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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

TMEM176A Gene

protein-coding GIFtS: 43
GCID: GC07P150497

transmembrane protein 176A

Explore 3 diseases affiliated with
TMEM176A via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Transmembrane Protein 176A¹ ²
HCA112¹ ² ³
Hepatocellular Carcinoma-Associated Antigen 112² ³
GS188²
Likley Ortholog Of Mouse GS188²

External Ids:	HGNC: 24930¹	Entrez Gene: 55365²	Ensembl: ENSG00000002933⁷	OMIM: 610334⁵	UniProtKB: Q96HP8³

Export aliases for TMEM176A gene to outside databases

Previous GC identifers: GC07P150128 GC07P144309

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000007.13 NC_018918.1 NT_007914.15 NT_079596.2

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the TMEM176A gene promoter:
E2F-3a E2F-4 E2F-5 AML1a E2F-2 Nkx2-5 HNF-4alpha1 Gfi-1 E2F-1 E2F
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: TMEM176A promoter sequence

Search SABiosciences Chromatin IP Primers for TMEM176A

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM176A

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q36.1 Ensembl cytogenetic band: 7q36.1 HGNC cytogenetic band: 7q36.1

TMEM176A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM176A gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07P150497: view genomic region (about GC identifiers)

Start:	150,497,491 bp from pter	End:	150,502,208 bp from pter
Size:	4,718 bases	Orientation:	plus strand

1 alternative location:

Chr7+,CRA_TCAG 149,827,144-149,831,498

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: T176A_HUMAN, Q96HP8 (See protein sequence)

Recommended Name: Transmembrane protein 176A

Size: 235 amino acids; 26116 Da

Subcellular location: Membrane; Multi-pass membrane protein (Potential)

Secondary accessions: D3DX00 Q9NYC7

Explore the universe of human proteins at neXtProt for TMEM176A: NX_Q96HP8

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q96HP8

TMEM176A Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_060957.2

ENSEMBL proteins:

ENSP00000417626 ENSP00000004103 ENSP00000420818 ENSP00000417834 ENSP00000420081

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	Uscn Proteins for TMEM176A

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral to membrane	IEA	--

TMEM176A for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

TMEM176A for domains About GeneDecksing

2 InterPro domains/families:

IPR007237 CD20-like

IPR009281 LR8

Graphical View of Domain Structure for InterPro Entry Q96HP8

ProtoNet protein and cluster: Q96HP8

UniProtKB/Swiss-Prot: T176A_HUMAN, Q96HP8

Similarity: Belongs to the TMEM176 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for TMEM176A

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

3 Interacting proteins for TMEM176A (ENSP00000004103⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HRSP12	ENSP00000254878⁴	STRING: ENSP00000254878
HIVEP1	ENSP00000368698⁴	STRING: ENSP00000368698
TGM2	ENSP00000355330⁴	STRING: ENSP00000355330

About this table

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:2001199	negative regulation of dendritic cell differentiation	IEA	--

TMEM176A for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for TMEM176A
Search CenterWatch for drugs/clinical trials and news about TMEM176A / T176A

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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About This Section

REFSEQ mRNAs for TMEM176A gene:

NM_018487.2

Unigene Cluster for TMEM176A:

Transmembrane protein 176A

Hs.647116 [show with all ESTs]

Unigene Representative Sequence: AK123468

11 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000484928 ENST00000004103(uc003whx.1) ENST00000494349 ENST00000475710

ENST00000461345 ENST00000475536 ENST00000468689 ENST00000462826 ENST00000475007

ENST00000481305 ENST00000474166

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Additional cDNA sequence:

AF258340.1 AK123468.1 BC008303.1

17 DOTS entries:

DT.100815781 DT.445312 DT.100815790 DT.100815787 DT.100815785 DT.121114851 DT.121114775 DT.95351238

DT.100771224 DT.121114861 DT.97859135 DT.100815782 DT.121114739 DT.215499 DT.92410774 DT.95135485

DT.97806896

24/193 AceView cDNA sequences (see all 193):

BM834831 CR618934 CR610177 CB529215 BM704606 NM_018487 BI759842 BX358333

CB177823 CB528816 BM663891 BI714836 BU949662 BU727852 AI023446 AI684645

CR597401 CR610583 AI246763 BE796523 CR609068 BF337607 BU069125 BM833487

GeneLoc Exon Structure

5/9 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176A (see all 9) About this scheme

ExUns:	1	^	2	^	3a	·	3b	^	4	^	5a	·	5b	^	6a	·	6b	^	7a	·	7b	^	8a	·	8b	·	8c	^	9	^	10a	·	10b	·	10c	·	10d
SP1:			-						-		-				-												-		-
SP2:			-						-		-				-						-		-				-		-
SP3:									-		-				-
SP4:							-		-		-				-												-		-
SP5:															-														-

ECgene alternative splicing isoforms for TMEM176A

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM176A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTATTGTTCC

About this image

TMEM176A expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Human kidney epithelial cell spheroids (Kidney spheroids for...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See TMEM176A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM176A

SOURCE GeneReport for Unigene cluster: Hs.647116

SABiosciences Custom PCR Arrays for TMEM176A

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of human and mouse.

