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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM176B Gene

protein-coding GIFtS: 44
GCID: GC07M150488

transmembrane protein 176B

Explore 1 disease affiliated with
TMEM176B via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 176B¹ ²
LR8¹ ² ³
LR8-Like Protein²
Protein LR8³

External Ids:	HGNC: 29596¹	Entrez Gene: 28959²	Ensembl: ENSG00000106565⁷	OMIM: 610385⁵	UniProtKB: Q3YBM2³

Export aliases for TMEM176B gene to outside databases

Previous GC identifers: GC07M150119 GC07M144300

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2

Function: May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar

granule cells (By similarity)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM176B gene promoter:
E2F-1 E2F Nkx2-5 E2F-2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TMEM176B promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM176B

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM176B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1

TMEM176B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM176B gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M150488: view genomic region (about GC identifiers)

Start:	150,488,373 bp from pter	End:	150,498,450 bp from pter
Size:	10,078 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 149,817,661-149,827,738

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2 (See protein sequence)

Recommended Name: Transmembrane protein 176B

Size: 270 amino acids; 29056 Da

Subcellular location: Nucleus membrane; Multi-pass membrane protein (By similarity)

Sequence caution: Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu;

Secondary accessions: B2RDK2 D3DWZ7 E9PAV4 Q5BJI2 Q9BT42 Q9Y609

Alternative splicing: 2 isoforms: Q3YBM2-1 Q3YBM2-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM176B: NX_Q3YBM2

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q3YBM2

TMEM176B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (4 alternative transcripts):

NP_001094781.1 NP_001094782.1 NP_001094784.1 NP_054739.3

ENSEMBL proteins:

ENSP00000419258 ENSP00000318409 ENSP00000410269 ENSP00000397810 ENSP00000404831

ENSP00000413531 ENSP00000434910

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Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--
GO:0031965	nuclear membrane	IEA	--

TMEM176B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM176B for domains About GeneDecksing

2 InterPro domains/families:

IPR007237 CD20-like

IPR009281 LR8

Graphical View of Domain Structure for InterPro Entry Q3YBM2

ProtoNet protein and cluster: Q3YBM2

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2

Similarity: Belongs to the TMEM176 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2

Function: May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar

granule cells (By similarity)

Induction: Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells

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In Situ Assay
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Animal Models:
Mouse knock-out Tmem176b^tm1Tto for TMEM176B
2 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Tmem176b):

behavior/neurological

nervous system

TMEM176B for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM176B

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0009887	organ morphogenesis	TAS	9922225
GO:0030154	cell differentiation	IEA	--
GO:2001199	negative regulation of dendritic cell differentiation	IEA	--

TMEM176B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM176B
Search CenterWatch for drugs/clinical trials and news about TMEM176B / T176B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for TMEM176B gene (5 alternative transcripts):

NM_001101313.1 NM_001101311.1 NM_001101312.1 NM_001101314.1 NM_014020.3

Unigene Cluster for TMEM176B:

Transmembrane protein 176B

Hs.647090 [show with all ESTs]

Unigene Representative Sequence: AK097304

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000492607 ENST00000326442 ENST00000447204(uc003whw.4) ENST00000429904(uc022apx.1)

ENST00000450753 ENST00000434545(uc003whu.4 uc003whv.4) ENST00000528038

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		hsa-miR-3175 hsa-miR-34a*
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Additional cDNA sequence:

AF115384.1 AK000841.1 AK097304.1 AK129525.1 AK315575.1 BC004358.1 BC014586.2 BC091471.1

DQ144974.1

22 DOTS entries:

DT.95351238 DT.97859251 DT.95093223 DT.312814 DT.121114748 DT.97763866 DT.100819339 DT.100819342

DT.121114854 DT.40298267 DT.95351228 DT.121114819 DT.121114853 DT.92013727 DT.92433346 DT.95188822

DT.95195686 DT.95232132 DT.95319839 DT.100819341 DT.121114798 DT.95351226

24/232 AceView cDNA sequences (see all 232):

CA843792 CR610447 AI625318 AV656418 CB991669 BM703410 BI518632 AI935867

BU731446 BX106738 BI759037 CR608087 BI760287 AI636809 AA372940 BI906550

BX389863 BG413472 BQ352588 BI910564 CB990768 BI771186 AW079674 BU729342

GeneLoc Exon Structure

5/8 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176B (see all 8) About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	^	5a	·	5b	·	5c	^	6	^	7	^	8a	·	8b	^	9	^	10a	·	10b
SP1:			-		-		-		-		-		-
SP2:							-		-		-		-
SP3:							-		-		-		-						-
SP4:
SP5:							-		-		-		-

