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TMEM168 Gene

protein-coding   GIFtS: 41
GCID: GC07M112405

Transmembrane Protein 168

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Transmembrane Protein 1681 2

External Ids:    HGNC: 258261   Entrez Gene: 644182   Ensembl: ENSG000001468027   UniProtKB: Q9H0V13   

Export aliases for TMEM168 gene to outside databases

Previous GC identifers: GC07M112193 GC07M106773


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for TMEM168 Gene:
TMEM168 (transmembrane protein 168) is a protein-coding gene.


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the TMEM168 gene promoter:
         GR   AML1a   GR-beta   Cdc5   Egr-2   CREB   POU2F1   deltaCREB   POU2F1a   GR-alpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): TMEM168 promoter sequence
   Search Chromatin IP Primers for TMEM168

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM168


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 7q31.32   Ensembl cytogenetic band:  7q31.1   HGNC cytogenetic band: 7q31.32

TMEM168 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
TMEM168 gene location

GeneLoc information about chromosome 7         GeneLoc Exon Structure

GeneLoc location for GC07M112405:  view genomic region     (about GC identifiers)

Start:
112,402,437 bp from pter      End:
112,430,647 bp from pter
Size:
28,211 bases      Orientation:
minus strand

1 alternative location:
Chr7-,CRA_TCAG 111,774,269-111,798,936     

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1 (See protein sequence)
Recommended Name: Transmembrane protein 168  
Size: 697 amino acids; 79755 Da
Sequence caution: Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D0T9 Q8NEK4 Q9H8J2

Explore the universe of human proteins at neXtProt for TMEM168: NX_Q9H0V1

Explore proteomics data for TMEM168 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn111, Asn533, Asn598
  • Modification sites at PhosphoSitePlus

  • See TMEM168 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001274426.1  NP_071929.3  

    ENSEMBL proteins: 
     ENSP00000323068   ENSP00000390696   ENSP00000410307   ENSP00000404253   ENSP00000407373  
     ENSP00000412462  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    ProtoNet protein and cluster: Q9H0V1

    UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1
    Similarity: Belongs to the TMEM168 family


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for TMEM168
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    hsa-mir-16-5p (MIRT031501), hsa-mir-101-3p (MIRT027266), hsa-mir-93-5p (MIRT027960), hsa-mir-26b-5p (MIRT028945), hsa-mir-221-3p (MIRT024146), hsa-mir-130b-3p (MIRT020118)

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    Selected qRT-PCR Assays for microRNAs that regulate TMEM168 (see all 39):
    hsa-miR-562 hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-124 hsa-miR-3658 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTMEM168 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM168


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    TM168_HUMAN, Q9H0V1: Membrane; Multi-pass membrane protein (Potential)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane3
    cytosol1
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016021integral component of membrane IEA--
    GO:0030133transport vesicle IDA--

    Find genes that share ontologies with TMEM168           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM168
    Interactions:

        Search GeneGlobe Interaction Network for TMEM168

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for TMEM168 (TM168)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for TMEM168 gene (2 alternative transcripts): 
    NM_001287497.1  NM_022484.5  

    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000312814(uc003vgn.3 uc010lju.3 uc011kmr.2) ENST00000454074
    ENST00000447395 ENST00000418785 ENST00000449743 ENST00000441474 ENST00000480969

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate TMEM168 (see all 39):
    hsa-miR-562 hsa-miR-300 hsa-miR-106a hsa-miR-3653 hsa-miR-519a hsa-miR-124 hsa-miR-3658 hsa-miR-93
    SwitchGear 3'UTR luciferase reporter plasmidTMEM168 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat TMEM168
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      QuantiTect SYBR Green Assays in human, mouse, rat TMEM168
      QuantiFast Probe-based Assays in human, mouse, rat TMEM168

    Selected AceView cDNA sequences (see all 108):

    AU138470 BX957054 AA825977 AI424672 BU677982 AI859107 BC030804 BE503373 
    AW235345 CD722891 AI866851 AU135490 BQ574888 AK025482 BQ026579 BQ897564 
    BG610832 BX421826 AA489091 AI569496 BF804245 AL136626 BQ017026 BX452293 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168    About this scheme

