUMAN, Q53S58 (See
protein sequence)Recommended Name: Transmembrane protein 177 Size: 311 amino acids; 33760 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: Q9BT20Explore the universe of human proteins at neXtProt for TMEM177: NX_Q53S58
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q53S58 TMEM177 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (3 alternative transcripts):
NP_001098668.1 NP_001098669.1 NP_085054.2 ENSEMBL proteins: ENSP00000385966 ENSP00000272521 ENSP00000405898 ENSP00000386430 ENSP00000402661 Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM177 for ontologies About GeneDecksing
TMEM177 Antibody Products: Assay Products for TMEM177: |
Protein
Domains / Families for TMEM177 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM177 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q53S58ProtoNet protein and cluster: Q53S58 UniProtKB/Swiss-Prot: TM177_HUMAN, Q53S58Similarity: Belongs to the TMEM177 family |
Function for TMEM177 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM177 (NM_001105199) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM177 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM177  |
In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM177 |
3 GenomeRNAi human phenotypes for TMEM177:
|
Pathways & Interactions for TMEM177 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM177
1 Interacting protein for TMEM177 (Q53S583) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds for TMEM177 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
Browse Tocris compounds for TMEM177 Search CenterWatch for drugs/clinical trials and news about TMEM177 / TM177 
|
Transcripts for TMEM177 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
) About This Section
| REFSEQ mRNAs for TMEM177 gene (3 alternative transcripts): NM_001105198.1 NM_001105199.1 NM_030577.2 Unigene Cluster for TMEM177: Transmembrane protein 177 Hs.439991 [show with all ESTs]Unigene Representative Sequence: AK0573136 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000401466(uc002tmc.1) ENST00000272521 ENST00000445518 ENST00000496203(uc002tme.2) ENST00000409951(uc010flh.3) ENST00000424086(uc010flg.1 uc002tmd.2)
Clone Products: |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 (see all 3) OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 3): TMEM177 (NM_001105199) | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM177 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM177  |
Additional cDNA sequence: AK057313.1 AK096890.1 AK130088.1 AK299078.1 AK308503.1 AK311734.1 BC004404.1 11 DOTS entries: DT.111952 DT.95159892 DT.120966979 DT.95307317 DT.100774967 DT.120967045 DT.100665608 DT.120967058 DT.40108127 DT.97844221 DT.102830479 24/112 AceView cDNA sequences (see all 112): CB113478 AA524744 CB113889 AW027286 BX406901 BM831931 BM713239 BU191020 AA306924 BX095026 BM811609 BQ681757 BM051833 BE408292 AW887728 AA602465 BC004404 AA243058 BE269849 BQ649903 BF059439 BM675428 BE397131 BU185402 GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM177 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | |
| SP1: | |   | - |   | - |   | |   | |   | |   | |
| SP2: | |   | |   | - |   | |   | |   | |   | |
| SP3: | |   | |   | |   | |   | |   | |   |
ECgene alternative splicing isoforms for TMEM177
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Expression for TMEM177 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM177 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this imageBioGPS CGAP TAG: AACATAAGGG
About this image See TMEM177 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for TMEM177
SOURCE GeneReport for Unigene cluster: Hs.439991 SABiosciences Custom PCR Arrays for TMEM177
Primer Products: |  | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM177 Browse OriGene validated miRNA SYBR primer pairs
| |  | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM177 | |  | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM177 | |  | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM177 | In Situ Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM177 |
Orthologs for TMEM177 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM177 gene from 5/15 species (see all 15) About this table
ENSEMBL Gene Tree for TMEM177 (if available) TreeFam Gene Tree for TMEM177 (if available)  |
Paralogs for TMEM177 gene(Paralogs according to
1HomoloGene, 2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68) About This Section
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Genomic Variants for TMEM177 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical significance | Chr 2 pos | Sequence | # | AA Chg | Type | More | # | Allele freq | Pop | Total sample | More |
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HapMap Linkage Disequilibrium report for TMEM177 (120436743 - 120444083 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV) variations for TMEM177: --  | SABiosciences Cancer Mutation PCR Assays |
|  | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM177 |
|
Disorders
/ Diseases for TMEM177 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications for TMEM177 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM177 gene integrated from 9 sources: (articles sorted by number of sources associating them with TMEM177) | |  | Utopia: connect your pdf to the dynamic world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
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External Searches for TMEM177 gene
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
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Genome Databases showing TMEM177 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM177 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM177 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| PharmGKB entry for TMEM177 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM177 gene: Search GeneIP for patents involving TMEM177
GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products for TMEM177 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
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| | | | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM177 | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM177 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM177 | | OriGene Protein Over-expression Lysate for TMEM177 | | Browse OriGene Fluorogenic Cell Assay Kits | | OriGene siRNA for TMEM177 | | Browse 3'-UTR reporter clones for miRNA target validation | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM177 | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | OriGene Custom Antibody Services for TMEM177 | | OriGene Custom Protein Services for TMEM177 | | OriGene Custom Immunoassay Development | | |
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| | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM177 | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM177 | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM177 | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM177 | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM177 | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM177 |
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 |  |  |  | |
| | | Search Tocris compounds for TMEM177 |
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 | | TMEM177 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM177 |
|  |  |  | | | Search ThermoFisher Antibodies for TMEM177 |
| | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM177 |
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