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Aliases for TMEM173 Gene

Aliases for TMEM173 Gene

  • Transmembrane Protein 173 2 3 4 5
  • Endoplasmic Reticulum Interferon Stimulator 3 4
  • HSTING 3 4
  • STING 3 4
  • HMITA 3 4
  • ERIS 3 4
  • MITA 3 4
  • N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner 3
  • Mitochondrial Mediator Of IRF3 Activation 3
  • Stimulator Of Interferon Genes Protein 3
  • Endoplasmic Reticulum IFN Stimulator 3
  • Stimulator Of Interferon Genes 2
  • Mediator Of IRF3 Activation 4
  • NET23 3
  • MPYS 3
  • SAVI 3

External Ids for TMEM173 Gene

Previous GeneCards Identifiers for TMEM173 Gene

  • GC05M138836
  • GC05M134001

Summaries for TMEM173 Gene

Entrez Gene Summary for TMEM173 Gene

  • This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]

GeneCards Summary for TMEM173 Gene

TMEM173 (Transmembrane Protein 173) is a Protein Coding gene. Diseases associated with TMEM173 include Sting-Associated Vasculopathy, Infantile-Onset and Chilblain Lupus. Among its related pathways are Immune System and Toll-Like receptor Signaling Pathways. GO annotations related to this gene include protein homodimerization activity and protein kinase binding.

UniProtKB/Swiss-Prot for TMEM173 Gene

  • Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2,3 phosphodiester linkage-specific ligand recognition. Can bind both 2-3 linked cGAMP and 3-3 linked cGAMP but is preferentially activated by 2-3 linked cGAMP (PubMed:26300263).

Tocris Summary for TMEM173 Gene

  • STING (stimulator of interferon genes) is a pattern recognition receptor and adapter protein that mediates an innate immune response following detection of cytoplasmic DNA. STING-dependent signaling is involved in certain autoimmune diseases and cancer immunology.

No data available for Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM173 Gene

Genomics for TMEM173 Gene

Regulatory Elements for TMEM173 Gene

Enhancers for TMEM173 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F139468 1.6 FANTOM5 Ensembl ENCODE 17.6 +10.7 10667 8.5 HDGF ATF1 ARNT SIN3A FEZF1 GATA2 FOS JUNB NCOA1 CREB3 TMEM173 DNAJC18 PROB1 ENSG00000283288 LOC101059986
GH05F139480 1.1 ENCODE 22.6 +0.9 888 3.3 PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 SP3 TBX21 KAT8 MEF2D ZNF610 TMEM173 DNAJC18 LOC101059986 ENSG00000283288
GH05F139478 0.8 ENCODE 22.4 +4.0 4041 1.1 TBP HDGF HDAC1 PKNOX1 CBX3 KLF17 GATA2 KLF7 SMARCA5 ZBTB2 TMEM173 LOC101059986 ENSG00000283288
GH05F139633 1.6 FANTOM5 ENCODE 10.4 -170.5 -170495 40.2 CREB3L1 MLX ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 DNAJC18 TMEM173 PSD2 LOC105379194 CXXC5 MZB1 NRG2 IGIP MATR3 PAIP2
GH05F139683 1.8 FANTOM5 Ensembl ENCODE 8.9 -210.0 -209962 19.0 HDGF PKNOX1 ARNT ARID4B FEZF1 DMAP1 ZNF2 YY1 ZNF766 ZNF143 CXXC5 PSD2 TMEM173 DNAJC18 IGIP NRG2 ENSG00000249526 RNU6-236P GC05M139718
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM173 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM173 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001414431 835 1401 ATF1 PKNOX1 SIN3A FEZF1 DMAP1 ZNF2 GLIS2 GATA2 KLF7 KDM4B

Genomic Location for TMEM173 Gene

Chromosome:
5
Start:
139,475,528 bp from pter
End:
139,482,935 bp from pter
Size:
7,408 bases
Orientation:
Minus strand

Genomic View for TMEM173 Gene

Genes around TMEM173 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM173 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM173 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM173 Gene

Proteins for TMEM173 Gene

  • Protein details for TMEM173 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86WV6-STING_HUMAN
    Recommended name:
    Stimulator of interferon genes protein
    Protein Accession:
    Q86WV6
    Secondary Accessions:
    • A8K3P6
    • B6EB35
    • D6RBX0
    • D6RE01
    • D6RID9

    Protein attributes for TMEM173 Gene

    Size:
    379 amino acids
    Molecular mass:
    42193 Da
    Quaternary structure:
    • Associates with the MHC-II complex (By similarity). Homodimer; Lys-63-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2.
    Miscellaneous:
    • Contrary to human and rat TMEM173/STING, mouse TMEM173/STING mediates not only responses to cyclic nucleotide signaling molecules, but is also strongly activated by antiviral and anticancer molecules, such as 5,6-dimethylxanthenone 4-acetic acid (DMXAA) and 10-carboxymethyl-9-acridanone (CMA).

