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Aliases for TMEM171 Gene

Aliases for TMEM171 Gene

  • Transmembrane Protein 171 2 3 5
  • Proline-Rich Protein PRP2 3
  • Prp2 3

External Ids for TMEM171 Gene

Previous GeneCards Identifiers for TMEM171 Gene

  • GC05P072454
  • GC05P067622

Summaries for TMEM171 Gene

GeneCards Summary for TMEM171 Gene

TMEM171 (Transmembrane Protein 171) is a Protein Coding gene.

Additional gene information for TMEM171 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM171 Gene

Genomics for TMEM171 Gene

Regulatory Elements for TMEM171 Gene

Enhancers for TMEM171 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05H073029 1.2 Ensembl ENCODE 10.9 -89.1 -89094 3 PKNOX1 ARNT ZFP64 ZNF133 SIN3A FEZF1 GLIS2 FOS TSHZ1 ZNF662 ANKRA2 ENSG00000272525 UTP15 TMEM171 ENSG00000272081 FCHO2 LOC728549 GC05P073101
GH05H073114 1.1 ENCODE dbSUPER 10.9 -2.3 -2317 6 CTCF FOXA2 TAF1 MAX CEBPG RAD21 YY1 E2F1 GATA3 ZBTB48 ANKRA2 UTP15 TMEM171 TNPO1 ENSG00000249085 ARHGEF28 GC05M073090
GH05H073201 1.1 Ensembl ENCODE 10.7 +81.7 81736 0 ELF3 PKNOX1 RB1 ZNF2 ZSCAN9 RAD21 YY1 SLC30A9 ZNF143 THAP11 ANKRA2 UTP15 TMEM174 TMEM171 TNPO1 LINC01386 LOC340090 ENSG00000249743
GH05H073122 1 Ensembl ENCODE dbSUPER 11.2 +2.6 2628 1 ZNF121 POLR2A FOXP2 TMEM171 TMEM174 FCHO2 GC05P073146
GH05H073187 1 Ensembl ENCODE 10.7 +68.9 68931 2 HINFP MAX ZMYM3 CEBPG ATF7 THAP11 YY2 HCFC1 L3MBTL2 NRF1 TMEM171 LINC01386 ENSG00000184084 LOC340090 TMEM174
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM171 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM171 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000182340 308 801 ZNF202 E2F1 POLR2A ZBTB48 TARDBP NRF1 ZNF600 ZBTB26 EZH2

Genomic Location for TMEM171 Gene

Chromosome:
5
Start:
73,120,292 bp from pter
End:
73,131,817 bp from pter
Size:
11,526 bases
Orientation:
Plus strand

Genomic View for TMEM171 Gene

Genes around TMEM171 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM171 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM171 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM171 Gene

Proteins for TMEM171 Gene

  • Protein details for TMEM171 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVE6-TM171_HUMAN
    Recommended name:
    Transmembrane protein 171
    Protein Accession:
    Q8WVE6
    Secondary Accessions:
    • Q8N0S1
    • Q8TDT7

    Protein attributes for TMEM171 Gene

    Size:
    324 amino acids
    Molecular mass:
    34760 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB89327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM171 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM171 Gene

Post-translational modifications for TMEM171 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM171 Gene

No data available for DME Specific Peptides for TMEM171 Gene

Domains & Families for TMEM171 Gene

Gene Families for TMEM171 Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM171 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM171 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM171: view

No data available for UniProtKB/Swiss-Prot for TMEM171 Gene

Function for TMEM171 Gene

Phenotypes From GWAS Catalog for TMEM171 Gene

Gene Ontology (GO) - Molecular Function for TMEM171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM171: view
genes like me logo Genes that share phenotypes with TMEM171: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM171
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM171 Gene

Localization for TMEM171 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM171 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM171 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM171: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM171 Gene

Pathways & Interactions for TMEM171 Gene

SuperPathways for TMEM171 Gene

No Data Available

Gene Ontology (GO) - Biological Process for TMEM171 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM171 Gene

Drugs & Compounds for TMEM171 Gene

No Compound Related Data Available

Transcripts for TMEM171 Gene

mRNA/cDNA for TMEM171 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM171 Gene

Transmembrane protein 171:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM171
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM171 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for TMEM171 Gene

GeneLoc Exon Structure for
TMEM171
ECgene alternative splicing isoforms for
TMEM171

Expression for TMEM171 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM171 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM171 Gene

This gene is overexpressed in Colon - Transverse (x13.7), Stomach (x8.4), Thyroid (x5.6), Spleen (x4.8), Small Intestine - Terminal Ileum (x4.8), and Kidney - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM171 Gene:

TMEM171

SOURCE GeneReport for Unigene cluster for TMEM171 Gene:

Hs.162246

Evidence on tissue expression from TISSUES for TMEM171 Gene

  • Skin(4.1)
  • Nervous system(4)
genes like me logo Genes that share expression patterns with TMEM171: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM171 Gene

Orthologs for TMEM171 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM171 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM171 33 34
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia TMEM171 33 34
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Tmem171 33
  • 79.13 (n)
mouse
(Mus musculus)
Mammalia Tmem171 33 16 34
  • 78.3 (n)
dog
(Canis familiaris)
Mammalia TMEM171 33 34
  • 76.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM171 34
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM171 34
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM171 33 34
  • 58.31 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM171 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem171 33
  • 59.49 (n)
Str.19439 33
African clawed frog
(Xenopus laevis)
Amphibia Xl.25760 33
Species where no ortholog for TMEM171 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM171 Gene

ENSEMBL:
Gene Tree for TMEM171 (if available)
TreeFam:
Gene Tree for TMEM171 (if available)

Paralogs for TMEM171 Gene

No data available for Paralogs for TMEM171 Gene

Variants for TMEM171 Gene

Sequence variations from dbSNP and Humsavar for TMEM171 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs1000090262 -- 73,128,226(+) TACTT(C/T)TCTAT intron-variant
rs1000787383 -- 73,129,500(+) GGTTT(C/T)CCTTT intron-variant
rs1001441331 -- 73,121,649(+) CTTTT(A/T)TCCCT intron-variant
rs1002555479 -- 73,125,881(+) ATATT(A/G)TGGAA intron-variant
rs1002648928 -- 73,125,528(+) TGGGT(A/G)TGATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM171 Gene

Variant ID Type Subtype PubMed ID
nsv1114692 CNV deletion 24896259
nsv598641 CNV loss 21841781
nsv830344 CNV gain+loss 17160897

Variation tolerance for TMEM171 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.50; 97.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM171 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM171

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM171 Gene

Disorders for TMEM171 Gene

Relevant External Links for TMEM171

Human Genome Epidemiology (HuGE) Navigator
TMEM171
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM171

No disorders were found for TMEM171 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM171 Gene

Publications for TMEM171 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S … Mitaku S (FEBS letters 2002) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin EL … Gygi SP (Cell 2015) 3 60

Products for TMEM171 Gene

Sources for TMEM171 Gene

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