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Aliases for TMEM176A Gene

Aliases for TMEM176A Gene

  • Transmembrane Protein 176A 2 3
  • HCA112 3 4 6
  • Hepatocellular Carcinoma-Associated Antigen 112 3 4
  • GS188 3 6
  • Likley Ortholog Of Mouse GS188 3
  • TEM176A 6

External Ids for TMEM176A Gene

Summaries for TMEM176A Gene

GeneCards Summary for TMEM176A Gene

TMEM176A (Transmembrane Protein 176A) is a Protein Coding gene. Diseases associated with TMEM176A include hepatocellular carcinoma. An important paralog of this gene is TMEM176B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM176A Gene

Genomics for TMEM176A Gene

Genomic Location for TMEM176A Gene

150,800,403 bp from pter
150,805,120 bp from pter
4,718 bases
Plus strand

Genomic View for TMEM176A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM176A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176A Gene

Regulatory Elements for TMEM176A Gene

Proteins for TMEM176A Gene

  • Protein details for TMEM176A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 176A
    Protein Accession:
    Secondary Accessions:
    • D3DX00
    • Q9NYC7

    Protein attributes for TMEM176A Gene

    235 amino acids
    Molecular mass:
    26116 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM176A Gene

Proteomics data for TMEM176A Gene at MOPED

Post-translational modifications for TMEM176A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM176A Gene

No data available for DME Specific Peptides for TMEM176A Gene

Domains for TMEM176A Gene

Protein Domains for TMEM176A Gene


Suggested Antigen Peptide Sequences for TMEM176A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM176 family.:
    • Q96HP8
genes like me logo Genes that share domains with TMEM176A: view

No data available for Gene Families for TMEM176A Gene

Function for TMEM176A Gene

Gene Ontology (GO) - Molecular Function for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM176A: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM176A Gene

Localization for TMEM176A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM176A Gene COMPARTMENTS Subcellular localization image for TMEM176A gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM176A: view

Pathways for TMEM176A Gene

SuperPathways for TMEM176A Gene

No Data Available

Interacting Proteins for TMEM176A Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000004103 for TMEM176A Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001199 negative regulation of dendritic cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM176A: view

No data available for Pathways by source for TMEM176A Gene

Transcripts for TMEM176A Gene

Unigene Clusters for TMEM176A Gene

Transmembrane protein 176A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - -

Relevant External Links for TMEM176A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM176A Gene

mRNA expression in normal human tissues for TMEM176A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM176A Gene

This gene is overexpressed in Liver (18.6) and Kidney - Cortex (4.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM176A Gene

SOURCE GeneReport for Unigene cluster for TMEM176A Gene Hs.647116

genes like me logo Genes that share expressions with TMEM176A: view

No data available for mRNA Expression by UniProt/SwissProt for TMEM176A Gene

Orthologs for TMEM176A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM176A 35
  • 98.58 (n)
  • 97.87 (a)
TMEM176A 36
  • 98 (a)
(Bos Taurus)
Mammalia TMEM176A 36
  • 55 (a)
(Canis familiaris)
Mammalia TMEM176A 35
  • 74.36 (n)
  • 61.11 (a)
TMEM176A 36
  • 57 (a)
(Mus musculus)
Mammalia Tmem176a 35
  • 66.67 (n)
  • 56.17 (a)
Tmem176a 16
Tmem176a 36
  • 52 (a)
(Monodelphis domestica)
Mammalia TMEM176A 36
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 27 (a)
(Rattus norvegicus)
Mammalia Tmem176a 35
  • 68.28 (n)
  • 58.15 (a)
Species with no ortholog for TMEM176A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM176A Gene

Gene Tree for TMEM176A (if available)
Gene Tree for TMEM176A (if available)

Paralogs for TMEM176A Gene

Paralogs for TMEM176A Gene

Selected SIMAP similar genes for TMEM176A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM176A: view

Variants for TMEM176A Gene

Sequence variations from dbSNP and Humsavar for TMEM176A Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs9088 - 150,804,428(+) CTCTG(A/G)CCCCT reference, missense
rs10378 - 150,804,367(-) CTGAA(A/C)AAGGC reference, missense
rs741061 -- 150,804,157(-) TGACA(A/G)GTTTG intron-variant
rs741062 -- 150,803,950(-) AATAC(C/G)CAAGC intron-variant
rs741063 -- 150,803,906(-) GAGAA(A/C)CTGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM176A Gene

Variant ID Type Subtype PubMed ID
nsv831187 CNV Loss 17160897

Relevant External Links for TMEM176A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176A Gene

Disorders for TMEM176A Gene

(1) MalaCards Diseases for TMEM176A Gene

Search for TMEM176A Gene in MalaCards »
genes like me logo Genes that share disorders with TMEM176A: view

No data available for UniProtKB/Swiss-Prot for TMEM176A Gene

Publications for TMEM176A Gene

  1. Large scale identification of human hepatocellular carcinoma- associated antigens by autoantibodies. (PMID: 12097419) Wang Y. … Chen W.-F. (J. Immunol. 2002) 2 3 4
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 2 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier L.W. … Wilson R.K. (Nature 2003) 3 4
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM176A Gene

Sources for TMEM176A Gene

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