TMEM175 Gene
protein-coding GIFtS: 43
GCID: GC04P000917
|
|
transmembrane protein 175
| |
Aliases
for TMEM175 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1751 2 | | MGC46181 |
Export aliases for TMEM175 gene to outside databases |
Summaries
for TMEM175 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM175 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000004.11 NC_018915.1 NT_037622.5
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM175 gene promoter:
AP-1 NRSF form 1 Egr-1 CUTL1 E4BP4 NRSF form 2 FOXO4 HFH-1 AP-2alpha AP-2alphaA
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM175
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM175 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 4p16.3 Ensembl cytogenetic band: 4p16.3 HGNC cytogenetic band: 4p16.3TMEM175 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 4 GeneLoc Exon Structure GeneLoc location for GC04P000917: view genomic region
(about GC identifiers)
Start:
|
926,175 bp from pter |
End:
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952,444 bp from pter |
Size:
|
26,270 bases |
Orientation:
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plus strand |
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Proteins
for TMEM175 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM175_HUMAN, Q9BSA9 (See
protein sequence)Recommended Name: Transmembrane protein 175 Size: 504 amino acids; 55615 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: D3DVN4 Q8ND13Alternative splicing: 2 isoforms: Q9BSA9-1 Q9BSA9-2 Explore the universe of human proteins at neXtProt for TMEM175: NX_Q9BSA9
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q9BSA9
TMEM175 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_115702.1
ENSEMBL proteins: ENSP00000424746 ENSP00000264771 ENSP00000427218 ENSP00000425181 ENSP00000425867 ENSP00000423751 ENSP00000421750 ENSP00000427626 ENSP00000427039 ENSP00000423669 ENSP00000424208 ENSP00000425763 ENSP00000422760
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM175 for ontologies About GeneDecksing
TMEM175 Antibody Products:
Assay Products for TMEM175: |
Protein
Domains /
Families
for TMEM175 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM175 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9BSA9ProtoNet protein and cluster: Q9BSA9 UniProtKB/Swiss-Prot: TM175_HUMAN, Q9BSA9Similarity: Belongs to the TMEM175 family |
Function
for TMEM175 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM175 (NM_032326) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM175 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM175 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM175 |
1 GenomeRNAi human phenotype for TMEM175:
|
Pathways & Interactions
for TMEM175 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM175
|
Drugs & Compounds
for TMEM175 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM175
Search CenterWatch for drugs/clinical trials and news about TMEM175 / TM175
|
Transcripts
for TMEM175 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM175 gene: NM_032326.2 Unigene Cluster for TMEM175: Transmembrane protein 175 Hs.478936 [show with all ESTs]Unigene Representative Sequence: BC06348818/22 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 22): ENST00000507319 ENST00000264771(uc003gbq.3) ENST00000513952(uc003gbs.3)
ENST00000514453 ENST00000505734(uc021xkf.1) ENST00000515492 ENST00000504744
ENST00000509508 ENST00000452360(uc003gbp.1) ENST00000515876(uc010ibl.1)
ENST00000513682 ENST00000515740 ENST00000438836(uc003gbt.3 uc003gbr.3)
ENST00000504505 ENST00000508204 ENST00000510493 ENST00000514546 ENST00000504850
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175 (see all 5)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM175 (NM_032326) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM175 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM175 |
Additional cDNA sequence: AK090848.1 AK293641.1 AK309132.1 AL834199.1 BC005158.2 BC047738.1 BC063488.1 BC095416.1 BC118552.1 18 DOTS entries: DT.100688642 DT.92424713 DT.211697 DT.92424708 DT.100027086 DT.100797804 DT.95160132 DT.100797802 DT.100797807 DT.121268334 DT.121268323 DT.121268472 DT.95160139 DT.121268406 DT.95160134 DT.121268369 DT.95160143 DT.97860625 24/168 AceView cDNA sequences (see all 168): CR599425 CA411836 CF242841 CR619330 BM717943 BM923852 CA841755 BM832202 BM919228 AI291113 NM_032326 BU742152 CR619221 R49453 AW886577 CA427123 BM987217 CA311241 BC047738 AL834199 CR622533 AA282971 CR617696 CA842049
GeneLoc Exon Structure
5/17 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM175 (see all 17) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | · | 4c | ^ | 5a | · | 5b | ^ | 6a | · | 6b | · | 6c | ^ | 7 | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13a | · | 13b |
|---|
|
| SP1: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | - | | - | | | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | - | | - | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | | | | | | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM175
|
Expression
for TMEM175 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM175 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCTTATTTC
About this image
See TMEM175 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM175
SOURCE GeneReport for Unigene cluster: Hs.478936
SABiosciences Custom PCR Arrays for TMEM175
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM175
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM175 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM175 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM175 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM175 |
Orthologs
for TMEM175 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM175 gene from 4/11 species (see all 11) About this table
ENSEMBL Gene Tree for TMEM175 (if available)
TreeFam Gene Tree for TMEM175 (if available) |
Paralogs
for TMEM175 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM175 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 5 variations for TMEM175
5 CNVs: 30190 3475 30187 30189 30188 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM175 |
|
Disorders
/ Diseases
for TMEM175 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM175 for disorders About GeneDecksing
1  disease for TMEM175: About MalaCardsparkinson's disease
Export disorders for TMEM175 gene to outside databases
|
Publications
for TMEM175 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM175 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM175) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Web-based genome-wide association study identifies tw o novel loci and a substantial genetic component for Parkinson's disease. (PubMed id 21738487)1 Do C.B....Eriksson N. (2011)
- Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide associat ion studies. (PubMed id 21292315)1 ....Wood N.W. (2011)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle. (PubMed id 18691976)2 Daub H.... Mann M. (2008)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for TMEM175 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM175 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM175 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM175 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM175 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM175 gene:
Search GeneIP for patents involving TMEM175
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM175 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM175 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM175 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM175 | | | OriGene Protein Over-expression Lysate for TMEM175 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM175 | | OriGene 3'-UTR Clone for TMEM175 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM175 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM175 | | OriGene Custom Protein Services for TMEM175 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM175 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM175 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM175 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM175 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM175 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM175 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM175 |
| |  |  |  |  | | | | |
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 |
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 | | | TMEM175 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM175 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM175 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM175 |
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