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TMEM173 Gene

protein-coding   GIFtS: 57
GCID: GC05M138836

Transmembrane Protein 173

  See TMEM173-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Transmembrane Protein 1731 2 3     hSTING2 3
STING2 3 5     MPYS2 5
Endoplasmic Reticulum Interferon Stimulator2 3     NET232
Mediator Of IRF3 Activation2 3     Endoplasmic Reticulum IFN Stimulator2
ERIS2 3     Mitochondrial Mediator Of IRF3 Activation2
MITA2 3     N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner2
hMITA2 3     Stimulator Of Interferon Genes Protein2

External Ids:    HGNC: 279621   Entrez Gene: 3400612   Ensembl: ENSG000001845847   OMIM: 6123745   UniProtKB: Q86WV63   
ORGUL members:         

Export aliases for TMEM173 gene to outside databases

Previous GC identifer: GC05M134001


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM173 Gene:
TMEM173 (transmembrane protein 173) is a protein-coding gene. Diseases associated with TMEM173 include ureterocele, and japanese encephalitis. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses
and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in
response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing
and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a
messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is
alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce
expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the
translocon possibly being able to influence the induction of type I interferons. May be involved in transduction
of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates
death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000005.10  NT_029289.12  NC_018916.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM173 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   Evi-1   GATA-1   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM173 promoter sequence
   Search Chromatin IP Primers for TMEM173

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM173


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

TMEM173 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM173 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M138836:  view genomic region     (about GC identifiers)

Start:
138,855,113 bp from pter      End:
138,862,520 bp from pter
Size:
7,408 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6 (See protein sequence)
Recommended Name: Stimulator of interferon genes protein  
Size: 379 amino acids; 42193 Da
Subunit: Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150
is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56.
Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2
Selected PDB 3D structures from and Proteopedia for TMEM173 (see all 13):
4EF4 (3D)        4EF5 (3D)        4EMT (3D)        4EMU (3D)        4F5D (3D)        4F5E (3D)    
Secondary accessions: A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9

Explore the universe of human proteins at neXtProt for TMEM173: NX_Q86WV6

Explore proteomics data for TMEM173 at MOPED

Post-translational modifications: 

  • Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1,
    leading to activation and production of IFN-beta1
  • Ubiquitinated. 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and
    recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta. 'Lys-48'-linked
    polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal
    degradation1
  • Ubiquitination2 at Lys150
  • Modification sites at PhosphoSitePlus

  • See TMEM173 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_938023.1  
    ENSEMBL proteins: 
     ENSP00000331288   ENSP00000427455  
    Reactome Protein details: Q86WV6

    TMEM173 Human Recombinant Protein Products:

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    Novus Biologicals TMEM173 Protein
    Novus Biologicals TMEM173 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM173

     
    Search eBioscience for Proteins for TMEM173 

    TMEM173 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Abcam antibodies for TMEM173
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    LSBio Antibodies in human, mouse, rat for TMEM173

    TMEM173 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for TMEM173
    Cloud-Clone Corp. CLIAs for TMEM173
    Search eBioscience for ELISAs for TMEM173 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q86WV6

    UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
    Domain: The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclic
    diguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP,
    the protein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT).
    Binding of c-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate
    both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of
    the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded,
    soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659)
    Similarity: Belongs to the TMEM173 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STING_HUMAN, Q86WV6
    Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses
    and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in
    response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing
    and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a
    messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is
    alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce
    expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the
    translocon possibly being able to influence the induction of type I interferons. May be involved in transduction
    of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates
    death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18724357
    GO:0008134transcription factor binding IDA18818105
    GO:0019901protein kinase binding IPI--
    GO:0031625ubiquitin protein ligase binding IEA--
    GO:0035438cyclic-di-GMP binding IDA--
         
    Find genes that share ontologies with TMEM173           About GenesLikeMe


    Phenotypes:
         4 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tmem173):
     hematopoietic system  homeostasis/metabolism  immune system  mortality/aging 

    Find genes that share phenotypes with TMEM173           About GenesLikeMe

    Animal Models:
         MGI mouse knock-outs for TMEM173: Tmem173tm1Gnb Tmem173tm1Camb

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM173
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for TMEM173

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM173
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM173

    miRNA
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    miRTarBase miRNAs that target TMEM173:
    hsa-mir-25-3p (MIRT050207)

    Block miRNA regulation of human, mouse, rat TMEM173 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate TMEM173:
    hsa-miR-3919 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTMEM173 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for TMEM173
    Predesigned siRNA for gene silencing in human, mouse, rat TMEM173

    Gene Editing
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    Clone
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    GenScript: all cDNA clones in your preferred vector: TMEM173 (NM_198282)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM173
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM173 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    STING_HUMAN, Q86WV6: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane;
    Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear
    region. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase
    TBK1 is recruited
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    mitochondrion5
    plasma membrane5
    cytosol4
    golgi apparatus2
    nucleus1
    peroxisome1

