Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM176A Gene

Aliases for TMEM176A Gene

  • Transmembrane Protein 176A 2 3 5
  • Hepatocellular Carcinoma-Associated Antigen 112 3 4
  • HCA112 3 4
  • Likley Ortholog Of Mouse GS188 3
  • GS188 3
  • MS4B1 3

External Ids for TMEM176A Gene

Previous GeneCards Identifiers for TMEM176A Gene

  • GC07P150128
  • GC07P150497
  • GC07P144309

Summaries for TMEM176A Gene

GeneCards Summary for TMEM176A Gene

TMEM176A (Transmembrane Protein 176A) is a Protein Coding gene. An important paralog of this gene is TMEM176B.

Additional gene information for TMEM176A Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM176A Gene

Genomics for TMEM176A Gene

GeneHancer (GH) Regulatory Elements for TMEM176A Gene

Promoters and enhancers for TMEM176A Gene
GeneHancer (GH) Identifier GH Type GH
GH Sources Gene Association Score Total Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor
Binding Sites
Gene Targets
GH07I150798 Promoter/Enhancer 1.8 EPDnew Ensembl ENCODE dbSUPER 568.9 +0.0 27 3.7 RXRA RNF2 SUZ12 REST YY1 SMARCA4 ZNF512 RBM39 EZH2 TMEM176A TMEM176B ENSG00000244151 NUB1 AOC1
GH07I150783 Enhancer 1.6 FANTOM5 Ensembl ENCODE dbSUPER 34.8 -13.2 -13162 7 PKNOX1 ATF1 SMAD1 ARNT YY1 TCF12 GATA2 E2F8 ATF7 RXRA TMEM176A TMEM176B AOC1 ENSG00000244151 NUB1 GIMAP1 ZNF862 GIMAP2 AGAP3 GIMAP8
GH07I150778 Enhancer 1 Ensembl ENCODE 19.6 -21.1 -21102 1.4 ATF1 RB1 ARNT IRF4 RAD21 RFX5 ZNF366 ZNF143 RCOR1 IKZF2 TMEM176B TMEM176A LOC105375566 BET1P1
GH07I150780 Enhancer 1 Ensembl ENCODE dbSUPER 17.9 -19.1 -19090 2.2 ZNF687 RXRA CEBPB CEBPG EBF1 YY1 CEBPA HNF4A LOC105375566 TMEM176B TMEM176A AOC1 BET1P1
GH07I150375 Promoter/Enhancer 2.5 EPDnew Ensembl ENCODE dbSUPER 5 -419.3 -419335 11.7 HDGF PKNOX1 FOXA2 SMAD1 ARID4B SIN3A DMAP1 IRF4 YY1 POLR2B ENSG00000284048 ZNF775 NUB1 REPIN1 ZNF777 ZNF767P ZNF862 ENSG00000244151 ZBED6CL TMEM176A
- Elite GeneHancer and/or Elite GeneHancer-gene association Download GeneHancer data dump

GeneHancers around TMEM176A on UCSC Golden Path with GeneCards custom track

Top Transcription factor binding sites by QIAGEN in the TMEM176A gene promoter:

Genomic Locations for TMEM176A Gene

Genomic Locations for TMEM176A Gene
4,718 bases
Plus strand

Genomic View for TMEM176A Gene

Genes around TMEM176A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM176A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM176A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM176A Gene

Proteins for TMEM176A Gene

  • Protein details for TMEM176A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 176A
    Protein Accession:
    Secondary Accessions:
    • D3DX00
    • Q9NYC7

    Protein attributes for TMEM176A Gene

    235 amino acids
    Molecular mass:
    26116 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM176A Gene

Post-translational modifications for TMEM176A Gene

No Post-translational modifications

No data available for DME Specific Peptides for TMEM176A Gene

Domains & Families for TMEM176A Gene

Gene Families for TMEM176A Gene

Protein Domains for TMEM176A Gene

Suggested Antigen Peptide Sequences for TMEM176A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM176 family.
  • Belongs to the TMEM176 family.
genes like me logo Genes that share domains with TMEM176A: view

Function for TMEM176A Gene

Phenotypes From GWAS Catalog for TMEM176A Gene

genes like me logo Genes that share phenotypes with TMEM176A: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM176A Gene

Localization for TMEM176A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM176A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM176A gene
Compartment Confidence
plasma membrane 3
extracellular 2
mitochondrion 2
peroxisome 1

Subcellular locations from the

Human Protein Atlas (HPA)

Gene Ontology (GO) - Cellular Components for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM176A: view

