Aliases for TMEM168 Gene
External Ids for TMEM168 Gene
- HGNC: 25826
- Entrez Gene: 64418
- Ensembl: ENSG00000146802
- UniProtKB: Q9H0V1
Previous GeneCards Identifiers for TMEM168 Gene
- GC07M112193
- GC07M112405
- GC07M106773
Summaries for TMEM168 Gene
GeneCards Summary for TMEM168 Gene
TMEM168 (Transmembrane Protein 168) is a Protein Coding gene.
No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM168 Gene
Genomics for TMEM168 Gene
Regulatory Elements for TMEM168 Gene
Enhancers for TMEM168 Gene
| GeneHancer Identifier | Score | Enhancer Sources | TSS distance (kb) | Number of Genes Away | Size (kb) | Transcription Factor Binding Sites within enhancer | Other Gene Targets for Enhancer |
|---|
Enhancers around TMEM168 on UCSC Golden Path with GeneCards custom track
Promoters for TMEM168 Gene
| Ensembl Regulatory Elements (ENSRs) | TSS Distance (bp) | Size (bp) | Binding Sites for Transcription Factors within promoters |
|---|
ENSRs around TMEM168 on UCSC Golden Path with GeneCards custom track
Regulatory Element Products
Genomic Location for TMEM168 Gene
- Chromosome:
- 7
- Start:
- 112,762,382 bp from pter
- End:
- 112,790,713 bp from pter
- Size:
- 28,332 bases
- Orientation:
- Minus strand
Genomic View for TMEM168 Gene
Genes around TMEM168 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 7q31.1 by Ensembl
- 7q31.32 by Entrez Gene
- 7q31.32 by HGNC
TMEM168 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for TMEM168 Gene
Proteins for TMEM168 Gene
-
Protein details for TMEM168 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- Q9H0V1-TM168_HUMAN
- Recommended name:
- Transmembrane protein 168
- Protein Accession:
- Q9H0V1
- A4D0T9
- B4DDS0
- Q8NEK4
- Q9H8J2
Protein attributes for TMEM168 Gene
- Size:
- 697 amino acids
- Molecular mass:
- 79755 Da
- Quaternary structure:
- No Data Available
- SequenceCaution:
-
- Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};
Protein Expression for TMEM168 Gene
Post-translational modifications for TMEM168 Gene
Other Protein References for TMEM168 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- Novus Biologicals Antibodies for TMEM168
- Invitrogen Antibodies for TMEM168
- GeneTex TMEM168 antibody for TMEM168
-
Santa Cruz Biotechnology (SCBT) Antibodies for TMEM168
Protein Products
-
OriGene Purified Proteins for TMEM168
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM168
- Origene Custom Protein Services for TMEM168
- Novus Biologicals proteins for TMEM168
- Search GeneTex for Proteins for TMEM168
Assay Products
No data available for DME Specific Peptides for TMEM168 Gene
Domains & Families for TMEM168 Gene
Suggested Antigen Peptide Sequences for TMEM168 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
Q9H0V1- Family:
-
- Belongs to the TMEM168 family.
No data available for Gene Families for TMEM168 Gene
Function for TMEM168 Gene
Phenotypes for TMEM168 Gene
- GenomeRNAi human phenotypes for TMEM168:
Animal Model Products
-
Taconic Biosciences Mouse Models for TMEM168
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM168 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM168 gene
- Search ViGene Biosciences for TMEM168
CRISPR Products
-
OriGene CRISPR knockouts for TMEM168
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM168
- GenScript: Design CRISPR guide RNA sequences for TMEM168
miRNA for TMEM168 Gene
- miRTarBase miRNAs that target TMEM168
-
- hsa-mir-130b-3p (MIRT020118)
- hsa-mir-221-3p (MIRT024146)
- hsa-mir-101-3p (MIRT027266)
- hsa-mir-93-5p (MIRT027960)
- hsa-mir-26b-5p (MIRT028945)
- hsa-mir-16-5p (MIRT031501)
- hsa-mir-5698 (MIRT665799)
- hsa-mir-6836-3p (MIRT665800)
- hsa-mir-5001-3p (MIRT665801)
- hsa-mir-891a-3p (MIRT665802)
- hsa-mir-143-5p (MIRT665803)
- hsa-mir-6829-3p (MIRT665804)
- hsa-mir-6791-3p (MIRT665805)
- hsa-mir-6778-3p (MIRT665806)
- hsa-mir-6499-3p (MIRT665807)
- hsa-mir-4772-3p (MIRT665808)
- hsa-mir-6787-3p (MIRT665809)
- hsa-mir-1304-3p (MIRT665810)
- hsa-mir-5693 (MIRT665811)
- hsa-mir-6736-3p (MIRT665812)
- hsa-mir-6890-3p (MIRT665813)
- hsa-mir-216a-5p (MIRT665814)
- hsa-mir-122-5p (MIRT678576)
miRNA Products
- Search ViGene Biosciences for TMEM168
Clone Products
- OriGene clones in human for TMEM168
- OriGene ORF clones in human,mouse,rat for TMEM168
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Cell Line Products
-
ViGene Biosciences adenoviral particle packaged cDNA for TMEM168 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for TMEM168 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for TMEM168 gene
Flow Cytometry Products
No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM168 Gene
Localization for TMEM168 Gene
Subcellular locations from UniProtKB/Swiss-Prot for TMEM168 Gene
- Membrane; Multi-pass membrane protein.