    Gene Ontology (GO): Selected cellular component terms (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IDA18818105
    GO:0005777peroxisome IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005794Golgi apparatus IEA--

    Find genes that share ontologies with TMEM173           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for TMEM173 About    
    See pathways by source

    SuperPathContained pathways About
    1Cytosolic sensors of pathogen-associated DNA
    ZBP1(DAI) mediated induction of type I IFNs0.81
    Regulation of innate immune responses to cytosolic DNA0.00
    Cytosolic sensors of pathogen-associated DNA0.38
    STING mediated induction of host immune responses0.00
    Cytosolic DNA-sensing pathway0.33
    STAT6-mediated induction of chemokines0.00
    IRF3 mediated activation of type 1 IFN0.00
    IRF3-mediated induction of type I IFN0.00
    2RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.47
    3NF-kappaB Signaling
    NF-kappaB Signaling
    4Lymphocyte Signaling
    Lymphocyte Signaling


    Find genes that share SuperPaths with TMEM173           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TMEM173
        Lymphocyte Signaling
    NF-kappaB Signaling

    5 Reactome Pathways for TMEM173
        STING mediated induction of host immune responses
    Regulation of innate immune responses to cytosolic DNA
    STAT6-mediated induction of chemokines
    IRF3 mediated activation of type 1 IFN
    IRF3-mediated induction of type I IFN


    2 Kegg Pathways  (Kegg details for TMEM173):
        RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway

        Pathway & Disease-focused RT2 Profiler PCR Array including TMEM173: 
              Type I Interferon Response in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for TMEM173

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for TMEM173 (Q86WV61, 3 ENSP000003312884) via UniProtKB, MINT, STRING, and/or I2D (see all 46)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFI16Q166661, 3, ENSP000003571134EBI-2800345,EBI-2867186 I2D: score=2 STRING: ENSP00000357113
    TBK1Q9UHD21, 3, ENSP000003299674EBI-2800345,EBI-356402 I2D: score=2 STRING: ENSP00000329967
    CCDC47Q96A331, 3, ENSP000002257264EBI-2800345,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    DDOSTP396561, 3, ENSP000003641884EBI-2800345,EBI-358866 I2D: score=1 STRING: ENSP00000364188
    IRAK1P516171, 3, ENSP000003589974EBI-2800345,EBI-358664 I2D: score=1 STRING: ENSP00000358997
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002218activation of innate immune response IMP18818105
    GO:0002230positive regulation of defense response to virus by host IMP18818105
    GO:0006915apoptotic process IEA--
    GO:0032092positive regulation of protein binding IDA18818105
    GO:0032479regulation of type I interferon production TAS--

    Find genes that share ontologies with TMEM173           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM173 (STING)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM173 gene: 
    NM_198282.2  

    Unigene Cluster for TMEM173:

    Transmembrane protein 173
    Hs.379754  [show with all ESTs]
    Unigene Representative Sequence: NM_198282
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507297(uc003lep.3) ENST00000330794 ENST00000509573 ENST00000512606
    ENST00000503287 ENST00000511886 ENST00000502825 ENST00000510817 ENST00000514119
    ENST00000515507 ENST00000511850 ENST00000503838 ENST00000502362 ENST00000514348
    ENST00000514542
    miRNA
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    hsa-miR-3919 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTMEM173 3' UTR sequence
    Inhib. RNA
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    GenScript: all cDNA clones in your preferred vector: TMEM173 (NM_198282)
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173
    Primer
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    OriGene qPCR primer pairs and template standards for TMEM173
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM173
      QuantiTect SYBR Green Assays in human, mouse, rat TMEM173
      QuantiFast Probe-based Assays in human, mouse, rat TMEM173

    Additional mRNA sequence: 

    AK129800.1 AK290661.1 BC047779.1 FJ222241.1 

    14 DOTS entries:

    DT.319535  DT.85102793  DT.100794223  DT.100794224  DT.95153472  DT.120865796  DT.95153468  DT.100794218 
    DT.120865780  DT.95153475  DT.100794222  DT.100794226  DT.40117681  DT.97769662 

    Selected AceView cDNA sequences (see all 261):

    AI366477 BC047779 AW130852 AA262996 AI983894 BX444332 BU615201 BM981219 
    AX775913 AI689302 AJ430435 Z43230 BQ181009 NM_198282 CF131970 BM708269 
    BG677925 BQ447049 CA313409 BE745101 AI624549 AA435604 AA705005 BU631356 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for TMEM173 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                      -                 -                       -                             -                                       
    SP2:                                                        -                       -     -                       -                                       
    SP3:                                      -                 -     -     -     -     -                             -                                       
    SP4:                                                        -     -     -     -     -                             -                                       
    SP5:                                                                                -                             -           -     -     -               


    ECgene alternative splicing isoforms for TMEM173

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    TMEM173 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM173 Expression
    About this image