ECgene alternative splicing isoforms for TMEM176B

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM176B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AACAGATATT

About this image

TMEM176B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Inner Nuclear Layer

GABAergic Amacrine Cells

Amacrine, Retina

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM176B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM176B

SOURCE GeneReport for Unigene cluster: Hs.647090

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2

Tissue specificity: Expressed in lung and dermal fibroblasts

SABiosciences Custom PCR Arrays for TMEM176B

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

--

ENSEMBL Gene Tree for TMEM176B (if available)
TreeFam Gene Tree for TMEM176B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM176B gene

TMEM176A²

1 SIMAP similar gene for TMEM176B using alignment to 1 protein entry: T176B_HUMAN:

TMEM176A

TMEM176B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs3757410^1,2	C,F,H,	--	150487961(-)	`GTCTTC/TCTTCC`	4	--	ds500¹		24		EA NS NA WA CSA	4182
rs148923173^1,2		--	150488026(+)	`ATTACC/TGCAAA`	4	--	ds500¹		0	--	--	--	--
rs3757409^1,2	C,F,A,	--	150488082(-)	`TGGAAT/CGAGAT`	4	--	ds500¹		8		EA WA NA CSA	1861
rs185421487^1,2		--	150488336(+)	`CCTTTC/TATGGC`	4	--	ds500¹		0	--	--	--	--
rs112079476^1,2		--	150488342(+)	`ATGGCA/G/TCACGA`	4	--	ds500¹		1		CSA	2
rs190182639^1,2		--	150488346(+)	`CGCACA/GAGGTG`	4	--	ds500¹		0	--	--	--	--
rs181135011^1,2		--	150488369(+)	`GAAACA/CATATC`	4	--	ds500¹		0	--	--	--	--
rs114041488^1,2	F,	--	150488465(+)	`AGAACC/GCCAGA`	4	--	ut3¹		1		WA	118
rs2302481^1,2	C,F,A,H,	--	150488468(-)	`CACTCT/CGGGGT`	4	--	ut3¹ ese³		26		EA MN NS NA WA CSA	4454
rs2302480^1,2	C,F,A,	--	150488495(-)	`TCTCCC/TCACAT`	4	--	ut3¹ ese³ trp³		9		EA NA WA CSA	1868

HapMap Linkage Disequilibrium report for TMEM176B (150488373 - 150498450 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM176B: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM176B for disorders           About GeneDecksing

OMIM gene information: 610385    OMIM disorders: --

1 disease for TMEM176B:    About MalaCards

proteinuria

Export disorders for TMEM176B gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM176B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM176B)

Utopia: connect your pdf to the dynamic
world of online information

Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. (PubMed id 9922225)^{1, 2, 3} Lurton J.... Narayanan A.S. (1999)
Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. (PubMed id 16095493)^{1, 2} Louvet C....Cuturi M.-C. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Abnormal accumulation of human transmembrane (TMEM)-17 6A and 176B proteins is associated with cancer pathology. (PubMed id 22244448)¹ Cuajungco M.P....Taylor K. (2012)
hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)¹ Lamesch P.... Vidal M. (2007)
Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)¹ Suzuki Y.... Sugano S. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (2003)
Gene expression profile of renal proximal tubules regulated by proteinuria. (PubMed id 11967007)¹ Nakajima H....Okubo K. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 28959	HGNC: 29596	AceView: LR8	Ensembl:ENSG00000106565	euGenes: HUgn28959
ECgene: TMEM176B	H-InvDB: TMEM176B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM176B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM176B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM176B gene:
Search GeneIP for patents involving TMEM176B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section


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	Browse OriGene Antibodies		OriGene shRNA RFP for TMEM176B
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ThermoFisher Antibody for TMEM176B

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176B

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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TMEM176B Gene

transmembrane protein 176B

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TMEM176B Gene

transmembrane protein 176B

Aliasesfor TMEM176B gene

Summariesfor TMEM176B gene

Genomic Viewsfor TMEM176B gene

Proteinsfor TMEM176B gene

Protein Domains /Familiesfor TMEM176B gene

Functionfor TMEM176B gene

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for TMEM176B gene

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for TMEM176B gene

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for TMEM176B gene

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for TMEM176B gene

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for TMEM176B gene

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