Free for academic non-profit institutions. Other users need a Commercial license

Aliases for TMEM168 Gene

Aliases for TMEM168 Gene

  • Transmembrane Protein 168 2 3 5

External Ids for TMEM168 Gene

Previous GeneCards Identifiers for TMEM168 Gene

  • GC07M112193
  • GC07M112405
  • GC07M106773

Summaries for TMEM168 Gene

GeneCards Summary for TMEM168 Gene

TMEM168 (Transmembrane Protein 168) is a Protein Coding gene.

Additional gene information for TMEM168 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM168 Gene

Genomics for TMEM168 Gene

Regulatory Elements for TMEM168 Gene

Enhancers for TMEM168 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH07H113085 1 ENCODE 16.4 -296.5 -296526 2 PKNOX1 ATF1 ZNF2 ZNF766 GLIS2 GATA2 FOS ATF7 SP3 MCM3 TMEM168 SMIM30 GPR85 ENSG00000279288
GH07H112898 1.2 Ensembl ENCODE 11.2 -108.1 -108075 0 ELF3 FOXA2 ATF1 RB1 MLX ARNT ARID4B DNMT3B THRB RAD21 TMEM168 BMT2
GH07H112495 0.8 ENCODE 16.4 +294.7 294673 0 CTCF CEBPG ZNF2 RAD21 CC2D1A ZSCAN5C SMC3 ZNF143 MAFK MIXL1 TMEM168 LSMEM1 NPM1P14
GH07H112448 1.2 ENCODE 10.5 +339.5 339461 6 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZNF610 GLIS1 NBN NR2C1 IFRD1 LSMEM1 MTCYBP24 MTND5P8 MTND6P24 LOC101928012 ENSG00000270997 TMEM168 GPR85 IMMP2L
GH07H112788 1.1 ENCODE 11.2 +0.9 941 2 HDGF HNRNPUL1 PKNOX1 ARNT ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF766 TMEM168 GC07P112762
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM168 on UCSC Golden Path with GeneCards custom track

Promoters for TMEM168 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for TMEM168 Gene

112,762,382 bp from pter
112,790,713 bp from pter
28,332 bases
Minus strand

Genomic View for TMEM168 Gene

Genes around TMEM168 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM168 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM168 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM168 Gene

Proteins for TMEM168 Gene

  • Protein details for TMEM168 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Transmembrane protein 168
    Protein Accession:
    Secondary Accessions:
    • A4D0T9
    • B4DDS0
    • Q8NEK4
    • Q9H8J2

    Protein attributes for TMEM168 Gene

    697 amino acids
    Molecular mass:
    79755 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305};

    Alternative splice isoforms for TMEM168 Gene


neXtProt entry for TMEM168 Gene

Post-translational modifications for TMEM168 Gene

  • Glycosylation at Asn111, Asn533, and Asn598
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for TMEM168 Gene

Domains & Families for TMEM168 Gene

Gene Families for TMEM168 Gene

Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins
  • Predicted secreted proteins

Protein Domains for TMEM168 Gene


Suggested Antigen Peptide Sequences for TMEM168 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the TMEM168 family.
  • Belongs to the TMEM168 family.
genes like me logo Genes that share domains with TMEM168: view

Function for TMEM168 Gene

Phenotypes for TMEM168 Gene

GenomeRNAi human phenotypes for TMEM168:
genes like me logo Genes that share phenotypes with TMEM168: view

Animal Model Products

  • Taconic Biosciences Mouse Models for TMEM168

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM168
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM168 Gene

Localization for TMEM168 Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM168 Gene

Membrane; Multi-pass membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM168 gene
Compartment Confidence
plasma membrane 3
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for TMEM168 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
GO:0030133 transport vesicle IDA --
genes like me logo Genes that share ontologies with TMEM168: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM168 Gene

Pathways & Interactions for TMEM168 Gene

SuperPathways for TMEM168 Gene

No Data Available

Interacting Proteins for TMEM168 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000323068 Q9H0V1-TM168_HUMAN for TMEM168 Gene via STRING IID

