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Aliases for TMEM177 Gene

Aliases for TMEM177 Gene

  • Transmembrane Protein 177 2 3 5

External Ids for TMEM177 Gene

Previous GeneCards Identifiers for TMEM177 Gene

  • GC02P120153
  • GC02P120436
  • GC02P112761

Summaries for TMEM177 Gene

GeneCards Summary for TMEM177 Gene

TMEM177 (Transmembrane Protein 177) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM177 Gene

Genomics for TMEM177 Gene

Regulatory Elements for TMEM177 Gene

Enhancers for TMEM177 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around TMEM177 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM177 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM177 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM177 Gene

Chromosome:
2
Start:
119,679,167 bp from pter
End:
119,686,507 bp from pter
Size:
7,341 bases
Orientation:
Plus strand

Genomic View for TMEM177 Gene

Genes around TMEM177 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM177 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM177 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM177 Gene

Proteins for TMEM177 Gene

  • Protein details for TMEM177 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q53S58-TM177_HUMAN
    Recommended name:
    Transmembrane protein 177
    Protein Accession:
    Q53S58
    Secondary Accessions:
    • Q9BT20

    Protein attributes for TMEM177 Gene

    Size:
    311 amino acids
    Molecular mass:
    33760 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM177 Gene

Proteomics data for TMEM177 Gene at MOPED

Post-translational modifications for TMEM177 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM177 Gene

No data available for DME Specific Peptides for TMEM177 Gene

Domains & Families for TMEM177 Gene

Protein Domains for TMEM177 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM177 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q53S58

UniProtKB/Swiss-Prot:

TM177_HUMAN :
  • Belongs to the TMEM177 family.
Family:
  • Belongs to the TMEM177 family.
genes like me logo Genes that share domains with TMEM177: view

No data available for Gene Families for TMEM177 Gene

Function for TMEM177 Gene

genes like me logo Genes that share phenotypes with TMEM177: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM177 Gene

Localization for TMEM177 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM177 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM177 Gene COMPARTMENTS Subcellular localization image for TMEM177 gene
Compartment Confidence
mitochondrion 2
plasma membrane 2
cytosol 1
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM177 Gene

Pathways & Interactions for TMEM177 Gene

SuperPathways for TMEM177 Gene

No Data Available

Interacting Proteins for TMEM177 Gene

Gene Ontology (GO) - Biological Process for TMEM177 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM177 Gene

Drugs & Compounds for TMEM177 Gene

No Compound Related Data Available

Transcripts for TMEM177 Gene

Unigene Clusters for TMEM177 Gene

Transmembrane protein 177:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM177 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c
SP1: - -
SP2: -
SP3:

Relevant External Links for TMEM177 Gene

GeneLoc Exon Structure for
TMEM177
ECgene alternative splicing isoforms for
TMEM177

Expression for TMEM177 Gene

mRNA expression in normal human tissues for TMEM177 Gene

Protein differential expression in normal tissues from HIPED for TMEM177 Gene

This gene is overexpressed in Heart (23.6), Frontal cortex (19.1), Adrenal (8.2), and Islet of Langerhans (7.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for TMEM177 Gene



SOURCE GeneReport for Unigene cluster for TMEM177 Gene Hs.439991

genes like me logo Genes that share expression patterns with TMEM177: view

Protein tissue co-expression partners for TMEM177 Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM177 Gene

Orthologs for TMEM177 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM177 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM177 35
  • 82.96 (n)
  • 80.71 (a)
TMEM177 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM177 35
  • 85.1 (n)
  • 82.32 (a)
TMEM177 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem177 35
  • 81.94 (n)
  • 78.71 (a)
Tmem177 16
Tmem177 36
  • 78 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM177 35
  • 99.25 (n)
  • 99.04 (a)
TMEM177 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem177 35
  • 82.42 (n)
  • 79.29 (a)
chicken
(Gallus gallus)
Aves TMEM177 35
  • 55.78 (n)
  • 48 (a)
TMEM177 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM177 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem177 35
  • 55.04 (n)
  • 46.18 (a)
zebrafish
(Danio rerio)
Actinopterygii tmem177 35
  • 54.61 (n)
  • 42.76 (a)
tmem177 36
  • 42 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP006719 35
  • 42.67 (n)
  • 28.4 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG33506 35
  • 42.12 (n)
  • 25.27 (a)
CG33506 36
  • 22 (a)
OneToOne
Species with no ortholog for TMEM177:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM177 Gene

ENSEMBL:
Gene Tree for TMEM177 (if available)
TreeFam:
Gene Tree for TMEM177 (if available)

Paralogs for TMEM177 Gene

No data available for Paralogs for TMEM177 Gene

Variants for TMEM177 Gene

Sequence variations from dbSNP and Humsavar for TMEM177 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs11684353 - 119,680,939(+) GTTTG(C/G/T)AGTTC reference, missense
rs13011768 - 119,680,947(+) TTCCA(A/G)TCTCG reference, missense
rs1983406 - 119,681,654(-) TCCCC(A/C/G/T)TCTTT reference, missense
rs1568538 -- 119,677,981(-) TGAGC(A/C)CCCCC upstream-variant-2KB
rs1568539 -- 119,677,817(-) gactt(A/G)agagt upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM177 Gene

Variant ID Type Subtype PubMed ID
nsv874963 CNV Gain 21882294
dgv4290n71 CNV Gain 21882294
nsv874967 CNV Gain 21882294

Variation tolerance for TMEM177 Gene

Residual Variation Intolerance Score: 79.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.80% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM177 Gene

Disorders for TMEM177 Gene

Relevant External Links for TMEM177

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM177

No disorders were found for TMEM177 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM177 Gene

Publications for TMEM177 Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  4. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  5. A genome-wide RNAi screen identifies multiple synthetic lethal interactions with the Ras oncogene. (PMID: 19490893) Luo J. … Elledge S.J. (Cell 2009) 3

Products for TMEM177 Gene

Sources for TMEM177 Gene

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