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Aliases for TMEM170B Gene

Aliases for TMEM170B Gene

  • Transmembrane Protein 170B 2 3

External Ids for TMEM170B Gene

Previous GeneCards Identifiers for TMEM170B Gene

  • GC06P011645
  • GC06P011538
  • GC06P011471

Summaries for TMEM170B Gene

GeneCards Summary for TMEM170B Gene

TMEM170B (Transmembrane Protein 170B) is a Protein Coding gene. An important paralog of this gene is TMEM170A.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170B Gene

Genomics for TMEM170B Gene

Regulatory Elements for TMEM170B Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM170B Gene

Start:
11,538,227 bp from pter
End:
11,583,524 bp from pter
Size:
45,298 bases
Orientation:
Plus strand

Genomic View for TMEM170B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM170B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170B Gene

Proteins for TMEM170B Gene

  • Protein details for TMEM170B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T4T1-T170B_HUMAN
    Recommended name:
    Transmembrane protein 170B
    Protein Accession:
    Q5T4T1
    Secondary Accessions:

    Protein attributes for TMEM170B Gene

    Size:
    132 amino acids
    Molecular mass:
    14360 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM170B Gene

Proteomics data for TMEM170B Gene at MOPED

Post-translational modifications for TMEM170B Gene

  • Glycosylation at Asn12
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM170B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM170B Gene

Domains for TMEM170B Gene

Protein Domains for TMEM170B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM170B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T4T1

UniProtKB/Swiss-Prot:

T170B_HUMAN :
  • Q5T4T1
Family:
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170B: view

No data available for Gene Families for TMEM170B Gene

Function for TMEM170B Gene

Animal Model Products

CRISPR Products

miRNA for TMEM170B Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM170B

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM170B Gene

Localization for TMEM170B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170B Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM170B Gene COMPARTMENTS Subcellular localization image for TMEM170B gene
Compartment Confidence
extracellular 2
plasma membrane 2
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM170B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM170B: view

Pathways for TMEM170B Gene

SuperPathways for TMEM170B Gene

No Data Available

Interacting Proteins for TMEM170B Gene

Gene Ontology (GO) - Biological Process for TMEM170B Gene

None

No data available for Pathways by source for TMEM170B Gene

Transcripts for TMEM170B Gene

mRNA/cDNA for TMEM170B Gene

(0) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for TMEM170B Gene

Transmembrane protein 170B:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM170B

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for TMEM170B
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170B Gene

No ASD Table

Relevant External Links for TMEM170B Gene

GeneLoc Exon Structure for
TMEM170B
ECgene alternative splicing isoforms for
TMEM170B

Expression for TMEM170B Gene

mRNA expression in normal human tissues for TMEM170B Gene

SOURCE GeneReport for Unigene cluster for TMEM170B Gene Hs.146317

genes like me logo Genes that share expressions with TMEM170B: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein expression and mRNA Expression by UniProt/SwissProt for TMEM170B Gene

Orthologs for TMEM170B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM170B 35
  • 100 (n)
  • 100 (a)
TMEM170B 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM170B 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM170B 35
  • 91.41 (n)
  • 99.24 (a)
TMEM170B 36
  • 61 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem170b 35
  • 91.16 (n)
  • 97.73 (a)
Tmem170b 16
Tmem170b 36
  • 98 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM170B 36
  • 58 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM170B 36
  • 93 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem170b 35
  • 88.89 (n)
  • 96.97 (a)
chicken
(Gallus gallus)
Aves TMEM170B 35
  • 86.11 (n)
  • 93.18 (a)
TMEM170B 36
  • 93 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM170B 36
  • 92 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170b 35
  • 79.04 (n)
  • 88.64 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC100536306 35
  • 70.93 (n)
  • 72.8 (a)
tmem170b 36
  • 59 (a)
OneToMany
TMEM170B (2 of 2) 36
  • 59 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG12341 36
  • 38 (a)
OneToMany
Species with no ortholog for TMEM170B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170B Gene

ENSEMBL:
Gene Tree for TMEM170B (if available)
TreeFam:
Gene Tree for TMEM170B (if available)

Paralogs for TMEM170B Gene

Paralogs for TMEM170B Gene

Selected SIMAP similar genes for TMEM170B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM170B: view

Variants for TMEM170B Gene

Sequence variations from dbSNP and Humsavar for TMEM170B Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs295051 -- 11,579,496(+) GTTTT(A/G)TAAAA utr-variant-3-prime
rs295052 -- 11,582,399(-) GTCAC(A/T)GGTGA utr-variant-3-prime
rs295053 -- 11,583,880(-) GCCTC(A/G)CACCT downstream-variant-500B
rs471560 -- 11,555,679(+) tgtct(A/G)cttct intron-variant
rs471752 -- 11,546,264(+) ttaga(A/G)gtaga intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170B Gene

Variant ID Type Subtype PubMed ID
esv2514109 CNV Deletion 19546169
esv990232 CNV Deletion 20482838
esv2007122 CNV Deletion 18987734
esv3032 CNV Deletion 18987735
esv2731593 CNV Deletion 23290073
esv9101 CNV Loss 19470904
esv1451399 CNV Deletion 17803354
esv2526594 CNV Deletion 19546169
nsv5200 CNV Insertion 18451855

Relevant External Links for TMEM170B Gene

HapMap Linkage Disequilibrium report
TMEM170B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170B Gene

Disorders for TMEM170B Gene

Relevant External Links for TMEM170B

Genetic Association Database (GAD)
TMEM170B
genes like me logo Genes that share disorders with TMEM170B: view

No data available for UniProtKB/Swiss-Prot for TMEM170B Gene

Publications for TMEM170B Gene

  1. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  2. Genome-wide association and linkage analyses of hemostatic factors and hematological phenotypes in the Framingham Heart Study. (PMID: 17903294) Yang Q. … O'Donnell C.J. (BMC Med. Genet. 2007) 48
  3. The DNA sequence and analysis of human chromosome 6. (PMID: 14574404) Mungall A.J. … Beck S. (Nature 2003) 4

Products for TMEM170B Gene

Sources for TMEM170B Gene

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