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Aliases for TMEM170B Gene

Aliases for TMEM170B Gene

  • Transmembrane Protein 170B 2 3 5

External Ids for TMEM170B Gene

Previous GeneCards Identifiers for TMEM170B Gene

  • GC06P011645
  • GC06P011538
  • GC06P011471

Summaries for TMEM170B Gene

GeneCards Summary for TMEM170B Gene

TMEM170B (Transmembrane Protein 170B) is a Protein Coding gene. An important paralog of this gene is TMEM170A.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170B Gene

Genomics for TMEM170B Gene

Regulatory Elements for TMEM170B Gene

Enhancers for TMEM170B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06G011495 1.6 FANTOM5 Ensembl ENCODE 46.2 -41.5 -41495 2.2 PKNOX1 MLX ARNT WRNIP1 ARID4B SIN3A BRCA1 YY1 SLC30A9 ZNF766 TMEM170B ENSG00000247925 NEDD9 PIR46736 RNU1-64P
GH06G011519 1.5 FANTOM5 Ensembl ENCODE dbSUPER 34.4 -18.4 -18429 1.3 PKNOX1 MTA2 GATAD2B DPF2 TBX21 ARID3A EED IKZF1 TARDBP ETV6 TMEM170B NEDD9 HIVEP1 THAP12P5
GH06G011322 1.9 FANTOM5 Ensembl ENCODE dbSUPER 23.2 -214.5 -214476 2.7 HDGF PKNOX1 MLX ARID4B DMAP1 ZNF48 YY1 SLC30A9 ZNF207 MXD4 TMEM170B NEDD9 MAK C6orf52 LOC105374925 GC06M011330
GH06G011205 1.9 FANTOM5 Ensembl ENCODE dbSUPER 20.6 -322.5 -322465 19.9 HNRNPUL1 HDGF PKNOX1 FOXA2 MLX ZFP64 ARID4B SIN3A DMAP1 FEZF1 TMEM170B ENSG00000247925 NEDD9 MAK GC06M011208 LOC105374925
GH06G011585 1.6 FANTOM5 Ensembl ENCODE dbSUPER 22.4 +51.1 51064 8.3 RAD21 RFX5 YY1 SCRT2 ZNF143 MIXL1 ZNF654 CEBPB REST TBX21 TMEM170B EDN1 PIR31990 ENSG00000271897
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM170B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM170B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000193162 -96 2601 HDGF HNRNPUL1 PKNOX1 MLX ARID4B DMAP1 ZBTB7B YY1 ZNF143 ZNF207

Genomic Location for TMEM170B Gene

Chromosome:
6
Start:
11,538,196 bp from pter
End:
11,583,524 bp from pter
Size:
45,329 bases
Orientation:
Plus strand

Genomic View for TMEM170B Gene

Genes around TMEM170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170B Gene

Proteins for TMEM170B Gene

  • Protein details for TMEM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4T1-T170B_HUMAN
    Recommended name:
    Transmembrane protein 170B
    Protein Accession:
    Q5T4T1

    Protein attributes for TMEM170B Gene

    Size:
    132 amino acids
    Molecular mass:
    14360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM170B Gene

Post-translational modifications for TMEM170B Gene

  • Glycosylation at Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM170B Gene

Domains & Families for TMEM170B Gene

Protein Domains for TMEM170B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4T1

UniProtKB/Swiss-Prot:

T170B_HUMAN :
  • Belongs to the TMEM170 family.
Family:
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170B: view

No data available for Gene Families for TMEM170B Gene

Function for TMEM170B Gene

Animal Model Products

CRISPR Products

miRNA for TMEM170B Gene

Inhibitory RNA Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM170B Gene

Localization for TMEM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM170B gene
Compartment Confidence
plasma membrane 2
extracellular 2
cytoskeleton 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM170B: view

Pathways & Interactions for TMEM170B Gene

SuperPathways for TMEM170B Gene

No Data Available

Interacting Proteins for TMEM170B Gene

Gene Ontology (GO) - Biological Process for TMEM170B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM170B Gene

Drugs & Compounds for TMEM170B Gene

No Compound Related Data Available

Transcripts for TMEM170B Gene

mRNA/cDNA for TMEM170B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM170B Gene

Transmembrane protein 170B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170B Gene

No ASD Table

Relevant External Links for TMEM170B Gene

GeneLoc Exon Structure for
TMEM170B
ECgene alternative splicing isoforms for
TMEM170B

Expression for TMEM170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM170B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM170B Gene:

TMEM170B

SOURCE GeneReport for Unigene cluster for TMEM170B Gene:

Hs.146317
genes like me logo Genes that share expression patterns with TMEM170B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM170B Gene

Orthologs for TMEM170B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM170B 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia TMEM170B 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM170B 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM170B 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Tmem170b 34 16 35
  • 91.16 (n)
rat
(Rattus norvegicus)
Mammalia Tmem170b 34
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM170B 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM170B 34 35
  • 86.11 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM170B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170b 34
  • 79.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536306 34
  • 70.93 (n)
tmem170b 35
  • 59 (a)
OneToMany
TMEM170B (2 of 2) 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12341 35
  • 38 (a)
OneToMany
Species where no ortholog for TMEM170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170B Gene

ENSEMBL:
Gene Tree for TMEM170B (if available)
TreeFam:
Gene Tree for TMEM170B (if available)

Paralogs for TMEM170B Gene

Paralogs for TMEM170B Gene

(1) SIMAP similar genes for TMEM170B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM170B: view

Variants for TMEM170B Gene

Sequence variations from dbSNP and Humsavar for TMEM170B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs1000002795 -- 11,563,091(+) TAGCA(C/T)TTTGA intron-variant
rs1000026837 -- 11,567,106(+) GGTGG(A/G)GGCAG intron-variant
rs1000051631 -- 11,562,831(+) ATATC(C/T)ACCAC intron-variant
rs1000057842 -- 11,567,348(+) GGGGC(A/G)GCTCA intron-variant
rs1000282397 -- 11,561,455(+) CTTTT(C/G)CTCTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170B Gene

Variant ID Type Subtype PubMed ID
dgv3271n106 CNV deletion 24896259
esv1451399 CNV deletion 17803354
esv2007122 CNV deletion 18987734
esv2514109 CNV deletion 19546169
esv2526594 CNV deletion 19546169
esv2731593 CNV deletion 23290073
esv3032 CNV loss 18987735
esv3288384 CNV deletion 24192839
esv3567277 CNV deletion 23714750
esv9101 CNV loss 19470904
esv990232 CNV deletion 20482838
nsv1015234 CNV loss 25217958
nsv1071785 CNV deletion 25765185
nsv1152252 CNV deletion 26484159
nsv5200 CNV insertion 18451855
nsv600989 CNV loss 21841781
nsv950769 CNV duplication 24416366
nsv956949 CNV deletion 24416366

Variation tolerance for TMEM170B Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM170B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170B Gene

Disorders for TMEM170B Gene

Relevant External Links for TMEM170B

Genetic Association Database (GAD)
TMEM170B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM170B

No disorders were found for TMEM170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM170B Gene

Publications for TMEM170B Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 46 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for TMEM170B Gene

Sources for TMEM170B Gene

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