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Aliases for TMEM174 Gene

Aliases for TMEM174 Gene

  • Transmembrane Protein 174 2 3

External Ids for TMEM174 Gene

Previous GeneCards Identifiers for TMEM174 Gene

  • GC05P072499
  • GC05P067674

Summaries for TMEM174 Gene

GeneCards Summary for TMEM174 Gene

TMEM174 (Transmembrane Protein 174) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM174 Gene

Genomics for TMEM174 Gene

Regulatory Elements for TMEM174 Gene

Genomic Location for TMEM174 Gene

Chromosome:
5
Start:
73,173,195 bp from pter
End:
73,175,143 bp from pter
Size:
1,949 bases
Orientation:
Plus strand

Genomic View for TMEM174 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM174 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM174 Gene

Proteins for TMEM174 Gene

  • Protein details for TMEM174 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUU8-TM174_HUMAN
    Recommended name:
    Transmembrane protein 174
    Protein Accession:
    Q8WUU8
    Secondary Accessions:
    • B2RDA0
    • Q96N81

    Protein attributes for TMEM174 Gene

    Size:
    243 amino acids
    Molecular mass:
    26287 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM174 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM174 Gene

Proteomics data for TMEM174 Gene at MOPED

Post-translational modifications for TMEM174 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM174 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM174 Gene

Domains & Families for TMEM174 Gene

Protein Domains for TMEM174 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM174 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM174: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM174 Gene

Function for TMEM174 Gene

Gene Ontology (GO) - Molecular Function for TMEM174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM174: view

Phenotypes for TMEM174 Gene

GenomeRNAi human phenotypes for TMEM174:
genes like me logo Genes that share phenotypes with TMEM174: view

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM174

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM174 Gene

Localization for TMEM174 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM174 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM174 Gene COMPARTMENTS Subcellular localization image for TMEM174 gene
Compartment Confidence
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for TMEM174 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005789 endoplasmic reticulum membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM174: view

Pathways & Interactions for TMEM174 Gene

SuperPathways for TMEM174 Gene

No Data Available

Interacting Proteins for TMEM174 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000296776%0d%0a9606.ENSP00000358081%0d%0a9606.ENSP00000221566%0d%0a
Selected Interacting proteins: Q8WUU8-TM174_HUMAN ENSP00000296776 for TMEM174 Gene via UniProtKB STRING

Gene Ontology (GO) - Biological Process for TMEM174 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM174 Gene

Drugs & Compounds for TMEM174 Gene

No Compound Related Data Available

Transcripts for TMEM174 Gene

mRNA/cDNA for TMEM174 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(39) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM174 Gene

Transmembrane protein 174:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM174

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM174 Gene

ExUns: 1a · 1b ^ 2
SP1:
SP2:

Relevant External Links for TMEM174 Gene

GeneLoc Exon Structure for
TMEM174
ECgene alternative splicing isoforms for
TMEM174

Expression for TMEM174 Gene

mRNA expression in normal human tissues for TMEM174 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM174 Gene

This gene is overexpressed in Kidney - Cortex (x52.3).

SOURCE GeneReport for Unigene cluster for TMEM174 Gene Hs.508588

mRNA Expression by UniProt/SwissProt for TMEM174 Gene

Q8WUU8-TM174_HUMAN
Tissue specificity: Predominantly expressed in kidney.
genes like me logo Genes that share expression patterns with TMEM174: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for TMEM174 Gene

Orthologs for TMEM174 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM174 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM174 35
  • 85.05 (n)
  • 81.48 (a)
TMEM174 36
  • 81 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM174 35
  • 79.77 (n)
  • 76.86 (a)
TMEM174 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem174 35
  • 82.85 (n)
  • 81.48 (a)
Tmem174 16
Tmem174 36
  • 81 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM174 35
  • 98.9 (n)
  • 98.77 (a)
TMEM174 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem174 35
  • 83.13 (n)
  • 80.25 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM174 36
  • 73 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM174 35
  • 64.18 (n)
  • 58.92 (a)
TMEM174 36
  • 60 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM174 36
  • 46 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem174 35
  • 62.3 (n)
  • 63.35 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC101885856 35
  • 57.69 (n)
  • 54.34 (a)
tmem174 36
  • 47 (a)
OneToOne
Species with no ortholog for TMEM174:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM174 Gene

ENSEMBL:
Gene Tree for TMEM174 (if available)
TreeFam:
Gene Tree for TMEM174 (if available)

Paralogs for TMEM174 Gene

No data available for Paralogs for TMEM174 Gene

Variants for TMEM174 Gene

Structural Variations from Database of Genomic Variants (DGV) for TMEM174 Gene

Variant ID Type Subtype PubMed ID
nsv830344 CNV Gain+Loss 17160897
nsv4873 CNV Insertion 18451855

Variation tolerance for TMEM174 Gene

Residual Variation Intolerance Score: 88.44% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.23; 40.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM174 Gene

HapMap Linkage Disequilibrium report
TMEM174

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Sequence variations from dbSNP and Humsavar for TMEM174 Gene

Disorders for TMEM174 Gene

Relevant External Links for TMEM174

Genetic Association Database (GAD)
TMEM174
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM174
genes like me logo Genes that share disorders with TMEM174: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM174 Gene

Publications for TMEM174 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 67
  2. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 67
  3. Bcl2-associated athanogene 3 interactome analysis reveals a new role in modulating proteasome activity. (PMID: 23824909) Chen Y. … Ge F. (Mol. Cell Proteomics 2013) 67
  4. Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations. (PMID: 22797727) Okada Y. … Tanaka T. (Nat. Genet. 2012) 67
  5. Human TMEM174 that is highly expressed in kidney tissue activates AP- 1 and promotes cell proliferation. (PMID: 20331980) Wang P. … Ma D. (Biochem. Biophys. Res. Commun. 2010) 67

Products for TMEM174 Gene

Sources for TMEM174 Gene

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