    TMEM173 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    TMEM173 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM173 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.379754

    UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
    Tissue specificity: Ubiquitously expressed

        Pathway & Disease-focused RT2 Profiler PCR Array including TMEM173: 
              Type I Interferon Response in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for TMEM173
    OriGene qSTAR qPCR primer pairs in human, mouse for TMEM173
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM173
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM173
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM173 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1731 , 5 transmembrane protein 1731, 5 76.92(n)1
    69.23(a)1
      18 (19.23 cM)5
    725121  NM_028261.11  NP_082537.11 
     357336785 
    chicken
    (Gallus gallus)
    Aves TMEM1731 transmembrane protein 173 56.33(n)
    45.71(a)
      768990  XM_001232170.3  XP_001232171.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1736
    transmembrane protein 173
    39(a)
    1 ↔ 1
    4(79262422-79280185)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia tmem1731 transmembrane protein 173 51.46(n)
    42.3(a)
      100127621  NM_001112974.1  NP_001106445.2 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem1731 transmembrane protein 173 47.85(n)
    39.93(a)
      101243556  NM_001278837.1  NP_001265766.1 


    ENSEMBL Gene Tree for TMEM173 (if available)
    TreeFam Gene Tree for TMEM173 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM173 (see all 203)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402638071,2
    --138854755(+) TGTCCA/GTTTGC 1 -- int10--------
    rs1823258471,2
    --138855027(+) TGCATA/GTGCAG 1 -- int10--------
    rs1504354851,2
    --138855037(+) GGCAGA/GTTTGG 1 -- int10--------
    rs1381998131,2
    --138855071(+) CTGTTA/TTATCG 1 -- int10--------
    rs1861589201,2
    --138855100(+) AAAGAC/TGACAC 1 -- int10--------
    rs115547781,2
    C--138855164(-) TTATAC/TTCCAC 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs152291,2
    C--138855265(+) AATCCT/CAGAGA 1 -- ut31 ese32Minor allele frequency- C:0.00MN NA 186
    rs1906240061,2
    --138855300(+) CCGGCA/GGGAGA 1 -- ut310--------
    rs1138459321,2
    C--138855340(+) GGAGCC/G/TGGGGG 2 -- ut311CSA 1
    rs1423652601,2
    --138855468(+) TTCGGC/TGTCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM173 (138855113 - 138862520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM173:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv519808CNV Loss19592680
    nsv516200CNV Loss19592680

    Human Gene Mutation Database (HGMD): TMEM173
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing TMEM173
    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM173

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 612374    OMIM disorders: --

    3 diseases for TMEM173:    
    About MalaCards
    ureterocele    japanese encephalitis    neurogenic bladder

    4 diseases from the University of Copenhagen DISEASES database for TMEM173:
    Vesicoureteral reflux     Neurogenic bladder     Ureterocele     Hypersensitivity reaction type I disease

    Find genes that share disorders with TMEM173           About GenesLikeMe

    Genetic Association Database (GAD): TMEM173
    Human Genome Epidemiology (HuGE) Navigator: TMEM173 (1 document)

    Export disorders for TMEM173 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM173 gene, integrated from 10 sources (see all 48):
    (articles sorted by number of sources associating them with TMEM173)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. (PubMed id 23722158)1, 2 Ablasser A.... Hornung V. (Nature 2013)
    2. The innate immune DNA sensor cGAS produces a noncanonical cyclic dinucleotide that activates human STING. (PubMed id 23707065)1, 2 Diner E.J.... Vance R.E. (Cell Rep. 2013)
    3. The structural basis for the sensing and binding of cyclic di-GMP by STING. (PubMed id 22728659)1, 2 Huang Y.H.... Su X.D. (Nat. Struct. Mol. Biol. 2012)
    4. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. (PubMed id 22728658)1, 2 Shu C.... Li P. (Nat. Struct. Mol. Biol. 2012)
    5. Crystal structures of STING protein reveal basis for recognition of cyclic di-GMP. (PubMed id 22728660)1, 2 Shang G.... Gu L. (Nat. Struct. Mol. Biol. 2012)
    6. Cyclic di-GMP sensing via the innate immune signaling protein STING. (PubMed id 22705373)1, 2 Yin Q.... Wu H. (Mol. Cell 2012)
    7. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. (PubMed id 21074459)1, 2 Tsuchida T.... Akira S. (Immunity 2010)
    8. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (PubMed id 19285439)1, 2 Zhong B.... Shu H.B. (Immunity 2009)
    9. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1, 4 Graubert T.A....Walter M.J. (PLoS ONE 2009)
    10. ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y.... Shu H.B. (Proc. Natl. Acad. Sci. U.S.A. 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 340061 HGNC: 27962 AceView: LOC340061 Ensembl:ENSG00000184584 euGenes: HUgn340061
    ECgene: TMEM173 Kegg: 340061 H-InvDB: TMEM173

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM173 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM173 gene:
    Search GeneIP for patents involving TMEM173

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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