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Aliases for TMEM169 Gene

Aliases for TMEM169 Gene

  • Transmembrane Protein 169 2 3 5

External Ids for TMEM169 Gene

Previous GeneCards Identifiers for TMEM169 Gene

  • GC02P216654
  • GC02P216946
  • GC02P208803

Summaries for TMEM169 Gene

GeneCards Summary for TMEM169 Gene

TMEM169 (Transmembrane Protein 169) is a Protein Coding gene.

Additional gene information for TMEM169 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM169 Gene

Genomics for TMEM169 Gene

Regulatory Elements for TMEM169 Gene

Enhancers for TMEM169 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02H216000 1.6 FANTOM5 Ensembl ENCODE dbSUPER 12.1 -79.6 -79624 2.7 HDGF RB1 SUZ12 YBX1 EBF1 BATF ZIC2 RELA ZKSCAN1 LCORL XRCC5 PECR TMEM169 SMARCAL1 MREG GC02M216014 ENSG00000226276
GH02H216186 1.2 Ensembl ENCODE 10.2 +106.6 106604 3 FOXA2 YY1 TCF12 ZNF766 GATA2 FOS NCOA1 REST ZNF592 MEF2D XRCC5 ENSG00000231092 TMEM169 PECR ENSG00000241520 LOC100421349 ENSG00000279348
GH02H216031 1 ENCODE dbSUPER 10.5 -49.6 -49640 1.2 PKNOX1 TBL1XR1 BACH1 BATF RELA ZNF366 FOS ATF7 ETV6 RUNX3 PECR XRCC5 TMEM169 MREG GC02M216014
GH02H215982 1 ENCODE 10.4 -98.9 -98930 1.8 PKNOX1 FOXA2 ATF1 ARID4B YY1 FOS ATF7 RUNX3 MXD4 NFYC XRCC5 SMARCAL1 MREG TMEM169 PECR GC02M216014 ENSG00000226276
GH02H216034 0.9 ENCODE dbSUPER 10.8 -47.7 -47704 0.2 HDGF CTCF ZNF687 SAP130 RB1 TRIM22 RAD21 ZNF592 YY1 POLR2A PECR TMEM169 XRCC5 MREG
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM169 on UCSC Golden Path with GeneCards custom track

Genomic Locations for TMEM169 Gene

Genomic Locations for TMEM169 Gene
chr2:216,081,866-216,102,783
(GRCh38/hg38)
Size:
20,918 bases
Orientation:
Plus strand
chr2:216,946,589-216,967,506
(GRCh37/hg19)

Genomic View for TMEM169 Gene

Genes around TMEM169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM169 Gene

Proteins for TMEM169 Gene

  • Protein details for TMEM169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH4-TM169_HUMAN
    Recommended name:
    Transmembrane protein 169
    Protein Accession:
    Q96HH4
    Secondary Accessions:
    • B2R8W6

    Protein attributes for TMEM169 Gene

    Size:
    297 amino acids
    Molecular mass:
    33611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM169 Gene

Post-translational modifications for TMEM169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM169 Gene

Domains & Families for TMEM169 Gene

Gene Families for TMEM169 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for TMEM169 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM169 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM169: view

No data available for UniProtKB/Swiss-Prot for TMEM169 Gene

Function for TMEM169 Gene

Phenotypes From GWAS Catalog for TMEM169 Gene

genes like me logo Genes that share phenotypes with TMEM169: view

Animal Model Products

Clone Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM169 Gene

Localization for TMEM169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM169 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM169 gene
Compartment Confidence
plasma membrane 3

Subcellular locations from the

Human Protein Atlas (HPA)
  • Focal adhesion sites (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for TMEM169 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM169: view

Pathways & Interactions for TMEM169 Gene

SuperPathways for TMEM169 Gene

No Data Available

Interacting Proteins for TMEM169 Gene

Gene Ontology (GO) - Biological Process for TMEM169 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM169 Gene

Drugs & Compounds for TMEM169 Gene

No Compound Related Data Available

Transcripts for TMEM169 Gene

Unigene Clusters for TMEM169 Gene

Transmembrane protein 169:
Representative Sequences:

Clone Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM169 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TMEM169 Gene

GeneLoc Exon Structure for
TMEM169
ECgene alternative splicing isoforms for
TMEM169

Expression for TMEM169 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM169 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM169 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM169 Gene



NURSA nuclear receptor signaling pathways regulating expression of TMEM169 Gene:

TMEM169

SOURCE GeneReport for Unigene cluster for TMEM169 Gene:

Hs.334916

Evidence on tissue expression from TISSUES for TMEM169 Gene

  • Nervous system(4.4)
  • Eye(4)
genes like me logo Genes that share expression patterns with TMEM169: view

No data available for Protein differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM169 Gene

Orthologs for TMEM169 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM169 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia TMEM169 33 34
  • 99.55 (n)
dog
(Canis familiaris)
Mammalia -- 34
  • 91 (a)
OneToMany
TMEM169 33
  • 90.46 (n)
-- 34
  • 84 (a)
OneToMany
cow
(Bos Taurus)
Mammalia TMEM169 33 34
  • 86.53 (n)
mouse
(Mus musculus)
Mammalia Tmem169 33 16 34
  • 85.52 (n)
rat
(Rattus norvegicus)
Mammalia Tmem169 33
  • 85.52 (n)
oppossum
(Monodelphis domestica)
Mammalia TMEM169 34
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM169 33 34
  • 70.28 (n)
lizard
(Anolis carolinensis)
Reptilia TMEM169 34
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem169 33
  • 67.57 (n)
Str.12596 33
zebrafish
(Danio rerio)
Actinopterygii LOC570044 33
  • 62.24 (n)
CR339053.3 34
  • 58 (a)
OneToMany
tmem169 34
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4596 34
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 37 (a)
OneToOne
Species where no ortholog for TMEM169 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM169 Gene

ENSEMBL:
Gene Tree for TMEM169 (if available)
TreeFam:
Gene Tree for TMEM169 (if available)

Paralogs for TMEM169 Gene

No data available for Paralogs for TMEM169 Gene

Variants for TMEM169 Gene

Sequence variations from dbSNP and Humsavar for TMEM169 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs1000061409 -- 216,102,590(+) ATGTA(A/T)GGTGC utr-variant-3-prime
rs1000294906 -- 216,089,613(+) AACCA(C/T)GCCAA intron-variant
rs1000327145 -- 216,089,866(+) AGGTC(A/G)AGTGT intron-variant
rs1000794897 -- 216,095,185(+) CAGGC(A/T)CAAGC intron-variant
rs1000862439 -- 216,096,890(+) GAGAA(A/G)ATTTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM169 Gene

Variant ID Type Subtype PubMed ID
nsv998837 CNV gain 25217958
nsv523434 CNV loss 19592680
nsv1011506 CNV gain 25217958
esv8814 CNV gain 19470904
esv3352752 CNV duplication 20981092

Variation tolerance for TMEM169 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM169 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
TMEM169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM169 Gene

Disorders for TMEM169 Gene

Relevant External Links for TMEM169

Genetic Association Database (GAD)
TMEM169
Human Genome Epidemiology (HuGE) Navigator
TMEM169
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM169

No disorders were found for TMEM169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM169 Gene

Publications for TMEM169 Gene

  1. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PMID: 20463177) Hersh CP … Silverman EK (American journal of respiratory and critical care medicine 2010) 3 45 60
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier LW … Wilson RK (Nature 2005) 3 4 60
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60

Products for TMEM169 Gene

Sources for TMEM169 Gene

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