    Three dimensional structures from OCA and Proteopedia for TMEM173 Gene

neXtProt entry for TMEM173 Gene

Post-translational modifications for TMEM173 Gene

  • Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1, leading to activation and production of IFN-beta.
  • Ubiquitinated. Lys-63-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta. Lys-48-linked polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation.
  • Ubiquitination at Lys 150
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM173 Gene

Antibody Products

  • R&D Systems Antibodies for TMEM173 (STING/TMEM173)
  • Cloud-Clone Corp. Antibodies for TMEM173

No data available for DME Specific Peptides for TMEM173 Gene

Domains & Families for TMEM173 Gene

Protein Domains for TMEM173 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM173 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q86WV6

UniProtKB/Swiss-Prot:

STING_HUMAN :
  • The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclic diguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP, the protein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT). Binding of c-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659).
  • Belongs to the TMEM173 family.
Domain:
  • The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclic diguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP, the protein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT). Binding of c-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659).
Family:
  • Belongs to the TMEM173 family.
genes like me logo Genes that share domains with TMEM173: view

No data available for Gene Families for TMEM173 Gene

Function for TMEM173 Gene

Molecular function for TMEM173 Gene

UniProtKB/Swiss-Prot Function:
Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Essential for the induction of IFN-beta in response to human herpes simplex virus 1 (HHV-1) infection. Exhibits 2,3 phosphodiester linkage-specific ligand recognition. Can bind both 2-3 linked cGAMP and 3-3 linked cGAMP but is preferentially activated by 2-3 linked cGAMP (PubMed:26300263).

Gene Ontology (GO) - Molecular Function for TMEM173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 18724357
GO:0008134 transcription factor binding IDA 18818105
GO:0019901 protein kinase binding IPI 21074459
GO:0031625 ubiquitin protein ligase binding IEA --
GO:0035438 cyclic-di-GMP binding IDA 22705373
genes like me logo Genes that share ontologies with TMEM173: view
genes like me logo Genes that share phenotypes with TMEM173: view

Human Phenotype Ontology for TMEM173 Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Models for TMEM173 Gene

MGI Knock Outs for TMEM173:

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for TMEM173 Gene

Localization for TMEM173 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM173 Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Cytoplasm. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1 is recruited.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM173 gene
Compartment Confidence
plasma membrane 5
mitochondrion 5
endoplasmic reticulum 5
cytosol 5
nucleus 4
peroxisome 3
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for TMEM173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005739 mitochondrion IEA --
GO:0005741 mitochondrial outer membrane IDA 18818105
GO:0005777 peroxisome IEA --
GO:0005783 endoplasmic reticulum IEA --
genes like me logo Genes that share ontologies with TMEM173: view

Pathways & Interactions for TMEM173 Gene

genes like me logo Genes that share pathways with TMEM173: view

Gene Ontology (GO) - Biological Process for TMEM173 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002218 activation of innate immune response IEA,IMP 18818105
GO:0002230 positive regulation of defense response to virus by host IMP 18818105
GO:0002376 immune system process IEA --
GO:0006915 apoptotic process IEA --
GO:0032092 positive regulation of protein binding IDA 18818105
genes like me logo Genes that share ontologies with TMEM173: view

No data available for SIGNOR curated interactions for TMEM173 Gene

Drugs & Compounds for TMEM173 Gene

(4) Additional Compounds for TMEM173 Gene - From: Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
2',3'-cGAMP sodium salt
3',3'-cGAMP sodium salt
c-Di-AMP sodium salt
c-Di-GMP sodium salt

(4) Tocris Compounds for TMEM173 Gene

Compound Action Cas Number
2',3'-cGAMP sodium salt Endogenous high affinity STING agonist
3',3'-cGAMP sodium salt STING agonist
c-Di-AMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling
c-Di-GMP sodium salt Endogenous STING and DDX41 agonist; activates STING-dependent signaling
genes like me logo Genes that share compounds with TMEM173: view

Transcripts for TMEM173 Gene

Unigene Clusters for TMEM173 Gene

Transmembrane protein 173:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM173 Gene

ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
SP1: - - - -
SP2: - - - -
SP3: - - - - - - -
SP4: - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - -
SP8: - - -
SP9: - -
SP10: -
SP11:

Relevant External Links for TMEM173 Gene

GeneLoc Exon Structure for
TMEM173
ECgene alternative splicing isoforms for
TMEM173

Expression for TMEM173 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM173 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM173 Gene

This gene is overexpressed in Nasal epithelium (17.4), Monocytes (16.8), and Peripheral blood mononuclear cells (8.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM173 Gene



Protein tissue co-expression partners for TMEM173 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM173 Gene:

TMEM173

SOURCE GeneReport for Unigene cluster for TMEM173 Gene:

