Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM170B Gene

Aliases for TMEM170B Gene

  • Transmembrane Protein 170B 2 3 5

External Ids for TMEM170B Gene

Previous GeneCards Identifiers for TMEM170B Gene

  • GC06P011645
  • GC06P011538
  • GC06P011471

Summaries for TMEM170B Gene

GeneCards Summary for TMEM170B Gene

TMEM170B (Transmembrane Protein 170B) is a Protein Coding gene. An important paralog of this gene is TMEM170A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170B Gene

Genomics for TMEM170B Gene

Regulatory Elements for TMEM170B Gene

Enhancers for TMEM170B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH06F011494 1.2 FANTOM5 Ensembl ENCODE 46.2 -41.9 -41871 3.8 PKNOX1 ARNT MLX WRNIP1 ARID4B SIN3A BRCA1 YY1 SLC30A9 ZNF766 TMEM170B ENSG00000247925 ENSG00000233656 NEDD9 RNU1-64P PIR46736
GH06F011519 1.3 FANTOM5 Ensembl ENCODE 34.4 -18.4 -18396 1.6 PKNOX1 MTA2 TARDBP IKZF1 ETV6 TBX21 SPI1 TMEM170B NEDD9 HIVEP1 THAP12P5
GH06F011491 0.8 Ensembl ENCODE 34.2 -45.6 -45595 1.6 HDGF TBL1XR1 WRNIP1 CHD4 CEBPG EBF1 HBP1 ZFHX2 EGR1 CBX5 TMEM170B ENSG00000247925 ENSG00000233656 PIR46736 RNU1-64P
GH06F011524 1.1 Ensembl ENCODE 29.5 -11.9 -11931 2.7 CTCF MAX MAFG CEBPB EP300 PPARG YY1 ZNF316 ATF3 CEBPA TMEM170B ELOVL2 ELOVL2-AS1 THAP12P5
GH06F011514 0.2 ENCODE 28.6 -23.3 -23343 0.6 TBP CHD4 BMI1 EBF1 YY1 RELA CBX5 EED ETV6 CREM TMEM170B THAP12P5
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around TMEM170B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM170B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001211019 4 3201 PKNOX1 MLX ARID4B DMAP1 YY1 ZNF143 ZNF207 ZNF263 SP3 SP5

Genomic Location for TMEM170B Gene

Chromosome:
6
Start:
11,538,196 bp from pter
End:
11,583,524 bp from pter
Size:
45,329 bases
Orientation:
Plus strand

Genomic View for TMEM170B Gene

Genes around TMEM170B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM170B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170B Gene

Proteins for TMEM170B Gene

  • Protein details for TMEM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4T1-T170B_HUMAN
    Recommended name:
    Transmembrane protein 170B
    Protein Accession:
    Q5T4T1

    Protein attributes for TMEM170B Gene

    Size:
    132 amino acids
    Molecular mass:
    14360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM170B Gene

Post-translational modifications for TMEM170B Gene

  • Glycosylation at Asn 12
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM170B Gene

Domains & Families for TMEM170B Gene

Protein Domains for TMEM170B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4T1

UniProtKB/Swiss-Prot:

T170B_HUMAN :
  • Belongs to the TMEM170 family.
Family:
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170B: view

No data available for Gene Families for TMEM170B Gene

Function for TMEM170B Gene

Animal Model Products

miRNA for TMEM170B Gene

Inhibitory RNA Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM170B Gene

Localization for TMEM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM170B Gene COMPARTMENTS Subcellular localization image for TMEM170B gene
Compartment Confidence
cytoskeleton 2
extracellular 2
plasma membrane 2
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for TMEM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM170B: view

Pathways & Interactions for TMEM170B Gene

SuperPathways for TMEM170B Gene

No Data Available

Interacting Proteins for TMEM170B Gene

Gene Ontology (GO) - Biological Process for TMEM170B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM170B Gene

Transcripts for TMEM170B Gene

mRNA/cDNA for TMEM170B Gene

(1) REFSEQ mRNAs :
(0) Additional mRNA sequences :
-
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM170B Gene

Transmembrane protein 170B:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170B Gene

No ASD Table

Relevant External Links for TMEM170B Gene

GeneLoc Exon Structure for
TMEM170B
ECgene alternative splicing isoforms for
TMEM170B

Expression for TMEM170B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for TMEM170B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM170B Gene:

TMEM170B

SOURCE GeneReport for Unigene cluster for TMEM170B Gene:

Hs.146317
genes like me logo Genes that share expression patterns with TMEM170B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for TMEM170B Gene

Orthologs for TMEM170B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM170B 34 35
  • 100 (n)
cow
(Bos Taurus)
Mammalia TMEM170B 35
  • 96 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM170B 35
  • 93 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM170B 34 35
  • 91.41 (n)
mouse
(Mus musculus)
Mammalia Tmem170b 34 16 35
  • 91.16 (n)
rat
(Rattus norvegicus)
Mammalia Tmem170b 34
  • 88.89 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM170B 35
  • 58 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM170B 34 35
  • 86.11 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM170B 35
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170b 34
  • 79.04 (n)
zebrafish
(Danio rerio)
Actinopterygii LOC100536306 34
  • 70.93 (n)
tmem170b 35
  • 59 (a)
OneToMany
TMEM170B (2 of 2) 35
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12341 35
  • 38 (a)
OneToMany
Species where no ortholog for TMEM170B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170B Gene

ENSEMBL:
Gene Tree for TMEM170B (if available)
TreeFam:
Gene Tree for TMEM170B (if available)

Paralogs for TMEM170B Gene

Paralogs for TMEM170B Gene

(1) SIMAP similar genes for TMEM170B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM170B: view

Variants for TMEM170B Gene

Sequence variations from dbSNP and Humsavar for TMEM170B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs10046197 -- 11,559,142(+) ttcct(A/G)tgatt intron-variant
rs10456073 -- 11,570,244(+) ATTCC(C/T)AAACT intron-variant
rs10537142 -- 11,568,431(+) GTGTA(-/AT/TA)TATAT intron-variant
rs10947402 -- 11,545,678(+) actgg(C/T)ttatg intron-variant
rs10947403 -- 11,550,235(+) TGGCG(C/T)AGTCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170B Gene

Variant ID Type Subtype PubMed ID
dgv3271n106 CNV deletion 24896259
esv1451399 CNV deletion 17803354
esv2007122 CNV deletion 18987734
esv2514109 CNV deletion 19546169
esv2526594 CNV deletion 19546169
esv2731593 CNV deletion 23290073
esv3032 CNV loss 18987735
esv3288384 CNV deletion 24192839
esv3567277 CNV deletion 23714750
esv9101 CNV loss 19470904
esv990232 CNV deletion 20482838
nsv1015234 CNV loss 25217958
nsv1071785 CNV deletion 25765185
nsv1152252 CNV deletion 26484159
nsv5200 CNV insertion 18451855
nsv600989 CNV loss 21841781
nsv950769 CNV duplication 24416366
nsv956949 CNV deletion 24416366

Variation tolerance for TMEM170B Gene

Residual Variation Intolerance Score: 49% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.19; 4.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM170B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170B Gene

Disorders for TMEM170B Gene

Relevant External Links for TMEM170B

Genetic Association Database (GAD)
TMEM170B
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM170B

No disorders were found for TMEM170B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM170B Gene

Publications for TMEM170B Gene

  1. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 46 64
  2. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3 64
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4 64

Products for TMEM170B Gene

Sources for TMEM170B Gene

Content
Loading form....