Orthologs for TMEM176A gene from 1/7 species (see all 7) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem176a^{1 , 5}	transmembrane protein 176A^{1, 5}	67.1(n)¹ 56.96(a)¹		6 (23.75 cM)⁵ 66058¹ NM_001098271.1¹ NP_001091741.1¹ 48841483⁵

ENSEMBL Gene Tree for TMEM176A (if available)
TreeFam Gene Tree for TMEM176A (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for TMEM176A gene

TMEM176B²

1 SIMAP similar gene for TMEM176A using alignment to 4 protein entries: T176A_HUMAN (see all proteins):

TMEM176B

TMEM176A for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs741067^1,2	C,F,A,H,	--	150500455(+)	`CCTGTG/ACTAAG`	1	--	int¹		31		NS MN EA NA WA CSA EU	3085
rs741066^1,2	C,F,	--	150500520(+)	`ATTTAC/G/TGAGAA`	3	Y *	stg¹ syn¹ ese³		11		NA WA CSA EA EU	6281
rs200528970^1,2		--	150500523(+)	`TACGAA/GAAACG`	2	E	syn¹		0	--	--	--	--
rs117401275^1,2	C,F,	--	150500527(+)	`AGAAAC/TGGGGT`	2	R W	mis¹		3		NA EU	5991
rs35972858^1,2	C,F,	--	150500534(-)	`ATGTAC/TCACCC`	2	D G	mis¹		6		NA CSA WA EA EU	6183
rs186094117^1,2		--	150500560(+)	`GGAAGG/TGCATG`	1	--	int¹		0	--	--	--	--
rs741065^1,2	C,F,A,H,	--	150500576(+)	`GGACCA/GGGTTC`	1	--	int¹		10		NA WA CSA EA	374
rs77405077^1,2	C,F,	--	150500593(+)	`GAGGTC/TACCCC`	1	--	int¹		1		EA	120
rs191087163^1,2		--	150500595(+)	`GGTCAC/TCCCAA`	1	--	int¹		0	--	--	--	--
rs202229693^1,2		--	150500699(+)	`TCCTCC/GCTCCC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM176A (150497491 - 150502208 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM176A: --

SABiosciences Cancer Mutation PCR Assays

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

TMEM176A for disorders           About GeneDecksing

OMIM gene information: 610334    OMIM disorders: --

3 diseases for TMEM176A:    About MalaCards

hepatocellular carcinoma carcinoma proteinuria

Export disorders for TMEM176A gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM176A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM176A)

Utopia: connect your pdf to the dynamic
world of online information

Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PubMed id 12097419)^{1, 2, 3} Wang Y....Chen W.-F. (2002)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence of human chromosome 7. (PubMed id 12853948)^{1, 2} Hillier L.W.... Wilson R.K. (2003)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)^{1, 3} Bonaldo M.F.... Soares M.B. (1996)
Abnormal accumulation of human transmembrane (TMEM)-17 6A and 176B proteins is associated with cancer pathology. (PubMed id 22244448)¹ Cuajungco M.P....Taylor K. (2012)
Hundreds of variants clustered in genomic loci and bi ological pathways affect human height. (PubMed id 20881960)¹ Lango Allen H....Hirschhorn J.N. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)¹ Ota T.... Sugano S. (2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)¹ Scherer S.W.... Tsui L.-C. (2003)
Gene expression profile of renal proximal tubules regulated by proteinuria. (PubMed id 11967007)¹ Nakajima H....Okubo K. (2002)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 55365	HGNC: 24930	AceView: HCA112	Ensembl:ENSG00000002933	euGenes: HUgn55365
ECgene: TMEM176A	H-InvDB: TMEM176A

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM176A	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM176A gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM176A gene:
Search GeneIP for patents involving TMEM176A

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM176A

GeneCards Homepage - Last full update: 18 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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TMEM176A Gene

transmembrane protein 176A

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TMEM176A Gene

transmembrane protein 176A

Aliasesfor TMEM176A gene

Summariesfor TMEM176A gene

Genomic Viewsfor TMEM176A gene

Proteinsfor TMEM176A gene

Protein Domains /Familiesfor TMEM176A gene

Functionfor TMEM176A gene

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External Searches for TMEM176A gene

Genome Databases showing TMEM176A gene

Other Databases showing TMEM176A gene

Specialized Databases showing TMEM176A gene

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for TMEM176A gene

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for TMEM176A gene

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for TMEM176A gene

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for TMEM176A gene

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for TMEM176A gene

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for TMEM176A gene

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Expression
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for TMEM176A gene

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