TMEM168 Gene
protein-coding GIFtS: 41
GCID: GC07M112405
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|
Transmembrane Protein 168
| |
Aliases
for TMEM168 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
10fRNAdb,
12H-InvDB,
13NCBI,
14NONCODE,
and/or 15RNAdb)
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| Aliases |
|---|
| Transmembrane Protein 1681 2 |
Export aliases for TMEM168 gene to outside databasesPrevious GC identifers: GC07M112193 GC07M106773 |
Summaries
for TMEM168 gene(According to Entrez Gene,
GeneCards,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
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GeneCards Summary for TMEM168 Gene:
TMEM168 (transmembrane protein 168) is a protein-coding gene.
|
Genomic Views
for TMEM168 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 75),
Regulatory elements and Epigenetics data according to
QIAGEN, and/or
SwitchGear Genomics)
About This Section
TryGeneCards Plus | Regulatory elements:
 Regulatory transcription factor binding sites in the TMEM168 gene promoter:
GR AML1a GR-beta Cdc5 Egr-2 CREB POU2F1 deltaCREB POU2F1a GR-alpha
Other transcription factors
Search Chromatin IP Primers for TMEM168
Epigenetics:
| | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM168 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 7q31.32 Ensembl cytogenetic band: 7q31.1 HGNC cytogenetic band: 7q31.32TMEM168 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 7 GeneLoc Exon Structure GeneLoc location for GC07M112405: view genomic region
(about GC identifiers)
Start:
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112,402,437 bp from pter |
End:
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112,430,647 bp from pter |
Size:
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28,211 bases |
Orientation:
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minus strand |
1 alternative location:
| Chr7-,CRA_TCAG 111,774,269-111,798,936 |
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Proteins
for TMEM168 gene
(According to
1UniProtKB,
HORDE,
2neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to PhosphoSitePlus,
Specific Peptides from DME,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Cloud-Clone Corp.,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Cloud-Clone Corp.,
Antibodies by
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
LSBio,
Abcam, and/or
Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1 (See
protein sequence)Recommended Name: Transmembrane protein 168 Size: 697 amino acids; 79755 Da
Sequence caution: Sequence=AAQ96836.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Sequence=BAB14624.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
Secondary accessions: A4D0T9 Q8NEK4 Q9H8J2Explore the universe of human proteins at neXtProt for TMEM168: NX_Q9H0V1
Explore proteomics data for TMEM168 at MOPED
Post-translational modifications:  Glycosylation2 at Asn111, Asn533, Asn598 Modification sites at PhosphoSitePlus
See TMEM168 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB
REFSEQ proteins (2 alternative transcripts):
NP_001274426.1 NP_071929.3
ENSEMBL proteins: ENSP00000323068 ENSP00000390696 ENSP00000410307 ENSP00000404253 ENSP00000407373 ENSP00000412462
TMEM168 Human Recombinant
Protein Products:TMEM168 Antibody
Products:TMEM168 Assay Products: |
Domains /
Families
for TMEM168 gene(According to HGNC, IUPHAR, InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
TryGeneCards Plus | ProtoNet protein and cluster: Q9H0V1 UniProtKB/Swiss-Prot: TM168_HUMAN, Q9H0V1Similarity: Belongs to the TMEM168 family |
Function
for TMEM168 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
inGenious Targeting Laboratory,
genOway,
transcription factor targeting from QIAGEN
and/or HOMER,
miRNA Gene Targets from miRTarBase,
shRNA from
OriGene,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
SwitchGear Genomics,
Gene Editing from DNA2.0,
Clones from OriGene,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
ESI BIO,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Animal Models:
Inhib. RNA
Products: |  | OriGene RNAi products in human, mouse, rat for TMEM168
| | | Predesigned siRNA for gene silencing in human, mouse, rat TMEM168 |
Cell Line
Products: |  | GenScript Custom overexpressing Cell Line Services for TMEM168 | |  | Browse ESI BIO Cell Lines and PureStem Progenitors for TMEM168  | In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM168 |
Localization
for TMEM168 gene
(According to UniProtKB, COMPARTMENTS Subcellular localization database,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene.)