    ExUns: 1a · 1b · 1c · 1d ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7a · 7b · 7c ^ 8a · 8b
    SP1:                                                  -                                       
    SP2:                          -           -           -                                       
    SP3:                          -     -     -     -     -                                       
    SP4:                                                                                          
    SP5:                          -                                                               


    ECgene alternative splicing isoforms for TMEM168

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    TMEM168 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TAATGTATTC
    TMEM168 Expression
    About this image

    TMEM168 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    TMEM168 Protein Expression
        Custom PCR Arrays for TMEM168
    Primer
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    QuantiFast Probe-based Assays in human, mouse, rat TMEM168
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM168

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for TMEM168 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Tmem1681 , 5 transmembrane protein 1681, 5 89.29(n)1
    95.41(a)1
      6 (5.68 cM)5
    1011181  NM_028990.41  NP_083266.11 
     135806875 
    chicken
    (Gallus gallus)
    Aves TMEM1681 transmembrane protein 168 79.72(n)
    85.8(a)
      417777  XM_416021.4  XP_416021.2 
    lizard
    (Anolis carolinensis)
    Reptilia TMEM1686
    transmembrane protein 168
    85(a)
    1 ↔ 1
    5(58582852-58591964)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC043897.12   -- 77.48(n)    BC043897.1 
    zebrafish
    (Danio rerio)
    Actinopterygii tmem168b1 transmembrane protein 168b 61.73(n)
    63.51(a)
      558640  XM_681870.4  XP_686962.3 


    ENSEMBL Gene Tree for TMEM168 (if available)
    TreeFam Gene Tree for TMEM168 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for TMEM168 (see all 508)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 7 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1932754301,2
    --112405331(+) TTTTTA/GGTTTT 1 -- ds50010--------
    rs1854235511,2
    --112405350(+) AGGAAA/CTACAT 1 -- ds50010--------
    rs12348941,2
    C,F,H--112405419(+) AGTACC/GACCTT 1 -- ds50017Minor allele frequency- G:0.06NS EA NA WA 508
    rs1416925561,2
    --112405586(+) TTTAAC/TATTTG 1 -- ds50010--------
    rs594323181,2
    F--112405689(+) GAAACG/TTCCAA 1 -- ds50010--------
    rs2019851141,2
    --112405776(+) ATCAT-/TAAA  
            
    TAAAA
    1 -- ds50010--------
    rs1394658291,2
    --112405845(+) CAGAAA/GTAATC 1 -- ut310--------
    rs1428982561,2
    C--112405911(+) TCCTA-/ACTT  
            
    ACTTA
    1 -- ut310--------
    rs343779631,2
    C--112405983(+) GCTAT-/AAAAAA 1 -- ut311Minor allele frequency- A:0.00CSA 2
    rs2015708221,2
    --112405990(+) AAAAA-/TGGCTT 1 -- ut310--------

    HapMap Linkage Disequilibrium report for TMEM168 (112402437 - 112430647 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for TMEM168:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2422365CNV Duplication17116639
    esv2752144CNV Gain17911159
    nsv464689CNV Gain19166990
    nsv7405OTHER Inversion18451855

    Site Specific Mutation Identification with PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for TMEM168

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    Find genes that share disorders with TMEM168           About GenesLikeMe

    Genetic Association Database (GAD): TMEM168
    Human Genome Epidemiology (HuGE) Navigator: TMEM168 (1 document)

    Export disorders for TMEM168 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for TMEM168 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with TMEM168)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    4. A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
    5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
    6. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    7. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
    8. Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
    9. The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
    10. Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2 Wiemann S.... Poustka A. (Genome Res. 2001)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 64418 HGNC: 25826 AceView: FLJ13576 Ensembl:ENSG00000146802 euGenes: HUgn64418
    ECgene: TMEM168 H-InvDB: TMEM168

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for TMEM168 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for TMEM168 gene:
    Search GeneIP for patents involving TMEM168

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Search Addgene for plasmids for TMEM168
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      eBioscience FlowRNA Probe Sets
           
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