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TMEM176A Gene

protein-coding   GIFtS: 46
GCID: GC07P150497

Transmembrane Protein 176A

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 176A1 2
HCA1122 3 5
Hepatocellular Carcinoma-Associated Antigen 1122 3
GS1882 5
Likley Ortholog Of Mouse GS1882
TEM176A5

External Ids:    HGNC: 249301   Entrez Gene: 553652   Ensembl: ENSG000000029337   OMIM: 6103345   UniProtKB: Q96HP83   
ORGUL members:         

Export aliases for TMEM176A gene to outside databases

Previous GC identifers: GC07P150128 GC07P144309


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM176A Gene:
TMEM176A (transmembrane protein 176A) is a protein-coding gene. Diseases associated with TMEM176A include hepatocellular carcinoma, and proteinuria. An important paralog of this gene is TMEM176B.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000007.14  NC_018918.2  NT_007933.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM176A gene promoter:
         E2F-3a   E2F-4   E2F-5   AML1a   E2F-2   Nkx2-5   HNF-4alpha1   Gfi-1   E2F-1   E2F   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM176A promoter sequence
   Search Chromatin IP Primers for TMEM176A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM176A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1   Ensembl cytogenetic band:  7q36.1   HGNC cytogenetic band: 7q36.1

TMEM176A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM176A gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07P150497:  view genomic region     (about GC identifiers)

Start:
150,497,491 bp from pter      End:
150,502,208 bp from pter
Size:
4,718 bases      Orientation:
plus strand

1 alternative location:
Chr7+,CRA_TCAG 149,827,144-149,831,498     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: T176A_HUMAN, Q96HP8 (See protein sequence)
Recommended Name: Transmembrane protein 176A  
Size: 235 amino acids; 26116 Da
Secondary accessions: D3DX00 Q9NYC7

Explore the universe of human proteins at neXtProt for TMEM176A: NX_Q96HP8

Explore proteomics data for TMEM176A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See TMEM176A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_060957.2  
    ENSEMBL proteins: 
     ENSP00000417626   ENSP00000004103   ENSP00000420818   ENSP00000417834   ENSP00000420081  

    TMEM176A Human Recombinant Protein Products:

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    LSBio Antibodies in human, mouse, rat for TMEM176A

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    Cloud-Clone Corp. ELISAs for TMEM176A
    Cloud-Clone Corp. CLIAs for TMEM176A


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR007237 CD20-like
     IPR009281 LR8

    Graphical View of Domain Structure for InterPro Entry Q96HP8

    ProtoNet protein and cluster: Q96HP8

    UniProtKB/Swiss-Prot: T176A_HUMAN, Q96HP8
    Similarity: Belongs to the TMEM176 family


    TMEM176A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
         
    TMEM176A for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM176A
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM176A
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM176A

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM176A

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    GenScript: all cDNA clones in your preferred vector: TMEM176A (NM_018487)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM176A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176A

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    T176A_HUMAN, Q96HP8: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    extracellular2
    mitochondrion1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--

    TMEM176A for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM176A
    Interactions:

        Search GeneGlobe Interaction Network for TMEM176A

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for TMEM176A (ENSP000000041034) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HRSP12ENSP000002548784STRING: ENSP00000254878
    HIVEP1ENSP000003686984STRING: ENSP00000368698
    TGM2ENSP000003553304STRING: ENSP00000355330
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:2001199negative regulation of dendritic cell differentiation IEA--

    TMEM176A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM176A (T176A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for TMEM176A gene: 
    NM_018487.2  

    Unigene Cluster for TMEM176A:

    Transmembrane protein 176A
    Hs.647116  [show with all ESTs]
    Unigene Representative Sequence: AK123468
    11 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000484928 ENST00000004103(uc003whx.1) ENST00000494349 ENST00000475710
    ENST00000461345 ENST00000475536 ENST00000468689 ENST00000462826 ENST00000475007
    ENST00000481305 ENST00000474166
    miRNA
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    SwitchGear 3'UTR luciferase reporter plasmidTMEM176A 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM176A
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176A
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    OriGene qPCR primer pairs and template standards for TMEM176A
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM176A
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM176A
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM176A
      QuantiFast Probe-based Assays in human, mouse, rat TMEM176A

    Additional mRNA sequence: 

    AF258340.1 AK123468.1 BC008303.1 

    17 DOTS entries:

    DT.100815781  DT.445312  DT.100815790  DT.100815787  DT.100815785  DT.121114851  DT.121114775  DT.95351238 
    DT.100771224  DT.121114861  DT.97859135  DT.100815782  DT.121114739  DT.215499  DT.92410774  DT.95135485 
    DT.97806896 

    Selected AceView cDNA sequences (see all 193):

    BI759842 AI684645 BU069125 CR610583 CR597401 CB177823 CR609068 BU949662 
    BF337607 CR610177 AI023446 BI714836 NM_018487 CB528816 BM704606 BU727852 
    CB529215 CR618934 BM663891 BE796523 BM834831 BX358333 AI246763 BV200302 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176A (see all 9)    About this scheme

    ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d
    SP1:        -                 -     -           -                                   -     -                           
    SP2:        -                 -     -           -                 -     -           -     -                           
    SP3:                          -     -           -                                                                     
    SP4:                    -     -     -           -                                   -     -                           
    SP5:                                            -                                         -                           


    ECgene alternative splicing isoforms for TMEM176A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM176A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTATTGTTCC
    TMEM176A Expression
    About this image


    TMEM176A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 13) fully expand
     
     Blood (Cardiovascular System)    fully expand to see all 3 entries
             Hematopoietic Stem Cells Hematopoietic Bone Marrow
     
     Primitive Streak (Early Embryonic Tissues)    fully expand to see all 2 entries
             Notochord Cells Notochord
             Notochord
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Adult Oligodendrocyte Precursor Cells Lateral Ventricle
     
     Thymus (Hematopoietic System)
             Thymus
     
     Cartilage (Muscoskeletal System)
             Notochord Cells Notochord
    TMEM176A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM176A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.647116
        Custom PCR Arrays for TMEM176A
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM176A

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of human and mouse.

    Orthologs for TMEM176A gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem176a1 , 5 transmembrane protein 176A1, 5 66.67(n)1
    56.17(a)1
      6 (23.75 cM)5
    660581  NM_001098271.11  NP_001091741.11 
     488414835 


    ENSEMBL Gene Tree for TMEM176A (if available)
    TreeFam Gene Tree for TMEM176A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for TMEM176A gene
    TMEM176B2  
    1 SIMAP similar gene for TMEM176A using alignment to 4 protein entries:     T176A_HUMAN (see all proteins):
    TMEM176B

    TMEM176A for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM176A (see all 88)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs7410671,2
    C,F,A,H--150500455(+) CCTGTG/ACTAAG 1 -- int131Minor allele frequency- A:0.26NS MN EA NA WA CSA EU 3085
    rs7410661,2
    C,F--150500520(+) ATTTAC/G/TGAGAA 3 Y * stg1 syn1 ese311NA WA CSA EA EU 6281
    rs2005289701,2
    --150500523(+) TACGAA/GAAACG 2 E syn10--------
    rs1174012751,2
    C,F--150500527(+) AGAAAC/TGGGGT 2 R W mis13Minor allele frequency- T:0.01NA EU 5991
    rs359728581,2
    C,F--150500534(-) ATGTAC/TCACCC 2 D G mis16Minor allele frequency- T:0.04NA CSA WA EA EU 6183
    rs1860941171,2
    --150500560(+) GGAAGG/TGCATG 1 -- int10--------
    rs7410651,2
    C,F,A,H--150500576(+) GGACCA/GGGTTC 1 -- int110Minor allele frequency- G:0.40NA WA CSA EA 374
    rs774050771,2
    C,F--150500593(+) GAGGTC/TACCCC 1 -- int11Minor allele frequency- T:0.09EA 120
    rs1910871631,2
    C--150500595(+) GGTCAC/TCCCAA 1 -- int10--------
    rs2022296931,2
    C--150500699(+) TCCTCC/GCTCCC 1 -- int10--------

    HapMap Linkage Disequilibrium report for TMEM176A (150497491 - 150502208 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for TMEM176A:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv831187CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM176A
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM176A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 610334    OMIM disorders: --

    3 diseases for TMEM176A:    
    About MalaCards
    hepatocellular carcinoma    proteinuria    neuronitis


    TMEM176A for disorders           About GeneDecksing


    Export disorders for TMEM176A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM176A gene, integrated from 10 sources (see all 13):
    (articles sorted by number of sources associating them with TMEM176A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)1, 2, 3 Wang Y....Chen W.-F. (J. Immunol. 2002)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. The DNA sequence of human chromosome 7. (PubMed id 12853948)1, 2 Hillier L.W.... Wilson R.K. (Nature 2003)
    4. Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)1, 3 Bonaldo M.F.... Soares M.B. (Genome Res. 1996)
    5. Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture. (PubMed id 23563607)1 Berndt S.I....Ingelsson E. (Nat. Genet. 2013)
    6. Abnormal accumulation of human transmembrane (TMEM)-176A and 176B proteins is associated with cancer pathology. (PubMed id 22244448)1 Cuajungco M.P....Taylor K. (Acta Histochem. 2012)
    7. Toward an understanding of the protein interaction network of the human liver. (PubMed id 21988832)1 Wang J....Yang X. (Mol. Syst. Biol. 2011)
    8. Identification of VKORC1 interaction partners by split-ubiquitin system and coimmunoprecipitation. (PubMed id 21103663)1 Schaafhausen A....MA1ller C.R. (Thromb. Haemost. 2011)
    9. Hundreds of variants clustered in genomic loci and biological pathways affect human height. (PubMed id 20881960)1 Lango Allen H....Hirschhorn J.N. (Nature 2010)
    10. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (Nat. Genet. 2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 55365 HGNC: 24930 AceView: HCA112 Ensembl:ENSG00000002933 euGenes: HUgn55365
    ECgene: TMEM176A H-InvDB: TMEM176A

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM176A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM176A gene:
    Search GeneIP for patents involving TMEM176A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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