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TMEM176B Gene

protein-coding   GIFtS: 45
GCID: GC07M150488

Transmembrane Protein 176B

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 176B1 2
LR82 3 5
LR8-Like Protein2
Protein LR83

External Ids:    HGNC: 295961   Entrez Gene: 289592   Ensembl: ENSG000001065657   OMIM: 6103855   UniProtKB: Q3YBM23   

Export aliases for TMEM176B gene to outside databases

Previous GC identifers: GC07M150119 GC07M144300


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM176B Gene:
TMEM176B (transmembrane protein 176B) is a protein-coding gene. Diseases associated with TMEM176B include labyrinthitis, and proteinuria. An important paralog of this gene is TMEM176A.

UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2
Function: May play a role in the process of maturation of dendritic cells. Required for the development of
cerebellar granule cells (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NT_007933.16  NC_018918.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM176B gene promoter:
         E2F-1   E2F   Nkx2-5   E2F-2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): TMEM176B promoter sequence
   Search Chromatin IP Primers for TMEM176B

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM176B


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

TMEM176B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM176B gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M150488:  view genomic region     (about GC identifiers)

Start:
150,488,373 bp from pter      End:
150,498,448 bp from pter
Size:
10,076 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 149,817,661-149,827,738     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2 (See protein sequence)
Recommended Name: Transmembrane protein 176B  
Size: 270 amino acids; 29056 Da
Sequence caution: Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu;
Secondary accessions: B2RDK2 D3DWZ7 E9PAV4 Q5BJI2 Q9BT42 Q9Y609
Alternative splicing: 2 isoforms:  Q3YBM2-1   Q3YBM2-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for TMEM176B: NX_Q3YBM2

Explore proteomics data for TMEM176B at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM176B Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (4 alternative transcripts): 
    NP_001094781.1  NP_001094782.1  NP_001094784.1  NP_054739.3  

    ENSEMBL proteins: 
     ENSP00000419258   ENSP00000318409   ENSP00000410269   ENSP00000397810   ENSP00000404831  
     ENSP00000413531  

    TMEM176B Human Recombinant Protein Products:

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    OriGene Protein Over-expression Lysate for TMEM176B
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    Novus Biologicals TMEM176B Protein
    Novus Biologicals TMEM176B Lysates
    Browse Sino Biological Recombinant Proteins
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    Cloud-Clone Corp. Proteins for TMEM176B

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    LSBio Antibodies in human, mouse, rat for TMEM176B

    TMEM176B Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Cloud-Clone Corp. ELISAs for TMEM176B
    Cloud-Clone Corp. CLIAs for TMEM176B


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007237 CD20-like
     IPR009281 LR8

    Graphical View of Domain Structure for InterPro Entry Q3YBM2

    ProtoNet protein and cluster: Q3YBM2

    UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2
    Similarity: Belongs to the TMEM176 family


    TMEM176B for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: T176B_HUMAN, Q3YBM2
    Function: May play a role in the process of maturation of dendritic cells. Required for the development of
    cerebellar granule cells (By similarity)
    Induction: Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TMEM176B for ontologies           About GeneDecksing


    Phenotypes:
         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Tmem176b):
     behavior/neurological  nervous system 

    TMEM176B for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Tmem176btm1Tto for TMEM176B

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM176B
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM176B

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM176B
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM176B

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat TMEM176B using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMEM176B:
    hsa-miR-3175 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM176B 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM176B
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM176B

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for TMEM176B

    Clone
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    OriGene clones in human, mouse for TMEM176B (see all 26)
    OriGene ORF clones in mouse, rat for TMEM176B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): TMEM176B (NM_001101311)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM176B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176B

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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM176B 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM176B


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T176B_HUMAN, Q3YBM2: Nucleus membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    plasma membrane3

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0031965nuclear membrane IEA--

    TMEM176B for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM176B
    Interactions:

        Search GeneGlobe Interaction Network for TMEM176B

    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0009887organ morphogenesis TAS9922225
    GO:0030154cell differentiation IEA--
    GO:2001199negative regulation of dendritic cell differentiation IEA--

    TMEM176B for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM176B (T176B)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM176B gene (5 alternative transcripts): 
    NM_001101313.1  NM_001101311.1  NM_001101312.1  NM_001101314.1  NM_014020.3  

    Unigene Cluster for TMEM176B:

    Transmembrane protein 176B
    Hs.647090  [show with all ESTs]
    Unigene Representative Sequence: AK097304
    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000492607 ENST00000326442 ENST00000447204(uc003whw.4) ENST00000429904(uc022apx.1)
    ENST00000450753 ENST00000434545(uc003whu.4 uc003whv.4)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat TMEM176B using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMEM176B:
    hsa-miR-3175 hsa-miR-34a*
    SwitchGear 3'UTR luciferase reporter plasmidTMEM176B 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for TMEM176B
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM176B
    Clone
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    OriGene clones in human, mouse for TMEM176B (see all 26)
    OriGene ORF clones in mouse, rat for TMEM176B
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 4): TMEM176B (NM_001101311)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM176B
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176B
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for TMEM176B
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM176B
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM176B
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM176B
      QuantiFast Probe-based Assays in human, mouse, rat TMEM176B

    Additional mRNA sequence: 

