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Aliases for TMEM167B Gene

Aliases for TMEM167B Gene

  • Transmembrane Protein 167B 2 3 4 5
  • C1orf119 3 4
  • Chromosome 1 Open Reading Frame 119 2
  • Protein Kish-B 3
  • Protein X 013 3
  • AD-020 3

External Ids for TMEM167B Gene

Previous HGNC Symbols for TMEM167B Gene

  • C1orf119

Previous GeneCards Identifiers for TMEM167B Gene

  • GC01P109432
  • GC01P109630
  • GC01P107526

Summaries for TMEM167B Gene

GeneCards Summary for TMEM167B Gene

TMEM167B (Transmembrane Protein 167B) is a Protein Coding gene. An important paralog of this gene is TMEM167A.

UniProtKB/Swiss-Prot for TMEM167B Gene

  • Involved in the early part of the secretory pathway.

Additional gene information for TMEM167B Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM167B Gene

Genomics for TMEM167B Gene

Regulatory Elements for TMEM167B Gene

Enhancers for TMEM167B Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01H109132 1.5 Ensembl ENCODE dbSUPER 18.2 +46.5 46462 7 PKNOX1 ATF1 ARNT ARID4B FEZF1 TCF12 ZNF766 GATA2 ELK1 NCOA1 TMEM167B ENSG00000258634 CLCC1 SARS SORT1 C1orf194 KIAA1324 GPSM2 GC01M109207
GH01H109148 1.8 FANTOM5 Ensembl ENCODE dbSUPER 8.2 +61.0 60953 4 HDGF FOXA2 ZFP64 FEZF1 YY1 TCF12 ZNF766 FOS REST SMARCA4 KIAA1324 TMEM167B AKNAD1 C1orf194 GC01M109207
GH01H109161 1.3 Ensembl ENCODE dbSUPER 10.4 +72.8 72752 3 HDAC1 PKNOX1 BACH1 CEBPG ZKSCAN1 IRF9 ZNF664 E2F1 CTBP1 GATA3 KIAA1324 SARS TMEM167B C1orf194 GC01M109207
GH01H108813 1.2 ENCODE dbSUPER 9.7 -274.0 -274005 4 PKNOX1 ATF1 FEZF1 YY1 GLIS2 FOS ATF7 REST ZNF592 SMARCA4 AKNAD1 SPATA42 ENSG00000232971 TMEM167B STXBP3 LOC105378891 GC01P108791
GH01H109184 1 Ensembl dbSUPER 10.6 +96.2 96167 2 KLF1 FOXA2 ZIC2 ZNF121 ZFHX2 ZNF316 POLR2A EGR1 ZBTB48 ZSCAN29 KIAA1324 SARS TMEM167B GC01M109207 C1orf194
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around TMEM167B on UCSC Golden Path with GeneCards custom track

Promoters for TMEM167B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000011026 1097 3001 MLX ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC ZC3H11A

Genomic Location for TMEM167B Gene

109,089,803 bp from pter
109,096,934 bp from pter
7,132 bases
Plus strand

Genomic View for TMEM167B Gene

Genes around TMEM167B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167B Gene

Proteins for TMEM167B Gene

  • Protein details for TMEM167B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Protein kish-B
    Protein Accession:
    Secondary Accessions:
    • B2RUU9

    Protein attributes for TMEM167B Gene

    74 amino acids
    Molecular mass:
    8294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167B Gene

Post-translational modifications for TMEM167B Gene

No Post-translational modifications

Other Protein References for TMEM167B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM167B Gene

Domains & Families for TMEM167B Gene

Gene Families for TMEM167B Gene

Human Protein Atlas (HPA):
  • Predicted membrane proteins

Protein Domains for TMEM167B Gene


Suggested Antigen Peptide Sequences for TMEM167B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the KISH family.
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167B: view

Function for TMEM167B Gene

Molecular function for TMEM167B Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.
genes like me logo Genes that share phenotypes with TMEM167B: view

Animal Model Products

CRISPR Products

miRNA for TMEM167B Gene

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM167B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM167B Gene

Localization for TMEM167B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167B Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for TMEM167B gene
Compartment Confidence
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000139 Golgi membrane IEA --
GO:0005794 Golgi apparatus IEA --
GO:0012505 endomembrane system IBA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167B: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for TMEM167B Gene

