TMEM170A Gene
protein-coding GIFtS: 45
GCID: GC16M075476
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transmembrane protein 170A(Previous name: transmembrane protein 170 )
(Previous symbol: TMEM170)
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Aliases
for TMEM170A gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 170A1 2 | | TMEM1701 2 3 | | Transmembrane Protein 1701 2 | | FLJ376111 |
Export aliases for TMEM170A gene to outside databasesPrevious GC identifers: GC16M074039 GC16M061232 |
Summaries
for TMEM170A gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM170A gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000016.9 NC_018927.1 NT_010498.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM170A gene promoter:
STAT5B NF-1 Lmo2 CUTL1 POU3F2 (N-Oct-5a) POU3F2 (N-Oct-5b) POU3F2 Arnt Chx10 Pax-4a
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM170A
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM170A |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 16q23.1 Ensembl cytogenetic band: 16q23.1 HGNC cytogenetic band: 16q23.1TMEM170A Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16M075476: view genomic region
(about GC identifiers)
Start:
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75,476,952 bp from pter |
End:
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75,499,395 bp from pter |
Size:
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22,444 bases |
Orientation:
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minus strand |
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Proteins
for TMEM170A gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: T170A_HUMAN, Q8WVE7 (See
protein sequence)Recommended Name: Transmembrane protein 170A Size: 144 amino acids; 15250 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R4R3 B4DPS4 D3DUK2 Q7Z6F3Alternative splicing: 2 isoforms: Q8WVE7-1 Q8WVE7-2 Explore the universe of human proteins at neXtProt for TMEM170A: NX_Q8WVE7
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WVE7
TMEM170A Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_660297.1
ENSEMBL proteins: ENSP00000350230 ENSP00000454552 ENSP00000455491 ENSP00000454404 ENSP00000456509 ENSP00000456194 ENSP00000455938
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM170A for ontologies About GeneDecksing
TMEM170A Antibody Products:
Assay Products for TMEM170A: |
Protein
Domains /
Families
for TMEM170A gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM170A for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q8WVE7ProtoNet protein and cluster: Q8WVE7 UniProtKB/Swiss-Prot: T170A_HUMAN, Q8WVE7Similarity: Belongs to the TMEM170 family |
Function
for TMEM170A gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM170A (NM_145254) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM170A | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM170A |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM170A |
1 GenomeRNAi human phenotype for TMEM170A:
|
Pathways & Interactions
for TMEM170A gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM170A
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM170A (ENSP000003502304) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TMEM170A gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM170A
Search CenterWatch for drugs/clinical trials and news about TMEM170A / T170A
|
Transcripts
for TMEM170A gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM170A gene: NM_145254.1 Unigene Cluster for TMEM170A: Transmembrane protein 170A Hs.487510 [show with all ESTs]Unigene Representative Sequence: BX6484847 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000357613(uc002feb.3 uc002fec.3) ENST00000568559(uc002fed.1 uc002fee.1)
ENST00000569540 ENST00000561878 ENST00000567796 ENST00000566980 ENST00000569276
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM170A (NM_145254) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM170A | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM170A |
Additional cDNA sequence: AK094930.1 AK298475.1 AK311919.1 AY302139.1 BC018082.1 BC031860.1 BX647432.1 BX648429.1 BX648484.1 16 DOTS entries: DT.110533 DT.99954833 DT.308494 DT.412326 DT.100774917 DT.424679 DT.120669658 DT.120669709 DT.95112285 DT.92432493 DT.101975064 DT.100774915 DT.102840376 DT.97784450 DT.120669650 DT.120669768 24/163 AceView cDNA sequences (see all 163): BX503857 AI376117 BQ423692 AA877133 CA950584 AI890125 AI376622 AA886733 AA348459 BG199544 BG681520 BX473419 AA348460 AY302139 AI917687 AI337404 AI886060 AA702611 AA716413 BF594624 BX503183 BF967170 BU154224 NM_145254
GeneLoc Exon Structure
5/7 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM170A (see all 7) About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6a | · | 6b | · | 6c | ^ | 7a | · | 7b | · | 7c | · | 7d | · | 7e |
|---|
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| SP1: | | | | | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | | | - | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | | | - | | - | | | | | | | | | | | | |
| SP4: | | | | | | | | | - | | - | | - | | - | | | | | | - | | | | | | | | | | | | |
| SP5: | | | | | | | | | | | - | | - | | - | | | | | | - | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM170A
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Expression
for TMEM170A gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM170A expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AATATTCTAA
About this image
See TMEM170A Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM170A
SOURCE GeneReport for Unigene cluster: Hs.487510
SABiosciences Custom PCR Arrays for TMEM170A
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM170A
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM170A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM170A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM170A | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM170A |
Orthologs
for TMEM170A gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM170A gene from 4/17 species (see all 17) About this table
ENSEMBL Gene Tree for TMEM170A (if available)
TreeFam Gene Tree for TMEM170A (if available) |
Paralogs
for TMEM170A gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM170A gene
- TMEM170B2 ENSG000002617172
1 SIMAP similar gene for TMEM170A using alignment to 5 protein entries: T170A_HUMAN (see all proteins):TMEM170B
TMEM170A for paralogs About GeneDecksing
|
Genomic Variants
for TMEM170A gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 16 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM170A (75476952 - 75499395 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM170A
1 CNV: 4013 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM170A |
|
Disorders
/ Diseases
for TMEM170A gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM170A for disorders About GeneDecksing
1  disease for TMEM170A: About MalaCardscholesterol
Human Genome Epidemiology (HuGE) Navigator: TMEM170A (1 document)
Export disorders for TMEM170A gene to outside databases
|
Publications
for TMEM170A gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM170A gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM170A) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Fine mapping and association studies of a high-densit y lipoprotein cholesterol linkage region on chromosome 16 in French-Canadian su bjects. (PubMed id 19844255)1 Dastani Z....Genest J. (2010)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Hepatitis C virus core protein interacts with 14-3-3 protein and activates the kinase Raf-1. (PubMed id )2 Aoki H.... Hino O. (2000)
|
External Searches for TMEM170A gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM170A gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM170A gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM170A gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM170A | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for TMEM170A gene:
Search GeneIP for patents involving TMEM170A
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM170A gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM170A | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM170A | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM170A | | | OriGene Protein Over-expression Lysate for TMEM170A | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM170A | | OriGene 3'-UTR Clone for TMEM170A | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM170A | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM170A | | OriGene Custom Protein Services for TMEM170A | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM170A | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM170A | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM170A | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM170A | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM170A | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM170A |
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 | | | TMEM170A Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM170A |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM170A |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM170A |
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