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Aliases for TMEM174 Gene

Aliases for TMEM174 Gene

  • Transmembrane Protein 174 2 3 5

External Ids for TMEM174 Gene

Previous GeneCards Identifiers for TMEM174 Gene

  • GC05P072499
  • GC05P067674

Summaries for TMEM174 Gene

GeneCards Summary for TMEM174 Gene

TMEM174 (Transmembrane Protein 174) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM174 Gene

Genomics for TMEM174 Gene

Regulatory Elements for TMEM174 Gene

Genomic Location for TMEM174 Gene

73,173,195 bp from pter
73,175,143 bp from pter
1,949 bases
Plus strand

Genomic View for TMEM174 Gene

Genes around TMEM174 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM174 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM174 Gene

Proteins for TMEM174 Gene

  • Protein details for TMEM174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 174
    Protein Accession:
    Secondary Accessions:
    • B2RDA0
    • Q96N81

    Protein attributes for TMEM174 Gene

    243 amino acids
    Molecular mass:
    26287 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM174 Gene


neXtProt entry for TMEM174 Gene

Proteomics data for TMEM174 Gene at MOPED

Post-translational modifications for TMEM174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM174 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

No data available for DME Specific Peptides for TMEM174 Gene

Domains & Families for TMEM174 Gene

Protein Domains for TMEM174 Gene


Suggested Antigen Peptide Sequences for TMEM174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM174: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM174 Gene

Function for TMEM174 Gene

genes like me logo Genes that share phenotypes with TMEM174: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM174 Gene

Localization for TMEM174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM174 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM174 Gene COMPARTMENTS Subcellular localization image for TMEM174 gene
Compartment Confidence
endoplasmic reticulum 3
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM174: view

Pathways & Interactions for TMEM174 Gene

SuperPathways for TMEM174 Gene

No Data Available

Interacting Proteins for TMEM174 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000296776 Q8WUU8-TM174_HUMAN for TMEM174 Gene via STRING UniProtKB

Gene Ontology (GO) - Biological Process for TMEM174 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM174 Gene

Drugs & Compounds for TMEM174 Gene

No Compound Related Data Available

Transcripts for TMEM174 Gene

mRNA/cDNA for TMEM174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM174 Gene

Transmembrane protein 174:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM174 Gene

ExUns: 1a · 1b ^ 2

Relevant External Links for TMEM174 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM174 Gene

mRNA expression in normal human tissues for TMEM174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM174 Gene

This gene is overexpressed in Kidney - Cortex (x52.3).

SOURCE GeneReport for Unigene cluster for TMEM174 Gene Hs.508588

mRNA Expression by UniProt/SwissProt for TMEM174 Gene

Tissue specificity: Predominantly expressed in kidney.
genes like me logo Genes that share expression patterns with TMEM174: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMEM174 Gene

Orthologs for TMEM174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM174 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM174 36
  • 99 (a)
TMEM174 35
  • 98.9 (n)
  • 98.77 (a)
(Bos Taurus)
Mammalia TMEM174 36
  • 81 (a)
TMEM174 35
  • 85.05 (n)
  • 81.48 (a)
(Canis familiaris)
Mammalia TMEM174 35
  • 79.77 (n)
  • 76.86 (a)
TMEM174 36
  • 77 (a)
(Mus musculus)
Mammalia Tmem174 16
Tmem174 36
  • 81 (a)
Tmem174 35
  • 82.85 (n)
  • 81.48 (a)
(Monodelphis domestica)
Mammalia TMEM174 36
  • 73 (a)
(Rattus norvegicus)
Mammalia Tmem174 35
  • 83.13 (n)
  • 80.25 (a)
(Gallus gallus)
Aves TMEM174 35
  • 64.18 (n)
  • 58.92 (a)
TMEM174 36
  • 60 (a)
(Anolis carolinensis)
Reptilia TMEM174 36
  • 46 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem174 35
  • 62.3 (n)
  • 63.35 (a)
(Danio rerio)
Actinopterygii tmem174 36
  • 47 (a)
LOC101885856 35
  • 57.69 (n)
  • 54.34 (a)
Species with no ortholog for TMEM174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM174 Gene

Gene Tree for TMEM174 (if available)
Gene Tree for TMEM174 (if available)

Paralogs for TMEM174 Gene

No data available for Paralogs for TMEM174 Gene

Variants for TMEM174 Gene

Sequence variations from dbSNP and Humsavar for TMEM174 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs998243 -- 73,175,026(-) TCCAC(A/G)GACCT utr-variant-3-prime
rs7700840 -- 73,172,493(+) AATGA(A/G)CTGAA upstream-variant-2KB
rs34059261 -- 73,173,569(+) GGTCC(A/C/T)GGACT reference, missense
rs34083675 -- 73,172,605(+) TTGGG(A/T)AGGAC upstream-variant-2KB
rs35311930 -- 73,175,274(+) GGTAA(-/G)GGGTG downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for TMEM174 Gene

Variant ID Type Subtype PubMed ID
nsv830344 CNV Gain+Loss 17160897
nsv4873 CNV Insertion 18451855

Variation tolerance for TMEM174 Gene

Residual Variation Intolerance Score: 88.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM174 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM174 Gene

Disorders for TMEM174 Gene

Relevant External Links for TMEM174

Genetic Association Database (GAD)
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM174 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM174 Gene

Publications for TMEM174 Gene

  1. Human TMEM174 that is highly expressed in kidney tissue activates AP- 1 and promotes cell proliferation. (PMID: 20331980) Wang P. … Ma D. (Biochem. Biophys. Res. Commun. 2010) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 3
  5. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 3

Products for TMEM174 Gene

Sources for TMEM174 Gene

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