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Aliases for TMEM170A Gene

Aliases for TMEM170A Gene

  • Transmembrane Protein 170A 2 3 5
  • Transmembrane Protein 170 2 3
  • TMEM170 3 4

External Ids for TMEM170A Gene

Previous HGNC Symbols for TMEM170A Gene

  • TMEM170

Previous GeneCards Identifiers for TMEM170A Gene

  • GC16M074039
  • GC16M075476
  • GC16M061232

Summaries for TMEM170A Gene

GeneCards Summary for TMEM170A Gene

TMEM170A (Transmembrane Protein 170A) is a Protein Coding gene. An important paralog of this gene is ENSG00000261717.

UniProtKB/Swiss-Prot for TMEM170A Gene

  • Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM170A Gene

Genomics for TMEM170A Gene

Regulatory Elements for TMEM170A Gene

Enhancers for TMEM170A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G075482 1.4 ENCODE dbSUPER 6.3 -19.6 -19645 4.6 HDGF FOXA2 PKNOX1 ARNT CREB3L1 MLX ZFP64 ARID4B SIN3A DMAP1 ENSG00000261783 CHST5 TMEM231 GLG1 TMEM170A BCAR1 ENSG00000203472 CHST6
GH16G075260 1.9 FANTOM5 Ensembl ENCODE dbSUPER 4.5 +200.8 200764 7.9 HDGF PKNOX1 MLX ARID4B SIN3A YBX1 FEZF1 DMAP1 ZNF2 YY1 BCAR1 ENSG00000259972 CTRB2 ENSG00000261783 TMEM170A TERF2IP LOC105371344
GH16G075564 1.5 FANTOM5 ENCODE 4.9 -100.7 -100749 3.2 HDGF PKNOX1 ARNT ARID4B SIN3A FEZF1 DMAP1 ZBTB7B YY1 ZNF143 TMEM231 TMEM170A GABARAPL2 ENSG00000276408
GH16G075459 0.9 Ensembl ENCODE 6.3 +4.8 4839 1.6 PHF8 SP5 SAP130 ZMYM3 RBBP5 POLR2A GABPB1 MBD1 CREB1 KDM1A ENSG00000261783 TMEM170A ENSG00000261717 ENSG00000261476
GH16G075732 0.9 Ensembl ENCODE 4.7 -268.2 -268190 1.7 HDAC1 KLF1 ZNF680 ZNF217 ZFHX2 GATA3 EGR1 PBX2 IKZF1 KDM1A ADAT1 TMEM170A CPHXL GC16P075766
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM170A on UCSC Golden Path with GeneCards custom track

Promoters for TMEM170A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000088007 637 1801 HDGF HNRNPUL1 PKNOX1 MLX CREB3L1 WRNIP1 SIN3A ARID4B DMAP1 FEZF1

Genomic Location for TMEM170A Gene

Chromosome:
16
Start:
75,443,054 bp from pter
End:
75,465,497 bp from pter
Size:
22,444 bases
Orientation:
Minus strand

Genomic View for TMEM170A Gene

Genes around TMEM170A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM170A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM170A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM170A Gene

Proteins for TMEM170A Gene

  • Protein details for TMEM170A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WVE7-T170A_HUMAN
    Recommended name:
    Transmembrane protein 170A
    Protein Accession:
    Q8WVE7
    Secondary Accessions:
    • B2R4R3
    • B4DPS4
    • D3DUK2
    • Q7Z6F3

    Protein attributes for TMEM170A Gene

    Size:
    144 amino acids
    Molecular mass:
    15250 Da
    Quaternary structure:
    • Interacts with RTN4 (PubMed:26906412).

    Alternative splice isoforms for TMEM170A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for TMEM170A Gene

Post-translational modifications for TMEM170A Gene

  • Ubiquitination at Lys23
  • Glycosylation at isoforms=230 and Asn36
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM170A Gene

Domains & Families for TMEM170A Gene

Protein Domains for TMEM170A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM170A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WVE7

UniProtKB/Swiss-Prot:

T170A_HUMAN :
  • Belongs to the TMEM170 family.
Family:
  • Belongs to the TMEM170 family.
genes like me logo Genes that share domains with TMEM170A: view

No data available for Gene Families for TMEM170A Gene

Function for TMEM170A Gene

Molecular function for TMEM170A Gene

UniProtKB/Swiss-Prot Function:
Acts as a regulator of endoplasmic reticulum (ER) and nuclear envelope (NE) morphogenesis. Affects the ratio between tubular ER and ER sheets by promoting sheet formation at the expense of tubules. Influences NE expansion, nuclear pore complex formation and proper localization of inner nuclear membrane proteins (PubMed:26906412).