Gene Ontology (GO) - Biological Process for TMEM168 Gene


No data available for Pathways by source and SIGNOR curated interactions for TMEM168 Gene

Drugs & Compounds for TMEM168 Gene

No Compound Related Data Available

Transcripts for TMEM168 Gene

Unigene Clusters for TMEM168 Gene

Transmembrane protein 168:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM168
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168 Gene

ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
SP1: -
SP2: - - -
SP3: - - - - -
SP5: -

Relevant External Links for TMEM168 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM168 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM168 Gene

Protein differential expression in normal tissues from HIPED for TMEM168 Gene

This gene is overexpressed in Placenta (36.0), Breast (13.4), and Testis (7.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for TMEM168 Gene

Protein tissue co-expression partners for TMEM168 Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM168 Gene:


SOURCE GeneReport for Unigene cluster for TMEM168 Gene:


Evidence on tissue expression from TISSUES for TMEM168 Gene

  • Nervous system(4.5)
genes like me logo Genes that share expression patterns with TMEM168: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM168 Gene

Orthologs for TMEM168 Gene

This gene was present in the common ancestor of chordates.

Orthologs for TMEM168 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM168 33 34
  • 99.82 (n)
(Canis familiaris)
Mammalia TMEM168 33 34
  • 93.11 (n)
(Bos Taurus)
Mammalia TMEM168 33 34
  • 93.07 (n)
(Monodelphis domestica)
Mammalia TMEM168 34
  • 92 (a)
(Mus musculus)
Mammalia Tmem168 33 16 34
  • 89.29 (n)
(Rattus norvegicus)
Mammalia Tmem168 33
  • 89.19 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM168 34
  • 87 (a)
(Gallus gallus)
Aves TMEM168 33 34
  • 79.72 (n)
(Anolis carolinensis)
Reptilia TMEM168 34
  • 85 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem168 33
  • 75.05 (n)
(Danio rerio)
Actinopterygii tmem168b 33 34
  • 61.73 (n)
tmem168a 34
  • 60 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 34 (a)
-- 34
  • 34 (a)
Species where no ortholog for TMEM168 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for TMEM168 Gene

Gene Tree for TMEM168 (if available)
Gene Tree for TMEM168 (if available)

Paralogs for TMEM168 Gene

No data available for Paralogs for TMEM168 Gene

Variants for TMEM168 Gene

Sequence variations from dbSNP and Humsavar for TMEM168 Gene

SNP ID Clin Chr 07 pos Sequence Context AA Info Type
rs1000288077 -- 112,785,675(+) CTAAT(A/T)GTCAT intron-variant
rs1000355479 -- 112,768,343(+) CATCT(A/G)AACCC intron-variant
rs1000412152 -- 112,785,958(+) ATCCC(A/G)GAACT intron-variant
rs1000505659 -- 112,778,111(+) CCAGG(A/T)TGAAC intron-variant, nc-transcript-variant, utr-variant-3-prime
rs1000690226 -- 112,775,614(+) AAAAA(A/C)CAAAA intron-variant, nc-transcript-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for TMEM168 Gene

Variant ID Type Subtype PubMed ID
esv2422365 CNV duplication 17116639
esv2752144 CNV gain 17911159
nsv464689 CNV gain 19166990
nsv608200 CNV gain 21841781
nsv608226 CNV gain 21841781
nsv7405 OTHER inversion 18451855

Variation tolerance for TMEM168 Gene

Residual Variation Intolerance Score: 14.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.36; 53.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM168 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM168 Gene

Disorders for TMEM168 Gene

Relevant External Links for TMEM168

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM168 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM168 Gene

Publications for TMEM168 Gene

  1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PMID: 19240061) Trynka G … Wijmenga C (Gut 2009) 3 45 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for TMEM168 Gene

Sources for TMEM168 Gene

Loading form....