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Aliases for TMEM167B Gene

Aliases for TMEM167B Gene

  • Transmembrane Protein 167B 2 3 4 5
  • C1orf119 3 4
  • Chromosome 1 Open Reading Frame 119 2
  • Protein X 013 3
  • AD-020 3

External Ids for TMEM167B Gene

Previous HGNC Symbols for TMEM167B Gene

  • C1orf119

Previous GeneCards Identifiers for TMEM167B Gene

  • GC01P109432
  • GC01P109630
  • GC01P107526

Summaries for TMEM167B Gene

GeneCards Summary for TMEM167B Gene

TMEM167B (Transmembrane Protein 167B) is a Protein Coding gene.

UniProtKB/Swiss-Prot for TMEM167B Gene

  • Involved in the early part of the secretory pathway.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for TMEM167B Gene

Genomics for TMEM167B Gene

Regulatory Elements for TMEM167B Gene

Promoters for TMEM167B Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around TMEM167B on UCSC Golden Path with GeneCards custom track

Genomic Location for TMEM167B Gene

Chromosome:
1
Start:
109,089,803 bp from pter
End:
109,096,934 bp from pter
Size:
7,132 bases
Orientation:
Plus strand

Genomic View for TMEM167B Gene

Genes around TMEM167B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
TMEM167B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for TMEM167B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for TMEM167B Gene

Proteins for TMEM167B Gene

  • Protein details for TMEM167B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9NRX6-KISHB_HUMAN
    Recommended name:
    Protein kish-B
    Protein Accession:
    Q9NRX6
    Secondary Accessions:
    • B2RUU9

    Protein attributes for TMEM167B Gene

    Size:
    74 amino acids
    Molecular mass:
    8294 Da
    Quaternary structure:
    No Data Available

neXtProt entry for TMEM167B Gene

Proteomics data for TMEM167B Gene at MOPED

Post-translational modifications for TMEM167B Gene

No Post-translational modifications

Other Protein References for TMEM167B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for TMEM167B Gene

Domains & Families for TMEM167B Gene

Protein Domains for TMEM167B Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for TMEM167B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9NRX6

UniProtKB/Swiss-Prot:

KISHB_HUMAN :
  • Belongs to the KISH family.
Family:
  • Belongs to the KISH family.
genes like me logo Genes that share domains with TMEM167B: view

No data available for Gene Families for TMEM167B Gene

Function for TMEM167B Gene

Molecular function for TMEM167B Gene

UniProtKB/Swiss-Prot Function:
Involved in the early part of the secretory pathway.
genes like me logo Genes that share phenotypes with TMEM167B: view

Animal Model Products

CRISPR Products

miRNA for TMEM167B Gene

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for TMEM167B Gene

Localization for TMEM167B Gene

Subcellular locations from UniProtKB/Swiss-Prot for TMEM167B Gene

Golgi apparatus membrane; Single-pass type I membrane protein.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for TMEM167B Gene COMPARTMENTS Subcellular localization image for TMEM167B gene
Compartment Confidence
extracellular 3
golgi apparatus 3

Gene Ontology (GO) - Cellular Components for TMEM167B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with TMEM167B: view

Pathways & Interactions for TMEM167B Gene

SuperPathways for TMEM167B Gene

No Data Available

Interacting Proteins for TMEM167B Gene

Gene Ontology (GO) - Biological Process for TMEM167B Gene

None

No data available for Pathways by source and SIGNOR curated interactions for TMEM167B Gene

Drugs & Compounds for TMEM167B Gene

No Compound Related Data Available

Transcripts for TMEM167B Gene

Unigene Clusters for TMEM167B Gene

Transmembrane protein 167B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for TMEM167B Gene

No ASD Table

Relevant External Links for TMEM167B Gene

GeneLoc Exon Structure for
TMEM167B
ECgene alternative splicing isoforms for
TMEM167B

Expression for TMEM167B Gene

mRNA expression in normal human tissues for TMEM167B Gene

Protein differential expression in normal tissues from HIPED for TMEM167B Gene

This gene is overexpressed in Placenta (21.6), Oral epithelium (10.6), Prostate (8.1), and Gallbladder (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for TMEM167B Gene



SOURCE GeneReport for Unigene cluster for TMEM167B Gene Hs.82933

genes like me logo Genes that share expression patterns with TMEM167B: view

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for TMEM167B Gene

Orthologs for TMEM167B Gene

This gene was present in the common ancestor of animals.

Orthologs for TMEM167B Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TMEM167B 35
  • 94.59 (n)
  • 98.65 (a)
TMEM167B 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia TMEM167B 35
  • 96.4 (n)
  • 98.65 (a)
TMEM167B 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Tmem167b 35
  • 93.69 (n)
  • 98.65 (a)
Tmem167b 16
Tmem167b 36
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TMEM167B 35
  • 100 (n)
  • 100 (a)
TMEM167B 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Tmem167b 35
  • 94.59 (n)
  • 98.65 (a)
oppossum
(Monodelphis domestica)
Mammalia TMEM167B 36
  • 40 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia TMEM167B 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves TMEM167B 35
  • 71.62 (n)
  • 79.73 (a)
TMEM167B 36
  • 80 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TMEM167B 36
  • 89 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia tmem167b 35
  • 72.52 (n)
  • 85.14 (a)
African clawed frog
(Xenopus laevis)
Amphibia Xl.19645 35
zebrafish
(Danio rerio)
Actinopterygii tmem167b 35
  • 75.23 (n)
  • 81.08 (a)
tmem167b 36
  • 81 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea K07F5.15 35
  • 63.43 (n)
  • 66.67 (a)
Species with no ortholog for TMEM167B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for TMEM167B Gene

ENSEMBL:
Gene Tree for TMEM167B (if available)
TreeFam:
Gene Tree for TMEM167B (if available)

Paralogs for TMEM167B Gene

(1) SIMAP similar genes for TMEM167B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with TMEM167B: view

No data available for Paralogs for TMEM167B Gene

Variants for TMEM167B Gene

Sequence variations from dbSNP and Humsavar for TMEM167B Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs6765 -- 109,096,568(+) TGAGA(G/T)GTTTT utr-variant-3-prime
rs10292 -- 109,096,488(-) GAACT(A/G)TGGAA utr-variant-3-prime
rs14707 -- 109,096,825(-) ACAGG(A/G)TTTAT utr-variant-3-prime
rs551001 -- 109,094,607(+) GTCCC(C/G)AGGAT utr-variant-3-prime
rs512671 -- 109,092,776(+) TGTTG(A/G)GGTTA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for TMEM167B Gene

Variant ID Type Subtype PubMed ID
nsv831026 CNV Loss 17160897

Variation tolerance for TMEM167B Gene

Residual Variation Intolerance Score: 49.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.13; 3.05% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for TMEM167B Gene

HapMap Linkage Disequilibrium report
TMEM167B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for TMEM167B Gene

Disorders for TMEM167B Gene

Relevant External Links for TMEM167B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
TMEM167B

No disorders were found for TMEM167B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for TMEM167B Gene

Publications for TMEM167B Gene

  1. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4 67
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 2 3
  3. Ubiquitin-mediated proteolysis of HuR by heat shock. (PMID: 19322201) Abdelmohsen K. … Gorospe M. (EMBO J. 2009) 3
  4. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3
  5. Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions. (PMID: 15342556) Suzuki Y. … Sugano S. (Genome Res. 2004) 3

Products for TMEM167B Gene

Sources for TMEM167B Gene

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