Gene Ontology (GO) - Molecular Function for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 26906412
genes like me logo Genes that share ontologies with TMEM170A: view
genes like me logo Genes that share phenotypes with TMEM170A: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM170A

CRISPR Products

miRNA for TMEM170A Gene

miRTarBase miRNAs that target TMEM170A

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM170A Gene

Localization for TMEM170A Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM170A Gene

Endoplasmic reticulum membrane; Multi-pass membrane protein. Nucleus envelope.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM170A gene
Compartment Confidence
nucleus 5
endoplasmic reticulum 5
plasma membrane 3
extracellular 1

Gene Ontology (GO) - Cellular Components for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005635 nuclear envelope IEA,IDA 26906412
GO:0005783 endoplasmic reticulum IEA --
GO:0005789 endoplasmic reticulum membrane IEA,IDA 26906412
GO:0016020 membrane IEA --
genes like me logo Genes that share ontologies with TMEM170A: view

Pathways & Interactions for TMEM170A Gene

SuperPathways for TMEM170A Gene

No Data Available

Interacting Proteins for TMEM170A Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000454404%0d%0a9606.ENSP00000363055%0d%0a9606.ENSP00000369373%0d%0a9606.ENSP00000381717%0d%0a
Selected Interacting proteins: ENSP00000454404 for TMEM170A Gene via STRING

Gene Ontology (GO) - Biological Process for TMEM170A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006998 nuclear envelope organization IMP 26906412
GO:0051292 nuclear pore complex assembly IMP 26906412
GO:0071786 endoplasmic reticulum tubular network organization IMP 26906412
genes like me logo Genes that share ontologies with TMEM170A: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM170A Gene

Transcripts for TMEM170A Gene

Unigene Clusters for TMEM170A Gene

Transmembrane protein 170A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170A Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7a · 7b · 7c · 7d · 7e
SP1: -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - -
SP6: - - - -
SP7:

Relevant External Links for TMEM170A Gene

GeneLoc Exon Structure for
TMEM170A
ECgene alternative splicing isoforms for
TMEM170A

Expression for TMEM170A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM170A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for TMEM170A Gene

This gene is overexpressed in Placenta (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM170A Gene



Protein tissue co-expression partners for TMEM170A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of TMEM170A Gene:

TMEM170A

SOURCE GeneReport for Unigene cluster for TMEM170A Gene:

Hs.487510

Evidence on tissue expression from TISSUES for TMEM170A Gene

  • Nervous system(4.3)
genes like me logo Genes that share expression patterns with TMEM170A: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM170A Gene

Orthologs for TMEM170A Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM170A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM170A 34 35
  • 99.07 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 97 (a)
OneToMany
dog
(Canis familiaris)
Mammalia TMEM170A 34
  • 95.14 (n)
cow
(Bos Taurus)
Mammalia TMEM170A 34 35
  • 92.84 (n)
rat
(Rattus norvegicus)
Mammalia Tmem170a 34
  • 92.13 (n)
mouse
(Mus musculus)
Mammalia Tmem170 34 16 35
  • 91.9 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 83 (a)
OneToMany
chicken
(Gallus gallus)
Aves TMEM170A 34 35
  • 77.86 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 69 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem170a 34
  • 73.13 (n)
zebrafish
(Danio rerio)
Actinopterygii tmem170a 34 35
  • 59.9 (n)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005150 34
  • 53.09 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG12341 34 35
  • 52.91 (n)
Species where no ortholog for TMEM170A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM170A Gene

ENSEMBL:
Gene Tree for TMEM170A (if available)
TreeFam:
Gene Tree for TMEM170A (if available)

Paralogs for TMEM170A Gene

Paralogs for TMEM170A Gene

(1) SIMAP similar genes for TMEM170A Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with TMEM170A: view

Variants for TMEM170A Gene

Sequence variations from dbSNP and Humsavar for TMEM170A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000009800 -- 75,464,189(+) CAAGA(C/G)CCGCT intron-variant
rs1000098741 -- 75,459,546(+) GTCCT(A/C/G)CTGGG intron-variant
rs1000100254 -- 75,456,914(+) AAGCA(G/T)AAAGA intron-variant
rs1000118170 -- 75,456,712(+) TGCCT(A/G)CATCT intron-variant
rs1000369283 -- 75,455,041(+) ACGTA(A/C)TACTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM170A Gene

Variant ID Type Subtype PubMed ID
esv2714709 CNV deletion 23290073
esv2758657 CNV gain 17122850
esv3553676 CNV deletion 23714750
nsv1063718 CNV gain 25217958
nsv1065995 CNV loss 25217958
nsv457521 CNV gain 19166990
nsv521596 CNV loss 19592680
nsv525955 CNV loss 19592680
nsv572979 CNV gain 21841781

Variation tolerance for TMEM170A Gene

Residual Variation Intolerance Score: 61.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.50; 10.84% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM170A Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM170A

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM170A Gene

Disorders for TMEM170A Gene

Relevant External Links for TMEM170A

Genetic Association Database (GAD)
TMEM170A
Human Genome Epidemiology (HuGE) Navigator
TMEM170A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM170A

No disorders were found for TMEM170A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM170A Gene

Publications for TMEM170A Gene

  1. Transmembrane protein TMEM170A is a novel regulator of ER and NE morphogenesis in human cells. (PMID: 26906412) Christodoulou A. … Mattaj I.W. (J. Cell. Sci. 2016) 2 3 4 64
  2. Fine mapping and association studies of a high-density lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian subjects. (PMID: 19844255) Dastani Z. … Genest J. (Eur. J. Hum. Genet. 2010) 3 46 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3 64
  5. Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer. (PMID: 25086665) Wolpin B.M. … Amundadottir L.T. (Nat. Genet. 2014) 3 64

Products for TMEM170A Gene

Sources for TMEM170A Gene

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