TMEM173 Gene
protein-coding GIFtS: 51
GCID: GC05M138836
|
|
transmembrane protein 173
| |
Aliases
for TMEM173 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1731 2 3 | | HSTING1 | | STING2 3 5 | | MPYS2 5 | | NET231 2 | | FLJ385771 | | Endoplasmic Reticulum Interferon Stimulator2 3 | | Endoplasmic Reticulum IFN Stimulator2 | | Mediator Of IRF3 Activation2 3 | | Mitochondrial Mediator Of IRF3 Activation2 | | ERIS2 3 | | N-Terminal Methionine-Proline-Tyrosine-Serine Plasma Membrane Tetraspanner2 | | MITA2 3 | | Stimulator Of Interferon Genes Protein2 | | HMITA1 | | |
Export aliases for TMEM173 gene to outside databasesPrevious GC identifer: GC05M134001 |
Summaries
for TMEM173 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses andpromotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in responseto non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and bindingcyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced inresponse to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated andTMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type Iinterferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly beingable to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via itsassociation with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation ofthe extracellular signal-regulated kinase (ERK) pathway
|
Genomic Views
for TMEM173 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000005.9 NC_018916.1 NT_029289.11
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM173 gene promoter:
c-Fos AP-1 JunB Fra-1 FosB Evi-1 GATA-1 POU2F1 POU2F1a c-Jun
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM173
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM173 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 5q31.2 Ensembl cytogenetic band: 5q31.2 HGNC cytogenetic band: 5q31.2TMEM173 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 5 GeneLoc Exon Structure GeneLoc location for GC05M138836: view genomic region
(about GC identifiers)
Start:
|
138,855,113 bp from pter |
End:
|
138,862,520 bp from pter |
Size:
|
7,408 bases |
Orientation:
|
minus strand |
|
Proteins
for TMEM173 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6 (See
protein sequence)Recommended Name: Stimulator of interferon genes protein Size: 379 amino acids; 42193 Da
Subunit: Associates with the MHC-II complex (By similarity). Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 isrequired for homodimerization. Interacts with DDX58/RIG-I, MAVS and SSR2. Interacts with RNF5 and TRIM56. Interactswith TBK1; when homodimer, leading to subsequent production of IFN-beta. Interacts with IFIT1 and IFIT2
Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein. Mitochondrion outer membrane;Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein (By similarity). Cytoplasm, perinuclearregion. Note=In response to double-stranded DNA stimulation, relocalizes to perinuclear region, where the kinase TBK1is recruited
6/10 PDB 3D structures from  and Proteopedia  for TMEM173 (see all 10):4EF4 (3D)
4EF5 (3D)
4EMT (3D)
4EMU (3D)
4F5D (3D)
4F5E (3D)
Secondary accessions: A8K3P6 B6EB35 D6RBX0 D6RE01 D6RID9Explore the universe of human proteins at neXtProt for TMEM173: NX_Q86WV6
Post-translational modifications:
Phosphorylated on tyrosine residues upon MHC-II aggregation (By similarity). Phosphorylated on Ser-358 by TBK1, leadingto activation and production of IFN-beta1
Ubiquitinated. 'Lys-63'-linked ubiquitination mediated by TRIM56 at Lys-150 promotes homodimerization and recruitmentof the antiviral kinase TBK1 and subsequent production of IFN-beta. 'Lys-48'-linked polyubiquitination at Lys-150occurring after viral infection is mediated by RNF5 and leads to proteasomal degradation1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q86WV6
TMEM173 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_938023.1
ENSEMBL proteins: ENSP00000331288 ENSP00000427455 Reactome Protein details: Q86WV6
Human Recombinant Protein Products:
Gene Ontology (GO): 5/7 cellular component terms (GO ID links to tree view) (see all 7): About this table
TMEM173 for ontologies About GeneDecksing
TMEM173 Antibody Products:
Assay Products for TMEM173: |
Protein
Domains /
Families
for TMEM173 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q86WV6 UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6Domain: The c-di-GMP-binding domain (CBD) forms a homodimer via hydrophobic interactions and binds both the cyclicdiguanylate monophosphate (c-di-GMP) and the cyclic GMP-AMP (cGAMP) messengers. In absence of c-di-GMP or cGAMP, theprotein is autoinhibited by an intramolecular interaction between the CBD and the C-terminal tail (CTT). Binding ofc-di-GMP or cGAMP to the CBD releases the autoinhibition by displacing the CTT, leading to activate both NF-kappa-Band IRF3 transcription pathways to induce expression of type I interferon. The N-terminal part of the CBD region wasinitially though to contain a fifth transmembrane region (TM5) but is part of the folded, soluble CBD(PubMed:22579474, PubMed:22705373, PubMed:22728658, PubMed:22728660 and PubMed:22728659)Similarity: Belongs to the TMEM173 family |
Function
