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Aliases for TMEM170A Gene

Aliases for TMEM170A Gene

  • Transmembrane Protein 170A 2 3 5
  • Transmembrane Protein 170 2 3
  • TMEM170 3 4

External Ids for TMEM170A Gene

Previous HGNC Symbols for TMEM170A Gene

  • TMEM170

Previous GeneCards Identifiers for TMEM170A Gene

  • GC16M074039
  • GC16M075476
  • GC16M061232

Summaries for TMEM170A Gene

GeneCards Summary for TMEM170A Gene

TMEM170A (Transmembrane Protein 170A) is a Protein Coding gene. An important paralog of this gene is TMEM170B.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170A Gene

Genomics for TMEM170A Gene

Regulatory Elements for TMEM170A Gene

Promoters for TMEM170A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM170A on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM170A Gene

75,443,054 bp from pter
75,465,497 bp from pter
22,444 bases
Minus strand

Genomic View for TMEM170A Gene

Genes around TMEM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170A Gene

Proteins for TMEM170A Gene

  • Protein details for TMEM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 170A
    Protein Accession:
    Secondary Accessions:
    • B2R4R3
    • B4DPS4
    • D3DUK2
    • Q7Z6F3

    Protein attributes for TMEM170A Gene

    144 amino acids
    Molecular mass:
    15250 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for TMEM170A Gene


neXtProt entry for TMEM170A Gene

Proteomics data for TMEM170A Gene at MOPED

Post-translational modifications for TMEM170A Gene

  • Ubiquitination at Lys 23
  • Glycosylation at Asn 30 and Asn 36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM170A Gene

Domains & Families for TMEM170A Gene

Protein Domains for TMEM170A Gene


Suggested Antigen Peptide Sequences for TMEM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM170 family.
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170A: view

No data available for Gene Families for TMEM170A Gene

Function for TMEM170A Gene

genes like me logo Genes that share phenotypes with TMEM170A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM170A

CRISPR Products

miRNA for TMEM170A Gene

miRTarBase miRNAs that target TMEM170A

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM170A Gene

Localization for TMEM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170A Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM170A Gene COMPARTMENTS Subcellular localization image for TMEM170A gene
Compartment Confidence
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM170A: view

Pathways & Interactions for TMEM170A Gene

SuperPathways for TMEM170A Gene

No Data Available

Interacting Proteins for TMEM170A Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
Selected Interacting proteins: ENSP00000454404 for TMEM170A Gene via STRING

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM170A Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM170A Gene

Drugs & Compounds for TMEM170A Gene

No Compound Related Data Available

Transcripts for TMEM170A Gene

Unigene Clusters for TMEM170A Gene

Transmembrane protein 170A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -

Relevant External Links for TMEM170A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM170A Gene

mRNA expression in normal human tissues for TMEM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM170A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM170A Gene

SOURCE GeneReport for Unigene cluster for TMEM170A Gene Hs.487510

genes like me logo Genes that share expression patterns with TMEM170A: view

Protein tissue co-expression partners for TMEM170A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM170A Gene

Orthologs for TMEM170A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia TMEM170A 35
  • 92.84 (n)
  • 97.52 (a)
TMEM170A 36
  • 98 (a)
(Canis familiaris)
Mammalia TMEM170A 35
  • 95.14 (n)
  • 96.53 (a)
(Mus musculus)
Mammalia Tmem170 35
  • 91.9 (n)
  • 95.83 (a)
Tmem170 16
Tmem170 36
  • 96 (a)
(Pan troglodytes)
Mammalia TMEM170A 35
  • 99.07 (n)
  • 99.31 (a)
TMEM170A 36
  • 99 (a)
(Rattus norvegicus)
Mammalia Tmem170a 35
  • 92.13 (n)
  • 95.83 (a)
(Monodelphis domestica)
Mammalia -- 36
  • 97 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 83 (a)
(Gallus gallus)
Aves TMEM170A 35
  • 77.86 (n)
  • 86.72 (a)
TMEM170A 36
  • 83 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 69 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170a 35
  • 73.13 (n)
  • 88.37 (a)
(Danio rerio)
Actinopterygii tmem170a 35
  • 59.9 (n)
  • 66.41 (a)
tmem170a 36
  • 61 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005150 35
  • 53.09 (n)
  • 49.07 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG12341 35
  • 52.91 (n)
  • 51.38 (a)
CG12341 36
  • 45 (a)
Species with no ortholog for TMEM170A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170A Gene

Gene Tree for TMEM170A (if available)
Gene Tree for TMEM170A (if available)

Paralogs for TMEM170A Gene

Paralogs for TMEM170A Gene

(1) SIMAP similar genes for TMEM170A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM170A: view

Variants for TMEM170A Gene

Sequence variations from dbSNP and Humsavar for TMEM170A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1540 -- 75,447,287(+) GCTTG(A/C/G)GTAAA utr-variant-3-prime
rs37586 -- 75,443,816(+) AAGCA(C/T)GATGG utr-variant-3-prime
rs37591 -- 75,462,644(+) ctata(A/C)aacaa intron-variant
rs37592 -- 75,462,893(+) tcatg(C/G)ataga intron-variant
rs37593 -- 75,463,009(+) CTACA(C/T)CTAAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170A Gene

Variant ID Type Subtype PubMed ID
dgv902e1 CNV Complex 17122850
nsv521596 CNV Loss 19592680
nsv525955 CNV Loss 19592680
esv2714709 CNV Deletion 23290073
nsv457521 CNV Gain 19166990

Variation tolerance for TMEM170A Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM170A Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170A Gene

Disorders for TMEM170A Gene

Relevant External Links for TMEM170A

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM170A Gene

Publications for TMEM170A Gene

  1. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3
  4. Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk. (PMID: 23152477) Gertow K. … Hamsten A. (Circ Cardiovasc Genet 2012) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM170A Gene

Sources for TMEM170A Gene

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