TMEM17 Gene
protein-coding GIFtS: 38
GCID: GC02M062727
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transmembrane protein 17
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Aliases
for TMEM17 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 171 2 | | FLJ345831 |
Export aliases for TMEM17 gene to outside databasesPrevious GC identifers: GC02M062702 GC02M062639 GC02M062581 GC02M062465 |
Summaries
for TMEM17 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: TMM17_HUMAN, Q86X19Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primarycilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasmamembranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)
|
Genomic Views
for TMEM17 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM17 gene promoter:
MEF-2A FOXJ2 (long isoform) FOXD3 Nkx2-5 aMEF-2 FOXJ2 GATA-2
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM17
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM17 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p15 Ensembl cytogenetic band: 2p15 HGNC cytogenetic band: 2p15TMEM17 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02M062727: view genomic region
(about GC identifiers)
Start:
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62,727,356 bp from pter |
End:
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62,739,029 bp from pter |
Size:
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11,674 bases |
Orientation:
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minus strand |
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Proteins
for TMEM17 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TMM17_HUMAN, Q86X19 (See
protein sequence)Recommended Name: Transmembrane protein 17 Size: 198 amino acids; 23046 Da
Subunit: Part of the tectonic-like complex (also named B9 complex) (By similarity)
Subcellular location: Cell projection, cilium membrane; Multi-pass membrane protein (By similarity). Note=Localizes tothe transition zone of primary cilia (By similarity)
Secondary accessions: Q53QP7 Q53R98Explore the universe of human proteins at neXtProt for TMEM17: NX_Q86X19
TMEM17 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_938017.2
ENSEMBL proteins: ENSP00000335094
Human Recombinant Protein Products:
Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table
TMEM17 for ontologies About GeneDecksing
TMEM17 Antibody Products:
Assay Products for TMEM17: |
Protein
Domains /
Families
for TMEM17 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM17 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q86X19ProtoNet protein and cluster: Q86X19 UniProtKB/Swiss-Prot: TMM17_HUMAN, Q86X19Similarity: Belongs to the TMEM17 family |
Function
for TMEM17 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: TMM17_HUMAN, Q86X19Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primarycilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasmamembranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity)
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TMEM17 (NM_001101311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM17 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM17 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM17 |
2 GenomeRNAi human phenotypes for TMEM17:
|
Pathways & Interactions
for TMEM17 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM17
STRING Interaction
Network Preview (showing 5 interactants - click image to see 11)
5/11 Interacting proteins for TMEM17 (ENSP000003350944) via UniProtKB, MINT, STRING, and/or I2D (see all 11)About this table
Gene Ontology (GO): 2 biological process terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0007224 | smoothened signaling pathway |
ISS | -- | | GO:0042384 | cilium assembly |
ISS | -- |
TMEM17 for ontologies About GeneDecksing
|
Drugs & Compounds
for TMEM17 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM17
Search CenterWatch for drugs/clinical trials and news about TMEM17 / TMM17
|
Transcripts
for TMEM17 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM17 gene: NM_198276.2 Unigene Cluster for TMEM17: Transmembrane protein 17 Hs.308028 [show with all ESTs]Unigene Representative Sequence: AK0919023 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000335390(uc002sbt.2) ENST00000479763(uc002sbv.1) ENST00000494919(uc002sbu.2)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TMEM17 (NM_001101311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM17 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM17 |
Additional cDNA sequence: AK091902.1 AK124081.1 BC047439.1 5 DOTS entries: DT.40261238 DT.101980853 DT.100745267 DT.75100457 DT.99984913 24/30 AceView cDNA sequences (see all 30): AI732286 BU949759 BX105045 BQ269162 AI821451 AI820820 AI820709 CB104980 AA084725 BU951178 AK091902 AI922002 AX747245 NM_198276 AI126611 BU952614 AW895489 R70171 AK124081 BQ268895 BC047439 CB112933 BG255056 BI598556
GeneLoc Exon Structure
|
Expression
for TMEM17 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM17 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM17 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM17
SOURCE GeneReport for Unigene cluster: Hs.308028
SABiosciences Custom PCR Arrays for TMEM17
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM17
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM17 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM17 |
Orthologs
for TMEM17 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM17 gene from 4/16 species (see all 16) About this table
ENSEMBL Gene Tree for TMEM17 (if available)
TreeFam Gene Tree for TMEM17 (if available) |
Paralogs
for TMEM17 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM17 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM17 (62727356 - 62739029 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for TMEM17: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM17 |
|
Disorders
/ Diseases
for TMEM17 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
 TMEM17 for disorders About MalaCards
TMEM17 for disorders About GeneDecksing
OMIM gene information: 614950
OMIM disorders: --
Export disorders for TMEM17 gene to outside databases
|
Publications
for TMEM17 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM17 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM17) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci. (PubMed id 22412388)1 Kenny E.E....Peter I. (2012)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1 Ota T.... Sugano S. (2004)
|
External Searches for TMEM17 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM17 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM17 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM17 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM17 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM17 gene:
Search GeneIP for patents involving TMEM17
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM17 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM17 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM17 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM17 | | | OriGene Protein Over-expression Lysate for TMEM17 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM17 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM17 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM17 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM17 | | OriGene Custom Protein Services for TMEM17 | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM17 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM17 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM17 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM17 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM17 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM17 |
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 |  |  |  | |
| | | | Search Tocris compounds for TMEM17 |
| |  |  |  |  | | | | |
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 | | | TMEM17 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM17 |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM17 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM17 |
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