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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

TMEM173 Gene

protein-coding   GIFtS: 54
GCID: GC05M138836

Transmembrane Protein 173

Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Transmembrane Protein 1731 2 3     hSTING2 3
STING2 3 5     MPYS2 5
Endoplasmic Reticulum Interferon Stimulator2 3     NET232
Mediator Of IRF3 Activation2 3     Endoplasmic Reticulum IFN Stimulator2
ERIS2 3     Mitochondrial Mediator Of IRF3 Activation2
MITA2 3     N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner2
hMITA2 3     Stimulator Of Interferon Genes Protein2

External Ids:    HGNC: 279621   Entrez Gene: 3400612   Ensembl: ENSG000001845847   OMIM: 6123745   UniProtKB: Q86WV63   

Export aliases for TMEM173 gene to outside databases

Previous GC identifer: GC05M134001


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM173 Gene: 
TMEM173 (transmembrane protein 173) is a protein-coding gene. Diseases associated with TMEM173 include ureterocele, and neurogenic bladder, and among its related super-pathways are Cytosolic sensors of pathogen-associated DNA and IRF3-mediated induction of type I IFN. GO annotations related to this gene include protein homodimerization activity and transcription factor binding.

UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses
and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in
response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing
and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a
messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is
alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce
expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the
translocon possibly being able to influence the induction of type I interferons. May be involved in transduction
of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates
death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000005.9  NT_029289.11  NC_018916.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the TMEM173 gene promoter:
         c-Fos   AP-1   JunB   Fra-1   FosB   Evi-1   GATA-1   POU2F1   POU2F1a   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidTMEM173 promoter sequence
   Search SABiosciences Chromatin IP Primers for TMEM173

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM173


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q31.2   Ensembl cytogenetic band:  5q31.2   HGNC cytogenetic band: 5q31.2

TMEM173 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM173 gene location

GeneLoc information about chromosome 5         GeneLoc Exon Structure

GeneLoc location for GC05M138836:  view genomic region     (about GC identifiers)

Start:
138,855,113 bp from pter      End:
138,862,520 bp from pter
Size:
7,408 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6 (See protein sequence)
Recommended Name: Stimulator of interferon genes protein  
Size: 379 amino acids; 42193 Da
Subunit: Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150
is required for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56.
Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane;
Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclear
region. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase
TBK1 is recruited
6/11 PDB 3D structures from and Proteopedia for TMEM173 (see all 11):
4EF4 (3D)        4EF5 (3D)        4EMT (3D)        4EMU (3D)        4F5D (3D)        4F5E (3D)    
Secondary accessions: A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9

Explore the universe of human proteins at neXtProt for TMEM173: NX_Q86WV6

Explore proteomics data for TMEM173 at MOPED 

Post-translational modifications:

  • UniProtKB: Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1,
    leading to activation and production of IFN-beta
  • UniProtKB: Ubiquitinated. 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and
    recruitment of the antiviral kinase TBK1 and subsequent production of IFN-beta. 'Lys-48'-linked
    polyubiquitination at Lys-150 occurring after viral infection is mediated by RNF5 and leads to proteasomal
    degradation
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q86WV6

  • TMEM173 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    TMEM173 Protein Expression
    REFSEQ proteins: NP_938023.1  
    ENSEMBL proteins: 
     ENSP00000331288   ENSP00000427455  
    Reactome Protein details: Q86WV6
    Human Recombinant Protein Products for TMEM173: 
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    Novus Biologicals TMEM173 Protein
    Novus Biologicals TMEM173 Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for TMEM173 

    Gene Ontology (GO): 5/9 cellular component terms (GO ID links to tree view) (see all 9):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005741mitochondrial outer membrane IDA18818105
    GO:0005777peroxisome IEA--
    GO:0005783endoplasmic reticulum ----
    GO:0005789endoplasmic reticulum membrane TAS--
    GO:0005794Golgi apparatus IEA--

    TMEM173 for ontologies           About GeneDecksing



    TMEM173 Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for TMEM173 

    Assay Products for TMEM173: 
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    Cloud-Clone Corp. CLIAs for TMEM173