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Subcellular locations from UniProtKB/Swiss-Prot TM168_HUMAN, Q9H0V1: Membrane; Multi-pass membrane protein (Potential)Subcellular locations from COMPARTMENTS:
| Compartment | Confidence |
|---|
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| plasma membrane | 3 | | cytosol | 1 | | endoplasmic reticulum | 1 | | nucleus | 1 |
Gene Ontology (GO): 2 cellular component terms: About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0016021 | integral component of membrane |
IEA | -- | | GO:0030133 | transport vesicle |
IDA | -- |
TMEM168 for ontologies About GeneDecksing
|
Pathways & Interactions
for TMEM168 gene
(SuperPaths according to PathCards,
Pathways according to
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Sino Biological,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
QIAGEN,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2014 via
Entrez Gene).
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Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for TMEM168
Interactions:
Search GeneGlobe Interaction Network for TMEM168
|
Drugs & Compounds
for TMEM168 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience,
ApexBio,
HMDB,
BitterDB, and/or
Novoseek,
Ligands according to IUPHAR,
and Drugs according to DrugBank,
Enzo Life Sciences, and/or
PharmGKB)
About This Section
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 Browse compounds at ApexBio
 Browse Tocris compounds for TMEM168 (TM168)
|
Transcripts
for TMEM168 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
Conferences by KenesGroup,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
SwitchGear Genomics,
Tagged/untagged cDNA clones from
OriGene,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene, and/or
QIAGEN
)
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REFSEQ mRNAs for TMEM168 gene (2 alternative transcripts): NM_001287497.1 NM_022484.5 7 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000312814(uc003vgn.3 uc010lju.3 uc011kmr.2) ENST00000454074
ENST00000447395 ENST00000418785 ENST00000449743 ENST00000441474 ENST00000480969
Inhib. RNA
Products: | | OriGene RNAi products in human, mouse, rat for TMEM168
| |
| | Predesigned siRNA for gene silencing in human, mouse, rat TMEM168 |
Primer
Products: | | OriGene qPCR primer pairs and template standards for TMEM168
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM168
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM168 | | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM168 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM168 |
Selected AceView cDNA sequences (see all 108): AU138470 BX957054 AA825977 AI424672 BU677982 AI859107 BC030804 BE503373 AW235345 CD722891 AI866851 AU135490 BQ574888 AK025482 BQ026579 BQ897564 BG610832 BX421826 AA489091 AI569496 BF804245 AL136626 BQ017026 BX452293
GeneLoc Exon Structure
5 Alternative Splicing Database (ASD) splice patterns (SP) for TMEM168 About this scheme
| ExUns: | 1a | · | 1b | · | 1c | · | 1d | ^ | 2 | ^ | 3a | · | 3b | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | · | 7c | ^ | 8a | · | 8b |
|---|
|
| SP1: | | | | | | | | | | | | | | | | | - | | | | | | | | | | | | | | |
| SP2: | | | | | | | | | - | | | | - | | | | - | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | - | | - | | - | | - | | - | | | | | | | | | | | | | | |
| SP4: | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | | |
| SP5: | | | | | | | | | - | | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for TMEM168
|
Expression
for TMEM168 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
Protein expression images according to data from SPIRE 1MOPED,
2PaxDb, and 3MaxQB,
plus additional links to
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
QIAGEN,
Primers from
OriGene, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
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TMEM168 expression in normal human tissues
(normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS <intensity>2/3
CGAP TAG: TAATGTATTC
About this image TMEM168 Protein expression data from MOPED1, PaxDb2 and
MaxQB3: About this image
Custom PCR Arrays for TMEM168
Primer
Products: | | OriGene qPCR primer pairs and template standards for TMEM168
OriGene qSTAR qPCR primer pairs in human, mouse for TMEM168
| | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM168 | | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM168 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM168 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM168 |
Orthologs
for TMEM168 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
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This gene was present in the common ancestor of chordates.