| Compartment | Confidence |
|---|---|
| plasma membrane | 3 |
| endoplasmic reticulum | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016021 | integral component of membrane | IEA | -- |
More details on SuperPathways for TMEM168Transcripts for TMEM168 Gene
mRNA/cDNA for TMEM168 Gene
- (4) REFSEQ mRNAs :
- (6) Additional mRNA sequences :
- (108) Selected AceView cDNA sequences:
- (7) Ensembl transcripts including schematic representations, and UCSC links where relevant :
Unigene Clusters for TMEM168 Gene
CRISPR Products
-
OriGene CRISPR knockouts for TMEM168
-
Santa Cruz Biotechnology (SCBT) CRISPR for TMEM168
- GenScript: Design CRISPR guide RNA sequences for TMEM168
miRNA Products
- Search ViGene Biosciences for TMEM168
Clone Products
- OriGene clones in human for TMEM168
- OriGene ORF clones in human,mouse,rat for TMEM168
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
Flow Cytometry Products
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | ||||||||||||||||||||||||||||
| SP2: | - | - | - | ||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | ||||||||||||||||||||||||
| SP4: | |||||||||||||||||||||||||||||
| SP5: | - |
Expression for TMEM168 Gene
This gene is overexpressed in Placenta (36.0), Breast (13.4), and Testis (7.5).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for TMEM168 Gene
SOURCE GeneReport for Unigene cluster for TMEM168 Gene Hs.709689
Primer Products
-
OriGene qPCR primer pairs for TMEM168
-
OriGene qPCR primer pairs and template standards for TMEM168
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM168 Gene
Orthologs for TMEM168 Gene
This gene was present in the common ancestor of chordates.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| cow (Bos Taurus) |
Mammalia | TMEM168 35 |
|
||
| TMEM168 36 |
|
OneToOne | |||
| dog (Canis familiaris) |
Mammalia | TMEM168 35 |
|
||
| TMEM168 36 |
|
OneToOne | |||
| mouse (Mus musculus) |
Mammalia | Tmem168 35 |
|
||
| Tmem168 16 |
|
||||
| Tmem168 36 |
|
OneToOne | |||
| chimpanzee (Pan troglodytes) |
Mammalia | TMEM168 35 |
|
||
| TMEM168 36 |
|
OneToOne | |||
| rat (Rattus norvegicus) |
Mammalia | Tmem168 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | TMEM168 36 |
|
OneToOne | |
| platypus (Ornithorhynchus anatinus) |
Mammalia | TMEM168 36 |
|
OneToOne | |
| chicken (Gallus gallus) |
Aves | TMEM168 35 |
|
||
| TMEM168 36 |
|
OneToOne | |||
| lizard (Anolis carolinensis) |
Reptilia | TMEM168 36 |
|
OneToOne | |
| tropical clawed frog (Silurana tropicalis) |
Amphibia | tmem168 35 |
|
||
| zebrafish (Danio rerio) |
Actinopterygii | tmem168b 35 |
|
||
| tmem168a 36 |
|
OneToMany | |||
| tmem168b 36 |
|
OneToMany | |||
| sea squirt (Ciona savignyi) |
Ascidiacea | -- 36 |
|
OneToMany | |
| -- 36 |
|
OneToMany |
- Species with no ortholog for TMEM168:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- fruit fly (Drosophila melanogaster)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- wheat (Triticum aestivum)
- worm (Caenorhabditis elegans)
Paralogs for TMEM168 Gene
No data available for Paralogs for TMEM168 Gene
Variants for TMEM168 Gene
| SNP ID | Clin | Chr 07 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs6950471 | -- | 112,767,181(+) | TATCC(C/T)GCTTT | nc-transcript-variant, utr-variant-3-prime | |
| rs6950616 | -- | 112,787,693(+) | acagg(C/T)gtgag | intron-variant | |