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    ProtoNet protein and cluster: Q86WV6

    UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
    Domain: The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclic
    diguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP,
    the protein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT).
    Binding of c-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate
    both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of
    the CBD region was initially though to contain a fifth transmembrane region (TM5) but is part of the folded,
    soluble CBD (PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659)
    Similarity: Belongs to the TMEM173 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: STING_HUMAN, Q86WV6
    Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses
    and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in
    response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing
    and binding cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a
    messenger produced in response to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is
    alleviated and TMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce
    expression of type I interferon and exert a potent anti-viral state. May be involved in translocon function, the
    translocon possibly being able to influence the induction of type I interferons. May be involved in transduction
    of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates
    death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding IPI18724357
    GO:0008134transcription factor binding IDA18818105
    GO:0019901protein kinase binding IPI--
    GO:0031625ubiquitin protein ligase binding IEA--
    GO:0035438cyclic-di-GMP binding IDA--
         
    TMEM173 for ontologies           About GeneDecksing


    Phenotypes:
         3 MGI mutant phenotypes (inferred from 3 alleles(MGI details for Tmem173):
     homeostasis/metabolism  immune system  mortality/aging 

    TMEM173 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for TMEM173: Tmem173tm1Gnb Tmem173tm1Camb

       inGenious Targeting Laboratory - Custom generated mouse model solutions for TMEM173 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for TMEM173

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for TMEM173 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for TMEM173 

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM173:
    hsa-miR-3919 hsa-miR-24
    SwitchGear 3'UTR luciferase reporter plasmidTMEM173 3' UTR sequence
    Inhib. RNA
    Products:
        
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    GenScript: all cDNA clones in your preferred vector: TMEM173 (NM_198282)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM173
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    Sirion Biotech Customized lentivirus for stable overexpression of TMEM173 
                         Customized lentivirus expression plasmids for stable overexpression of TMEM173 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for TMEM173 About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Cytosolic DNA-sensing pathway
    Cytosolic DNA-sensing pathway0.36
    Cytosolic sensors of pathogen-associated DNA 0.36
    2IRF3-mediated induction of type I IFN
    IRF3-mediated induction of type I IFN0.50
    STING mediated induction of host immune responses0.43
    STAT6-mediated induction of chemokines0.50
    3Immune System
    Immune System0.56
    Innate Immune System0.50
    4RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways
    RIG-I-like receptor signaling pathway0.52
    5Regulation of innate immune responses to cytosolic DNA
    Regulation of innate immune responses to cytosolic DNA

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    2 Cell Signaling Technology (CST) Pathways for TMEM173
        Lymphocyte Signaling
    NF-kappaB Signaling

    5/7        Reactome Pathways for TMEM173 (see all 7)
        Cytosolic sensors of pathogen-associated DNA
    Regulation of innate immune responses to cytosolic DNA
    STING mediated induction of host immune responses
    STAT6-mediated induction of chemokines
    IRF3-mediated induction of type I IFN


    2         Kegg Pathways  (Kegg details for TMEM173):
        RIG-I-like receptor signaling pathway
    Cytosolic DNA-sensing pathway


    TMEM173 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM173

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/44 Interacting proteins for TMEM173 (Q86WV61, 3 ENSP000003312884) via UniProtKB, MINT, STRING, and/or I2D (see all 44)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    IFI16Q166661, 3, ENSP000003571134EBI-2800345,EBI-2867186 I2D: score=2 STRING: ENSP00000357113
    CCDC47Q96A331, 3, ENSP000002257264EBI-2800345,EBI-720151 I2D: score=1 STRING: ENSP00000225726
    DDOSTP396561, 3, ENSP000003641884EBI-2800345,EBI-358866 I2D: score=1 STRING: ENSP00000364188
    IRAK1P516171, 3, ENSP000003589974EBI-2800345,EBI-358664 I2D: score=1 STRING: ENSP00000358997
    MBOAT7Q96N661, 3, ENSP000002456154EBI-2800345,EBI-6116499 I2D: score=1 STRING: ENSP00000245615
    About this table