Pathways & Interactions for TMEM167B Gene

SuperPathways for TMEM167B Gene

No Data Available

Interacting Proteins for TMEM167B Gene

Selected Interacting proteins: Q9NRX6-KISHB_HUMAN for TMEM167B Gene via IID

Symbol External ID(s) Details

Gene Ontology (GO) - Biological Process for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0009306 protein secretion IBA --
GO:0046907 intracellular transport IBA --
genes like me logo Genes that share ontologies with TMEM167B: view

No data available for Pathways by source and SIGNOR curated interactions for TMEM167B Gene

Drugs & Compounds for TMEM167B Gene

No Compound Related Data Available

Transcripts for TMEM167B Gene

mRNA/cDNA for TMEM167B Gene

Unigene Clusters for TMEM167B Gene

Transmembrane protein 167B:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for TMEM167B
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167B Gene

No ASD Table

Relevant External Links for TMEM167B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for TMEM167B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for TMEM167B Gene

Protein differential expression in normal tissues from HIPED for TMEM167B Gene

This gene is overexpressed in Placenta (21.6), Oral epithelium (10.6), Prostate (8.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for TMEM167B Gene

NURSA nuclear receptor signaling pathways regulating expression of TMEM167B Gene:


SOURCE GeneReport for Unigene cluster for TMEM167B Gene:


Evidence on tissue expression from TISSUES for TMEM167B Gene

  • Nervous system(4.9)
  • Adrenal gland(4.3)
  • Skin(4.3)
  • Lung(2.6)
genes like me logo Genes that share expression patterns with TMEM167B: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for TMEM167B Gene

Orthologs for TMEM167B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM167B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia TMEM167B 33 34
  • 100 (n)
(Canis familiaris)
Mammalia TMEM167B 33 34
  • 96.4 (n)
(Bos Taurus)
Mammalia TMEM167B 33 34
  • 94.59 (n)
(Rattus norvegicus)
Mammalia Tmem167b 33
  • 94.59 (n)
(Mus musculus)
Mammalia Tmem167b 33 16 34
  • 93.69 (n)
(Ornithorhynchus anatinus)
Mammalia TMEM167B 34
  • 92 (a)
(Monodelphis domestica)
Mammalia TMEM167B 34
  • 40 (a)
(Gallus gallus)
Aves TMEM167B 33 34
  • 71.62 (n)
(Anolis carolinensis)
Reptilia TMEM167B 34
  • 89 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem167b 33
  • 72.52 (n)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19645 33
(Danio rerio)
Actinopterygii tmem167b 33 34
  • 75.23 (n)
(Caenorhabditis elegans)
Secernentea K07F5.15 33
  • 63.43 (n)
Species where no ortholog for TMEM167B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM167B Gene

Gene Tree for TMEM167B (if available)
Gene Tree for TMEM167B (if available)

Paralogs for TMEM167B Gene

Paralogs for TMEM167B Gene

(1) SIMAP similar genes for TMEM167B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM167B: view

Variants for TMEM167B Gene

Sequence variations from dbSNP and Humsavar for TMEM167B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000055214 -- 109,091,740(+) GGTAG(C/T)ACGTG intron-variant, nc-transcript-variant, upstream-variant-2KB
rs1000463595 -- 109,092,489(+) ATTCC(C/T)GGGAT intron-variant, upstream-variant-2KB
rs1000656111 -- 109,093,111(+) TTATA(C/T)TTGGT intron-variant
rs1000890721 -- 109,090,990(+) GCCCG(C/G)CCCCC intron-variant, upstream-variant-2KB
rs1000957868 -- 109,093,471(+) CAGGT(A/G)ACAGG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM167B Gene

Variant ID Type Subtype PubMed ID
esv3894001 CNV gain 25118596
nsv831026 CNV loss 17160897

Variation tolerance for TMEM167B Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM167B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM167B Gene

Disorders for TMEM167B Gene

Relevant External Links for TMEM167B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for TMEM167B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM167B Gene

Publications for TMEM167B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory SG … Prigmore E (Nature 2006) 3 4 60
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 2 3 60
  4. Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PMID: 10931946) Hu RM … Chen JL (Proceedings of the National Academy of Sciences of the United States of America 2000) 3 4 60
  5. A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PMID: 19942856) Wendler F … Munro S (The EMBO journal 2010) 4 60

Products for TMEM167B Gene

Sources for TMEM167B Gene

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