Pathways & Interactions for TMEM176A Gene

SuperPathways for TMEM176A Gene

No Data Available

Interacting Proteins for TMEM176A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000004103 Q96HP8-T176A_HUMAN for TMEM176A Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM176A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:2001199 negative regulation of dendritic cell differentiation IEA --
genes like me logo Genes that share ontologies with TMEM176A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM176A Gene

Drugs & Compounds for TMEM176A Gene

No Compound Related Data Available

Transcripts for TMEM176A Gene

Unigene Clusters for TMEM176A Gene

Transmembrane protein 176A:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM176A Gene

ExUns: 1 ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b ^ 8a · 8b · 8c ^ 9 ^ 10a · 10b · 10c · 10d
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - -
SP4: - - - - - -
SP5: - -
SP6: -
SP7: -
SP8: - -
SP9: - - - -

Relevant External Links for TMEM176A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM176A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM176A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM176A Gene

This gene is overexpressed in Liver (x18.6) and Kidney - Cortex (x4.8).

Protein differential expression in normal tissues from HIPED for TMEM176A Gene

This gene is overexpressed in Urine (40.4), Ovary (10.4), and Liver (6.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM176A Gene

Protein tissue co-expression partners for TMEM176A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM176A Gene:


SOURCE GeneReport for Unigene cluster for TMEM176A Gene:


Evidence on tissue expression from TISSUES for TMEM176A Gene

  • Lung(4.3)
  • Liver(2.7)
  • Kidney(2.5)
  • Gall bladder(2)
genes like me logo Genes that share expression patterns with TMEM176A: view

No data available for mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM176A Gene

Orthologs for TMEM176A Gene

This gene was present in the common ancestor of mammals.

Orthologs for TMEM176A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM176A 33 34
  • 98.58 (n)
(Canis familiaris)
Mammalia TMEM176A 33 34
  • 74.36 (n)
(Rattus norvegicus)
Mammalia Tmem176a 33
  • 68.28 (n)
(Mus musculus)
Mammalia Tmem176a 33 16 34
  • 66.67 (n)
(Bos Taurus)
Mammalia TMEM176A 34
  • 55 (a)
(Monodelphis domestica)
Mammalia TMEM176A 34
  • 32 (a)
(Ornithorhynchus anatinus)
Mammalia -- 34
  • 27 (a)
Species where no ortholog for TMEM176A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM176A Gene

Gene Tree for TMEM176A (if available)
Gene Tree for TMEM176A (if available)

Paralogs for TMEM176A Gene

Paralogs for TMEM176A Gene

(1) SIMAP similar genes for TMEM176A Gene using alignment to 4 proteins:

genes like me logo Genes that share paralogs with TMEM176A: view

Variants for TMEM176A Gene

Sequence variations from dbSNP and Humsavar for TMEM176A Gene

SNP ID Clin Chr 07 pos Variation AA Info Type
rs1000385570 -- 150,801,115(+) G/A intron_variant
rs1000693691 -- 150,800,282(+) G/A upstream_transcript_variant
rs1000853523 -- 150,801,986(+) A/T intron_variant
rs1001873796 -- 150,802,273(+) G/A coding_sequence_variant, missense_variant
rs1002186835 -- 150,804,648(+) A/G intron_variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM176A Gene

Variant ID Type Subtype PubMed ID
dgv3695n106 OTHER inversion 24896259
nsv1030109 CNV gain 25217958
nsv1067934 OTHER inversion 25765185
nsv1151906 OTHER inversion 26484159
nsv608990 CNV gain 21841781
nsv831187 CNV loss 17160897

Variation tolerance for TMEM176A Gene

Residual Variation Intolerance Score: 80.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.06; 60.69% of all genes are more intolerant (likely to be disease-causing)

Additional Variant Information for TMEM176A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM176A Gene

Disorders for TMEM176A Gene

Additional Disease Information for TMEM176A

No disorders were found for TMEM176A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM176A Gene

Publications for TMEM176A Gene

  1. Large scale identification of human hepatocellular carcinoma-associated antigens by autoantibodies. (PMID: 12097419) Wang Y … Chen WF (Journal of immunology (Baltimore, Md. : 1950) 2002) 2 3 4 58
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 58
  3. The DNA sequence of human chromosome 7. (PMID: 12853948) Hillier LW … Wilson RK (Nature 2003) 3 4 58
  4. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo MF … Soares MB (Genome research 1996) 2 3 58
  5. Methylation of TMEM176A is an independent prognostic marker and is involved in human colorectal cancer development. (PMID: 28678648) Gao D … Guo M (Epigenetics 2017) 3 58

Products for TMEM176A Gene

Sources for TMEM176A Gene

Loading form....