    Gene Ontology (GO): 5/14 biological process terms (GO ID links to tree view) (see all 14):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002218activation of innate immune response IMP18818105
    GO:0002230positive regulation of defense response to virus by host IMP18818105
    GO:0006915apoptotic process IEA--
    GO:0032092positive regulation of protein binding IDA18818105
    GO:0032479regulation of type I interferon production TAS--

    TMEM173 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for TMEM173 (STING)

    Search CenterWatch for drugs/clinical trials and news about TMEM173 / STING

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for TMEM173 gene: 
    NM_198282.2  

    Unigene Cluster for TMEM173:

    Transmembrane protein 173
    Hs.379754  [show with all ESTs]
    Unigene Representative Sequence: NM_198282
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000507297(uc003lep.3) ENST00000330794 ENST00000509573 ENST00000512606
    ENST00000503287 ENST00000511886 ENST00000502825 ENST00000510817 ENST00000514119
    ENST00000515507 ENST00000511850 ENST00000503838 ENST00000502362 ENST00000514348
    ENST00000514542
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    2 QIAGEN miScript miRNA Assays for microRNAs that regulate TMEM173:
    hsa-miR-3919 hsa-miR-24
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    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for TMEM173
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM173

    Additional mRNA sequence: 

    AK129800.1 AK290661.1 BC047779.1 FJ222241.1 

    14 DOTS entries:

    DT.319535  DT.85102793  DT.100794223  DT.100794224  DT.95153472  DT.120865796  DT.95153468  DT.100794218 
    DT.120865780  DT.95153475  DT.100794222  DT.100794226  DT.40117681  DT.97769662 

    24/261 AceView cDNA sequences (see all 261):

    BU731116 AA393113 NM_198282 BU615201 BC047779 BU684977 AA435604 AX775913 
    CA394242 BU631356 AI689302 BQ447049 AA477628 BE743722 CA313409 CA442357 
    BI522421 AK129800 BE745101 BQ181009 AA262996 BM708269 AA858156 AJ430435 

    GeneLoc Exon Structure

    5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM173 (see all 11)    About this scheme

    ExUns: 1a · 1b · 1c · 1d · 1e · 1f ^ 2a · 2b · 2c · 2d ^ 3a · 3b · 3c · 3d ^ 4a · 4b ^ 5a · 5b ^ 6a · 6b ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                      -                 -                       -                             -                                       
    SP2:                                                        -                       -     -                       -                                       
    SP3:                                      -                 -     -     -     -     -                             -                                       
    SP4:                                                        -     -     -     -     -                             -                                       
    SP5:                                                                                -                             -           -     -     -               


    ECgene alternative splicing isoforms for TMEM173

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TMEM173 expression in normal human tissues (normalized intensities)      TMEM173 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    TMEM173 Expression
    About this image


    TMEM173 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 2 entries
             Peripheral blood-derived endothelial progenitor cells
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
     
     Bone (Muscoskeletal System)
             BONE MARROW   
     
     Blood (Muscoskeletal System)
             BONE MARROW   

    See TMEM173 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for TMEM173

    SOURCE GeneReport for Unigene cluster: Hs.379754

    UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6
    Tissue specificity: Ubiquitously expressed

        SABiosciences Expression via Pathway-Focused PCR Array including TMEM173: 
              Type I Interferon Response in human mouse rat

    Primer
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM173 gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1731 , 5 transmembrane protein 1731, 5 76.95(n)1
    69.41(a)1
      18 (19.23 cM)5
    725121  NM_028261.11  NP_082537.11 
     357336785 
    chicken
    (Gallus gallus)
    Aves TMEM1731 transmembrane protein 173 55.71(n)
    45.03(a)
      768990  XM_001232170.2  XP_001232171.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1736
    Uncharacterized protein
    40(a)
    1 ↔ 1
    4(79262422-79280185)
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5708721 transmembrane protein 173-like 48.93(n)
    40.06(a)
      570872  XM_694397.5  XP_699489.3 


