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Aliases for TMEM176B Gene

Aliases for TMEM176B Gene

  • Transmembrane Protein 176B 2 3 5
  • LR8 3 4
  • LR8-Like Protein 3
  • Protein LR8 4
  • MS4B2 3

External Ids for TMEM176B Gene

Previous GeneCards Identifiers for TMEM176B Gene

  • GC07M150119
  • GC07M150488
  • GC07M144300

Summaries for TMEM176B Gene

GeneCards Summary for TMEM176B Gene

TMEM176B (Transmembrane Protein 176B) is a Protein Coding gene. An important paralog of this gene is TMEM176A.

UniProtKB/Swiss-Prot for TMEM176B Gene

  • May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM176B Gene

Genomics for TMEM176B Gene

Regulatory Elements for TMEM176B Gene

Promoters for TMEM176B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM176B on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the TMEM176B gene promoter:

Genomic Location for TMEM176B Gene

Chromosome:
7
Start:
150,791,285 bp from pter
End:
150,801,360 bp from pter
Size:
10,076 bases
Orientation:
Minus strand

Genomic View for TMEM176B Gene

Genes around TMEM176B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM176B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM176B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176B Gene

Proteins for TMEM176B Gene

  • Protein details for TMEM176B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q3YBM2-T176B_HUMAN
    Recommended name:
    Transmembrane protein 176B
    Protein Accession:
    Q3YBM2
    Secondary Accessions:
    • B2RDK2
    • D3DWZ7
    • E9PAV4
    • Q5BJI2
    • Q9BT42
    • Q9Y609

    Protein attributes for TMEM176B Gene

    Size:
    270 amino acids
    Molecular mass:
    29056 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM176B Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM176B Gene

Proteomics data for TMEM176B Gene at MOPED

Post-translational modifications for TMEM176B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM176B Gene

Domains & Families for TMEM176B Gene

Gene Families for TMEM176B Gene

Protein Domains for TMEM176B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM176B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q3YBM2

UniProtKB/Swiss-Prot:

T176B_HUMAN :
  • Belongs to the TMEM176 family.
Family:
  • Belongs to the TMEM176 family.
genes like me logo Genes that share domains with TMEM176B: view

Function for TMEM176B Gene

Molecular function for TMEM176B Gene

UniProtKB/Swiss-Prot Function:
May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.
genes like me logo Genes that share phenotypes with TMEM176B: view

Animal Models for TMEM176B Gene

MGI Knock Outs for TMEM176B:

Animal Model Products

CRISPR Products

miRNA for TMEM176B Gene

miRTarBase miRNAs that target TMEM176B

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for TMEM176B Gene

Localization for TMEM176B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176B Gene

Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM176B Gene COMPARTMENTS Subcellular localization image for TMEM176B gene
Compartment Confidence
nucleus 3
plasma membrane 3
extracellular 1

No data available for Gene Ontology (GO) - Cellular Components for TMEM176B Gene

Pathways & Interactions for TMEM176B Gene

SuperPathways for TMEM176B Gene

No Data Available

Interacting Proteins for TMEM176B Gene

Gene Ontology (GO) - Biological Process for TMEM176B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM176B Gene

Drugs & Compounds for TMEM176B Gene

No Compound Related Data Available

Transcripts for TMEM176B Gene

Unigene Clusters for TMEM176B Gene

Transmembrane protein 176B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP4:
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - -

Relevant External Links for TMEM176B Gene

GeneLoc Exon Structure for
TMEM176B
ECgene alternative splicing isoforms for
TMEM176B

Expression for TMEM176B Gene

mRNA expression in normal human tissues for TMEM176B Gene

mRNA differential expression in normal tissues according to GTEx for TMEM176B Gene

This gene is overexpressed in Liver (x17.3).

Protein differential expression in normal tissues from HIPED for TMEM176B Gene

This gene is overexpressed in Monocytes (22.3), Liver (21.6), Ovary (10.5), and Colon (7.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM176B Gene



SOURCE GeneReport for Unigene cluster for TMEM176B Gene Hs.647090

mRNA Expression by UniProt/SwissProt for TMEM176B Gene

Q3YBM2-T176B_HUMAN
Tissue specificity: Expressed in lung and dermal fibroblasts.
genes like me logo Genes that share expression patterns with TMEM176B: view

Protein tissue co-expression partners for TMEM176B Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for TMEM176B Gene

Orthologs for TMEM176B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM176B 35
  • 99.51 (n)
  • 98.52 (a)
TMEM176B 36
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM176B 36
  • 65 (a)
OneToOne
TMEM176B 35
  • 77.78 (n)
  • 66.29 (a)
dog
(Canis familiaris)
Mammalia TMEM176B 35
  • 77.65 (n)
  • 67.42 (a)
TMEM176B 36
  • 62 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem176b 36
  • 52 (a)
OneToOne
Tmem176b 16
Tmem176b 35
  • 69.44 (n)
  • 56.35 (a)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Tmem176b 35
  • 68.36 (n)
  • 54.3 (a)
Species with no ortholog for TMEM176B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM176B Gene

ENSEMBL:
Gene Tree for TMEM176B (if available)
TreeFam:
Gene Tree for TMEM176B (if available)

Paralogs for TMEM176B Gene

Paralogs for TMEM176B Gene

(1) SIMAP similar genes for TMEM176B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM176B: view

Variants for TMEM176B Gene

Sequence variations from dbSNP and Humsavar for TMEM176B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs11546671 - 150,796,407(-) CTGTG(C/T)CTTCC reference, missense
rs28434777 - 150,794,068(+) CTGAG(C/T)CACCT intron-variant, reference, missense
rs3173833 - 150,793,996(-) TGCTG(A/C/T)GTGCC intron-variant, reference, missense
rs2072443 - 150,793,288(-) CCCTG(A/G)CAGGC reference, missense
rs17256042 - 150,793,150(+) TCGCC(A/G)CATCC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for TMEM176B Gene

Variant ID Type Subtype PubMed ID
nsv831187 CNV Loss 17160897
nsv519444 CNV Loss 19592680

Variation tolerance for TMEM176B Gene

Residual Variation Intolerance Score: 93% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.69; 89.26% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM176B Gene

HapMap Linkage Disequilibrium report
TMEM176B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176B Gene

Disorders for TMEM176B Gene

Relevant External Links for TMEM176B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM176B

No disorders were found for TMEM176B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM176B Gene

Publications for TMEM176B Gene

  1. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. (PMID: 9922225) Lurton J. … Narayanan A.S. (Am. J. Respir. Cell Mol. Biol. 1999) 2 3 4 67
  2. Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology. (PMID: 22244448) Cuajungco M.P. … Taylor K. (Acta Histochem. 2012) 3
  3. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3
  4. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. (PMID: 16095493) Louvet C. … Cuturi M.-C. (Am. J. Transplant. 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM176B Gene

Sources for TMEM176B Gene

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