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TMEM168 Gene

protein-coding GIFtS: 41
GCID: GC07M112405

Transmembrane Protein 168

Try our

MalaCards

disease database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, ¹⁰fRNAdb, ¹²H-InvDB, ¹³NCBI, ¹⁴NONCODE, and/or ¹⁵RNAdb)
About This Section

Aliases
Transmembrane Protein 168¹ ²

External Ids:	HGNC: 25826¹	Entrez Gene: 64418²	Ensembl: ENSG00000146802⁷	UniProtKB: Q9H0V1³

Export aliases for TMEM168 gene to outside databases

Previous GC identifers: GC07M112193 GC07M106773

(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for TMEM168 Gene:

TMEM168 (transmembrane protein 168) is a protein-coding gene.

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

Regulatory elements:

Regulatory transcription factor binding sites in the TMEM168 gene promoter:
GR AML1a GR-beta Cdc5 Egr-2 CREB POU2F1 deltaCREB POU2F1a GR-alpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMEM168 promoter sequence

Search Chromatin IP Primers for TMEM168

Epigenetics:

DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM168

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.32 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31.32

TMEM168 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM168 gene location

GeneLoc information about chromosome 7 GeneLoc Exon Structure

GeneLoc location for GC07M112405: view genomic region (about GC identifiers)

Start:	112,402,437 bp from pter	End:	112,430,647 bp from pter
Size:	28,211 bases	Orientation:	minus strand

1 alternative location:

Chr7-,CRA_TCAG 111,774,269-111,798,936

(According to ¹UniProtKB, HORDE, ²neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, antibodies-online, and/or GeneTex,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
About This Section

UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1 (See protein sequence)

Recommended Name: Transmembrane protein 168

Size: 697 amino acids; 79755 Da

Sequence caution: Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;

Secondary accessions: A4D0T9 Q8NEK4 Q9H8J2

Explore the universe of human proteins at neXtProt for TMEM168: NX_Q9H0V1

Explore proteomics data for TMEM168 at MOPED

Post-translational modifications:

Glycosylation² at Asn111, Asn533, Asn598

Modification sites at PhosphoSitePlus

See TMEM168 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

REFSEQ proteins (2 alternative transcripts):

NP_001274426.1 NP_071929.3

ENSEMBL proteins:

ENSP00000323068 ENSP00000390696 ENSP00000410307 ENSP00000404253 ENSP00000407373

ENSP00000412462

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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GenesLikeMe)
About This Section

ProtoNet protein and cluster: Q9H0V1

UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1

Similarity: Belongs to the TMEM168 family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Animal Models:

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(According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Subcellular locations from UniProtKB/Swiss-Prot

TM168_HUMAN, Q9H0V1: Membrane; Multi-pass membrane protein (Potential)

Subcellular locations from COMPARTMENTS:

Compartment	Confidence
plasma membrane	3
cytosol	1
endoplasmic reticulum	1
nucleus	1

About this image

Gene Ontology (GO): 2 cellular component terms: About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0016021	integral component of membrane	IEA	--
GO:0030133	transport vesicle	IDA	--

Find genes that share ontologies with TMEM168 About GenesLikeMe

(SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GenesLikeMe, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene, Sets of similar genes according to GenesLikeMe)
About This Section

Custom Pathway & Disease-focused RT² Profiler PCR Arrays for TMEM168
Interactions:

Search GeneGlobe Interaction Network for TMEM168

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, Sets of similar genes according to GenesLikeMe)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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Browse Tocris compounds for TMEM168 (TM168)

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
About This Section

REFSEQ mRNAs for TMEM168 gene (3 alternative transcripts):

NM_001287497.1 NM_022484.5 XM_005250527.1

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000312814(uc003vgn.3 uc010lju.3 uc011kmr.2) ENST00000454074

ENST00000447395 ENST00000418785 ENST00000449743 ENST00000441474 ENST00000480969

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Selected AceView cDNA sequences (see all 108):

AU138470 BX957054 AA825977 AI424672 BU677982 AI859107 BC030804 BE503373

AW235345 CD722891 AI866851 AU135490 BQ574888 AK025482 BQ026579 BQ897564

BG610832 BX421826 AA489091 AI569496 BF804245 AL136626 BQ017026 BX452293

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168 About this scheme

ExUns:	1a	·	1b	·	1c	·	1d	^	2	^	3a	·	3b	^	4	^	5	^	6	^	7a	·	7b	·	7c	^	8a	·	8b
SP1:																	-
SP2:									-				-				-
SP3:									-		-		-		-		-
SP4:
SP5:									-

ECgene alternative splicing isoforms for TMEM168

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GenesLikeMe, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE ¹MOPED, ²PaxDb, and ³MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

TMEM168 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>^2/3
CGAP TAG: TAATGTATTC

About this image

TMEM168 Protein expression data from MOPED¹, PaxDb² and MaxQB³:

About this image

TMEM168 Protein Expression

Custom PCR Arrays for TMEM168

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for TMEM168 gene from Selected species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Tmem168^{1 , 5}	transmembrane protein 168^{1, 5}	89.29(n)¹ 95.41(a)¹		6 (5.68 cM)⁵ 101118¹ NM_028990.4¹ NP_083266.1¹ 13580687⁵
chicken (Gallus gallus)	Aves	TMEM168¹	transmembrane protein 168	79.72(n) 85.8(a)		417777 XM_416021.4 XP_416021.2
lizard (Anolis carolinensis)	Reptilia	TMEM168⁶	transmembrane protein 168	85(a)	1 ↔ 1	5(58582852-58591964)
African clawed frog (Xenopus laevis)	Amphibia	BC043897.1²	--	77.48(n)		BC043897.1
zebrafish (Danio rerio)	Actinopterygii	tmem168b¹	transmembrane protein 168b	61.73(n) 63.51(a)		558640 XM_681870.4 XP_686962.3

ENSEMBL Gene Tree for TMEM168 (if available)
TreeFam Gene Tree for TMEM168 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68,Sets of similar genes according to GenesLikeMe)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, ⁴UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
About This Section

SNP ID	Valid	Clinical significance	Chr 7 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs193275430^1,2		--	112405331(+)	`TTTTTA/GGTTTT`	1	--	ds500¹		0	--	--	--	--
rs185423551^1,2		--	112405350(+)	`AGGAAA/CTACAT`	1	--	ds500¹		0	--	--	--	--
rs1234894^1,2	C,F,H	--	112405419(+)	`AGTACC/GACCTT`	1	--	ds500¹		7		NS EA NA WA	508
rs141692556^1,2		--	112405586(+)	`TTTAAC/TATTTG`	1	--	ds500¹		0	--	--	--	--
rs59432318^1,2	F	--	112405689(+)	`GAAACG/TTCCAA`	1	--	ds500¹		0	--	--	--	--
rs201985114^1,2		--	112405776(+)	`ATCAT-/TAAA TAAAA`	1	--	ds500¹		0	--	--	--	--
rs139465829^1,2		--	112405845(+)	`CAGAAA/GTAATC`	1	--	ut3¹		0	--	--	--	--
rs142898256^1,2	C	--	112405911(+)	`TCCTA-/ACTT ACTTA`	1	--	ut3¹		0	--	--	--	--
rs34377963^1,2	C	--	112405983(+)	`GCTAT-/AAAAAA`	1	--	ut3¹		1		CSA	2
rs201570822^1,2		--	112405990(+)	`AAAAA-/TGGCTT`	1	--	ut3¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for TMEM168 (112402437 - 112430647 bp)

Structural Variations
Database of Genomic Variants (DGV) 4 variations for TMEM168: About this table

Variant ID	Type	Subtype	PubMed ID
esv2422365	CNV	Duplication	17116639
esv2752144	CNV	Gain	17911159
nsv464689	CNV	Gain	19166990
nsv7405	OTHER	Inversion	18451855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB, Sets of similar genes according to GenesLikeMe)
About This Section

Find genes that share disorders with TMEM168 About GenesLikeMe

Genetic Association Database (GAD): TMEM168
Human Genome Epidemiology (HuGE) Navigator: TMEM168 (1 document)

Export disorders for TMEM168 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for TMEM168 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with TMEM168)

Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)^{1, 4} Trynka G....Wijmenga C. (Gut 2009)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (Nat. Genet. 2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)^{1, 3} Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)¹ Long P....Rose S. (Eur. J. Neurosci. 2012)
Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)¹ Kimura K.... Sugano S. (Genome Res. 2006)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S.... Malek J. (Genome Res. 2004)
Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)¹ Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)² Scherer S.W.... Tsui L.-C. (Science 2003)
The DNA sequence of human chromosome 7. (PubMed id 12853948)² Hillier L.W.... Wilson R.K. (Nature 2003)
Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)² Wiemann S.... Poustka A. (Genome Res. 2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 64418	HGNC: 25826	AceView: FLJ13576	Ensembl:ENSG00000146802	euGenes: HUgn64418
ECgene: TMEM168	H-InvDB: TMEM168

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for TMEM168	Pharmacogenomics, SNPs, Pathways

Intellectual Property for TMEM168 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for TMEM168 gene:
Search GeneIP for patents involving TMEM168

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, GeneTex, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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About This Section


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	Regulatory tfbs in TMEM168 promoter

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TMEM168 Gene

Transmembrane Protein 168

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Export list of displayed genes

TMEM168 Gene

Transmembrane Protein 168

Aliasesfor TMEM168 gene

Summariesfor TMEM168 gene

Genomic Viewsfor TMEM168 gene

Proteinsfor TMEM168 gene

TMEM168 Human Recombinant Protein Products:

TMEM168 Antibody Products:

TMEM168 Assay Products:

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Functionfor TMEM168 gene

Localizationfor TMEM168 gene

Pathways & Interactionsfor TMEM168 gene

Drugs & Compoundsfor TMEM168 gene

Transcriptsfor TMEM168 gene

Expression for TMEM168 gene

Orthologsfor TMEM168 gene

Paralogsfor TMEM168 gene

Genomic Variantsfor TMEM168 gene

Disorders / Diseasesfor TMEM168 gene

Publicationsfor TMEM168 gene

External Searches for TMEM168 gene

Genome Databases showing TMEM168 gene

Other Databases showing TMEM168 gene

Specialized Databases showing TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

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for TMEM168 gene

Transcripts
for TMEM168 gene

Expression
for TMEM168 gene

Orthologs
for TMEM168 gene

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for TMEM168 gene

Genomic Variants
for TMEM168 gene

Disorders / Diseases
for TMEM168 gene

Publications
for TMEM168 gene

Intellectual Property
for TMEM168 gene

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for TMEM168 gene