    AF115384.1 AK000841.1 AK097304.1 AK129525.1 AK315575.1 BC004358.1 BC014586.2 BC091471.1 
    DQ144974.1 

    22 DOTS entries:

    DT.95351238  DT.97859251  DT.95093223  DT.312814  DT.121114748  DT.97763866  DT.100819339  DT.100819342 
    DT.121114854  DT.40298267  DT.95351228  DT.121114819  DT.121114853  DT.92013727  DT.92433346  DT.95188822 
    DT.95195686  DT.95232132  DT.95319839  DT.100819341  DT.121114798  DT.95351226 

    Selected AceView cDNA sequences (see all 232):

    BU729342 BX106738 CR608087 BI759037 BG413472 BI760287 AV656418 AI636809 
    BI906550 BX389863 AI625318 BU731446 CR610447 BM703410 BI910564 BQ352588 
    AA372940 BI771186 BI518632 CB991669 AW079674 AI935867 CA843792 CB990768 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176B (see all 8)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
    SP1:        -     -     -     -     -     -                                                         
    SP2:                    -     -     -     -                                                         
    SP3:                    -     -     -     -                 -                                       
    SP4:                                                                                                
    SP5:                    -     -     -     -                                                         


    ECgene alternative splicing isoforms for TMEM176B

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM176B expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: AACAGATATT
    TMEM176B Expression
    About this image


    TMEM176B expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 15) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Thalamus
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             GABAergic Amacrine Cells Inner Nuclear Layer
             Lens
     
     Neural Tube (Nervous System)    fully expand to see all 2 entries
             Metencephalon
     
     Blood (Hematopoietic System)    fully expand to see all 2 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
    TMEM176B Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM176B Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647090

    UniProtKB/Swiss-Prot: T176B_HUMAN, Q3YBM2
    Tissue specificity: Expressed in lung and dermal fibroblasts

        Custom PCR Arrays for TMEM176B
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM176B
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM176B

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TMEM176B gene from Selected species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem176b1 , 5 transmembrane protein 176B1, 5 69.44(n)1
    56.35(a)1
      6 (23.75 cM)5
    659631  NM_001164208.11  NP_001157680.11 
     488338115 


    ENSEMBL Gene Tree for TMEM176B (if available)
    TreeFam Gene Tree for TMEM176B (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM176B gene
    TMEM176A2  
    1 SIMAP similar gene for TMEM176B using alignment to 1 protein entry:     T176B_HUMAN:
    TMEM176A

    TMEM176B for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM176B (see all 277)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs37574101,2
    C,F,H--150487961(-) GTCTTC/TCTTCC 4 -- ds500124Minor allele frequency- T:0.19EA NS NA WA CSA 4182
    rs1489231731,2
    --150488026(+) ATTACC/TGCAAA 4 -- ds50010--------
    rs37574091,2
    C,F,A--150488082(-) TGGAAT/CGAGAT 4 -- ds50018Minor allele frequency- C:0.10EA WA NA CSA 1861
    rs1854214871,2
    --150488336(+) CCTTTC/TATGGC 4 -- ds50010--------
    rs1120794761,2
    F--150488342(+) ATGGCA/G/TCACGA 4 -- ds50011CSA 2
    rs1901826391,2
    --150488346(+) CGCACA/GAGGTG 4 -- ds50010--------
    rs1811350111,2
    --150488369(+) GAAACA/CATATC 4 -- ds50010--------
    rs1140414881,2
    C,F--150488465(+) AGAACC/GCCAGA 4 -- ut311Minor allele frequency- G:0.02WA 118
    rs23024811,2
    C,F,A,H--150488468(-) CACTCT/CGGGGT 4 -- ut31 ese326Minor allele frequency- C:0.11EA MN NS NA WA CSA 4454
    rs23024801,2
    C,F,A--150488495(-) TCTCCC/TCACAT 4 -- ut31 ese3 trp39Minor allele frequency- T:0.09EA NA WA CSA 1868

    HapMap Linkage Disequilibrium report for TMEM176B (150488373 - 150498448 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM176B:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831187CNV Loss17160897
    nsv519444CNV Loss19592680

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM176B
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM176B

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610385    OMIM disorders: --

    2 diseases for TMEM176B:    
    About MalaCards
    labyrinthitis    proteinuria


    TMEM176B for disorders           About GeneDecksing


    Export disorders for TMEM176B gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM176B gene integrated from 10 sources:
    (articles sorted by number of sources associating them with TMEM176B)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. (PubMed id 9922225)1, 2, 3 Lurton J.... Narayanan A.S. (Am. J. Respir. Cell Mol. Biol. 1999)
    2. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. (PubMed id 16095493)1, 2 Louvet C....Cuturi M.-C. (Am. J. Transplant. 2005)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology. (PubMed id 22244448)1 Cuajungco M.P....Taylor K. (Acta Histochem. 2012)
    6. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)
    7. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PubMed id 15342556)1 Suzuki Y.... Sugano S. (Genome Res. 2004)
    8. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    9. Gene expression profile of renal proximal tubules regulated by proteinuria. (PubMed id 11967007)1 Nakajima H....Okubo K. (Kidney Int. 2002)
    10. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)

    (in PubMed, OMIM, and NCBI Bookshelf)
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 28959 HGNC: 29596 AceView: LR8 Ensembl:ENSG00000106565 euGenes: HUgn28959
    ECgene: TMEM176B H-InvDB: TMEM176B

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for TMEM176B Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM176B gene:
    Search GeneIP for patents involving TMEM176B

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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