| rs1227166 | -- | 112,775,752(-) | AATGA(A/C)CCCTT | intron-variant | |
| rs1227167 | -- | 112,774,675(-) | tgaac(C/G)tggga | intron-variant | |
| rs1227168 | -- | 112,773,298(-) | GGAGA(C/T)ATTAT | intron-variant |
| Variant ID | Type | Subtype | PubMed ID |
|---|---|---|---|
| esv2422365 | CNV | Duplication | 17116639 |
| nsv464689 | CNV | Gain | 19166990 |
| nsv7405 | OTHER | Inversion | 18451855 |
| esv2752144 | CNV | Gain | 17911159 |
Residual Variation Intolerance Score:
14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
3.36;
53.86% of all genes are more intolerant (likely to be disease-causing)
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for TMEM168 Gene
Disorders for TMEM168 Gene
Relevant External Links for TMEM168
No disorders were found for TMEM168 Gene.
No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM168 Gene
Publications for TMEM168 Gene
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48 67
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
- Phospho-tyrosine dependent protein-protein interaction network. (PMID: 25814554) Grossmann A. … Stelzl U. (Mol. Syst. Biol. 2015) 3
- A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
- A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PMID: 22779921) Long P. … Rose S. (Eur. J. Neurosci. 2012) 3
Products for TMEM168 Gene
- Browse R&D Systems for Antibodies
- Browse R&D Systems for Human Recombinant Proteins
- Browse R&D Systems for biochemical assays
- Browse Primary Antibodies
- Browse Proteins and Enzymes
- Browse ELISAs
- Browse Activity Assays
- Browse cDNA Clones
- Browse Cell Culture Products
- Browse Cell Selection and Detection Kits
- Browse DNA Damage and Repair Kits
- Browse ELISpot/FluoroSpot Kits and Development Modules
- Browse Flow Cytometry Kits
- Browse Immunoprecipitation Assays
- Browse Luminex Assays
- Browse Peptides
- Browse Proteome Profiler Antibody Arrays
- Browse Small Molecules
- Custom Antibody Services
- Browse OriGene ELISA Kits
- Custom Assay Services
- OriGene Purified Proteins for TMEM168
- Search Origene for MassSpec and Protein Over-expression Lysates for TMEM168
- Origene Custom Protein Services for TMEM168
- Origene siRNA, shRNA, mouse_rna, rat_shrna, and RNAi products in human, mouse, rat for TMEM168
- Browse OriGene Inhibitory RNA Products For TMEM168
- OriGene qPCR primer pairs for TMEM168
- OriGene qPCR primer pairs and template standards for TMEM168
- OriGene CRISPR knockouts for TMEM168
- OriGene clones in human for TMEM168
- OriGene ORF clones in human,mouse,rat for TMEM168
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- GenScript: Next-day shipping cDNA clones in your preferred vector
- GenScript Custom Purified and Recombinant Proteins Services for TMEM168
- GenScript Custom Assay Services for TMEM168
- GenScript Custom overexpressing Cell Line Services for TMEM168
- GenScript: Design CRISPR guide RNA sequences for TMEM168
- Design optimal peptide antigens
- CloneReady with Over 120,000 Genes
- Gene Synthesis: Any Gene in Any Vector
- Vector-based siRNA and miRNA, Ready for Transfection
- Gene Mutant Library, Variants up to 10^11
- Plasmid Preparation
- GenScript Custom Peptide Services for TMEM168
- Novus Biologicals Antibodies for TMEM168
- Novus Biologicals proteins for TMEM168
- Novus Biologicals
