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Aliases for TMEM168 Gene

Aliases for TMEM168 Gene

  • Transmembrane Protein 168 2 3

External Ids for TMEM168 Gene

Previous GeneCards Identifiers for TMEM168 Gene

  • GC07M112193
  • GC07M112405
  • GC07M106773

Summaries for TMEM168 Gene

GeneCards Summary for TMEM168 Gene

TMEM168 (Transmembrane Protein 168) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM168 Gene

Genomics for TMEM168 Gene

Regulatory Elements for TMEM168 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for TMEM168 Gene

112,762,382 bp from pter
112,790,713 bp from pter
28,332 bases
Minus strand

Genomic View for TMEM168 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for TMEM168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM168 Gene

Proteins for TMEM168 Gene

  • Protein details for TMEM168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 168
    Protein Accession:
    Secondary Accessions:
    • A4D0T9
    • B4DDS0
    • Q8NEK4
    • Q9H8J2

    Protein attributes for TMEM168 Gene

    697 amino acids
    Molecular mass:
    79755 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM168 Gene


neXtProt entry for TMEM168 Gene

Proteomics data for TMEM168 Gene at MOPED

Post-translational modifications for TMEM168 Gene

  • Glycosylation at Asn111, Asn533, and Asn598
  • Modification sites at PhosphoSitePlus

Other Protein References for TMEM168 Gene

No data available for DME Specific Peptides for TMEM168 Gene

Domains for TMEM168 Gene

Protein Domains for TMEM168 Gene


Suggested Antigen Peptide Sequences for TMEM168 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q9H0V1
  • Belongs to the TMEM168 family.
genes like me logo Genes that share domains with TMEM168: view

No data available for Gene Families for TMEM168 Gene

Function for TMEM168 Gene

Animal Model Products

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM168

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for TMEM168 Gene

Localization for TMEM168 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM168 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Jensen Localization Image for TMEM168 Gene COMPARTMENTS Subcellular localization image for TMEM168 gene
Compartment Confidence
plasma membrane 3
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for TMEM168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with TMEM168: view

Pathways for TMEM168 Gene

SuperPathways for TMEM168 Gene

No Data Available

Interacting Proteins for TMEM168 Gene

Gene Ontology (GO) - Biological Process for TMEM168 Gene


No data available for Pathways by source for TMEM168 Gene

Transcripts for TMEM168 Gene

Unigene Clusters for TMEM168 Gene

Transmembrane protein 168:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for TMEM168

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2: - - -
SP3: - - - - -
SP5: -

Relevant External Links for TMEM168 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM168 Gene

mRNA expression in normal human tissues for TMEM168 Gene

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for TMEM168 Gene

SOURCE GeneReport for Unigene cluster for TMEM168 Gene Hs.709689

genes like me logo Genes that share expressions with TMEM168: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for TMEM168 Gene

Orthologs for TMEM168 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM168 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM168 35
  • 99.82 (n)
  • 100 (a)
TMEM168 36
  • 98 (a)
(Bos Taurus)
Mammalia TMEM168 35
  • 93.07 (n)
  • 96.84 (a)
TMEM168 36
  • 97 (a)
(Canis familiaris)
Mammalia TMEM168 35
  • 93.11 (n)
  • 97.41 (a)
TMEM168 36
  • 97 (a)
(Mus musculus)
Mammalia Tmem168 35
  • 89.29 (n)
  • 95.41 (a)
Tmem168 16
Tmem168 36
  • 95 (a)
(Monodelphis domestica)
Mammalia TMEM168 36
  • 92 (a)
(Ornithorhynchus anatinus)
Mammalia TMEM168 36
  • 87 (a)
(Rattus norvegicus)
Mammalia Tmem168 35
  • 89.19 (n)
  • 95.98 (a)
(Gallus gallus)
Aves TMEM168 35
  • 79.72 (n)
  • 85.8 (a)
TMEM168 36
  • 85 (a)
(Anolis carolinensis)
Reptilia TMEM168 36
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem168 35
  • 75.05 (n)
  • 82.47 (a)
(Danio rerio)
Actinopterygii tmem168a 36
  • 60 (a)
tmem168b 35
  • 61.73 (n)
  • 63.51 (a)
tmem168b 36
  • 63 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 34 (a)
-- 36
  • 34 (a)
Species with no ortholog for TMEM168:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM168 Gene

Gene Tree for TMEM168 (if available)
Gene Tree for TMEM168 (if available)

Paralogs for TMEM168 Gene

No data available for Paralogs for TMEM168 Gene

Variants for TMEM168 Gene

Sequence variations from dbSNP and Humsavar for TMEM168 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type MAF
rs2457 -- 112,780,879(-) atcac(C/T)gccaa intron-variant
rs1227166 -- 112,775,752(-) AATGA(A/C)CCCTT intron-variant
rs1227167 -- 112,774,675(-) tgaac(C/G)tggga intron-variant
rs1227168 -- 112,773,298(-) GGAGA(C/T)ATTAT intron-variant
rs1227169 -- 112,772,408(-) ATTTA(C/T)GTTAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM168 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV Duplication 17116639
nsv464689 CNV Gain 19166990
nsv7405 OTHER Inversion 18451855
esv2752144 CNV Gain 17911159

Relevant External Links for TMEM168 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM168 Gene

Disorders for TMEM168 Gene

Relevant External Links for TMEM168

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with TMEM168: view

No data available for UniProtKB/Swiss-Prot for TMEM168 Gene

Publications for TMEM168 Gene

  1. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G. … Wijmenga C. (Gut 2009) 3 48
  4. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PMID: 22779921) Long P. … Rose S. (Eur. J. Neurosci. 2012) 3
  5. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PMID: 11230166) Wiemann S. … Poustka A. (Genome Res. 2001) 4

Products for TMEM168 Gene

  • antibodies-online peptides for TMEM168
  • antibodies-online antibodies for TMEM168
  • antibodies-online kits for TMEM168

Sources for TMEM168 Gene

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