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Aliases for TMEM175 Gene

Aliases for TMEM175 Gene

  • Transmembrane Protein 175 2 3

External Ids for TMEM175 Gene

Summaries for TMEM175 Gene

GeneCards Summary for TMEM175 Gene

TMEM175 (Transmembrane Protein 175) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM175 Gene

Genomics for TMEM175 Gene

Genomic Location for TMEM175 Gene

Start:
932,387 bp from pter
End:
958,656 bp from pter
Size:
26,270 bases
Orientation:
Plus strand

Genomic View for TMEM175 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM175 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM175 Gene

Regulatory Elements for TMEM175 Gene

Proteins for TMEM175 Gene

  • Protein details for TMEM175 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9BSA9-TM175_HUMAN
    Recommended name:
    Transmembrane protein 175
    Protein Accession:
    Q9BSA9
    Secondary Accessions:
    • D3DVN4
    • Q8ND13

    Protein attributes for TMEM175 Gene

    Size:
    504 amino acids
    Molecular mass:
    55615 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM175 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM175 Gene

Proteomics data for TMEM175 Gene at MOPED

Post-translational modifications for TMEM175 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM175 Gene

Domains for TMEM175 Gene

Protein Domains for TMEM175 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TM175_HUMAN
Family:
  • Belongs to the TMEM175 family.:
    • Q9BSA9
genes like me logo Genes that share domains with TMEM175: view

No data available for Gene Families for TMEM175 Gene

Function for TMEM175 Gene

Phenotypes for TMEM175 Gene

GenomeRNAi human phenotypes for TMEM175:
genes like me logo Genes that share phenotypes with TMEM175: view

miRNA for TMEM175 Gene

miRTarBase miRNAs that target TMEM175

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM175 Gene

Localization for TMEM175 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM175 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM175 Gene COMPARTMENTS Subcellular localization image for TMEM175 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for TMEM175 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005765 lysosomal membrane IDA 17897319
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM175: view

Pathways for TMEM175 Gene

SuperPathways for TMEM175 Gene

No Data Available

Interacting Proteins for TMEM175 Gene

Gene Ontology (GO) - Biological Process for TMEM175 Gene

None

No data available for Pathways by source for TMEM175 Gene

Transcripts for TMEM175 Gene

Unigene Clusters for TMEM175 Gene

Transmembrane protein 175:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM175 Gene

ExUns: 1a · 1b · 1c · 1d · 1e ^ 2 ^ 3 ^ 4a · 4b · 4c ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12 ^ 13a · 13b
SP1: - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - -
SP4: - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - -
SP8:
SP9: - - - - -
SP10: - - - - - - -
SP11: - - - -
SP12: - - - - - - -
SP13: -
SP14: -
SP15: - - - - -
SP16:
SP17: -

Relevant External Links for TMEM175 Gene

GeneLoc Exon Structure for
TMEM175
ECgene alternative splicing isoforms for
TMEM175

Expression for TMEM175 Gene

mRNA expression in normal human tissues for TMEM175 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM175 Gene

SOURCE GeneReport for Unigene cluster for TMEM175 Gene Hs.478936

genes like me logo Genes that share expressions with TMEM175: view

Orthologs for TMEM175 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM175 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM175 36
  • 98.2 (n)
  • 98.05 (a)
cow
(Bos Taurus)
Mammalia TMEM175 36
  • 82.53 (n)
  • 80.17 (a)
TMEM175 37
  • 75 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM175 36
  • 83.73 (n)
  • 81.53 (a)
TMEM175 37
  • 81 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem175 36
  • 80.09 (n)
  • 81.76 (a)
Tmem175 16
Tmem175 37
  • 82 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM175 37
  • 66 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM175 37
  • 65 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem175 36
  • 80.29 (n)
  • 81.96 (a)
chicken
(Gallus gallus)
Aves TMEM175 36
  • 62.96 (n)
  • 65.13 (a)
TMEM175 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM175 37
  • 61 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii tmem175 36
  • 63.41 (n)
  • 61.96 (a)
tmem175 37
  • 55 (a)
OneToOne
Species with no ortholog for TMEM175:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM175 Gene

ENSEMBL:
Gene Tree for TMEM175 (if available)
TreeFam:
Gene Tree for TMEM175 (if available)

Paralogs for TMEM175 Gene

Selected SIMAP similar genes for TMEM175 Gene using alignment to 9 proteins:

genes like me logo Genes that share paralogs with TMEM175: view

No data available for Paralogs for TMEM175 Gene

Variants for TMEM175 Gene

Sequence variations from dbSNP and Humsavar for TMEM175 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type MAF
rs935965 -- 934,896(-) cacct(A/G)caact intron-variant
rs935977 -- 949,752(+) ACCGC(A/G)GCCCC intron-variant
rs1051613 -- 957,391(+) GAACC(A/G)TGGAG intron-variant
rs1982455 -- 936,255(-) caatt(A/C)tcttg intron-variant
rs2290402 -- 947,730(+) GGCAG(C/T)GGCCC utr-variant-5-prime, intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM175 Gene

Variant ID Type Subtype PubMed ID
nsv822425 CNV Loss 20364138
dgv1564e1 CNV Complex 17122850
dgv5390n71 CNV Loss 21882294
dgv5391n71 CNV Loss 21882294
nsv469998 CNV Loss 18288195
esv29984 CNV Loss 17803354
dgv5395n71 CNV Loss 21882294
nsv878286 CNV Gain 21882294
nsv878287 CNV Loss 21882294
esv2726739 CNV Deletion 23290073
dgv5396n71 CNV Loss 21882294
dgv5397n71 CNV Loss 21882294
nsv878292 CNV Loss 21882294

Relevant External Links for TMEM175 Gene

HapMap Linkage Disequilibrium report
TMEM175

Disorders for TMEM175 Gene

Relevant External Links for TMEM175

Genetic Association Database (GAD)
TMEM175
genes like me logo Genes that share disorders with TMEM175: view

No data available for UniProtKB/Swiss-Prot for TMEM175 Gene

Publications for TMEM175 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies. (PMID: 21292315) . … Wood N.W. (Lancet 2011) 3 49
  4. Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease. (PMID: 21738487) Do C.B. … Eriksson N. (PLoS Genet. 2011) 3 49
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for TMEM175 Gene

Sources for TMEM175 Gene

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