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Aliases for TMEM176B Gene

Aliases for TMEM176B Gene

  • Transmembrane Protein 176B 2 3
  • LR8 3 4 6
  • LR8-Like Protein 3
  • Protein LR8 4

External Ids for TMEM176B Gene

Previous GeneCards Identifiers for TMEM176B Gene

  • GC07M150119
  • GC07M150488
  • GC07M144300

Summaries for TMEM176B Gene

GeneCards Summary for TMEM176B Gene

TMEM176B (Transmembrane Protein 176B) is a Protein Coding gene. An important paralog of this gene is TMEM176A.

UniProtKB/Swiss-Prot for TMEM176B Gene

  • May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM176B Gene

Genomics for TMEM176B Gene

Regulatory Elements for TMEM176B Gene

Transcription factor binding sites by QIAGEN in the TMEM176B gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM176B Gene

150,791,285 bp from pter
150,801,360 bp from pter
10,076 bases
Minus strand

Genomic View for TMEM176B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM176B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176B Gene

Proteins for TMEM176B Gene

  • Protein details for TMEM176B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 176B
    Protein Accession:
    Secondary Accessions:
    • B2RDK2
    • D3DWZ7
    • E9PAV4
    • Q5BJI2
    • Q9BT42
    • Q9Y609

    Protein attributes for TMEM176B Gene

    270 amino acids
    Molecular mass:
    29056 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAH91471.1; Type=Erroneous termination; Positions=30; Note=Translated as Glu.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM176B Gene


neXtProt entry for TMEM176B Gene

Proteomics data for TMEM176B Gene at MOPED

Post-translational modifications for TMEM176B Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM176B Gene

Domains for TMEM176B Gene

Protein Domains for TMEM176B Gene


Suggested Antigen Peptide Sequences for TMEM176B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q3YBM2
  • Belongs to the TMEM176 family.
genes like me logo Genes that share domains with TMEM176B: view

No data available for Gene Families for TMEM176B Gene

Function for TMEM176B Gene

Molecular function for TMEM176B Gene

UniProtKB/Swiss-Prot Function: May play a role in the process of maturation of dendritic cells. Required for the development of cerebellar granule cells (By similarity).
UniProtKB/Swiss-Prot Induction: Up-regulated in fibrotic lung. Down-regulated in activated dendritic cells.

Gene Ontology (GO) - Molecular Function for TMEM176B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM176B: view

Phenotypes for TMEM176B Gene

genes like me logo Genes that share phenotypes with TMEM176B: view

Animal Models for TMEM176B Gene

MGI Knock Outs for TMEM176B:

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM176B Gene

Localization for TMEM176B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176B Gene

Nucleus membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM176B Gene COMPARTMENTS Subcellular localization image for TMEM176B gene
Compartment Confidence
nucleus 5
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM176B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0016021 integral component of membrane IEA --
GO:0031965 nuclear membrane IEA --
genes like me logo Genes that share ontologies with TMEM176B: view

Pathways for TMEM176B Gene

SuperPathways for TMEM176B Gene

No Data Available

Interacting Proteins for TMEM176B Gene

Gene Ontology (GO) - Biological Process for TMEM176B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009887 organ morphogenesis TAS 9922225
GO:0030154 cell differentiation IEA --
GO:2001199 negative regulation of dendritic cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM176B: view

No data available for Pathways by source for TMEM176B Gene

Transcripts for TMEM176B Gene

Unigene Clusters for TMEM176B Gene

Transmembrane protein 176B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM176B

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176B Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5a · 5b · 5c ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10a · 10b
SP1: - - - - - -
SP2: - - - -
SP3: - - - - -
SP5: - - - -
SP6: - - -
SP7: - -
SP8: - - -

Relevant External Links for TMEM176B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM176B Gene

mRNA expression in normal human tissues for TMEM176B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM176B Gene

This gene is overexpressed in Liver (17.3).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for TMEM176B Gene

SOURCE GeneReport for Unigene cluster for TMEM176B Gene Hs.647090

mRNA Expression by UniProt/SwissProt for TMEM176B Gene

Tissue specificity: Expressed in lung and dermal fibroblasts.
genes like me logo Genes that share expressions with TMEM176B: view

In Situ Assay Products

Orthologs for TMEM176B Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM176B 35
  • 99.51 (n)
  • 98.52 (a)
TMEM176B 36
  • 99 (a)
(Bos Taurus)
Mammalia TMEM176B 35
  • 77.78 (n)
  • 66.29 (a)
TMEM176B 36
  • 65 (a)
(Canis familiaris)
Mammalia TMEM176B 35
  • 77.65 (n)
  • 67.42 (a)
TMEM176B 36
  • 62 (a)
(Mus musculus)
Mammalia Tmem176b 35
  • 69.44 (n)
  • 56.35 (a)
Tmem176b 16
Tmem176b 36
  • 52 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 44 (a)
(Rattus norvegicus)
Mammalia Tmem176b 35
  • 68.36 (n)
  • 54.3 (a)
Species with no ortholog for TMEM176B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM176B Gene

Gene Tree for TMEM176B (if available)
Gene Tree for TMEM176B (if available)

Paralogs for TMEM176B Gene

Paralogs for TMEM176B Gene

Selected SIMAP similar genes for TMEM176B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM176B: view

Variants for TMEM176B Gene

Sequence variations from dbSNP and Humsavar for TMEM176B Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2072442 -- 150,793,343(-) GGAGC(A/C/G)TGTGT intron-variant
rs2072443 - 150,793,288(-) CCCTG(A/G)CAGGC missense, reference
rs2075080 -- 150,796,354(-) CTGGG(C/G)TGGTG intron-variant
rs2075081 -- 150,792,712(-) GCCAT(C/T)CTCAC intron-variant
rs2302479 -- 150,791,528(-) TGAGC(C/T)GCCAA utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM176B Gene

Variant ID Type Subtype PubMed ID
nsv831187 CNV Loss 17160897
nsv519444 CNV Loss 19592680

Relevant External Links for TMEM176B Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176B Gene

Disorders for TMEM176B Gene

No disorders were found for TMEM176B Gene.

No data available for UniProtKB/Swiss-Prot for TMEM176B Gene

Publications for TMEM176B Gene

  1. Isolation of a gene product expressed by a subpopulation of human lung fibroblasts by differential display. (PMID: 9922225) Lurton J. … Narayanan A.S. (Am. J. Respir. Cell Mol. Biol. 1999) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Identification of a new member of the CD20/FcepsilonRIbeta family overexpressed in tolerated allografts. (PMID: 16095493) Louvet C. … Cuturi M.-C. (Am. J. Transplant. 2005) 3 4
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM176B Gene

Sources for TMEM176B Gene

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