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Aliases for TMEM169 Gene

Aliases for TMEM169 Gene

  • Transmembrane Protein 169 2 3 5

External Ids for TMEM169 Gene

Previous GeneCards Identifiers for TMEM169 Gene

  • GC02P216654
  • GC02P216946
  • GC02P208803

Summaries for TMEM169 Gene

GeneCards Summary for TMEM169 Gene

TMEM169 (Transmembrane Protein 169) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM169 Gene

Genomics for TMEM169 Gene

Regulatory Elements for TMEM169 Gene

Promoters for TMEM169 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM169 on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM169 Gene

Chromosome:
2
Start:
216,081,866 bp from pter
End:
216,102,783 bp from pter
Size:
20,918 bases
Orientation:
Plus strand

Genomic View for TMEM169 Gene

Genes around TMEM169 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM169 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM169 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM169 Gene

Proteins for TMEM169 Gene

  • Protein details for TMEM169 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96HH4-TM169_HUMAN
    Recommended name:
    Transmembrane protein 169
    Protein Accession:
    Q96HH4
    Secondary Accessions:
    • B2R8W6

    Protein attributes for TMEM169 Gene

    Size:
    297 amino acids
    Molecular mass:
    33611 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM169 Gene

Proteomics data for TMEM169 Gene at MOPED

Post-translational modifications for TMEM169 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for TMEM169 Gene

Domains & Families for TMEM169 Gene

Protein Domains for TMEM169 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM169 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with TMEM169: view

No data available for Gene Families and UniProtKB/Swiss-Prot for TMEM169 Gene

Function for TMEM169 Gene

genes like me logo Genes that share phenotypes with TMEM169: view

Animal Model Products

CRISPR Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM169 Gene

Localization for TMEM169 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM169 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM169 Gene COMPARTMENTS Subcellular localization image for TMEM169 gene
Compartment Confidence
plasma membrane 3

No data available for Gene Ontology (GO) - Cellular Components for TMEM169 Gene

Pathways & Interactions for TMEM169 Gene

SuperPathways for TMEM169 Gene

No Data Available

Interacting Proteins for TMEM169 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295658%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000295658 for TMEM169 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for TMEM169 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM169 Gene

Drugs & Compounds for TMEM169 Gene

No Compound Related Data Available

Transcripts for TMEM169 Gene

Unigene Clusters for TMEM169 Gene

Transmembrane protein 169:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM169 Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3a · 3b ^ 4a · 4b
SP1: -
SP2: - -
SP3: - -
SP4: - -
SP5:

Relevant External Links for TMEM169 Gene

GeneLoc Exon Structure for
TMEM169
ECgene alternative splicing isoforms for
TMEM169

Expression for TMEM169 Gene

mRNA expression in normal human tissues for TMEM169 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for TMEM169 Gene

This gene is overexpressed in Brain - Frontal Cortex (BA9) (x4.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM169 Gene



SOURCE GeneReport for Unigene cluster for TMEM169 Gene Hs.334916

genes like me logo Genes that share expression patterns with TMEM169: view

Primer Products

In Situ Assay Products

No data available for Protein differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM169 Gene

Orthologs for TMEM169 Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM169 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM169 35
  • 86.53 (n)
  • 88.55 (a)
TMEM169 36
  • 89 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM169 35
  • 90.46 (n)
  • 91.25 (a)
-- 36
  • 84 (a)
OneToMany
-- 36
  • 91 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Tmem169 35
  • 85.52 (n)
  • 87.88 (a)
Tmem169 16
Tmem169 36
  • 88 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM169 35
  • 99.55 (n)
  • 99.66 (a)
TMEM169 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem169 35
  • 85.52 (n)
  • 87.54 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM169 36
  • 81 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM169 35
  • 70.28 (n)
  • 67.46 (a)
TMEM169 36
  • 64 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM169 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.12596 35
tmem169 35
  • 67.57 (n)
  • 66.55 (a)
zebrafish
(Danio rerio)
Actinopterygii LOC570044 35
  • 62.24 (n)
  • 60.15 (a)
CR339053.3 36
  • 58 (a)
OneToMany
tmem169 36
  • 50 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG4596 36
  • 22 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 37 (a)
OneToOne
Species with no ortholog for TMEM169:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM169 Gene

ENSEMBL:
Gene Tree for TMEM169 (if available)
TreeFam:
Gene Tree for TMEM169 (if available)

Paralogs for TMEM169 Gene

No data available for Paralogs for TMEM169 Gene

Variants for TMEM169 Gene

Sequence variations from dbSNP and Humsavar for TMEM169 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs828919 -- 216,088,018(+) attgc(A/G)catgg intron-variant
rs828920 -- 216,090,612(+) CAGAA(C/T)ACTAA intron-variant
rs828921 -- 216,090,736(+) acgca(C/T)ataat intron-variant
rs828922 -- 216,091,945(+) AATCA(C/T)GTTTC intron-variant
rs828923 -- 216,094,507(+) TTAAC(A/G)GGCTG intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for TMEM169 Gene

Variant ID Type Subtype PubMed ID
esv8814 CNV Gain 19470904
nsv523434 CNV Loss 19592680

Variation tolerance for TMEM169 Gene

Residual Variation Intolerance Score: 27.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.35; 41.78% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM169 Gene

HapMap Linkage Disequilibrium report
TMEM169

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM169 Gene

Disorders for TMEM169 Gene

Relevant External Links for TMEM169

Genetic Association Database (GAD)
TMEM169
Human Genome Epidemiology (HuGE) Navigator
TMEM169
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM169

No disorders were found for TMEM169 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM169 Gene

Publications for TMEM169 Gene

  1. Multistudy fine mapping of chromosome 2q identifies XRCC5 as a chronic obstructive pulmonary disease susceptibility gene. (PMID: 20463177) Hersh C.P. … Silverman E.K. (Am. J. Respir. Crit. Care Med. 2010) 3 48 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 3
  5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3

Products for TMEM169 Gene

Sources for TMEM169 Gene

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