for TMEM173 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6Function: Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses andpromotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in responseto non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by recognizing and bindingcyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced inresponse to DNA virus in the cytosol: upon binding of c-di-GMP or cGAMP, autoinhibition is alleviated andTMEM173/STING is able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type Iinterferon and exert a potent anti-viral state. May be involved in translocon function, the translocon possibly beingable to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via itsassociation with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation ofthe extracellular signal-regulated kinase (ERK) pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM173 (NM_198282) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM173 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173 |
Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table
TMEM173 for ontologies About GeneDecksing
Animal Models:
Mouse knock-outs for TMEM173: Tmem173tm1Gnb Tmem173tm1Camb
3 MGI mutant phenotypes (inferred from 3 alleles ) (MGI details for Tmem173):
TMEM173 for phenotypes About GeneDecksing
|
Pathways & Interactions
for TMEM173 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Unified GeneCards pathways - 5/7 super-pathways (see all 7) About this table
See pathways by source
| Super-pathway | contained gene-specific pathways |
|---|
| 1 | Immune System | | | 2 | Lymphocyte Signaling | | | 3 | Cytosolic DNA-sensing pathway | | | 4 | NF-kappaB Signaling | | | 5 | RIP-mediated NFkB activation via DAI | |
Pathway sources
See GeneCards unified pathways
Show all pathways
2 
Cell Signaling Technology (CST) Pathways for TMEM173
4 
Reactome Pathways for TMEM173
2 
Kegg Pathways (Kegg details for TMEM173):
TMEM173 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM173
STRING Interaction
Network Preview (showing 5 interactants - click image to see 25)
5/38 Interacting proteins for TMEM173 (Q86WV61, 3 ENSP000003312884) via UniProtKB, MINT, STRING, and/or I2D (see all 38)| Interactant | Interaction Details |
|---|
| GeneCard | External ID(s) |
|---|
| IFI16 | Q166661, 3, ENSP000003571134 | EBI-2800345,EBI-2867186 I2D:
score=2 STRING: ENSP00000357113 | | CCDC47 | Q96A331, 3, ENSP000002257264 | EBI-2800345,EBI-720151 I2D:
score=1 STRING: ENSP00000225726 | | DDOST | P396561, 3, ENSP000003641884 | EBI-2800345,EBI-358866 I2D:
score=1 STRING: ENSP00000364188 | | IRAK1 | P516171, 3, ENSP000003589974 | EBI-2800345,EBI-358664 I2D:
score=1 STRING: ENSP00000358997 | | MBOAT7 | Q96N661, 3, ENSP000002456154 | EBI-2800345,EBI-6116499 I2D:
score=1 STRING: ENSP00000245615 |
About this table
Gene Ontology (GO): 5/12 biological process terms (GO ID links to tree view) (see all 12): About this table
TMEM173 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM173 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM173
Search CenterWatch for drugs/clinical trials and news about TMEM173 / STING
|
Transcripts
for TMEM173 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM173 gene: NM_198282.2 Unigene Cluster for TMEM173: Transmembrane protein 173 Hs.379754 [show with all ESTs]Unigene Representative Sequence: NM_19828215 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000507297(uc003lep.3) ENST00000330794 ENST00000509573 ENST00000512606
ENST00000503287 ENST00000511886 ENST00000502825 ENST00000510817 ENST00000514119
ENST00000515507 ENST00000511850 ENST00000503838 ENST00000502362 ENST00000514348
ENST00000514542
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM173 (NM_198282) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM173 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173 |
Additional cDNA sequence: AK129800.1 AK290661.1 BC047779.1 FJ222241.1 14 DOTS entries: DT.319535 DT.85102793 DT.100794223 DT.100794224 DT.95153472 DT.120865796 DT.95153468 DT.100794218 DT.120865780 DT.95153475 DT.100794222 DT.100794226 DT.40117681 DT.97769662 24/261 AceView cDNA sequences (see all 261): AA705005 AK129800 BU631356 AI624549 AA435604 BU684977 BI522421 AA922511 AA477628 AI689302 Z43230 AI366477 CF131970 BQ181009 CA313409 AA393113 BC047779 AW149890 BF844776 AJ430435 T31535 BX444332 BM708269 AK095896
GeneLoc Exon Structure
5/11 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM173 (see all 11) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | · | 1e | · | 1f | ^ | 2a | · | 2b | · | 2c | · | 2d | ^ | 3a | · | 3b | · | 3c | · | 3d | ^ | 4a | · | 4b | ^ | 5a | · | 5b | ^ | 6a | · | 6b | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | - | | | | | | - | | | | | | | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | | | | | | | | | | | - | | | | | | | | - | | - | | | | | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | - | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | - | | | | - | | - | | - | | | | | |
ECgene alternative splicing isoforms for TMEM173
|
Expression
for TMEM173 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM173 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM173 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM173