- Novus Biologicals Tissue Microarrays
- Taconic Biosciences Mouse Models for TMEM168
- Find your next knockout model in the Taconic Knockout Repository
- Genetically Engineered Models Available Immediately
- Humanized Mice
- ViGene Biosciences adenoviral particle packaged cDNA for TMEM168 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM168 gene
- ViGene Biosciences lentiviral particle packaged cDNA for TMEM168 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM168 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM168 gene
- ViGene Biosciences ready-to-package AAV shRNAs for TMEM168 gene
- Search ViGene Biosciences for TMEM168
- Search ViGene Biosciences for TMEM168
- Santa Cruz Biotechnology (SCBT) Antibodies for TMEM168
- Search Santa Cruz Biotechnology (SCBT) for TMEM168 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for TMEM168
Sources for TMEM168 Gene
- (1) GeneCards
- (2) HGNC
- (3) EntrezGene
- (4) Swiss-Prot
- (5) Ensembl
- (6) OMIM
- (7) GeneLoc
- (8) Gene Wiki
- (9) UCSC
- (10) PhosphoSitePlus
- (11) GO
- (12) TrEMBL
- (13) InterPro
- (14) ProtoNet
- (15) Blocks
- (16) MGI
- (17) IUBMB
- (18) KEGG
- (19) MINT
- (20) STRING
- (21) I2D
- (22) IntAct
- (23) Novoseek
- (24) PharmGKB
- (25) DrugBank
- (26) HMDB
- (27) UniGene
- (28) AceView
- (29) RNAdb
- (30) ASD
- (31) ECgene
- (32) GeneAnnot
- (33) SAGE
- (34) SOURCE
- (35) HomoloGene
- (36) PanEnsembl
- (37) euGenes
- (38) SGD
- (39) FlyBase
- (40) WormBase
- (41) Pseudogene
- (42) DGV
- (43) dbSNP
- (44) HapMap
- (45) GenAtlas
- (46) GeneTests
- (47) HGMD
- (48) GAD
- (49) LSDB
- (50) BGMUT
- (51) HuGE
- (52) eBioscience
- (53) Atlas
- (54) Cell Signaling Technology
- (55) GenBank
- (56) H-invDB
- (57) HORDE
- (58) HUGE
- (59) IMGT
- (60) Leiden
- (61) MILLIPORE
- (62) miRBase
- (63) DME
- (64) Nature
- (65) NCBI
- (66) OriGene
- (67) PubMed
- (68) R&D Systems
- (69) Salk
- (70) TGDB
- (71) Tufts
- (72) YEDA
- (73) CROW21
- (74) Tocris
- (75) Abcam
- (76) Novus
- (77) ProSpec
- (78) Sino Biological
- (79) GenScript
- (80) Qiagen
- (81) Cloud-Clone Corp.
- (82) Enzo Life Sciences
- (83) OCA
- (84) Proteopedia
- (85) MOPED
- (86) SPIRE
- (87) neXtProt
- (88) Reactome
- (89) GeneGo (Thomson Reuters)
- (90) fRNAdb
- (91) DISEASES
- (92) SIMAP
- (93) GenomeRNAi
- (94) LifeMap
- (95) miRTarBase
- (96) MalaCards
- (97) Invitrogen
- (98) BitterDB
- (99) Vector BioLabs
- (100) ESI-BIO
- (101) RefSeq
- (102) BioSystems
- (103) MaxQB
- (104) IUPHAR
- (105) BioGPS
- (106) Illumina
- (107) COMPARTMENTS
- (108) HOMER
- (109) PaxDb
- (110) ApexBio
- (111) Addgene
- (112) Advanced Cell Diagnostics
- (113) antibodies-online
- (114) CYP
- (115) NONCODE
- (116) SwitchGear Genomics
- (117) TreeFam
- (118) PathCards
- (119) GeneReviews
- (120) GeneTex
- (121) Taconic Biosciences
- (122) GTEx
- (123) ProteomicsDB
- (124) SCBT
- (125) DGIdb
- (126) ClinicalTrials
- (127) FDA Approved Drugs
- (128) RVIS
- (129) SIGNOR
- (130) diseasecard
- (131) NIH Rare Diseases
- (132) Orphanet
- (133) UMLS
- (134) GTR
- (135) Disease Ontology
- (136) Genetics Home Reference
- (137) MeSH
- (138) MedlinePlus
- (139) CDC
- (140) NINDS
- (141) NCBI Bookshelf
- (142) ClinVar
- (143) Gene Damage Index
- (144) ViGene Biosciences
- (145) HPO
- (146) UDN
- (147) VISTA
- (148) FANTOM5
- (149) ENCODE
- (150) ProSci
- (151) Horizon