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Aliases for TMEM171 Gene

Aliases for TMEM171 Gene

  • Transmembrane Protein 171 2 3 5
  • Proline-Rich Protein PRP2 3
  • Prp2 3

External Ids for TMEM171 Gene

Previous GeneCards Identifiers for TMEM171 Gene

  • GC05P072454
  • GC05P067622

Summaries for TMEM171 Gene

GeneCards Summary for TMEM171 Gene

TMEM171 (Transmembrane Protein 171) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM171 Gene

Genomics for TMEM171 Gene

Regulatory Elements for TMEM171 Gene

Enhancers for TMEM171 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH05F073029 1.2 Ensembl ENCODE 10.9 -89.1 -89094 3.2 PKNOX1 ZFP64 ZNF133 INSM2 SIN3A FEZF1 RAD21 ZEB1 YY1 ZNF335 FCHO2 ENSG00000272081 UTP15 PTCD2 ANKRA2 TMEM171 LOC728549 GC05P073101
GH05F073114 1.1 Ensembl ENCODE 10.9 -2.3 -2317 6.5 BCOR CTCF ZMYM3 RAD21 YY1 ZNF664 E2F1 GATA3 ZBTB48 POLR2A ANKRA2 PTCD2 UTP15 TMEM171 ENSG00000249085 ARHGEF28 GC05M073090
GH05F073201 1.1 Ensembl ENCODE 10.6 +81.7 81745 0.9 ELF3 PKNOX1 ZNF48 ZSCAN9 ZNF2 RAD21 SLC30A9 ZNF143 THAP11 ZNF202 ANKRA2 PTCD2 UTP15 TMEM174 TMEM171 LINC01386 LOC340090 LOC105379032
GH05F073187 1 Ensembl ENCODE 10.7 +68.9 68931 2.5 HINFP MAX ZMYM3 ZFHX2 EGR2 THAP11 YY2 HCFC1 L3MBTL2 NR2F1 TMEM171 UTP15 LINC01386 RPL7P22 ENSG00000184084 LOC340090 TMEM174
GH05F073369 1 Ensembl ENCODE 10.1 +250.7 250665 3.4 GTF2F1 PKNOX1 TAF1 JUN SIN3A ZNF384 FEZF1 FOS MAFK ZBTB20 LINC01386 TMEM171 BTF3 ENSG00000249149 GC05P073339
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM171 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM171 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001282592 308 1601 ZNF202 BCOR NRF1 CBX2 ZMYM3 RAD21 NR2F2 YY1 E2F1 ZBTB48

Genomic Location for TMEM171 Gene

Chromosome:
5
Start:
73,120,292 bp from pter
End:
73,131,817 bp from pter
Size:
11,526 bases
Orientation:
Plus strand

Genomic View for TMEM171 Gene

Genes around TMEM171 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM171 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM171 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM171 Gene

Proteins for TMEM171 Gene

  • Protein details for TMEM171 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVE6-TM171_HUMAN
    Recommended name:
    Transmembrane protein 171
    Protein Accession:
    Q8WVE6
    Secondary Accessions:
    • Q8N0S1
    • Q8TDT7

    Protein attributes for TMEM171 Gene

    Size:
    324 amino acids
    Molecular mass:
    34760 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=BAB89327.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM171 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM171 Gene

Post-translational modifications for TMEM171 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for TMEM171 Gene

No data available for DME Specific Peptides for TMEM171 Gene

Domains & Families for TMEM171 Gene

Protein Domains for TMEM171 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM171 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM171: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM171 Gene

Function for TMEM171 Gene

Gene Ontology (GO) - Molecular Function for TMEM171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with TMEM171: view
genes like me logo Genes that share phenotypes with TMEM171: view

Animal Model Products

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for TMEM171 Gene

Localization for TMEM171 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM171 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM171 gene
Compartment Confidence
plasma membrane 3

Gene Ontology (GO) - Cellular Components for TMEM171 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM171: view

Pathways & Interactions for TMEM171 Gene

SuperPathways for TMEM171 Gene

No Data Available

Interacting Proteins for TMEM171 Gene

Gene Ontology (GO) - Biological Process for TMEM171 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM171 Gene

Transcripts for TMEM171 Gene

mRNA/cDNA for TMEM171 Gene

(3) REFSEQ mRNAs :
(2) Additional mRNA sequences :
(21) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM171 Gene

Transmembrane protein 171:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM171 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4
SP1:
SP2:

Relevant External Links for TMEM171 Gene

GeneLoc Exon Structure for
TMEM171
ECgene alternative splicing isoforms for
TMEM171

Expression for TMEM171 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM171 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM171 Gene

This gene is overexpressed in Colon - Transverse (x13.7), Stomach (x8.4), Thyroid (x5.6), Spleen (x4.8), Small Intestine - Terminal Ileum (x4.8), and Kidney - Cortex (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of TMEM171 Gene:

TMEM171

SOURCE GeneReport for Unigene cluster for TMEM171 Gene:

Hs.162246
genes like me logo Genes that share expression patterns with TMEM171: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM171 Gene

Orthologs for TMEM171 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM171 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM171 34 35
  • 99.59 (n)
cow
(Bos Taurus)
Mammalia TMEM171 34 35
  • 81.36 (n)
rat
(Rattus norvegicus)
Mammalia Tmem171 34
  • 79.13 (n)
mouse
(Mus musculus)
Mammalia Tmem171 34 16 35
  • 78.3 (n)
dog
(Canis familiaris)
Mammalia TMEM171 34 35
  • 76.38 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM171 35
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM171 35
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM171 34 35
  • 58.31 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM171 35
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem171 34
  • 59.49 (n)
Str.19439 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.25760 34
Species where no ortholog for TMEM171 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)
  • zebrafish (Danio rerio)

Evolution for TMEM171 Gene

ENSEMBL:
Gene Tree for TMEM171 (if available)
TreeFam:
Gene Tree for TMEM171 (if available)

Paralogs for TMEM171 Gene

No data available for Paralogs for TMEM171 Gene

Variants for TMEM171 Gene

Sequence variations from dbSNP and Humsavar for TMEM171 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs10452487 -- 73,127,618(+) ctttg(C/T)atttt intron-variant
rs1083428 -- 73,130,948(+) AACTC(C/T)CATAT intron-variant
rs10942549 -- 73,130,310(+) GAGCA(C/G)GGCTG intron-variant
rs111458929 -- 73,128,689(+) CGAAA(C/T)TTGGG intron-variant
rs111666271 -- 73,120,952(+) GTGCT(A/G)TGAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM171 Gene

Variant ID Type Subtype PubMed ID
nsv1114692 CNV deletion 24896259
nsv598641 CNV loss 21841781
nsv830344 CNV gain+loss 17160897

Variation tolerance for TMEM171 Gene

Residual Variation Intolerance Score: 86.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.50; 97.18% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM171 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM171

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM171 Gene

Disorders for TMEM171 Gene

Relevant External Links for TMEM171

Human Genome Epidemiology (HuGE) Navigator
TMEM171
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM171

No disorders were found for TMEM171 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM171 Gene

Publications for TMEM171 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  3. Identification of G protein-coupled receptor genes from the human genome sequence. (PMID: 12044878) Takeda S. … Mitaku S. (FEBS Lett. 2002) 3 4 64
  4. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 64
  5. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 64

Products for TMEM171 Gene

Sources for TMEM171 Gene

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