SOURCE GeneReport for Unigene cluster: Hs.379754
UniProtKB/Swiss-Prot: STING_HUMAN, Q86WV6Tissue specificity: Ubiquitously expressed
SABiosciences Expression via Pathway-Focused PCR Array including TMEM173: | Type I Interferon Response in human mouse rat |
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM173
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM173 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM173 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM173 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173 |
Orthologs
for TMEM173 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for TMEM173 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for TMEM173 (if available)
TreeFam Gene Tree for TMEM173 (if available) |
Paralogs
for TMEM173 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM173 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 5 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM173 (138855113 - 138862520 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM173
1 CNV: 51578
Human Gene Mutation Database (HGMD): TMEM173
| SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for TMEM173 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM173 for disorders About GeneDecksing
OMIM gene information: 612374
OMIM disorders: --
4  diseases for TMEM173: About MalaCardsvesicoureteral reflux neurogenic bladder ureterocele myelodysplastic syndrome
4 diseases from the University of Copenhagen DISEASES database for TMEM173:Vesicoureteral reflux Neurogenic bladder Ureterocele Hypersensitivity reaction type I disease Human Genome Epidemiology (HuGE) Navigator: TMEM173 (1 document)
Export disorders for TMEM173 gene to outside databases
|
Publications
for TMEM173 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM173 gene, integrated from 9 sources (see all 35):
(articles sorted by number of sources associating them with TMEM173) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The structural basis for the sensing and binding of cy clic di-GMP by STING. (PubMed id 22728659)1, 2 Huang Y.H....Su X.D. (2012)
- Structure of STING bound to cyclic di-GMP reveals the mechanism of cyclic dinucleotide recognition by the immune system. (PubMed id 22728658)1, 2 Shu C....Li P. (2012)
- Crystal structures of STING protein reveal basis for r ecognition of cyclic di-GMP. (PubMed id 22728660)1, 2 Shang G....Gu L. (2012)
- Cyclic di-GMP sensing via the innate immune signaling protein STING. (PubMed id 22705373)1, 2 Yin Q.... Wu H. (2012)
- The ubiquitin ligase TRIM56 regulates innate immune responses to intracellular double-stranded DNA. (PubMed id 21074459)1, 2 Tsuchida T.... Akira S. (2010)
- The ubiquitin ligase RNF5 regulates antiviral responses by mediating degradation of the adaptor protein MITA. (PubMed id 19285439)1, 2 Zhong B....Shu H.B. (2009)
- ISG56 is a negative-feedback regulator of virus-trigg ered signaling and cellular antiviral response. (PubMed id 19416887)1, 2 Li Y....Shu H.B. (2009)
- ERIS, an endoplasmic reticulum IFN stimulator, activa tes innate immune signaling through dimerization. (PubMed id 19433799)1, 2 Sun W....Jiang Z. (2009)
- STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling. (PubMed id 18724357)1, 2 Ishikawa H. and Barber G.N. (2008)
- The adaptor protein MITA links virus-sensing receptors to IRF3 transcription factor activation. (PubMed id 18818105)1, 2 Zhong B.... Shu H.-B. (2008)
|
External Searches for TMEM173 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM173 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM173 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM173 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM173 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM173 gene:
Search GeneIP for patents involving TMEM173
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM173 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
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| | |  | OriGene Antibodies for TMEM173 | | Browse OriGene shRNA RFPs | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM173 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM173 | | | OriGene Protein Over-expression Lysate for TMEM173 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM173 | | OriGene 3'-UTR Clone for TMEM173 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM173 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM173 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM173 | | OriGene Custom Protein Services for TMEM173 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM173 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM173 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM173 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM173 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM173 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM173 |
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| | | | Search Tocris compounds for TMEM173 |
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 | | | TMEM173 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM173 |
|  |  |  | | | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM173 |
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