Orthologs for TMEM168 gene from Selected species (see all 13) About this table
ENSEMBL Gene Tree for TMEM168 (if available)
TreeFam Gene Tree for TMEM168 (if available) |
Paralogs
for TMEM168 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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Genomic Variants
for TMEM168 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
4UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD), the Human Cytochrome P450 Allele
Nomenclature Database, and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 7 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM168 (112402437 - 112430647 bp)
Structural Variations
Database of Genomic Variants (DGV) 4 variations for TMEM168: About this table
| | Site Specific Mutation Identification with PCR Assays |
| | SeqTarget long-range PCR primers for resequencing TMEM168 |
|
Disorders
/ Diseases
for TMEM168 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database, Conferences by KenesGroup,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
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TMEM168 for disorders About GeneDecksing
Genetic Association Database (GAD): TMEM168
Human Genome Epidemiology (HuGE) Navigator: TMEM168 (1 document)
Export disorders for TMEM168 gene to outside databases
|
Publications
for TMEM168 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
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PubMed articles for TMEM168 gene, integrated from 10 sources (see all 12):
(articles sorted by number of sources associating them with TMEM168) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Coeliac disease-associated risk variants in TNFAIP3 and REL implicate altered NF-kappaB signalling. (PubMed id 19240061)1, 4 Trynka G....Wijmenga C. (Gut 2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
- A yeast two-hybrid screen reveals that osteopontin associates with MAP1A and MAP1B in addition to other proteins linked to microtubule stability, apoptosis and protein degradation in the human brain. (PubMed id 22779921)1 Long P....Rose S. (Eur. J. Neurosci. 2012)
- Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (Genome Res. 2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
- Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. (PubMed id 15146197)1 Brandenberger R.... Stanton L.W. (Nat. Biotechnol. 2004)
- Human chromosome 7: DNA sequence and biology. (PubMed id 12690205)2 Scherer S.W.... Tsui L.-C. (Science 2003)
- The DNA sequence of human chromosome 7. (PubMed id 12853948)2 Hillier L.W.... Wilson R.K. (Nature 2003)
- Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. (PubMed id 11230166)2 Wiemann S.... Poustka A. (Genome Res. 2001)
|
External Searches for TMEM168 gene (in PubMed,
OMIM, and NCBI Bookshelf)
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|
Genome Databases showing TMEM168 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
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|
Other Databases showing TMEM168 gene
(According to HUGE)
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Specialized Databases showing TMEM168 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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| Name | Description |
| PharmGKB entry for TMEM168 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
TryGeneCards Plus | Patent Information for TMEM168 gene:
Search GeneIP for patents involving TMEM168
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM168 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or
ApexBio, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory,
genOway)
About This Section
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 | |
 |
| | | | |
 |
 |
|  | Block miRNA regulation of human, mouse, rat TMEM168 using miScript Target Protectors | | SeqTarget long-range PCR primers for resequencing TMEM168 | | | DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat TMEM168 | | Predesigned siRNA for gene silencing in human, mouse, rat TMEM168 | | | QuantiFast Probe-based Assays in human, mouse, rat TMEM168 | | QuantiTect SYBR Green Assays in human, mouse, rat TMEM168 | | | Custom PCR Arrays for TMEM168 | | Search Chromatin IP Primers for TMEM168 | | | Pre-validated RT2 qPCR Primer Assay in human, mouse, rat TMEM168 | | Search GeneGlobe Interaction Network for TMEM168 | | | Regulatory tfbs in TMEM168 promoter |
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 |  | | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM168 |
| |  |  |  |  | | | ThermoFisher Antibodies for TMEM168 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM168 |
| | | | LSBio Antibodies in human, mouse, rat for TMEM168 |
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