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Aliases for TMEM17 Gene

Aliases for TMEM17 Gene

  • Transmembrane Protein 17 2 3

External Ids for TMEM17 Gene

Summaries for TMEM17 Gene

GeneCards Summary for TMEM17 Gene

TMEM17 (Transmembrane Protein 17) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM17 Gene

  • Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM17 Gene

Genomics for TMEM17 Gene

Genomic Location for TMEM17 Gene

Start:
62,460,895 bp from pter
End:
62,511,894 bp from pter
Size:
51,000 bases
Orientation:
Minus strand

Genomic View for TMEM17 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM17 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM17 Gene

Regulatory Elements for TMEM17 Gene

Proteins for TMEM17 Gene

  • Protein details for TMEM17 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q86X19-TMM17_HUMAN
    Recommended name:
    Transmembrane protein 17
    Protein Accession:
    Q86X19
    Secondary Accessions:
    • Q53QP7
    • Q53R98

    Protein attributes for TMEM17 Gene

    Size:
    198 amino acids
    Molecular mass:
    23046 Da
    Quaternary structure:
    • Part of the tectonic-like complex (also named B9 complex).

neXtProt entry for TMEM17 Gene

Proteomics data for TMEM17 Gene at MOPED

Post-translational modifications for TMEM17 Gene

Other Protein References for TMEM17 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM17 Gene

Domains for TMEM17 Gene

Protein Domains for TMEM17 Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

TMM17_HUMAN
Family:
  • Belongs to the TMEM17 family.:
    • Q86X19
genes like me logo Genes that share domains with TMEM17: view

No data available for Gene Families for TMEM17 Gene

Function for TMEM17 Gene

Molecular function for TMEM17 Gene

UniProtKB/Swiss-Prot Function: Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling (By similarity).

Gene Ontology (GO) - Molecular Function for TMEM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with TMEM17: view

Phenotypes for TMEM17 Gene

GenomeRNAi human phenotypes for TMEM17:
genes like me logo Genes that share phenotypes with TMEM17: view

miRNA for TMEM17 Gene

miRTarBase miRNAs that target TMEM17

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM17 Gene

Localization for TMEM17 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM17 Gene

Cell projection, cilium membrane; Multi-pass membrane protein. Note=Localizes to the transition zone of primary cilia. {ECO:0000250}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM17 Gene COMPARTMENTS Subcellular localization image for TMEM17 gene
Compartment Confidence
plasma membrane 5
cytoskeleton 1
lysosome 1

Gene Ontology (GO) - Cellular Components for TMEM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016020 membrane --
GO:0016021 integral component of membrane IEA --
GO:0035869 ciliary transition zone ISS --
GO:0036038 TCTN-B9D complex ISS --
GO:0060170 ciliary membrane ISS --
genes like me logo Genes that share ontologies with TMEM17: view

Pathways for TMEM17 Gene

SuperPathways for TMEM17 Gene

No Data Available

Interacting Proteins for TMEM17 Gene

Gene Ontology (GO) - Biological Process for TMEM17 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007224 smoothened signaling pathway ISS --
GO:0042384 cilium assembly ISS --
genes like me logo Genes that share ontologies with TMEM17: view

No data available for Pathways by source for TMEM17 Gene

Transcripts for TMEM17 Gene

Unigene Clusters for TMEM17 Gene

Transmembrane protein 17:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM17 Gene

No ASD Table

Relevant External Links for TMEM17 Gene

GeneLoc Exon Structure for
TMEM17
ECgene alternative splicing isoforms for
TMEM17

Expression for TMEM17 Gene

mRNA expression in normal human tissues for TMEM17 Gene

mRNA differential expression in normal tissues according to GTEx for TMEM17 Gene

This gene is overexpressed in Brain - Hypothalamus (4.4).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for TMEM17 Gene

SOURCE GeneReport for Unigene cluster for TMEM17 Gene Hs.308028

genes like me logo Genes that share expressions with TMEM17: view

Orthologs for TMEM17 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM17 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM17 36
  • 99.66 (n)
  • 99.49 (a)
TMEM17 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia TMEM17 36
  • 90.24 (n)
  • 92.42 (a)
TMEM17 37
  • 92 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM17 36
  • 89.9 (n)
  • 90.4 (a)
TMEM17 37
  • 90 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem17 36
  • 82.83 (n)
  • 79.8 (a)
Tmem17 16
Tmem17 37
  • 80 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia TMEM17 37
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM17 37
  • 71 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem17 36
  • 79.8 (n)
  • 78.79 (a)
chicken
(Gallus gallus)
Aves TMEM17 36
  • 72.28 (n)
  • 67.39 (a)
TMEM17 37
  • 61 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM17 37
  • 60 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem17 36
  • 59.73 (n)
  • 56.65 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.3206 36
zebrafish
(Danio rerio)
Actinopterygii Dr.27616 36
tmem17 36
  • 61.62 (n)
  • 58.92 (a)
tmem17 37
  • 57 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 35 (a)
OneToOne
Species with no ortholog for TMEM17:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM17 Gene

ENSEMBL:
Gene Tree for TMEM17 (if available)
TreeFam:
Gene Tree for TMEM17 (if available)

Paralogs for TMEM17 Gene

No data available for Paralogs for TMEM17 Gene

Variants for TMEM17 Gene

Sequence variations from dbSNP and Humsavar for TMEM17 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs3924400 -- 62,467,558(+) TGAGC(A/G)CTTGT intron-variant
rs4233977 -- 62,468,622(+) CACCA(C/T)AGAGA intron-variant
rs4233978 -- 62,488,196(+) GTCTC(A/G)AGCTT intron-variant
rs4233979 -- 62,500,767(+) GTTTA(C/T)AAATA utr-variant-3-prime, downstream-variant-500B, intron-variant
rs4286259 -- 62,505,479(+) TTAAT(C/G)TCTTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM17 Gene

Variant ID Type Subtype PubMed ID
nsv7313 OTHER Inversion 18451855
nsv2751 CNV Loss 18451855

Relevant External Links for TMEM17 Gene

HapMap Linkage Disequilibrium report
TMEM17

Disorders for TMEM17 Gene

No disorders were found for TMEM17 Gene.

No data available for UniProtKB/Swiss-Prot for TMEM17 Gene

Publications for TMEM17 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3 4
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for TMEM17 Gene

Sources for TMEM17 Gene

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