TMEM167B Gene
protein-coding GIFtS: 38
GCID: GC01P109630
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transmembrane protein 167B(Previous name: chromosome 1 open reading frame 119 )
(Previous symbol: C1orf119)
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Aliases
for TMEM167B gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Transmembrane Protein 167B1 2 3 | | Chromosome 1 Open Reading Frame 1191 | | C1orf1191 2 3 | | Protein Kish-B2 | | AD-0201 | | Protein X 0132 | | FLJ907101 | | |
Export aliases for TMEM167B gene to outside databasesPrevious GC identifers: GC01P109432 GC01P107526 |
Summaries
for TMEM167B gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: KISHB_HUMAN, Q9NRX6Function: Involved in the early part of the secretory pathway
|
Genomic Views
for TMEM167B gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_032977.9
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the TMEM167B gene promoter:
COUP-TF1 TBP C/EBPbeta COUP HNF-4alpha2 HNF-4alpha1 SRY E2F-1 COUP-TF E2F
Other transcription factors
Search SABiosciences Chromatin IP Primers for TMEM167B
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM167B |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1p13.3 Ensembl cytogenetic band: 1p13.3 HGNC cytogenetic band: 1p13.3TMEM167B Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P109630: view genomic region
(about GC identifiers)
Start:
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109,633,357 bp from pter |
End:
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109,639,556 bp from pter |
Size:
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6,200 bases |
Orientation:
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plus strand |
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Proteins
for TMEM167B gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: KISHB_HUMAN, Q9NRX6 (See
protein sequence)Recommended Name: Protein kish-B precursor Size: 74 amino acids; 8294 Da
Subcellular location: Golgi apparatus membrane; Single-pass type I membrane protein
Secondary accessions: B2RUU9Explore the universe of human proteins at neXtProt for TMEM167B: NX_Q9NRX6
TMEM167B Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_064526.1
ENSEMBL proteins: ENSP00000342148
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
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| GO:0000139 | Golgi membrane |
IEA | -- | | GO:0016021 | integral to membrane |
IEA | -- |
TMEM167B for ontologies About GeneDecksing
TMEM167B Antibody Products:
Assay Products for TMEM167B: |
Protein
Domains /
Families
for TMEM167B gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
TMEM167B for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry Q9NRX6ProtoNet protein and cluster: Q9NRX6 UniProtKB/Swiss-Prot: KISHB_HUMAN, Q9NRX6Similarity: Belongs to the KISH family |
Function
for TMEM167B gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: KISHB_HUMAN, Q9NRX6Function: Involved in the early part of the secretory pathway
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: TMEM167B (NM_020141) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM167B | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167B |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167B |
3 GenomeRNAi human phenotypes for TMEM167B:
|
Pathways & Interactions
for TMEM167B gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for TMEM167B
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
1 Interacting protein for TMEM167B (ENSP000003421484) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for TMEM167B gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for TMEM167B
Search CenterWatch for drugs/clinical trials and news about TMEM167B / KISHB
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Transcripts
for TMEM167B gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for TMEM167B gene: NM_020141.3 Unigene Cluster for TMEM167B: Transmembrane protein 167B Hs.82933 [show with all ESTs]Unigene Representative Sequence: BC1718493 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000338272(uc001dwn.3 uc009weu.3) ENST00000479160 ENST00000473828
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: TMEM167B (NM_020141) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for TMEM167B | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167B |
Additional cDNA sequence: AF164793.1 AK075191.1 AK291293.1 AK310192.1 BC008739.2 BC065186.1 BC066918.1 BC067116.1 BC146873.1 BC146879.1 BC171849.1 10 DOTS entries: DT.448207 DT.97835115 DT.91753786 DT.121406204 DT.100815639 DT.95070328 DT.100815637 DT.100815638 DT.121406213 DT.92063548 24/290 AceView cDNA sequences (see all 290): BP379986 BU628252 AA782199 AA147573 BM710813 H94026 AI476366 AA486342 AI290888 AA460653 AA291193 BE935694 AI207900 BM716142 BC065186 AI298806 BQ216917 BC067116 BM976566 AI203990 BC008739 CB122059 BM667647 BQ933108
GeneLoc Exon Structure
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Expression
for TMEM167B gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| TMEM167B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See TMEM167B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for TMEM167B
SOURCE GeneReport for Unigene cluster: Hs.82933
SABiosciences Custom PCR Arrays for TMEM167B
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM167B
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat TMEM167B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM167B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM167B | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167B |
Orthologs
for TMEM167B gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for TMEM167B gene from 6/16 species (see all 16) About this table
ENSEMBL Gene Tree for TMEM167B (if available)
TreeFam Gene Tree for TMEM167B (if available) |
Paralogs
for TMEM167B gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for TMEM167B gene
- TMEM167A2
1 SIMAP similar gene for TMEM167B using alignment to 1 protein entry: KISHB_HUMAN:TMEM167A
TMEM167B for paralogs About GeneDecksing
|
Genomic Variants
for TMEM167B gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for TMEM167B (109633357 - 109639556 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for TMEM167B
1 CNV: 4241 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM167B |
|
Disorders
/ Diseases
for TMEM167B gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for TMEM167B gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for TMEM167B gene integrated from 9 sources:
(articles sorted by number of sources associating them with TMEM167B) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning. (PubMed id 10931946)1, 2 Hu R.-M.... Chen J.-L. (2000)
- A genome-wide RNA interference screen identifies two novel components of the metazoan secretory pathway. (PubMed id 19942856)2 Wendler F....Munro S. (2010)
- Ubiquitin-mediated proteolysis of HuR by heat shock. (PubMed id 19322201)1 Abdelmohsen K....Gorospe M. (2009)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
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External Searches for TMEM167B gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing TMEM167B gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing TMEM167B gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing TMEM167B gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for TMEM167B | Pharmacogenomics, SNPs, Pathways |
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About This Section
| Patent Information for TMEM167B gene:
Search GeneIP for patents involving TMEM167B
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for TMEM167B gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for TMEM167B | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for TMEM167B | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for TMEM167B | | | OriGene Protein Over-expression Lysate for TMEM167B | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for TMEM167B | | OriGene 3'-UTR Clone for TMEM167B | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for TMEM167B | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat TMEM167B | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing TMEM167B | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat TMEM167B | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat TMEM167B | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat TMEM167B | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat TMEM167B |
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 | | | TMEM167B Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for TMEM167B |
|  |  |  | | | | Search ThermoFisher Antibodies for TMEM167B |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat TMEM167B |
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