Hs.379754

mRNA Expression by UniProt/SwissProt for TMEM173 Gene:

Q86WV6-STING_HUMAN
Tissue specificity: Ubiquitously expressed. Expressed in skin endothelial cells, alveolar type 2 pneumocytes, bronchial epithelium and alveolar macrophages.
genes like me logo Genes that share expression patterns with TMEM173: view

Primer Products

No data available for mRNA differential expression in normal tissues for TMEM173 Gene

Orthologs for TMEM173 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM173 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM173 34 35
  • 99.38 (n)
cow
(Bos Taurus)
Mammalia TMEM173 34 35
  • 85.46 (n)
dog
(Canis familiaris)
Mammalia TMEM173 34 35
  • 84.05 (n)
rat
(Rattus norvegicus)
Mammalia Tmem173 34
  • 77.25 (n)
mouse
(Mus musculus)
Mammalia Tmem173 34 16 35
  • 76.92 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM173 35
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM173 35
  • 40 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM173 34 35
  • 56.33 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM173 35
  • 39 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem173 34
  • 51.46 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem173 34 35
  • 47.85 (n)
Species where no ortholog for TMEM173 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM173 Gene

ENSEMBL:
Gene Tree for TMEM173 (if available)
TreeFam:
Gene Tree for TMEM173 (if available)

Paralogs for TMEM173 Gene

No data available for Paralogs for TMEM173 Gene

Variants for TMEM173 Gene

Sequence variations from dbSNP and Humsavar for TMEM173 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs587777609 STING-associated vasculopathy, infantile-onset (SAVI) [MIM:615934], Pathogenic 139,480,849(+) CCACG(C/T)TGAAA reference, missense
rs587777610 STING-associated vasculopathy, infantile-onset (SAVI) [MIM:615934], Pathogenic 139,480,847(+) GGCCA(C/T)GTTGA reference, missense
rs587777611 STING-associated vasculopathy, infantile-onset (SAVI) [MIM:615934], Pathogenic 139,480,871(+) ACACA(C/G)TGCAG reference, missense
rs112179101 -- 139,480,488(+) TTGCA(C/G)TAGCC intron-variant
rs112829463 -- 139,476,333(+) GACAT(A/C/G/T)GTGGA reference, synonymous-codon, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM173 Gene

Variant ID Type Subtype PubMed ID
nsv516200 CNV loss 19592680
nsv519808 CNV loss 19592680

Variation tolerance for TMEM173 Gene

Residual Variation Intolerance Score: 81.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 12.88; 94.85% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM173 Gene

Human Gene Mutation Database (HGMD)
TMEM173
SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM173

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM173 Gene

Disorders for TMEM173 Gene

MalaCards: The human disease database

(3) MalaCards diseases for TMEM173 Gene - From: OMIM, ClinVar, Orphanet, Swiss-Prot, DISEASES, and GeneCards

Disorder Aliases PubMed IDs
sting-associated vasculopathy, infantile-onset
  • sting-associated vasculopathy with onset in infancy
chilblain lupus
  • lupus erythematosus, cutaneous
aicardi-goutieres syndrome 1, dominant and recessive
  • aicardi-goutieres syndrome
- elite association - COSMIC cancer census association via MalaCards

UniProtKB/Swiss-Prot

STING_HUMAN
  • STING-associated vasculopathy, infantile-onset (SAVI) [MIM:615934]: An autoinflammatory disease characterized by early-onset systemic inflammation and cutaneous vasculopathy, resulting in severe skin lesions. Violaceous, scaling lesions of fingers, toes, nose, cheeks and ears progress to acral necrosis in most of the patients. Some patients have severe interstitial lung disease. {ECO:0000269 PubMed:25029335}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Relevant External Links for TMEM173

Genetic Association Database (GAD)
TMEM173
Human Genome Epidemiology (HuGE) Navigator
TMEM173
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM173
genes like me logo Genes that share disorders with TMEM173: view

No data available for Genatlas for TMEM173 Gene

Publications for TMEM173 Gene

  1. STING is a direct innate immune sensor of cyclic di-GMP. (PMID: 21947006) Burdette D.L. … Vance R.E. (Nature 2011) 2 3 4 64
  2. Rat and human STINGs profile similarly towards anticancer/antiviral compounds. (PMID: 26669264) Zhang H. … Su X.D. (Sci Rep 2015) 3 4 64
  3. Activated STING in a vascular and pulmonary syndrome. (PMID: 25029335) Liu Y. … Goldbach-Mansky R. (N. Engl. J. Med. 2014) 3 4 64
  4. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. (PMID: 23707065) Diner E.J. … Vance R.E. (Cell Rep. 2013) 3 4 64
  5. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. (PMID: 23722158) Ablasser A. … Hornung V. (Nature 2013) 3 4 64

Products for TMEM173 Gene

Sources for TMEM173 Gene

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