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Aliases for TMEM174 Gene

Aliases for TMEM174 Gene

  • Transmembrane Protein 174 2 3

External Ids for TMEM174 Gene

Summaries for TMEM174 Gene

GeneCards Summary for TMEM174 Gene

TMEM174 (Transmembrane Protein 174) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM174 Gene

Genomics for TMEM174 Gene

Genomic Location for TMEM174 Gene

Start:
73,168,253 bp from pter
End:
73,175,246 bp from pter
Size:
6,994 bases
Orientation:
Plus strand

Genomic View for TMEM174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM174 Gene

Regulatory Elements for TMEM174 Gene

Proteins for TMEM174 Gene

  • Protein details for TMEM174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUU8-TM174_HUMAN
    Recommended name:
    Transmembrane protein 174
    Protein Accession:
    Q8WUU8
    Secondary Accessions:
    • B2RDA0
    • Q96N81

    Protein attributes for TMEM174 Gene

    Size:
    243 amino acids
    Molecular mass:
    26287 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM174 Gene

Proteomics data for TMEM174 Gene at MOPED

Post-translational modifications for TMEM174 Gene

No Post-translational modifications

Other Protein References for TMEM174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM174 Gene

Domains for TMEM174 Gene

Protein Domains for TMEM174 Gene

InterPro:
ProtoNet:
genes like me logo Genes that share domains with TMEM174: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM174 Gene

Function for TMEM174 Gene

Gene Ontology (GO) - Molecular Function for TMEM174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM174: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for TMEM174 Gene

Localization for TMEM174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM174 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM174 Gene COMPARTMENTS Subcellular localization image for TMEM174 gene
Compartment Confidence
endoplasmic reticulum 5
plasma membrane 3
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005783 endoplasmic reticulum --
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM174: view

Pathways for TMEM174 Gene

SuperPathways for TMEM174 Gene

No Data Available

Interacting Proteins for TMEM174 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296776%0d%0a9606.ENSP00000358081%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: ENSP00000296776 Q8WUU8-TM174_HUMAN for TMEM174 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM174 Gene

None

No data available for Pathways by source for TMEM174 Gene

Transcripts for TMEM174 Gene

mRNA/cDNA for TMEM174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM174 Gene

Transmembrane protein 174:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM174 Gene

ExUns: 1a · 1b ^ 2
SP1:
SP2:

Relevant External Links for TMEM174 Gene

GeneLoc Exon Structure for
TMEM174
ECgene alternative splicing isoforms for
TMEM174

Expression for TMEM174 Gene

mRNA expression in normal human tissues for TMEM174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM174 Gene

This gene is overexpressed in Kidney - Cortex (52.3).

SOURCE GeneReport for Unigene cluster for TMEM174 Gene Hs.508588

mRNA Expression by UniProt/SwissProt for TMEM174 Gene

Q8WUU8-TM174_HUMAN
Tissue specificity: Predominantly expressed in kidney.
genes like me logo Genes that share expressions with TMEM174: view

Orthologs for TMEM174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM174 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM174 36
  • 98.9 (n)
  • 98.77 (a)
TMEM174 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM174 36
  • 85.05 (n)
  • 81.48 (a)
TMEM174 37
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM174 36
  • 79.77 (n)
  • 76.86 (a)
TMEM174 37
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem174 36
  • 82.85 (n)
  • 81.48 (a)
Tmem174 16
Tmem174 37
  • 81 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM174 37
  • 73 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem174 36
  • 83.13 (n)
  • 80.25 (a)
chicken
(Gallus gallus)
Aves TMEM174 36
  • 64.18 (n)
  • 58.92 (a)
TMEM174 37
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM174 37
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem174 36
  • 62.3 (n)
  • 63.35 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885856 36
  • 57.69 (n)
  • 54.34 (a)
tmem174 37
  • 47 (a)
OneToOne
Species with no ortholog for TMEM174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM174 Gene

ENSEMBL:
Gene Tree for TMEM174 (if available)
TreeFam:
Gene Tree for TMEM174 (if available)

Paralogs for TMEM174 Gene

No data available for Paralogs for TMEM174 Gene

Variants for TMEM174 Gene

Sequence variations from dbSNP and Humsavar for TMEM174 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type MAF
rs597305 -- 73,167,365(+) ccagt(C/G)gctgg upstream-variant-2KB
rs611120 -- 73,168,182(+) atgtc(C/T)ggggg upstream-variant-2KB
rs625986 -- 73,169,167(+) ggcca(A/T)ggaag intron-variant
rs998243 -- 73,175,026(-) TCCAC(A/G)GACCT utr-variant-3-prime, downstream-variant-500B
rs1104891 -- 73,174,828(+) ATAGC(A/G)CTGTG utr-variant-3-prime, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM174 Gene

Variant ID Type Subtype PubMed ID
nsv830344 CNV Gain+Loss 17160897
nsv4873 CNV Insertion 18451855

Relevant External Links for TMEM174 Gene

HapMap Linkage Disequilibrium report
TMEM174

Disorders for TMEM174 Gene

Relevant External Links for TMEM174

Genetic Association Database (GAD)
TMEM174
genes like me logo Genes that share disorders with TMEM174: view

No data available for UniProtKB/Swiss-Prot for TMEM174 Gene

Publications for TMEM174 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Human TMEM174 that is highly expressed in kidney tissue activates AP- 1 and promotes cell proliferation. (PMID: 20331980) Wang P. … Ma D. (Biochem. Biophys. Res. Commun. 2010) 3 4
  5. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3

Products for TMEM174 Gene

Sources for TMEM174 Gene

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