TMEM169 Gene
protein-coding GIFtS: 43
GCID: GC02P216946
|
|
transmembrane protein 169
| |
Aliases
for TMEM169 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 1691 2 | | FLJ342631 |
Export aliases for TMEM169 gene to outside databasesPrevious GC identifers: GC02P216654 GC02P208803 |
Summaries
for TMEM169 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for TMEM169 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_005403.17
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM169 gene promoter:
LHX3b/Lhx3b Pax-5 Pax-2 Pax-2a Arnt IRF-2 HFH-1 LHX3a/Lhx3a Pax-4a ATF6
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM169
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM169 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2q35 Ensembl cytogenetic band: 2q35 HGNC cytogenetic band: 2q35TMEM169 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P216946: view genomic region
(about GC identifiers)
Start:
|
216,946,589 bp from pter |
End:
|
216,967,506 bp from pter |
Size:
|
20,918 bases |
Orientation:
|
plus strand |
|
Proteins
for TMEM169 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: TM169_HUMAN, Q96HH4 (See
protein sequence)Recommended Name: Transmembrane protein 169 Size: 297 amino acids; 33611 Da
Subcellular location: Membrane; Multi-pass membrane protein (Potential)
Secondary accessions: B2R8W6Explore the universe of human proteins at neXtProt for TMEM169: NX_Q96HH4
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q96HH4
TMEM169 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins (4 alternative transcripts):
NP_001135782.1 NP_001135783.1 NP_001135784.1 NP_612399.1
ENSEMBL proteins: ENSP00000400798 ENSP00000401305 ENSP00000295658 ENSP00000413257 ENSP00000384100 ENSP00000412524
Human Recombinant Protein Products for TMEM169:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral to membrane |
IEA | -- |
TMEM169 for ontologies About GeneDecksing
TMEM169 Antibody Products:
Assay Products for TMEM169: |
Protein
Domains /
Families
for TMEM169 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| ProtoNet protein and cluster: Q96HH4 |
Function
for TMEM169 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
Sirion Biotech,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Sirion Biotech,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
Sirion Biotech,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Phenotypes:
2 GenomeRNAi human phenotypes for TMEM169:
Animal Models:
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector (see all 4): TMEM169 (NM_001142311) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM169 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM169 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM169 |
|
Pathways & Interactions
for TMEM169 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM169
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM169 (ENSP000002956584) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for TMEM169 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM169
Search CenterWatch for drugs/clinical trials and news about TMEM169 / TM169
|
Transcripts
for TMEM169 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
Sirion Biotech,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM169 gene (4 alternative transcripts): NM_001142310.1 NM_001142311.1 NM_001142312.1 NM_138390.3 Unigene Cluster for TMEM169: Transmembrane protein 169 Hs.334916 [show with all ESTs]Unigene Representative Sequence: NM_0011423106 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000433112 ENST00000437356 ENST00000295658 ENST00000455479 ENST00000406027
ENST00000454545(uc010zjr.2 uc010zjs.2 uc002vfw.3 uc002vfv.4)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 (see all 6)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 (see all 5)
OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector (see all 4): TMEM169 (NM_001142311) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM169 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM169 |
Additional cDNA sequence: AK091582.1 AK172731.1 AK313536.1 BC008604.1 CR933667.1 2 DOTS entries: DT.110023 DT.97821831 24/1155 AceView cDNA sequences (see all 1155): BM994198 BM993519 BU174594 CA419507 BF196594 CD630736 CB136314 BM905671 BM679676 AA360339 BQ059109 AW291087 BQ084580 M30938 BQ069596 BQ924231 CB137578 BQ226911 BM672147 CA432960 CA428555 R06087 BP357985 F08076
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM169 About this scheme
| ExUns: | 1a | · | 1b | ^ | 2a | · | 2b | ^ | 3a | · | 3b | ^ | 4a | · | 4b |
|---|
|
| SP1: | | | | | - | | | | | | | | | | | | |
| SP2: | | | | | - | | - | | | | | | | | | | |
| SP3: | | | | | - | | - | | | | | | | | | | |
| SP4: | | | | | - | | - | | | | | | | | | | |
| SP5: | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM169
|
Expression
for TMEM169 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM169 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTCCCCACAG
About this image
See TMEM169 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM169
SOURCE GeneReport for Unigene cluster: Hs.334916
SABiosciences Custom PCR Arrays for TMEM169
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM169
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM169 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM169 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM169 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM169 |
Orthologs
for TMEM169 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM169 gene from 6/15 species (see all 15) About this table
ENSEMBL Gene Tree for TMEM169 (if available)
TreeFam Gene Tree for TMEM169 (if available) |
Paralogs
for TMEM169 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| -- |
Genomic Variants
for TMEM169 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 2 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM169 (216946589 - 216967506 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM169
1 Indel: 60346 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM169 |
|
Disorders
/ Diseases
for TMEM169 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
TMEM169 for disorders About GeneDecksing
2  diseases for TMEM169: About MalaCardschronic obstructive pulmonary disease pulmonary disease
Human Genome Epidemiology (HuGE) Navigator: TMEM169 (1 document)
Export disorders for TMEM169 gene to outside databases
|
Publications
for TMEM169 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM169 gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM169) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)1, 2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Systematic and quantitative assessment of the ubiquiti n-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (2011)
- Multistudy fine mapping of chromosome 2q identifies X RCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PubMed id 20463177)1 Hersh C.P....Silverman E.K. (2010)
- The full-ORF clone resource of the German cDNA consortium. (PubMed id 17974005)2 Bechtel S.... Schupp I. (2007)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
|
External Searches for TMEM169 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing TMEM169 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM169 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM169 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM169 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for TMEM169 gene:
Search GeneIP for patents involving TMEM169
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM169 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM169 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM169 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM169 | | | OriGene Protein Over-expression Lysate for TMEM169 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM169 | | OriGene 3'-UTR Clone for TMEM169 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM169 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for TMEM169 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for TMEM169 | | OriGene Custom Protein Services for TMEM169 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM169 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM169 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM169 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM169 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM169 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM169 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for TMEM169 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | TMEM169 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM169 |
|  |  |  |  | | | | Search ThermoFisher Antibodies for TMEM169 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM169 |
| |  | |
|
|
|