    ENSEMBL Gene Tree for TMEM173 (if available)
    TreeFam Gene Tree for TMEM173 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/203 SNPs in TMEM173 are shown (see all 203)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 5 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1402638071,2
    --138854755(+) TGTCCA/GTTTGC 1 -- int10--------
    rs1823258471,2
    --138855027(+) TGCATA/GTGCAG 1 -- int10--------
    rs1504354851,2
    --138855037(+) GGCAGA/GTTTGG 1 -- int10--------
    rs1381998131,2
    --138855071(+) CTGTTA/TTATCG 1 -- int10--------
    rs1861589201,2
    --138855100(+) AAAGAC/TGACAC 1 -- int10--------
    rs115547781,2
    C--138855164(-) TTATAC/TTCCAC 1 -- ut31 ese31Minor allele frequency- T:0.00NA 2
    rs152291,2
    C--138855265(+) AATCCT/CAGAGA 1 -- ut31 ese32Minor allele frequency- C:0.00MN NA 186
    rs1906240061,2
    --138855300(+) CCGGCA/GGGAGA 1 -- ut310--------
    rs1138459321,2
    C--138855340(+) GGAGCC/G/TGGGGG 2 -- ut311CSA 1
    rs1423652601,2
    --138855468(+) TTCGGC/TGTCCC 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM173 (138855113 - 138862520 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for TMEM173:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv519808CNV Loss19592680
    nsv516200CNV Loss19592680


    Human Gene Mutation Database (HGMD): TMEM173
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 612374    OMIM disorders: --

    5 diseases for TMEM173:    About MalaCards
    ureterocele    neurogenic bladder    vesicoureteral reflux    smallpox
    myelodysplastic syndromes

    4 diseases from the University of Copenhagen DISEASES database for TMEM173:
    Vesicoureteral reflux     Neurogenic bladder     Ureterocele     Hypersensitivity reaction type I disease

    TMEM173 for disorders           About GeneDecksing

    Genetic Association Database (GAD): TMEM173
    Human Genome Epidemiology (HuGE) Navigator: TMEM173 (1 document)

    Export disorders for TMEM173 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for TMEM173 gene, integrated from 9 sources (see all 43):
    (articles sorted by number of sources associating them with TMEM173)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. cGAS produces a 2'-5'-linked cyclic dinucleotide second messenger that activates STING. (PubMed id 23722158)1, 2 Ablasser A.... Hornung V. (2013)
    2. The structural basis for the sensing and binding of cy clic di-GMP by STING. (PubMed id 22728659)1, 2 Huang Y.H....Su X.D. (2012)
    3. Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. (PubMed id 22728658)1, 2 Shu C....Li P. (2012)
    4. Crystal structures of STING protein reveal basis for r ecognition of cyclic di-GMP. (PubMed id 22728660)1, 2 Shang G....Gu L. (2012)
    5. Cyclic di-GMP sensing via the innate immune signaling protein STING. (PubMed id 22705373)1, 2 Yin Q.... Wu H. (2012)
    6. The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. (PubMed id 21074459)1, 2 Tsuchida T.... Akira S. (2010)
    7. The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (PubMed id 19285439)1, 2 Zhong B....Shu H.B. (2009)
    8. Integrated genomic analysis implicates haploinsufficiency of multiple chromosome 5q31.2 genes in de novo myelodysplastic syndromes pathogenesis. (PubMed id 19240791)1, 4 Graubert T.A....Walter M.J. (2009)
    9. ISG56 is a negative-feedback regulator of virus-trigg ered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y....Shu H.B. (2009)
    10. ERIS, an endoplasmic reticulum IFN stimulator, activa tes innate immune signaling through dimerization. (PubMed id 19433799)1, 2 Sun W....Jiang Z. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 340061 HGNC: 27962 AceView: LOC340061 Ensembl:ENSG00000184584 euGenes: HUgn340061
    ECgene: TMEM173 Kegg: 340061 H-InvDB: TMEM173

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for TMEM173 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for TMEM173 gene:
    Search GeneIP for patents involving TMEM173

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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